TY  - JOUR
AU  - Mirković, Marija D.
AU  - Milanović, Zorana
AU  - Perić, Marko R.
AU  - Vranješ-Đurić, Sanja
AU  - Ognjanović, Miloš
AU  - Antić, Bratislav
AU  - Kuraica, Milorad
AU  - Krstić, Ivan
AU  - Kubovcikova, Martina
AU  - Antal, Iryna
AU  - Sobotova, Radka
AU  - Zavisova, Vlasta
AU  - Jurikova, Alena
AU  - Fabian, Martin
AU  - Koneracka, Martina
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10696
AB  - Surface modification of magnetic nanoparticles with poly-L-lysine, proline, and tryptophan was used to design potential theranostic agents for the application in cancer diagnosis and radionuclide-hyperthermia therapy. Characterization of bare and functionalized magnetic nanoparticles was performed in detail. The transparency of the examined magnetic nanoparticles was measured in the non-alternating magnetic field for a complete and better understanding of hyperthermia. For the first time amino acid-functionalized magnetic nanoparticles were labeled with theranostic radionuclides 131I and 177Lu. The specific absorption rate (SAR) procured for poly-L-lysine functionalized magnetic nanoparticles (SAR values of 99.7 W/g at H0 = 15.9 kA/m and resonant frequency of 252 kHz) demonstrated their possible application in magnetic hyperthermia. Poly-L-lysine functionalized magnetic nanoparticles labeled with 177Lu showed the highest radiochemical purity (>99.00 %) and in vitro stability in saline and serum (>98.00 % up to 96 h). The in vivo analysis performed after their intravenous administration in healthy Wistar rats presented good in vivo stability for several days. Encouraging results as well as magnetic and radiochemical properties of 177Lu–PLL-MNPs (80 °C) justify their further testing toward the potential use as theranostic agents for diagnostic and combined radionuclide-hyperthermia therapeutic applications.
T2  - International Journal of Pharmaceutics
T1  - Design and preparation of proline, tryptophan and poly-l-lysine functionalized magnetic nanoparticles and their radiolabeling with 131I and 177Lu for potential theranostic use
VL  - 628
SP  - 122288
DO  - 10.1016/j.ijpharm.2022.122288
ER  - 

@article{
author = "Mirković, Marija D. and Milanović, Zorana and Perić, Marko R. and Vranješ-Đurić, Sanja and Ognjanović, Miloš and Antić, Bratislav and Kuraica, Milorad and Krstić, Ivan and Kubovcikova, Martina and Antal, Iryna and Sobotova, Radka and Zavisova, Vlasta and Jurikova, Alena and Fabian, Martin and Koneracka, Martina",
year = "2022",
abstract = "Surface modification of magnetic nanoparticles with poly-L-lysine, proline, and tryptophan was used to design potential theranostic agents for the application in cancer diagnosis and radionuclide-hyperthermia therapy. Characterization of bare and functionalized magnetic nanoparticles was performed in detail. The transparency of the examined magnetic nanoparticles was measured in the non-alternating magnetic field for a complete and better understanding of hyperthermia. For the first time amino acid-functionalized magnetic nanoparticles were labeled with theranostic radionuclides 131I and 177Lu. The specific absorption rate (SAR) procured for poly-L-lysine functionalized magnetic nanoparticles (SAR values of 99.7 W/g at H0 = 15.9 kA/m and resonant frequency of 252 kHz) demonstrated their possible application in magnetic hyperthermia. Poly-L-lysine functionalized magnetic nanoparticles labeled with 177Lu showed the highest radiochemical purity (>99.00 %) and in vitro stability in saline and serum (>98.00 % up to 96 h). The in vivo analysis performed after their intravenous administration in healthy Wistar rats presented good in vivo stability for several days. Encouraging results as well as magnetic and radiochemical properties of 177Lu–PLL-MNPs (80 °C) justify their further testing toward the potential use as theranostic agents for diagnostic and combined radionuclide-hyperthermia therapeutic applications.",
journal = "International Journal of Pharmaceutics",
title = "Design and preparation of proline, tryptophan and poly-l-lysine functionalized magnetic nanoparticles and their radiolabeling with 131I and 177Lu for potential theranostic use",
volume = "628",
pages = "122288",
doi = "10.1016/j.ijpharm.2022.122288"
}

Mirković, M. D., Milanović, Z., Perić, M. R., Vranješ-Đurić, S., Ognjanović, M., Antić, B., Kuraica, M., Krstić, I., Kubovcikova, M., Antal, I., Sobotova, R., Zavisova, V., Jurikova, A., Fabian, M.,& Koneracka, M.. (2022). Design and preparation of proline, tryptophan and poly-l-lysine functionalized magnetic nanoparticles and their radiolabeling with 131I and 177Lu for potential theranostic use. in International Journal of Pharmaceutics, 628, 122288.
https://doi.org/10.1016/j.ijpharm.2022.122288

