TY  - JOUR
AU  - Pejić, Nataša
AU  - Kolar-Anić, Ljiljana
AU  - Maksimović, Jelena
AU  - Janković, Marija M.
AU  - Vukojević, Vladana
AU  - Anić, Slobodan
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1078
AB  - The temporal dynamics of the Bray-Liebhafsky reaction (iodate-based catalytic decomposition of hydrogen peroxide in an acidic aqueous solution) was experimentally characterized in a continuous stirred tank reactor by independently varying the temperature and the mixed inflow hydrogen peroxide concentration. When the temperature was the bifurcation parameter, the emergence/disappearance of oscillatory behavior via a supercritical Andronov-Hopf bifurcation was observed for different mixed inflow hydrogen peroxide concentrations. An increase in the mixed inflow hydrogen-peroxide concentration resulted in a shift of the bifurcation point towards higher values of temperature, but did not alter the bifurcation type.
PB  - Springer
T2  - Reaction Kinetics, Mechanisms and Catalysis
T1  - Dynamic transitions in the Bray-Liebhafsky oscillating reaction. Effect of hydrogen peroxide and temperature on bifurcation
VL  - 118
IS  - 1
SP  - 15
EP  - 26
DO  - 10.1007/s11144-016-0984-y
ER  - 

@article{
author = "Pejić, Nataša and Kolar-Anić, Ljiljana and Maksimović, Jelena and Janković, Marija M. and Vukojević, Vladana and Anić, Slobodan",
year = "2016",
abstract = "The temporal dynamics of the Bray-Liebhafsky reaction (iodate-based catalytic decomposition of hydrogen peroxide in an acidic aqueous solution) was experimentally characterized in a continuous stirred tank reactor by independently varying the temperature and the mixed inflow hydrogen peroxide concentration. When the temperature was the bifurcation parameter, the emergence/disappearance of oscillatory behavior via a supercritical Andronov-Hopf bifurcation was observed for different mixed inflow hydrogen peroxide concentrations. An increase in the mixed inflow hydrogen-peroxide concentration resulted in a shift of the bifurcation point towards higher values of temperature, but did not alter the bifurcation type.",
publisher = "Springer",
journal = "Reaction Kinetics, Mechanisms and Catalysis",
title = "Dynamic transitions in the Bray-Liebhafsky oscillating reaction. Effect of hydrogen peroxide and temperature on bifurcation",
volume = "118",
number = "1",
pages = "15-26",
doi = "10.1007/s11144-016-0984-y"
}

Pejić, N., Kolar-Anić, L., Maksimović, J., Janković, M. M., Vukojević, V.,& Anić, S.. (2016). Dynamic transitions in the Bray-Liebhafsky oscillating reaction. Effect of hydrogen peroxide and temperature on bifurcation. in Reaction Kinetics, Mechanisms and Catalysis
Springer., 118(1), 15-26.
https://doi.org/10.1007/s11144-016-0984-y

Pejić N, Kolar-Anić L, Maksimović J, Janković MM, Vukojević V, Anić S. Dynamic transitions in the Bray-Liebhafsky oscillating reaction. Effect of hydrogen peroxide and temperature on bifurcation. in Reaction Kinetics, Mechanisms and Catalysis. 2016;118(1):15-26.
doi:10.1007/s11144-016-0984-y .

Pejić, Nataša, Kolar-Anić, Ljiljana, Maksimović, Jelena, Janković, Marija M., Vukojević, Vladana, Anić, Slobodan, "Dynamic transitions in the Bray-Liebhafsky oscillating reaction. Effect of hydrogen peroxide and temperature on bifurcation" in Reaction Kinetics, Mechanisms and Catalysis, 118, no. 1 (2016):15-26,
https://doi.org/10.1007/s11144-016-0984-y . .

