TY  - JOUR
AU  - Milić, Mirjana M.
AU  - Jović Orsini, Nataša
AU  - Požek, Miroslav
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13123
AB  - Ferrofluids based on magnetic iron oxide nanoparticles (IONPs) have been widely studied as multipurpose agents in various medical applications including magnetic hyperthermia, targeted drug delivery and magnetic resonance imaging (MRI). To increase their stability and compatibility with the living cells and thus improve their suitability for these purposes, the IONPs are often functionalized with different organic or inorganic molecules. In this work we report on the preparation of polyvinilpyrrolidone (PVP) functionalized IONPs through a simple co-precipitation method and investigated their suitability for magnetic hyperthermia and as a MRI contrast agent. Spherical PVP-coated IONPs, with an average particle size of ≈ 15 nm, showed superparamagnetic behavior and high saturation magnetization Ms = 80.7 emug−1, at room temperature. The specific absorption rate (SAR), a measure of the heating ability, ranged from 17 W/g to 721 W/g (evaluated for various combinations of AC magnetic field amplitudes and frequencies), while the intrinsic loss power (ILP) was in the range from 0.53 nHm2 kg−1 to 2.34 nHm2 kg−1. In addition to relatively good heating ability, high T2 relaxivity, r2 = 126 mM−1 s−1 and high r2/r1 ratio demonstrated that the preparation procedure used here can yield nanoparticles suitable for MRI guided localized magnetic hyperthermia.
T2  - Applied Physics A
T1  - Evaluating PVP coated iron oxide particles for localized magnetic hyperthermia and MRI imaging
VL  - 130
IS  - 5
SP  - 275
DO  - 10.1007/s00339-024-07452-4
ER  - 

@article{
author = "Milić, Mirjana M. and Jović Orsini, Nataša and Požek, Miroslav",
year = "2024",
abstract = "Ferrofluids based on magnetic iron oxide nanoparticles (IONPs) have been widely studied as multipurpose agents in various medical applications including magnetic hyperthermia, targeted drug delivery and magnetic resonance imaging (MRI). To increase their stability and compatibility with the living cells and thus improve their suitability for these purposes, the IONPs are often functionalized with different organic or inorganic molecules. In this work we report on the preparation of polyvinilpyrrolidone (PVP) functionalized IONPs through a simple co-precipitation method and investigated their suitability for magnetic hyperthermia and as a MRI contrast agent. Spherical PVP-coated IONPs, with an average particle size of ≈ 15 nm, showed superparamagnetic behavior and high saturation magnetization Ms = 80.7 emug−1, at room temperature. The specific absorption rate (SAR), a measure of the heating ability, ranged from 17 W/g to 721 W/g (evaluated for various combinations of AC magnetic field amplitudes and frequencies), while the intrinsic loss power (ILP) was in the range from 0.53 nHm2 kg−1 to 2.34 nHm2 kg−1. In addition to relatively good heating ability, high T2 relaxivity, r2 = 126 mM−1 s−1 and high r2/r1 ratio demonstrated that the preparation procedure used here can yield nanoparticles suitable for MRI guided localized magnetic hyperthermia.",
journal = "Applied Physics A",
title = "Evaluating PVP coated iron oxide particles for localized magnetic hyperthermia and MRI imaging",
volume = "130",
number = "5",
pages = "275",
doi = "10.1007/s00339-024-07452-4"
}

Milić, M. M., Jović Orsini, N.,& Požek, M.. (2024). Evaluating PVP coated iron oxide particles for localized magnetic hyperthermia and MRI imaging. in Applied Physics A, 130(5), 275.
https://doi.org/10.1007/s00339-024-07452-4

Milić MM, Jović Orsini N, Požek M. Evaluating PVP coated iron oxide particles for localized magnetic hyperthermia and MRI imaging. in Applied Physics A. 2024;130(5):275.
doi:10.1007/s00339-024-07452-4 .

Milić, Mirjana M., Jović Orsini, Nataša, Požek, Miroslav, "Evaluating PVP coated iron oxide particles for localized magnetic hyperthermia and MRI imaging" in Applied Physics A, 130, no. 5 (2024):275,
https://doi.org/10.1007/s00339-024-07452-4 . .

