TY  - JOUR
AU  - Panić, Vesna V.
AU  - Jovanović, Jelena D.
AU  - Spasojević, Jelena P.
AU  - Savić, Sanja I.
AU  - Marković, Maja D.
AU  - Radulović, Aleksandra M.
AU  - Adnađević, Borivoj K.
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12960
AB  - High concentrations of LTA zeolite (27-52mass%) were embedded in poly(methacrylic acid) (PMAA) matrix to obtain composite hydrogels with porosity and active sites originating from both components. Substandard mechanics of PMAA and aggregation of zeolite particles, were thereby overcome. The composites had remarkably higher density than PMAA xerogel (1700 to1400 kg m−3), higher crosslinking density (54.8 to1.29 mol m−3) and lower swelling degree (41 to 420 kg kg−1). Zeolite particles were uniformly dispersed in PMAA matrix and there was no agglomeration or leaching of zeolite despite very high concentrations. XRD patterns revealed that the inclusion of zeolite particles affected the short-range order in the PMAA matrix. Being an active filler LTA zeolite notably improved thermal stability and mechanics of PMAA hydrogel, multiplying the storage modulus 5.2 times in dry and 21.8 times in swollen state. Structure–property correlations were provided making the base for further development of tailor-made zeolite-PMAA composite hydrogels.
T2  - Chemical Engineering Science
T1  - Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite
VL  - 292
SP  - 119981
DO  - 10.1016/j.ces.2024.119981
ER  - 

@article{
author = "Panić, Vesna V. and Jovanović, Jelena D. and Spasojević, Jelena P. and Savić, Sanja I. and Marković, Maja D. and Radulović, Aleksandra M. and Adnađević, Borivoj K.",
year = "2024",
abstract = "High concentrations of LTA zeolite (27-52mass%) were embedded in poly(methacrylic acid) (PMAA) matrix to obtain composite hydrogels with porosity and active sites originating from both components. Substandard mechanics of PMAA and aggregation of zeolite particles, were thereby overcome. The composites had remarkably higher density than PMAA xerogel (1700 to1400 kg m−3), higher crosslinking density (54.8 to1.29 mol m−3) and lower swelling degree (41 to 420 kg kg−1). Zeolite particles were uniformly dispersed in PMAA matrix and there was no agglomeration or leaching of zeolite despite very high concentrations. XRD patterns revealed that the inclusion of zeolite particles affected the short-range order in the PMAA matrix. Being an active filler LTA zeolite notably improved thermal stability and mechanics of PMAA hydrogel, multiplying the storage modulus 5.2 times in dry and 21.8 times in swollen state. Structure–property correlations were provided making the base for further development of tailor-made zeolite-PMAA composite hydrogels.",
journal = "Chemical Engineering Science",
title = "Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite",
volume = "292",
pages = "119981",
doi = "10.1016/j.ces.2024.119981"
}

Panić, V. V., Jovanović, J. D., Spasojević, J. P., Savić, S. I., Marković, M. D., Radulović, A. M.,& Adnađević, B. K.. (2024). Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite. in Chemical Engineering Science, 292, 119981.
https://doi.org/10.1016/j.ces.2024.119981

Panić VV, Jovanović JD, Spasojević JP, Savić SI, Marković MD, Radulović AM, Adnađević BK. Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite. in Chemical Engineering Science. 2024;292:119981.
doi:10.1016/j.ces.2024.119981 .

Panić, Vesna V., Jovanović, Jelena D., Spasojević, Jelena P., Savić, Sanja I., Marković, Maja D., Radulović, Aleksandra M., Adnađević, Borivoj K., "Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite" in Chemical Engineering Science, 292 (2024):119981,
https://doi.org/10.1016/j.ces.2024.119981 . .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Tadić, Julijana D.
AU  - Savić, Sanja I.
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana P.
AU  - Mijin, Dušan Ž.
AU  - Panić, Vesna V.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10262
AB  - Researchers are faced with everyday demands for safer and more efficient therapy for many diseases, especially serious one such as various types of cancer. Numerous anticancer drugs are poorly-water soluble and therefore their encapsulation and controlled release remain quite challenge. In present study, we deepened our research of hydrophilic carrier based on poly(methacrylic acid) and casein (PMAC) by investigating its potential for encapsulation and controlled release of novel poorly water-soluble dihydropyrimidion-azo-pyridon compound (DHPMP). DHPMP is a dye that has been proven to show cytotoxic activity against chronic myeloid leukemia K562 cells. By encapsulating DHPMP into the carrier and delivering it into the intestines, DHPMP absorption could be the fastest and the number of therapeutic doses and side effects can be reduced. Carriers based on PMAC and DHPMP (PMAC-DHPMP) were synthetized and characterized by FTIR, SEM and single compression tests. The swelling behavior of PMAC-DHPMP carriers and cumulative DHPMP release were investigated depending on the amount of crosslinker and encapsulated DHPMP in two media which were simulating pH environments in human stomach and intestines. The prolonged and controlled release of DHPMP was achieved. In vitro cytotoxic activity of PMAC-DHPMP carriers against K562 cells and the cell cycle analysis showed great potential of the carriers for application in leukemia treatment.
T2  - Journal of Biomedical Materials Research - Part A
T1  - Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment
DO  - 10.1002/jbm.a.37396
ER  - 