Mirković MD, Milanović Z, Perić MR, Vranješ-Đurić S, Ognjanović M, Antić B, Kuraica M, Krstić I, Kubovcikova M, Antal I, Sobotova R, Zavisova V, Jurikova A, Fabian M, Koneracka M. Design and preparation of proline, tryptophan and poly-l-lysine functionalized magnetic nanoparticles and their radiolabeling with 131I and 177Lu for potential theranostic use. in International Journal of Pharmaceutics. 2022;628:122288.
doi:10.1016/j.ijpharm.2022.122288 .

Mirković, Marija D., Milanović, Zorana, Perić, Marko R., Vranješ-Đurić, Sanja, Ognjanović, Miloš, Antić, Bratislav, Kuraica, Milorad, Krstić, Ivan, Kubovcikova, Martina, Antal, Iryna, Sobotova, Radka, Zavisova, Vlasta, Jurikova, Alena, Fabian, Martin, Koneracka, Martina, "Design and preparation of proline, tryptophan and poly-l-lysine functionalized magnetic nanoparticles and their radiolabeling with 131I and 177Lu for potential theranostic use" in International Journal of Pharmaceutics, 628 (2022):122288,
https://doi.org/10.1016/j.ijpharm.2022.122288 . .

TY  - JOUR
AU  - Radović, Magdalena
AU  - Mirković, Marija D.
AU  - Nikolić, Aleksandar S.
AU  - Kuraica, Milorad M.
AU  - Iskrenović, Predrag
AU  - Milanović, Zorana
AU  - Vranješ-Đurić, Sanja
AU  - Perić, Marko
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9850
AB  - Different phosphates and phosphonates have shown excellent coating ability toward magnetic nanoparticles, improving their stability and biocompatibility which enables their biomedical application. The magnetic hyperthermia efficiency of phosphates (IDP and IHP) and phosphonates (MDP and HEDP) coated Fe3O4 magnetic nanoparticles (MNPs) were evaluated in an alternating magnetic field. For a deeper understanding of hyperthermia, the behavior of investigated MNPs in the non-alternating magnetic field was monitored by measuring the transparency of the sample. To investigate their theranostic potential coated Fe3O4-MNPs were radiolabeled with radionuclide 177Lu. Phosphate coated MNPs were radiolabeled in high radiolabeling yield (> 99%) while phosphonate coated MNPs reached maximum radiolabeling yield of 78%. Regardless lower radiolabeling yield both radiolabeled phosphonate MNPs may be further purified reaching radiochemical purity of more than 95%. In vitro stabile radiolabeled nanoparticles in saline and HSA were obtained. The high heating ability of phosphates and phosphonates coated MNPs as sine qua non for efficient in vivo hyperthermia treatment and satisfactory radiolabeling yield justifies their further research in order to develop new theranostic agents. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
T2  - Journal of Inorganic and Organometallic Polymers and Materials
T1  - Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe3O4 Magnetic Nanoparticles
DO  - 10.1007/s10904-021-02059-1
ER  - 

@article{
author = "Radović, Magdalena and Mirković, Marija D. and Nikolić, Aleksandar S. and Kuraica, Milorad M. and Iskrenović, Predrag and Milanović, Zorana and Vranješ-Đurić, Sanja and Perić, Marko",
year = "2021",
abstract = "Different phosphates and phosphonates have shown excellent coating ability toward magnetic nanoparticles, improving their stability and biocompatibility which enables their biomedical application. The magnetic hyperthermia efficiency of phosphates (IDP and IHP) and phosphonates (MDP and HEDP) coated Fe3O4 magnetic nanoparticles (MNPs) were evaluated in an alternating magnetic field. For a deeper understanding of hyperthermia, the behavior of investigated MNPs in the non-alternating magnetic field was monitored by measuring the transparency of the sample. To investigate their theranostic potential coated Fe3O4-MNPs were radiolabeled with radionuclide 177Lu. Phosphate coated MNPs were radiolabeled in high radiolabeling yield (> 99%) while phosphonate coated MNPs reached maximum radiolabeling yield of 78%. Regardless lower radiolabeling yield both radiolabeled phosphonate MNPs may be further purified reaching radiochemical purity of more than 95%. In vitro stabile radiolabeled nanoparticles in saline and HSA were obtained. The high heating ability of phosphates and phosphonates coated MNPs as sine qua non for efficient in vivo hyperthermia treatment and satisfactory radiolabeling yield justifies their further research in order to develop new theranostic agents. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
journal = "Journal of Inorganic and Organometallic Polymers and Materials",
title = "Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe3O4 Magnetic Nanoparticles",
doi = "10.1007/s10904-021-02059-1"
}