TY  - JOUR
AU  - Babić-Stojić, Branka S.
AU  - Jokanović, Vukoman R.
AU  - Milivojević, Dušan
AU  - Pozek, Miroslav
AU  - Jagličić, Zvonko
AU  - Makovec, Darko
AU  - Jović Orsini, Nataša
AU  - Marković, Mirjana
AU  - Arsikin, Katarina M.
AU  - Paunović, Verica G.
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1889
AB  - Ultrasmall iron oxide (USPIO) nanoparticles, with diameter mostly less than 3 nm dispersed in an organic carrier fluid were synthesized by polyol route. The evolution of ZFC-FC magnetization curves with temperature, as well as the shift of the ac susceptibility peaks upon changing the frequency, reveal that the nanoparticles in the fluid are non-interacting and superparamagnetic with the blocking temperature T-B similar to 10 K. The Mossbauer spectra analysis proposed the core/shell structure of the nanoparticles consisting of stoichiometric gamma-Fe2O3 core and non-stoichiometric shell. The nanoparticle surface layer has a great influence on their properties which is principally manifested in significant reduction of the magnetization and in a large increase in magnetic anisotropy. Magnetic moments do not saturate in fields up to 5 T, even at the lowest measured temperature, T = 5 K. The average magnetic particle diameter is changed from 1.3 to 1.8 nm with increasing magnetic field from 0 to 5 T which is noticeably smaller than the particle sizes measured by TEM. The estimated effective magnetic anisotropy constant value, K-eff = 2 x 10(5) J/m(3), is two orders of magnitude higher than in the bulk maghemite. Measurements of the longitudinal and transverse NMR relaxivity parameters on water diluted nanoparticle dispersions at 1.5 T gave the values r(1) = 0.028 mmol(-1) s(-1), r(2) = 0.050 mmol(-1) s(-1) and their ratio r(2)/r(1) = 1.8. Continuous increase of the T-1-weighted MRI signal intensity with increasing Fe concentration in the nanoparticle dispersions was observed which makes this ferrofluid to behave as a positive T-1 contrast agent. (C) 2017 Elsevier B.V. All rights reserved.
T2  - Current Applied Physics
T1  - Ultrasmall iron oxide nanoparticles: Magnetic and NMR relaxometric properties
VL  - 18
IS  - 2
SP  - 141
EP  - 149
DO  - 10.1016/j.cap.2017.11.017
ER  - 

@article{
author = "Babić-Stojić, Branka S. and Jokanović, Vukoman R. and Milivojević, Dušan and Pozek, Miroslav and Jagličić, Zvonko and Makovec, Darko and Jović Orsini, Nataša and Marković, Mirjana and Arsikin, Katarina M. and Paunović, Verica G.",
year = "2018",
abstract = "Ultrasmall iron oxide (USPIO) nanoparticles, with diameter mostly less than 3 nm dispersed in an organic carrier fluid were synthesized by polyol route. The evolution of ZFC-FC magnetization curves with temperature, as well as the shift of the ac susceptibility peaks upon changing the frequency, reveal that the nanoparticles in the fluid are non-interacting and superparamagnetic with the blocking temperature T-B similar to 10 K. The Mossbauer spectra analysis proposed the core/shell structure of the nanoparticles consisting of stoichiometric gamma-Fe2O3 core and non-stoichiometric shell. The nanoparticle surface layer has a great influence on their properties which is principally manifested in significant reduction of the magnetization and in a large increase in magnetic anisotropy. Magnetic moments do not saturate in fields up to 5 T, even at the lowest measured temperature, T = 5 K. The average magnetic particle diameter is changed from 1.3 to 1.8 nm with increasing magnetic field from 0 to 5 T which is noticeably smaller than the particle sizes measured by TEM. The estimated effective magnetic anisotropy constant value, K-eff = 2 x 10(5) J/m(3), is two orders of magnitude higher than in the bulk maghemite. Measurements of the longitudinal and transverse NMR relaxivity parameters on water diluted nanoparticle dispersions at 1.5 T gave the values r(1) = 0.028 mmol(-1) s(-1), r(2) = 0.050 mmol(-1) s(-1) and their ratio r(2)/r(1) = 1.8. Continuous increase of the T-1-weighted MRI signal intensity with increasing Fe concentration in the nanoparticle dispersions was observed which makes this ferrofluid to behave as a positive T-1 contrast agent. (C) 2017 Elsevier B.V. All rights reserved.",
journal = "Current Applied Physics",
title = "Ultrasmall iron oxide nanoparticles: Magnetic and NMR relaxometric properties",
volume = "18",
number = "2",
pages = "141-149",
doi = "10.1016/j.cap.2017.11.017"
}