TY  - JOUR
AU  - Jelić, Smiljana
AU  - Čupić, Željko
AU  - Kolar-Anić, Ljiljana
AU  - Vukojević, Vladana
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3974
AB  - Two methods for dynamic systems analysis, Stoichiometric Network Analysis (SNA) and Quenching of Small Amplitude Oscillations (QA), are used to study the behaviour of a vital biological system. Both methods use geometric approaches for the study of complex reaction systems. In SNA, methods based on convex polytopes geometry are applied for stability analysis and optimization of reaction networks. QA relies on a geometric representation of the concentration phase space, introduces the concept of manifolds and the singular perturbation theory to study the dynamics of complex processes. The analyzed system, the Hypothalamic-Pituitary-Adrenal (HPA) axis, as a major constituent of the neuroendocrine system has a critical role in integrating biological responses in basal conditions and during stress. Self-regulation in the HPA system was modeled through a positive and negative feedback effect of cortisol. A systematically reduced low-dimensional model of HPA activity in humans was fine-tuned by SNA, until quantitative agreement with experimental findings was achieved. By QA, we revealed an important dynamic regulatory mechanism that is a natural consequence of the intrinsic rhythmicity of the considered system.
T2  - International Journal of Nonlinear Sciences and Numerical Simulation
T1  - Predictive Modeling of the Hypothalamic-Pituitary-Adrenal (HPA) Function. Dynamic Systems Theory Approach by Stoichiometric Network Analysis and Quenching Small Amplitude Oscillations
VL  - 10
IS  - 11-12
SP  - 1451
EP  - 1472
UR  - https://hdl.handle.net/21.15107/rcub_vinar_3974
ER  - 

@article{
author = "Jelić, Smiljana and Čupić, Željko and Kolar-Anić, Ljiljana and Vukojević, Vladana",
year = "2009",
abstract = "Two methods for dynamic systems analysis, Stoichiometric Network Analysis (SNA) and Quenching of Small Amplitude Oscillations (QA), are used to study the behaviour of a vital biological system. Both methods use geometric approaches for the study of complex reaction systems. In SNA, methods based on convex polytopes geometry are applied for stability analysis and optimization of reaction networks. QA relies on a geometric representation of the concentration phase space, introduces the concept of manifolds and the singular perturbation theory to study the dynamics of complex processes. The analyzed system, the Hypothalamic-Pituitary-Adrenal (HPA) axis, as a major constituent of the neuroendocrine system has a critical role in integrating biological responses in basal conditions and during stress. Self-regulation in the HPA system was modeled through a positive and negative feedback effect of cortisol. A systematically reduced low-dimensional model of HPA activity in humans was fine-tuned by SNA, until quantitative agreement with experimental findings was achieved. By QA, we revealed an important dynamic regulatory mechanism that is a natural consequence of the intrinsic rhythmicity of the considered system.",
journal = "International Journal of Nonlinear Sciences and Numerical Simulation",
title = "Predictive Modeling of the Hypothalamic-Pituitary-Adrenal (HPA) Function. Dynamic Systems Theory Approach by Stoichiometric Network Analysis and Quenching Small Amplitude Oscillations",
volume = "10",
number = "11-12",
pages = "1451-1472",
url = "https://hdl.handle.net/21.15107/rcub_vinar_3974"
}

Jelić, S., Čupić, Ž., Kolar-Anić, L.,& Vukojević, V.. (2009). Predictive Modeling of the Hypothalamic-Pituitary-Adrenal (HPA) Function. Dynamic Systems Theory Approach by Stoichiometric Network Analysis and Quenching Small Amplitude Oscillations. in International Journal of Nonlinear Sciences and Numerical Simulation, 10(11-12), 1451-1472.
https://hdl.handle.net/21.15107/rcub_vinar_3974

Jelić S, Čupić Ž, Kolar-Anić L, Vukojević V. Predictive Modeling of the Hypothalamic-Pituitary-Adrenal (HPA) Function. Dynamic Systems Theory Approach by Stoichiometric Network Analysis and Quenching Small Amplitude Oscillations. in International Journal of Nonlinear Sciences and Numerical Simulation. 2009;10(11-12):1451-1472.
https://hdl.handle.net/21.15107/rcub_vinar_3974 .

Jelić, Smiljana, Čupić, Željko, Kolar-Anić, Ljiljana, Vukojević, Vladana, "Predictive Modeling of the Hypothalamic-Pituitary-Adrenal (HPA) Function. Dynamic Systems Theory Approach by Stoichiometric Network Analysis and Quenching Small Amplitude Oscillations" in International Journal of Nonlinear Sciences and Numerical Simulation, 10, no. 11-12 (2009):1451-1472,
https://hdl.handle.net/21.15107/rcub_vinar_3974 .