TY  - JOUR
AU  - Velazquez, Eric J.
AU  - Lee, Kerry L.
AU  - Deja, Marek A.
AU  - Jain, Anil
AU  - Sopko, George
AU  - Marchenko, Andrey
AU  - Ali, Imtiaz S.
AU  - Pohost, Gerald
AU  - Gradinac, Sinisa
AU  - Abraham, William T.
AU  - Yii, Michael
AU  - Prabhakaran, Dorairaj
AU  - Szwed, Hanna
AU  - Ferrazzi, Paolo
AU  - Petrie, Mark C.
AU  - O'Connor, Christopher M.
AU  - Panchavinnin, Pradit
AU  - She, Lilin
AU  - Bonow, Robert O.
AU  - Rankin, Gena Roush
AU  - Jones, Robert H.
AU  - Rouleau, Jean-Lucien
AU  - STICH Investigators
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4287
AB  - BACKGROUND The role of coronary-artery bypass grafting (CABG) in the treatment of patients with coronary artery disease and heart failure has not been clearly established. METHODS Between July 2002 and May 2007, a total of 1212 patients with an ejection fraction of 35% or less and coronary artery disease amenable to CABG were randomly assigned to medical therapy alone (602 patients) or medical therapy plus CABG (610 patients). The primary outcome was the rate of death from any cause. Major secondary outcomes included the rates of death from cardiovascular causes and of death from any cause or hospitalization for cardiovascular causes. RESULTS The primary outcome occurred in 244 patients (41%) in the medical-therapy group and 218 (36%) in the CABG group (hazard ratio with CABG, 0.86; 95% confidence interval [CI], 0.72 to 1.04; P = 0.12). A total of 201 patients (33%) in the medical-therapy group and 168 (28%) in the CABG group died from an adjudicated cardiovascular cause (hazard ratio with CABG, 0.81; 95% CI, 0.66 to 1.00; P = 0.05). Death from any cause or hospitalization for cardiovascular causes occurred in 411 patients (68%) in the medical-therapy group and 351 (58%) in the CABG group (hazard ratio with CABG, 0.74; 95% CI, 0.64 to 0.85; P LT 0.001). By the end of the follow-up period (median, 56 months), 100 patients in the medical-therapy group (17%) underwent CABG, and 555 patients in the CABG group (91%) underwent CABG. CONCLUSIONS In this randomized trial, there was no significant difference between medical therapy alone and medical therapy plus CABG with respect to the primary end point of death from any cause. Patients assigned to CABG, as compared with those assigned to medical therapy alone, had lower rates of death from cardiovascular causes and of death from any cause or hospitalization for cardiovascular causes.
T2  - New England Journal of Medicine
T1  - Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction
VL  - 364
IS  - 17
SP  - 1607
EP  - 1616
DO  - 10.1056/NEJMoa1100356
ER  - 

@article{
author = "Velazquez, Eric J. and Lee, Kerry L. and Deja, Marek A. and Jain, Anil and Sopko, George and Marchenko, Andrey and Ali, Imtiaz S. and Pohost, Gerald and Gradinac, Sinisa and Abraham, William T. and Yii, Michael and Prabhakaran, Dorairaj and Szwed, Hanna and Ferrazzi, Paolo and Petrie, Mark C. and O'Connor, Christopher M. and Panchavinnin, Pradit and She, Lilin and Bonow, Robert O. and Rankin, Gena Roush and Jones, Robert H. and Rouleau, Jean-Lucien and STICH Investigators",
year = "2011",
abstract = "BACKGROUND The role of coronary-artery bypass grafting (CABG) in the treatment of patients with coronary artery disease and heart failure has not been clearly established. METHODS Between July 2002 and May 2007, a total of 1212 patients with an ejection fraction of 35% or less and coronary artery disease amenable to CABG were randomly assigned to medical therapy alone (602 patients) or medical therapy plus CABG (610 patients). The primary outcome was the rate of death from any cause. Major secondary outcomes included the rates of death from cardiovascular causes and of death from any cause or hospitalization for cardiovascular causes. RESULTS The primary outcome occurred in 244 patients (41%) in the medical-therapy group and 218 (36%) in the CABG group (hazard ratio with CABG, 0.86; 95% confidence interval [CI], 0.72 to 1.04; P = 0.12). A total of 201 patients (33%) in the medical-therapy group and 168 (28%) in the CABG group died from an adjudicated cardiovascular cause (hazard ratio with CABG, 0.81; 95% CI, 0.66 to 1.00; P = 0.05). Death from any cause or hospitalization for cardiovascular causes occurred in 411 patients (68%) in the medical-therapy group and 351 (58%) in the CABG group (hazard ratio with CABG, 0.74; 95% CI, 0.64 to 0.85; P LT 0.001). By the end of the follow-up period (median, 56 months), 100 patients in the medical-therapy group (17%) underwent CABG, and 555 patients in the CABG group (91%) underwent CABG. CONCLUSIONS In this randomized trial, there was no significant difference between medical therapy alone and medical therapy plus CABG with respect to the primary end point of death from any cause. Patients assigned to CABG, as compared with those assigned to medical therapy alone, had lower rates of death from cardiovascular causes and of death from any cause or hospitalization for cardiovascular causes.",
journal = "New England Journal of Medicine",
title = "Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction",
volume = "364",
number = "17",
pages = "1607-1616",
doi = "10.1056/NEJMoa1100356"
}

Velazquez, E. J., Lee, K. L., Deja, M. A., Jain, A., Sopko, G., Marchenko, A., Ali, I. S., Pohost, G., Gradinac, S., Abraham, W. T., Yii, M., Prabhakaran, D., Szwed, H., Ferrazzi, P., Petrie, M. C., O'Connor, C. M., Panchavinnin, P., She, L., Bonow, R. O., Rankin, G. R., Jones, R. H., Rouleau, J.,& STICH Investigators. (2011). Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction. in New England Journal of Medicine, 364(17), 1607-1616.
https://doi.org/10.1056/NEJMoa1100356

Velazquez EJ, Lee KL, Deja MA, Jain A, Sopko G, Marchenko A, Ali IS, Pohost G, Gradinac S, Abraham WT, Yii M, Prabhakaran D, Szwed H, Ferrazzi P, Petrie MC, O'Connor CM, Panchavinnin P, She L, Bonow RO, Rankin GR, Jones RH, Rouleau J, STICH Investigators. Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction. in New England Journal of Medicine. 2011;364(17):1607-1616.
doi:10.1056/NEJMoa1100356 .

Velazquez, Eric J., Lee, Kerry L., Deja, Marek A., Jain, Anil, Sopko, George, Marchenko, Andrey, Ali, Imtiaz S., Pohost, Gerald, Gradinac, Sinisa, Abraham, William T., Yii, Michael, Prabhakaran, Dorairaj, Szwed, Hanna, Ferrazzi, Paolo, Petrie, Mark C., O'Connor, Christopher M., Panchavinnin, Pradit, She, Lilin, Bonow, Robert O., Rankin, Gena Roush, Jones, Robert H., Rouleau, Jean-Lucien, STICH Investigators, "Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction" in New England Journal of Medicine, 364, no. 17 (2011):1607-1616,
https://doi.org/10.1056/NEJMoa1100356 . .