@article{
author = "Marković, Maja D. and Tadić, Julijana D. and Savić, Sanja I. and Matić, Ivana Z. and Stanojković, Tatjana P. and Mijin, Dušan Ž. and Panić, Vesna V.",
year = "2022",
abstract = "Researchers are faced with everyday demands for safer and more efficient therapy for many diseases, especially serious one such as various types of cancer. Numerous anticancer drugs are poorly-water soluble and therefore their encapsulation and controlled release remain quite challenge. In present study, we deepened our research of hydrophilic carrier based on poly(methacrylic acid) and casein (PMAC) by investigating its potential for encapsulation and controlled release of novel poorly water-soluble dihydropyrimidion-azo-pyridon compound (DHPMP). DHPMP is a dye that has been proven to show cytotoxic activity against chronic myeloid leukemia K562 cells. By encapsulating DHPMP into the carrier and delivering it into the intestines, DHPMP absorption could be the fastest and the number of therapeutic doses and side effects can be reduced. Carriers based on PMAC and DHPMP (PMAC-DHPMP) were synthetized and characterized by FTIR, SEM and single compression tests. The swelling behavior of PMAC-DHPMP carriers and cumulative DHPMP release were investigated depending on the amount of crosslinker and encapsulated DHPMP in two media which were simulating pH environments in human stomach and intestines. The prolonged and controlled release of DHPMP was achieved. In vitro cytotoxic activity of PMAC-DHPMP carriers against K562 cells and the cell cycle analysis showed great potential of the carriers for application in leukemia treatment.",
journal = "Journal of Biomedical Materials Research - Part A",
title = "Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment",
doi = "10.1002/jbm.a.37396"
}

Marković, M. D., Tadić, J. D., Savić, S. I., Matić, I. Z., Stanojković, T. P., Mijin, D. Ž.,& Panić, V. V.. (2022). Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment. in Journal of Biomedical Materials Research - Part A.
https://doi.org/10.1002/jbm.a.37396

Marković MD, Tadić JD, Savić SI, Matić IZ, Stanojković TP, Mijin DŽ, Panić VV. Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment. in Journal of Biomedical Materials Research - Part A. 2022;.
doi:10.1002/jbm.a.37396 .

Marković, Maja D., Tadić, Julijana D., Savić, Sanja I., Matić, Ivana Z., Stanojković, Tatjana P., Mijin, Dušan Ž., Panić, Vesna V., "Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment" in Journal of Biomedical Materials Research - Part A (2022),
https://doi.org/10.1002/jbm.a.37396 . .

TY  - CONF
AU  - Tadić, Julijana
AU  - Lađarević, Jelena
AU  - Marković, Maja
AU  - Ivanovska, Aleksandra
AU  - Kostić, Mirjana
AU  - Mijin, Dušan Ž.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10885
AB  - Schiff bases, or azomethine compounds, are commonly employed in the fields of organicsynthesis, metal complexes, materials, and engineering. Especially, they have gainedimportance in medicinal researches, considering their antimicrobial, anticancer, antiinflammatory, and antioxidant properties. On the other side, azo dyes are the most significantgroup of synthetic dyes, utilized in textile fiber dyeing. Conjugation of Schiff bases with azocompounds leads to the class of azo-azomethine dyes, which have numerous applicationsrelated to their coloration and biological properties. Viscose is a textile material widely used inthe medicine. Moreover, viscose fiber can be engineered in many ways which are significant inthe development of medical materials. The antioxidant effect is an important feature of medicaltextiles, such as wound dressings. In this work, the microwave-assisted synthesis andcharacterization of novel azo-azomethine dye are reported. The azo-azomethine dye is obtainedby the condensation between arylazo pyridone dye and 4-aminophenol. The structure ofsynthesized dye was determined by ATR-FTIR, NMR, and UV-Vis spectroscopy. Azoazomethine dye was used for dyeing viscose, and the washing fastness of dyed material wasevaluated according to the standard method. The viscose fabrics, before and after washing, wereanalyzed in terms of their color coordinates in the CIELab color space. The antioxidantproperties of azo-azomethine dye and dyed viscose fabrics were examined by the ABTSmethod.
PB  - Kragujevac : University of Kragujevac, Institute for Information Technologies
C3  - ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings
T1  - A Novel Azo-azomethine Dye: Synthesis, Dyeing and Antioxidant Properties
SP  - 379
EP  - 382
DO  - 10.46793/ICCBI21.379T
ER  - 