Radović, M., Mirković, M. D., Nikolić, A. S., Kuraica, M. M., Iskrenović, P., Milanović, Z., Vranješ-Đurić, S.,& Perić, M.. (2021). Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe3O4 Magnetic Nanoparticles. in Journal of Inorganic and Organometallic Polymers and Materials.
https://doi.org/10.1007/s10904-021-02059-1

Radović M, Mirković MD, Nikolić AS, Kuraica MM, Iskrenović P, Milanović Z, Vranješ-Đurić S, Perić M. Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe3O4 Magnetic Nanoparticles. in Journal of Inorganic and Organometallic Polymers and Materials. 2021;.
doi:10.1007/s10904-021-02059-1 .

Radović, Magdalena, Mirković, Marija D., Nikolić, Aleksandar S., Kuraica, Milorad M., Iskrenović, Predrag, Milanović, Zorana, Vranješ-Đurić, Sanja, Perić, Marko, "Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe3O4 Magnetic Nanoparticles" in Journal of Inorganic and Organometallic Polymers and Materials (2021),
https://doi.org/10.1007/s10904-021-02059-1 . .

TY  - JOUR
AU  - Lakić, Mladen
AU  - Anđelković, Ljubica
AU  - Šuljagić, Marija
AU  - Vulić, Predrag
AU  - Perić, Marko R.
AU  - Iskrenović, Predrag
AU  - Krstić, Ivan
AU  - Kuraica, Milorad M.
AU  - Nikolić, Aleksandar S.
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0925346719301995
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8114
AB  - Light-transmitting measurements of white light and a consequentially chosen laser beam of 655 nm propagating through citrate- and oleate-coated CoFe 2 O 4 , FeFe 2 O 4 and MgFe 2 O 4 nanoparticles under the influence of an external magnetic field were presented. New experimental settings were developed for the optical study of ferrites’ behavior in ferrofluid with the applied magnetic field strength within the 30–400 mT range. A magnetic field-induced change of light transmittance occurred and a precipitation of all studied samples was obtained. Optical investigations of ferrofluid suspensions revealed that, contrary to the linear aggregates of colloidal CoFe 2 O 4 and FeFe 2 O 4 , spheroidal aggregates were formed in the case of MgFe 2 O 4 . In all three cases, the surface modification resulted in decreased dipole–dipole interactions between ferrite cores, and thus, less precipitates were noticed. All oleate-coated nanoparticles have demonstrated weaker magnetic responses compared to the citrate-encapsulated samples. The aggregation of nanoparticles potentially increases cytotoxicity. Regarding non-linear clustering of MgFe 2 O 4 suspensions, it can be concluded that its excretion from the organism may likely be easier and faster when used in diagnosis and/or therapy. Therefore, more attention should be paid to the lowly toxic MgFe 2 O 4 regarding its medical application. © 2019
T2  - Optical Materials
T1  - Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite
VL  - 91
SP  - 279
EP  - 285
DO  - 10.1016/j.optmat.2019.03.031
ER  - 

@article{
author = "Lakić, Mladen and Anđelković, Ljubica and Šuljagić, Marija and Vulić, Predrag and Perić, Marko R. and Iskrenović, Predrag and Krstić, Ivan and Kuraica, Milorad M. and Nikolić, Aleksandar S.",
year = "2019",
abstract = "Light-transmitting measurements of white light and a consequentially chosen laser beam of 655 nm propagating through citrate- and oleate-coated CoFe 2 O 4 , FeFe 2 O 4 and MgFe 2 O 4 nanoparticles under the influence of an external magnetic field were presented. New experimental settings were developed for the optical study of ferrites’ behavior in ferrofluid with the applied magnetic field strength within the 30–400 mT range. A magnetic field-induced change of light transmittance occurred and a precipitation of all studied samples was obtained. Optical investigations of ferrofluid suspensions revealed that, contrary to the linear aggregates of colloidal CoFe 2 O 4 and FeFe 2 O 4 , spheroidal aggregates were formed in the case of MgFe 2 O 4 . In all three cases, the surface modification resulted in decreased dipole–dipole interactions between ferrite cores, and thus, less precipitates were noticed. All oleate-coated nanoparticles have demonstrated weaker magnetic responses compared to the citrate-encapsulated samples. The aggregation of nanoparticles potentially increases cytotoxicity. Regarding non-linear clustering of MgFe 2 O 4 suspensions, it can be concluded that its excretion from the organism may likely be easier and faster when used in diagnosis and/or therapy. Therefore, more attention should be paid to the lowly toxic MgFe 2 O 4 regarding its medical application. © 2019",
journal = "Optical Materials",
title = "Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite",
volume = "91",
pages = "279-285",
doi = "10.1016/j.optmat.2019.03.031"
}

