TY  - JOUR
AU  - Jovanović-Ćupić, Snežana P.
AU  - Glišić, Sanja
AU  - Stanojevic, M.
AU  - Vasiljević, N.
AU  - Bojić, Tijana
AU  - Božović, Ana M.
AU  - Dimitrijević, Bogomir B.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5858
AB  - Hepatitis C virus infection is the most common chronic blood-borne infection and one of the most important causes of chronic liver disease. Knowing the predictors associated with pegylated interferon/ribavirin (PEG-IFN/RBV) combination therapy response is important for evidence-based treatment recommendations. The goal of this study was to identify host and viral factors of response to PEG-IFN/RBV treatment in chronic hepatitis C genotype 1b patients. We have examined the relationship between gender, age, level of alanine aminotransferase (ALT), viral load and liver fibrosis progression on therapy response. ALT level and viral load were evaluated before starting treatment with combination therapy. The elevated levels of ALT and route of HCV transmission were found to be significantly associated with the response to therapy in HCV-infected patients. Our findings may be useful for estimating a patients likelihood Of achieving sustained viral response.
T2  - Archives of Biological Sciences
T1  - Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b
VL  - 66
IS  - 1
SP  - 193
EP  - 201
DO  - 10.2298/ABS1401193J
ER  - 

@article{
author = "Jovanović-Ćupić, Snežana P. and Glišić, Sanja and Stanojevic, M. and Vasiljević, N. and Bojić, Tijana and Božović, Ana M. and Dimitrijević, Bogomir B.",
year = "2014",
abstract = "Hepatitis C virus infection is the most common chronic blood-borne infection and one of the most important causes of chronic liver disease. Knowing the predictors associated with pegylated interferon/ribavirin (PEG-IFN/RBV) combination therapy response is important for evidence-based treatment recommendations. The goal of this study was to identify host and viral factors of response to PEG-IFN/RBV treatment in chronic hepatitis C genotype 1b patients. We have examined the relationship between gender, age, level of alanine aminotransferase (ALT), viral load and liver fibrosis progression on therapy response. ALT level and viral load were evaluated before starting treatment with combination therapy. The elevated levels of ALT and route of HCV transmission were found to be significantly associated with the response to therapy in HCV-infected patients. Our findings may be useful for estimating a patients likelihood Of achieving sustained viral response.",
journal = "Archives of Biological Sciences",
title = "Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b",
volume = "66",
number = "1",
pages = "193-201",
doi = "10.2298/ABS1401193J"
}

Jovanović-Ćupić, S. P., Glišić, S., Stanojevic, M., Vasiljević, N., Bojić, T., Božović, A. M.,& Dimitrijević, B. B.. (2014). Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b. in Archives of Biological Sciences, 66(1), 193-201.
https://doi.org/10.2298/ABS1401193J

Jovanović-Ćupić SP, Glišić S, Stanojevic M, Vasiljević N, Bojić T, Božović AM, Dimitrijević BB. Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b. in Archives of Biological Sciences. 2014;66(1):193-201.
doi:10.2298/ABS1401193J .

Jovanović-Ćupić, Snežana P., Glišić, Sanja, Stanojevic, M., Vasiljević, N., Bojić, Tijana, Božović, Ana M., Dimitrijević, Bogomir B., "Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b" in Archives of Biological Sciences, 66, no. 1 (2014):193-201,
https://doi.org/10.2298/ABS1401193J . .