@conference{
author = "Tadić, Julijana and Lađarević, Jelena and Marković, Maja and Ivanovska, Aleksandra and Kostić, Mirjana and Mijin, Dušan Ž.",
year = "2021",
abstract = "Schiff bases, or azomethine compounds, are commonly employed in the fields of organicsynthesis, metal complexes, materials, and engineering. Especially, they have gainedimportance in medicinal researches, considering their antimicrobial, anticancer, antiinflammatory, and antioxidant properties. On the other side, azo dyes are the most significantgroup of synthetic dyes, utilized in textile fiber dyeing. Conjugation of Schiff bases with azocompounds leads to the class of azo-azomethine dyes, which have numerous applicationsrelated to their coloration and biological properties. Viscose is a textile material widely used inthe medicine. Moreover, viscose fiber can be engineered in many ways which are significant inthe development of medical materials. The antioxidant effect is an important feature of medicaltextiles, such as wound dressings. In this work, the microwave-assisted synthesis andcharacterization of novel azo-azomethine dye are reported. The azo-azomethine dye is obtainedby the condensation between arylazo pyridone dye and 4-aminophenol. The structure ofsynthesized dye was determined by ATR-FTIR, NMR, and UV-Vis spectroscopy. Azoazomethine dye was used for dyeing viscose, and the washing fastness of dyed material wasevaluated according to the standard method. The viscose fabrics, before and after washing, wereanalyzed in terms of their color coordinates in the CIELab color space. The antioxidantproperties of azo-azomethine dye and dyed viscose fabrics were examined by the ABTSmethod.",
publisher = "Kragujevac : University of Kragujevac, Institute for Information Technologies",
journal = "ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings",
title = "A Novel Azo-azomethine Dye: Synthesis, Dyeing and Antioxidant Properties",
pages = "379-382",
doi = "10.46793/ICCBI21.379T"
}

Tadić, J., Lađarević, J., Marković, M., Ivanovska, A., Kostić, M.,& Mijin, D. Ž.. (2021). A Novel Azo-azomethine Dye: Synthesis, Dyeing and Antioxidant Properties. in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings
Kragujevac : University of Kragujevac, Institute for Information Technologies., 379-382.
https://doi.org/10.46793/ICCBI21.379T

Tadić J, Lađarević J, Marković M, Ivanovska A, Kostić M, Mijin DŽ. A Novel Azo-azomethine Dye: Synthesis, Dyeing and Antioxidant Properties. in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings. 2021;:379-382.
doi:10.46793/ICCBI21.379T .

Tadić, Julijana, Lađarević, Jelena, Marković, Maja, Ivanovska, Aleksandra, Kostić, Mirjana, Mijin, Dušan Ž., "A Novel Azo-azomethine Dye: Synthesis, Dyeing and Antioxidant Properties" in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings (2021):379-382,
https://doi.org/10.46793/ICCBI21.379T . .

TY  - CONF
AU  - Marković, Maja D.
AU  - Panić, Vesna V.
AU  - Tadić, Julijana D.
AU  - Pjanović, Rada V.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10884
AB  - Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficienttherapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based onpoly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pHsensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAAcan only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous researchwas directed towards overcoming this limitation: PMAA was modified with amphiphilic protein –casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study isfocused on investigation how variation of amount of one of the most important hydrogels networkparameter such as crosslinker affect PMAC swelling properties and caffeine release. The group ofhybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%,1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels andcaffeine release was investigated in two environments which simulated human stomach and intestines.Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved andthat its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can beeasily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential fortargeted delivery of poorly water-soluble active substances.
PB  - Kragujevac : University of Kragujevac, Institute for Information Technologies
C3  - ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings
T1  - Effect of crosslinker amount on hybrid hydrogels swelling and drug release
SP  - 125
EP  - 128
DO  - 10.46793/ICCBI21.125M
ER  - 

@conference{
author = "Marković, Maja D. and Panić, Vesna V. and Tadić, Julijana D. and Pjanović, Rada V.",
year = "2021",
abstract = "Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficienttherapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based onpoly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pHsensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAAcan only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous researchwas directed towards overcoming this limitation: PMAA was modified with amphiphilic protein –casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study isfocused on investigation how variation of amount of one of the most important hydrogels networkparameter such as crosslinker affect PMAC swelling properties and caffeine release. The group ofhybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%,1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels andcaffeine release was investigated in two environments which simulated human stomach and intestines.Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved andthat its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can beeasily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential fortargeted delivery of poorly water-soluble active substances.",
publisher = "Kragujevac : University of Kragujevac, Institute for Information Technologies",
journal = "ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings",
title = "Effect of crosslinker amount on hybrid hydrogels swelling and drug release",
pages = "125-128",
doi = "10.46793/ICCBI21.125M"
}