Lakić, M., Anđelković, L., Šuljagić, M., Vulić, P., Perić, M. R., Iskrenović, P., Krstić, I., Kuraica, M. M.,& Nikolić, A. S.. (2019). Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite. in Optical Materials, 91, 279-285.
https://doi.org/10.1016/j.optmat.2019.03.031

Lakić M, Anđelković L, Šuljagić M, Vulić P, Perić MR, Iskrenović P, Krstić I, Kuraica MM, Nikolić AS. Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite. in Optical Materials. 2019;91:279-285.
doi:10.1016/j.optmat.2019.03.031 .

Lakić, Mladen, Anđelković, Ljubica, Šuljagić, Marija, Vulić, Predrag, Perić, Marko R., Iskrenović, Predrag, Krstić, Ivan, Kuraica, Milorad M., Nikolić, Aleksandar S., "Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite" in Optical Materials, 91 (2019):279-285,
https://doi.org/10.1016/j.optmat.2019.03.031 . .

TY  - JOUR
AU  - Kuraica, Milorad M.
AU  - Iskrenović, Predrag
AU  - Perić, Marko R.
AU  - Krstić, Ivan
AU  - Nikolić, Aleksandar S.
PY  - 2018
UR  - http://link.springer.com/10.1007/s11696-017-0380-8
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7711
AB  - Using simple optical measurements, the selective spectral behavior of suspended nano-particles of magnetite (Fe3O4) and cobalt-ferrite (CoFe2O4) coated with starch, was observed through switching on/off of external magnetic field. The field strength was varied in the interval 30–300 mT. In these transient regimes, the unexpected and unusually large changes of transmitted light occur. An explanation is suggested, within the model based on ordering of magnetic moments of nano-particles along the lines of magnetic field into magnetic chains and organization of magnetic chains into spatial structure—a quasi-lattice. This fact indicates the possibility of more efficient local heating of nano-particles in the fast changing magnetic field; for instance when taking magnetic nano-particles for therapeutic purposes.
T2  - Chemical Papers
T1  - External magnetic field influence on magnetite and cobalt-ferrite nano-particles in ferrofluid
VL  - 72
IS  - 6
SP  - 1535
EP  - 1542
DO  - 10.1007/s11696-017-0380-8
ER  - 

@article{
author = "Kuraica, Milorad M. and Iskrenović, Predrag and Perić, Marko R. and Krstić, Ivan and Nikolić, Aleksandar S.",
year = "2018",
abstract = "Using simple optical measurements, the selective spectral behavior of suspended nano-particles of magnetite (Fe3O4) and cobalt-ferrite (CoFe2O4) coated with starch, was observed through switching on/off of external magnetic field. The field strength was varied in the interval 30–300 mT. In these transient regimes, the unexpected and unusually large changes of transmitted light occur. An explanation is suggested, within the model based on ordering of magnetic moments of nano-particles along the lines of magnetic field into magnetic chains and organization of magnetic chains into spatial structure—a quasi-lattice. This fact indicates the possibility of more efficient local heating of nano-particles in the fast changing magnetic field; for instance when taking magnetic nano-particles for therapeutic purposes.",
journal = "Chemical Papers",
title = "External magnetic field influence on magnetite and cobalt-ferrite nano-particles in ferrofluid",
volume = "72",
number = "6",
pages = "1535-1542",
doi = "10.1007/s11696-017-0380-8"
}

Kuraica, M. M., Iskrenović, P., Perić, M. R., Krstić, I.,& Nikolić, A. S.. (2018). External magnetic field influence on magnetite and cobalt-ferrite nano-particles in ferrofluid. in Chemical Papers, 72(6), 1535-1542.
https://doi.org/10.1007/s11696-017-0380-8

Kuraica MM, Iskrenović P, Perić MR, Krstić I, Nikolić AS. External magnetic field influence on magnetite and cobalt-ferrite nano-particles in ferrofluid. in Chemical Papers. 2018;72(6):1535-1542.
doi:10.1007/s11696-017-0380-8 .

Kuraica, Milorad M., Iskrenović, Predrag, Perić, Marko R., Krstić, Ivan, Nikolić, Aleksandar S., "External magnetic field influence on magnetite and cobalt-ferrite nano-particles in ferrofluid" in Chemical Papers, 72, no. 6 (2018):1535-1542,
https://doi.org/10.1007/s11696-017-0380-8 . .