Babić-Stojić, B. S., Jokanović, V. R., Milivojević, D., Pozek, M., Jagličić, Z., Makovec, D., Jović Orsini, N., Marković, M., Arsikin, K. M.,& Paunović, V. G.. (2018). Ultrasmall iron oxide nanoparticles: Magnetic and NMR relaxometric properties. in Current Applied Physics, 18(2), 141-149.
https://doi.org/10.1016/j.cap.2017.11.017

Babić-Stojić BS, Jokanović VR, Milivojević D, Pozek M, Jagličić Z, Makovec D, Jović Orsini N, Marković M, Arsikin KM, Paunović VG. Ultrasmall iron oxide nanoparticles: Magnetic and NMR relaxometric properties. in Current Applied Physics. 2018;18(2):141-149.
doi:10.1016/j.cap.2017.11.017 .

Babić-Stojić, Branka S., Jokanović, Vukoman R., Milivojević, Dušan, Pozek, Miroslav, Jagličić, Zvonko, Makovec, Darko, Jović Orsini, Nataša, Marković, Mirjana, Arsikin, Katarina M., Paunović, Verica G., "Ultrasmall iron oxide nanoparticles: Magnetic and NMR relaxometric properties" in Current Applied Physics, 18, no. 2 (2018):141-149,
https://doi.org/10.1016/j.cap.2017.11.017 . .

TY  - JOUR
AU  - Babić-Stojić, Branka S.
AU  - Jokanović, Vukoman R.
AU  - Milivojević, Dušan
AU  - Pozek, Miroslav
AU  - Jagličić, Zvonko
AU  - Makovec, Darko
AU  - Arsikin, Katarina M.
AU  - Paunović, Verica G.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/857
AB  - Gd2O3 nanoparticles of a few nm in size and their agglomerates dispersed in dextrose derived polymer template were synthesized by hydrothermal treatment. The produced nanosized material was investigated by TEM, FTIR spectroscopy, SQUID measurements and NMR relaxometry. Biological evaluation of this material was done by crystal violet and MTT assays to determine the cell viability. Longitudinal and transverse NMR relaxivities of water diluted Gd2O3 nanoparticle dispersions measured at the magnetic field of 1.5 T, estimated to be r(1)(Gd2O3)=9.6 s(-1) mM(-1) in the Gd concentration range 0.1-30 mM and r(2)(Gd2O3)=17.7 s(-1) mM(-1) in the lower concentration range 0.1-0.8 mM, are significantly higher than the corresponding relaxivities measured for the standard contrast agent r1 (Gd-DTPA)=4.1 s(-1) mM(-1) and r(2)(Gd-DTPA)= 5.1 s(-1) mM(-1). The ratio of the two relaxivities for Gd2O3 nanoparticles r(2)/r(1) = 1.8 is suitable for T-1-weighted imaging. Good MRI signal intensities of the water diluted Gd2O3 nanoparticle dispersions were recorded at lower Gd concentrations 0.2-0.8 mM. The Gd2O3 samples did not exert any significant cytotoxic effects at Gd concentrations of 0.2 mM and below. These properties of the produced Gd2O3 nanoparticles in hydrothermally modified dextrose make them promising for potential application in MRI for the design of a positive MRI contrast agent. (C) 2015 Elsevier B.V. All rights reserved.
T2  - Journal of Magnetism and Magnetic Materials
T1  - Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging
VL  - 403
SP  - 118
EP  - 126
DO  - 10.1016/j.jmmm.2015.11.075
ER  - 