Marković, M. D., Panić, V. V., Tadić, J. D.,& Pjanović, R. V.. (2021). Effect of crosslinker amount on hybrid hydrogels swelling and drug release. in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings
Kragujevac : University of Kragujevac, Institute for Information Technologies., 125-128.
https://doi.org/10.46793/ICCBI21.125M

Marković MD, Panić VV, Tadić JD, Pjanović RV. Effect of crosslinker amount on hybrid hydrogels swelling and drug release. in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings. 2021;:125-128.
doi:10.46793/ICCBI21.125M .

Marković, Maja D., Panić, Vesna V., Tadić, Julijana D., Pjanović, Rada V., "Effect of crosslinker amount on hybrid hydrogels swelling and drug release" in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings (2021):125-128,
https://doi.org/10.46793/ICCBI21.125M . .

TY  - CONF
AU  - Marković, Maja D.
AU  - Tadić, Julijana
AU  - Pjanović, Rada V.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11423
AB  - Nowadays, humanity are faced with many challenges which affect health of people all aroundthe globe (such as climate change, new diseases and/or already present ones for which cure hasnot been found yet – cancer). The efforts of researchers on the field of drug delivery systemsbring everyday novel tools for safer and more effective therapy. pH sensitive hydrogels basedon poly(methacrylic acid) are recognized as materials with huge potential for controlled releaseof drugs. The encapsulation and controlled release of many chemotherapeutics is quitechallenge due to their poorly water-solubility. In our previous research we overcome thisproblem by modifying hydrophilic pol(methacrylic acid) with amphiphilic casein and showedthat prepared material have potential for encapsulation and controlled release of poorly watersoluble model drug – caffeine (PMAC carriers). In present study we deepened further ourresearch and employed various models: Ritger-Peppas, Higuchi and Kopcha model to analyzehow the change of crosslinker amount affect the mechanism of release kinetics of caffeine inmedium with pH of 6.8 (which simulated the environment in human intestines). Obtainedresults showed that only by changing one parameter such as crosslinker amount it is possible tofine tune the type of drug release mechanism, due to which the PMAC carriers would be ableto respond to the specific demands of therapy.
PB  - University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary
C3  - The 27 th International Symposium on Analytical and Environmental Problems
T1  - Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount
SP  - 203
EP  - 207
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11423
ER  - 

@conference{
author = "Marković, Maja D. and Tadić, Julijana and Pjanović, Rada V.",
year = "2021",
abstract = "Nowadays, humanity are faced with many challenges which affect health of people all aroundthe globe (such as climate change, new diseases and/or already present ones for which cure hasnot been found yet – cancer). The efforts of researchers on the field of drug delivery systemsbring everyday novel tools for safer and more effective therapy. pH sensitive hydrogels basedon poly(methacrylic acid) are recognized as materials with huge potential for controlled releaseof drugs. The encapsulation and controlled release of many chemotherapeutics is quitechallenge due to their poorly water-solubility. In our previous research we overcome thisproblem by modifying hydrophilic pol(methacrylic acid) with amphiphilic casein and showedthat prepared material have potential for encapsulation and controlled release of poorly watersoluble model drug – caffeine (PMAC carriers). In present study we deepened further ourresearch and employed various models: Ritger-Peppas, Higuchi and Kopcha model to analyzehow the change of crosslinker amount affect the mechanism of release kinetics of caffeine inmedium with pH of 6.8 (which simulated the environment in human intestines). Obtainedresults showed that only by changing one parameter such as crosslinker amount it is possible tofine tune the type of drug release mechanism, due to which the PMAC carriers would be ableto respond to the specific demands of therapy.",
publisher = "University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary",
journal = "The 27 th International Symposium on Analytical and Environmental Problems",
title = "Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount",
pages = "203-207",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11423"
}

Marković, M. D., Tadić, J.,& Pjanović, R. V.. (2021). Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount. in The 27 th International Symposium on Analytical and Environmental Problems
University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary., 203-207.
https://hdl.handle.net/21.15107/rcub_vinar_11423

Marković MD, Tadić J, Pjanović RV. Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount. in The 27 th International Symposium on Analytical and Environmental Problems. 2021;:203-207.
https://hdl.handle.net/21.15107/rcub_vinar_11423 .

Marković, Maja D., Tadić, Julijana, Pjanović, Rada V., "Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount" in The 27 th International Symposium on Analytical and Environmental Problems (2021):203-207,
https://hdl.handle.net/21.15107/rcub_vinar_11423 .