TY  - JOUR
AU  - Panić, Vesna V.
AU  - Jovanović, Jelena D.
AU  - Spasojević, Jelena P.
AU  - Savić, Sanja I.
AU  - Marković, Maja D.
AU  - Radulović, Aleksandra M.
AU  - Adnađević, Borivoj K.
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12960
AB  - High concentrations of LTA zeolite (27-52mass%) were embedded in poly(methacrylic acid) (PMAA) matrix to obtain composite hydrogels with porosity and active sites originating from both components. Substandard mechanics of PMAA and aggregation of zeolite particles, were thereby overcome. The composites had remarkably higher density than PMAA xerogel (1700 to1400 kg m−3), higher crosslinking density (54.8 to1.29 mol m−3) and lower swelling degree (41 to 420 kg kg−1). Zeolite particles were uniformly dispersed in PMAA matrix and there was no agglomeration or leaching of zeolite despite very high concentrations. XRD patterns revealed that the inclusion of zeolite particles affected the short-range order in the PMAA matrix. Being an active filler LTA zeolite notably improved thermal stability and mechanics of PMAA hydrogel, multiplying the storage modulus 5.2 times in dry and 21.8 times in swollen state. Structure–property correlations were provided making the base for further development of tailor-made zeolite-PMAA composite hydrogels.
T2  - Chemical Engineering Science
T1  - Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite
VL  - 292
SP  - 119981
DO  - 10.1016/j.ces.2024.119981
ER  - 

@article{
author = "Panić, Vesna V. and Jovanović, Jelena D. and Spasojević, Jelena P. and Savić, Sanja I. and Marković, Maja D. and Radulović, Aleksandra M. and Adnađević, Borivoj K.",
year = "2024",
abstract = "High concentrations of LTA zeolite (27-52mass%) were embedded in poly(methacrylic acid) (PMAA) matrix to obtain composite hydrogels with porosity and active sites originating from both components. Substandard mechanics of PMAA and aggregation of zeolite particles, were thereby overcome. The composites had remarkably higher density than PMAA xerogel (1700 to1400 kg m−3), higher crosslinking density (54.8 to1.29 mol m−3) and lower swelling degree (41 to 420 kg kg−1). Zeolite particles were uniformly dispersed in PMAA matrix and there was no agglomeration or leaching of zeolite despite very high concentrations. XRD patterns revealed that the inclusion of zeolite particles affected the short-range order in the PMAA matrix. Being an active filler LTA zeolite notably improved thermal stability and mechanics of PMAA hydrogel, multiplying the storage modulus 5.2 times in dry and 21.8 times in swollen state. Structure–property correlations were provided making the base for further development of tailor-made zeolite-PMAA composite hydrogels.",
journal = "Chemical Engineering Science",
title = "Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite",
volume = "292",
pages = "119981",
doi = "10.1016/j.ces.2024.119981"
}

Panić, V. V., Jovanović, J. D., Spasojević, J. P., Savić, S. I., Marković, M. D., Radulović, A. M.,& Adnađević, B. K.. (2024). Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite. in Chemical Engineering Science, 292, 119981.
https://doi.org/10.1016/j.ces.2024.119981

Panić VV, Jovanović JD, Spasojević JP, Savić SI, Marković MD, Radulović AM, Adnađević BK. Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite. in Chemical Engineering Science. 2024;292:119981.
doi:10.1016/j.ces.2024.119981 .