TY  - CONF
AU  - Vasiljević, N.
AU  - Veljković, Nevena V.
AU  - Jovanović-Ćupić, Snežana P.
AU  - Glišić, Sanja
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4043
AB  - Background:Numerous studies have reported a relationship betweenhepatitis C virus (HCV) genotype and the response to interferon therapy.Despite high sensitivity and specificity, genotyping methods can be per-formed only on HCV RNA positive samples. Serotyping might be a rapidand cost effective method for determining HCV genotypes, especially inpatients with previously undetectable HCV RNA.Aim:The aim of this study was to select NS5A-derived peptides whichmay represent candidate specific markers for determination of HCVgenotypes by serotyping.Methods:The conserved structural and informational properties of HCVNS5A protein have been determined by the informational spectrum method(ISM), representing virtual spectroscopy method for analysis of relationshipbetween structure and function of proteins.Results:The ISM analysis revealed that NS5A proteins from HCV geno-types 1,2,3,4 and 6 encode the conserved information which is specific foreasch particular genotype, and which is represented by IS frequenciesF1(0.258), F2(0.271), F3(0.053), F4(0.205) and F6(0.146), respectively. TheNS5-derived peptides P1(120-152), P2(383-417), P3(405-439), P4(171-205), P6(374-408) are identified as domains that are essential for conservedinformation characterizing HCV genotypes 1, 2, 3, 4 and 6.Conclusions:Peptides P1, P2, P3, P4 and P6 derived from NS5A proteinrepresent candidate markers for simple and fast identification of HCVgenotypes by serotyping
C3  - Vox Sanguinis
T1  - Selection of Ns5a-Derived Peptides for Determination of Hcv Genotypes By Serotyping
VL  - 99
IS  - Supp: 1
SP  - 299
DO  - 10.1111/j.1423-0410.2010.01343_2.x
UR  - https://hdl.handle.net/21.15107/rcub_vinar_4043
ER  - 

@conference{
author = "Vasiljević, N. and Veljković, Nevena V. and Jovanović-Ćupić, Snežana P. and Glišić, Sanja",
year = "2010",
abstract = "Background:Numerous studies have reported a relationship betweenhepatitis C virus (HCV) genotype and the response to interferon therapy.Despite high sensitivity and specificity, genotyping methods can be per-formed only on HCV RNA positive samples. Serotyping might be a rapidand cost effective method for determining HCV genotypes, especially inpatients with previously undetectable HCV RNA.Aim:The aim of this study was to select NS5A-derived peptides whichmay represent candidate specific markers for determination of HCVgenotypes by serotyping.Methods:The conserved structural and informational properties of HCVNS5A protein have been determined by the informational spectrum method(ISM), representing virtual spectroscopy method for analysis of relationshipbetween structure and function of proteins.Results:The ISM analysis revealed that NS5A proteins from HCV geno-types 1,2,3,4 and 6 encode the conserved information which is specific foreasch particular genotype, and which is represented by IS frequenciesF1(0.258), F2(0.271), F3(0.053), F4(0.205) and F6(0.146), respectively. TheNS5-derived peptides P1(120-152), P2(383-417), P3(405-439), P4(171-205), P6(374-408) are identified as domains that are essential for conservedinformation characterizing HCV genotypes 1, 2, 3, 4 and 6.Conclusions:Peptides P1, P2, P3, P4 and P6 derived from NS5A proteinrepresent candidate markers for simple and fast identification of HCVgenotypes by serotyping",
journal = "Vox Sanguinis",
title = "Selection of Ns5a-Derived Peptides for Determination of Hcv Genotypes By Serotyping",
volume = "99",
number = "Supp: 1",
pages = "299",
doi = "10.1111/j.1423-0410.2010.01343_2.x",
url = "https://hdl.handle.net/21.15107/rcub_vinar_4043"
}

Vasiljević, N., Veljković, N. V., Jovanović-Ćupić, S. P.,& Glišić, S.. (2010). Selection of Ns5a-Derived Peptides for Determination of Hcv Genotypes By Serotyping. in Vox Sanguinis, 99(Supp: 1), 299.
https://doi.org/10.1111/j.1423-0410.2010.01343_2.x
https://hdl.handle.net/21.15107/rcub_vinar_4043

Vasiljević N, Veljković NV, Jovanović-Ćupić SP, Glišić S. Selection of Ns5a-Derived Peptides for Determination of Hcv Genotypes By Serotyping. in Vox Sanguinis. 2010;99(Supp: 1):299.
doi:10.1111/j.1423-0410.2010.01343_2.x
https://hdl.handle.net/21.15107/rcub_vinar_4043 .

Vasiljević, N., Veljković, Nevena V., Jovanović-Ćupić, Snežana P., Glišić, Sanja, "Selection of Ns5a-Derived Peptides for Determination of Hcv Genotypes By Serotyping" in Vox Sanguinis, 99, no. Supp: 1 (2010):299,
https://doi.org/10.1111/j.1423-0410.2010.01343_2.x .,
https://hdl.handle.net/21.15107/rcub_vinar_4043 .