@article{
author = "Babić-Stojić, Branka S. and Jokanović, Vukoman R. and Milivojević, Dušan and Pozek, Miroslav and Jagličić, Zvonko and Makovec, Darko and Arsikin, Katarina M. and Paunović, Verica G.",
year = "2016",
abstract = "Gd2O3 nanoparticles of a few nm in size and their agglomerates dispersed in dextrose derived polymer template were synthesized by hydrothermal treatment. The produced nanosized material was investigated by TEM, FTIR spectroscopy, SQUID measurements and NMR relaxometry. Biological evaluation of this material was done by crystal violet and MTT assays to determine the cell viability. Longitudinal and transverse NMR relaxivities of water diluted Gd2O3 nanoparticle dispersions measured at the magnetic field of 1.5 T, estimated to be r(1)(Gd2O3)=9.6 s(-1) mM(-1) in the Gd concentration range 0.1-30 mM and r(2)(Gd2O3)=17.7 s(-1) mM(-1) in the lower concentration range 0.1-0.8 mM, are significantly higher than the corresponding relaxivities measured for the standard contrast agent r1 (Gd-DTPA)=4.1 s(-1) mM(-1) and r(2)(Gd-DTPA)= 5.1 s(-1) mM(-1). The ratio of the two relaxivities for Gd2O3 nanoparticles r(2)/r(1) = 1.8 is suitable for T-1-weighted imaging. Good MRI signal intensities of the water diluted Gd2O3 nanoparticle dispersions were recorded at lower Gd concentrations 0.2-0.8 mM. The Gd2O3 samples did not exert any significant cytotoxic effects at Gd concentrations of 0.2 mM and below. These properties of the produced Gd2O3 nanoparticles in hydrothermally modified dextrose make them promising for potential application in MRI for the design of a positive MRI contrast agent. (C) 2015 Elsevier B.V. All rights reserved.",
journal = "Journal of Magnetism and Magnetic Materials",
title = "Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging",
volume = "403",
pages = "118-126",
doi = "10.1016/j.jmmm.2015.11.075"
}

Babić-Stojić, B. S., Jokanović, V. R., Milivojević, D., Pozek, M., Jagličić, Z., Makovec, D., Arsikin, K. M.,& Paunović, V. G.. (2016). Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging. in Journal of Magnetism and Magnetic Materials, 403, 118-126.
https://doi.org/10.1016/j.jmmm.2015.11.075

Babić-Stojić BS, Jokanović VR, Milivojević D, Pozek M, Jagličić Z, Makovec D, Arsikin KM, Paunović VG. Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging. in Journal of Magnetism and Magnetic Materials. 2016;403:118-126.
doi:10.1016/j.jmmm.2015.11.075 .

Babić-Stojić, Branka S., Jokanović, Vukoman R., Milivojević, Dušan, Pozek, Miroslav, Jagličić, Zvonko, Makovec, Darko, Arsikin, Katarina M., Paunović, Verica G., "Gd2O3 nanoparticles stabilized by hydrothermally modified dextrose for positive contrast magnetic resonance imaging" in Journal of Magnetism and Magnetic Materials, 403 (2016):118-126,
https://doi.org/10.1016/j.jmmm.2015.11.075 . .