Panić, Vesna V., Jovanović, Jelena D., Spasojević, Jelena P., Savić, Sanja I., Marković, Maja D., Radulović, Aleksandra M., Adnađević, Borivoj K., "Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite" in Chemical Engineering Science, 292 (2024):119981,
https://doi.org/10.1016/j.ces.2024.119981 . .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Tadić, Julijana D.
AU  - Savić, Sanja I.
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana P.
AU  - Mijin, Dušan Ž.
AU  - Panić, Vesna V.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10262
AB  - Researchers are faced with everyday demands for safer and more efficient therapy for many diseases, especially serious one such as various types of cancer. Numerous anticancer drugs are poorly-water soluble and therefore their encapsulation and controlled release remain quite challenge. In present study, we deepened our research of hydrophilic carrier based on poly(methacrylic acid) and casein (PMAC) by investigating its potential for encapsulation and controlled release of novel poorly water-soluble dihydropyrimidion-azo-pyridon compound (DHPMP). DHPMP is a dye that has been proven to show cytotoxic activity against chronic myeloid leukemia K562 cells. By encapsulating DHPMP into the carrier and delivering it into the intestines, DHPMP absorption could be the fastest and the number of therapeutic doses and side effects can be reduced. Carriers based on PMAC and DHPMP (PMAC-DHPMP) were synthetized and characterized by FTIR, SEM and single compression tests. The swelling behavior of PMAC-DHPMP carriers and cumulative DHPMP release were investigated depending on the amount of crosslinker and encapsulated DHPMP in two media which were simulating pH environments in human stomach and intestines. The prolonged and controlled release of DHPMP was achieved. In vitro cytotoxic activity of PMAC-DHPMP carriers against K562 cells and the cell cycle analysis showed great potential of the carriers for application in leukemia treatment.
T2  - Journal of Biomedical Materials Research - Part A
T1  - Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment
DO  - 10.1002/jbm.a.37396
ER  - 

@article{
author = "Marković, Maja D. and Tadić, Julijana D. and Savić, Sanja I. and Matić, Ivana Z. and Stanojković, Tatjana P. and Mijin, Dušan Ž. and Panić, Vesna V.",
year = "2022",
abstract = "Researchers are faced with everyday demands for safer and more efficient therapy for many diseases, especially serious one such as various types of cancer. Numerous anticancer drugs are poorly-water soluble and therefore their encapsulation and controlled release remain quite challenge. In present study, we deepened our research of hydrophilic carrier based on poly(methacrylic acid) and casein (PMAC) by investigating its potential for encapsulation and controlled release of novel poorly water-soluble dihydropyrimidion-azo-pyridon compound (DHPMP). DHPMP is a dye that has been proven to show cytotoxic activity against chronic myeloid leukemia K562 cells. By encapsulating DHPMP into the carrier and delivering it into the intestines, DHPMP absorption could be the fastest and the number of therapeutic doses and side effects can be reduced. Carriers based on PMAC and DHPMP (PMAC-DHPMP) were synthetized and characterized by FTIR, SEM and single compression tests. The swelling behavior of PMAC-DHPMP carriers and cumulative DHPMP release were investigated depending on the amount of crosslinker and encapsulated DHPMP in two media which were simulating pH environments in human stomach and intestines. The prolonged and controlled release of DHPMP was achieved. In vitro cytotoxic activity of PMAC-DHPMP carriers against K562 cells and the cell cycle analysis showed great potential of the carriers for application in leukemia treatment.",
journal = "Journal of Biomedical Materials Research - Part A",
title = "Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment",
doi = "10.1002/jbm.a.37396"
}

Marković, M. D., Tadić, J. D., Savić, S. I., Matić, I. Z., Stanojković, T. P., Mijin, D. Ž.,& Panić, V. V.. (2022). Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment. in Journal of Biomedical Materials Research - Part A.
https://doi.org/10.1002/jbm.a.37396

Marković MD, Tadić JD, Savić SI, Matić IZ, Stanojković TP, Mijin DŽ, Panić VV. Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment. in Journal of Biomedical Materials Research - Part A. 2022;.
doi:10.1002/jbm.a.37396 .

Marković, Maja D., Tadić, Julijana D., Savić, Sanja I., Matić, Ivana Z., Stanojković, Tatjana P., Mijin, Dušan Ž., Panić, Vesna V., "Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment" in Journal of Biomedical Materials Research - Part A (2022),
https://doi.org/10.1002/jbm.a.37396 . .