TY  - JOUR
AU  - Babić-Stojić, Branka S.
AU  - Jokanović, Vukoman R.
AU  - Milivojević, Dušan
AU  - Pozek, Miroslav
AU  - Jagličić, Zvonko
AU  - Makovec, Darko
AU  - Arsikin, Katarina M.
AU  - Paunović, Verica G.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/414
AB  - Gd2O3 nanoparticles and their agglomerates from approximately 10 to 80 nm in size suspended in an organic liquid were synthesized via polyol route. The reaction between diethylene glycol and added acetic acid, which occurred simultaneously with the synthesis of Gd2O3 nanoparticles, was catalyzed by sodium bisulfate to transform as much as possible diethylene glycol in corresponding ester at the end of complete reaction. The produced nanosized material of gadolinium oxide was investigated by TEM, DLS, FTIR spectroscopy, and NMR relaxometry. Biological evaluation of this material was done by MTT and crystal violet assays to determine the cell viability. Longitudinal and transverse relaxivities of water-diluted Gd2O3 nanoparticle suspensions estimated to be r(1) = 13.6 and r(2) = 14.7 s(-1) mM(-1) are about three times higher compared to the relaxivities obtained for standard contrast agent Gd-DTPA (Magnevist). Good MRI signal intensities of the water-diluted Gd2O3 nanoparticle suspensions were recorded in the Gd concentration range 0.2-0.3 mM for which the suspensions were not toxic exhibiting simultaneously higher signal intensities than those for Magnevist in the Gd concentration range 0.4-1 mM for which this standard contrast agent was not toxic. These properties make the produced Gd2O3 nanoparticle material promising for potential application as MRI contrast agent.
T2  - Journal of Nanoparticle Research
T1  - NMR relaxometric properties and cytotoxicity of Gd2O3 nanoparticle suspensions in an organic liquid
VL  - 16
IS  - 10
DO  - 10.1007/s11051-014-2663-0
ER  - 

@article{
author = "Babić-Stojić, Branka S. and Jokanović, Vukoman R. and Milivojević, Dušan and Pozek, Miroslav and Jagličić, Zvonko and Makovec, Darko and Arsikin, Katarina M. and Paunović, Verica G.",
year = "2014",
abstract = "Gd2O3 nanoparticles and their agglomerates from approximately 10 to 80 nm in size suspended in an organic liquid were synthesized via polyol route. The reaction between diethylene glycol and added acetic acid, which occurred simultaneously with the synthesis of Gd2O3 nanoparticles, was catalyzed by sodium bisulfate to transform as much as possible diethylene glycol in corresponding ester at the end of complete reaction. The produced nanosized material of gadolinium oxide was investigated by TEM, DLS, FTIR spectroscopy, and NMR relaxometry. Biological evaluation of this material was done by MTT and crystal violet assays to determine the cell viability. Longitudinal and transverse relaxivities of water-diluted Gd2O3 nanoparticle suspensions estimated to be r(1) = 13.6 and r(2) = 14.7 s(-1) mM(-1) are about three times higher compared to the relaxivities obtained for standard contrast agent Gd-DTPA (Magnevist). Good MRI signal intensities of the water-diluted Gd2O3 nanoparticle suspensions were recorded in the Gd concentration range 0.2-0.3 mM for which the suspensions were not toxic exhibiting simultaneously higher signal intensities than those for Magnevist in the Gd concentration range 0.4-1 mM for which this standard contrast agent was not toxic. These properties make the produced Gd2O3 nanoparticle material promising for potential application as MRI contrast agent.",
journal = "Journal of Nanoparticle Research",
title = "NMR relaxometric properties and cytotoxicity of Gd2O3 nanoparticle suspensions in an organic liquid",
volume = "16",
number = "10",
doi = "10.1007/s11051-014-2663-0"
}

Babić-Stojić, B. S., Jokanović, V. R., Milivojević, D., Pozek, M., Jagličić, Z., Makovec, D., Arsikin, K. M.,& Paunović, V. G.. (2014). NMR relaxometric properties and cytotoxicity of Gd2O3 nanoparticle suspensions in an organic liquid. in Journal of Nanoparticle Research, 16(10).
https://doi.org/10.1007/s11051-014-2663-0

Babić-Stojić BS, Jokanović VR, Milivojević D, Pozek M, Jagličić Z, Makovec D, Arsikin KM, Paunović VG. NMR relaxometric properties and cytotoxicity of Gd2O3 nanoparticle suspensions in an organic liquid. in Journal of Nanoparticle Research. 2014;16(10).
doi:10.1007/s11051-014-2663-0 .

Babić-Stojić, Branka S., Jokanović, Vukoman R., Milivojević, Dušan, Pozek, Miroslav, Jagličić, Zvonko, Makovec, Darko, Arsikin, Katarina M., Paunović, Verica G., "NMR relaxometric properties and cytotoxicity of Gd2O3 nanoparticle suspensions in an organic liquid" in Journal of Nanoparticle Research, 16, no. 10 (2014),
https://doi.org/10.1007/s11051-014-2663-0 . .