TY  - JOUR
AU  - Radaković-Ćosić, Jovana
AU  - Miković, Željko
AU  - Mandić-Rajčević, Stefan
AU  - Sudar-Milovanović, Emina
AU  - Stojsavljević, Aleksandar
AU  - Nikolić, Gorana
AU  - Radojičić, Ognjen
AU  - Perović, Milan
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10846
AB  - Infertility is a major global health issue, affecting approximately 9% of couples worldwide. Its prevalence increased steadily over the preceding decades, paralleling environmental and lifestyle changes. One assisted reproductive technique to overcome infertility is in vitro fertilization (IVF). The IVF procedure consists of several stages, one of which is controlled ovarian stimulation (COS) via various protocols allowing follicular recruitment and maturation in preparation for oocyte retrieval. Follicular fluid (FF) is the microenvironment in which oocytes develop during folliculogenesis, and FF information could be used to assess follicle and oocyte development and maturation stages. Nitric oxide (NO) is a component of FF that is being studied as a predictive factor of follicle maturation and egg quality and as a potential indicator of the success of COS during the IVF process. The hypothesis was that COS affects NO levels in the serum; more specifically, that NO levels in serum after COS correlate with NO levels in FF, based on literature data on the influence of female reproductive hormones on NO metabolism and data on the change in the hormonal milieu affected by COS use. Furthermore, it was hypothesized that NO levels in serum and FF after COS were related to the number of high-quality female reproductive cells obtained during IVF. Assuming that NO levels in serum after COS correlate with NO levels in FF, the central hypothesis of this study is that serum NO levels after COS could be a valuable predictor of oocyte quality and the number of high-quality female reproductive cells achieved by COS. As a result of the hypothesis, measuring NO could be a novel way to improve the efficiency of IVF treatment.
T2  - Medical Hypotheses
T1  - Does controlled ovarian stimulation during in vitro fertilization affect the level of nitric oxide a potential indicator of oocyte quality?
VL  - 174
SP  - 111061
DO  - 10.1016/j.mehy.2023.111061
ER  - 

@article{
author = "Radaković-Ćosić, Jovana and Miković, Željko and Mandić-Rajčević, Stefan and Sudar-Milovanović, Emina and Stojsavljević, Aleksandar and Nikolić, Gorana and Radojičić, Ognjen and Perović, Milan",
year = "2023",
abstract = "Infertility is a major global health issue, affecting approximately 9% of couples worldwide. Its prevalence increased steadily over the preceding decades, paralleling environmental and lifestyle changes. One assisted reproductive technique to overcome infertility is in vitro fertilization (IVF). The IVF procedure consists of several stages, one of which is controlled ovarian stimulation (COS) via various protocols allowing follicular recruitment and maturation in preparation for oocyte retrieval. Follicular fluid (FF) is the microenvironment in which oocytes develop during folliculogenesis, and FF information could be used to assess follicle and oocyte development and maturation stages. Nitric oxide (NO) is a component of FF that is being studied as a predictive factor of follicle maturation and egg quality and as a potential indicator of the success of COS during the IVF process. The hypothesis was that COS affects NO levels in the serum; more specifically, that NO levels in serum after COS correlate with NO levels in FF, based on literature data on the influence of female reproductive hormones on NO metabolism and data on the change in the hormonal milieu affected by COS use. Furthermore, it was hypothesized that NO levels in serum and FF after COS were related to the number of high-quality female reproductive cells obtained during IVF. Assuming that NO levels in serum after COS correlate with NO levels in FF, the central hypothesis of this study is that serum NO levels after COS could be a valuable predictor of oocyte quality and the number of high-quality female reproductive cells achieved by COS. As a result of the hypothesis, measuring NO could be a novel way to improve the efficiency of IVF treatment.",
journal = "Medical Hypotheses",
title = "Does controlled ovarian stimulation during in vitro fertilization affect the level of nitric oxide a potential indicator of oocyte quality?",
volume = "174",
pages = "111061",
doi = "10.1016/j.mehy.2023.111061"
}

Radaković-Ćosić, J., Miković, Ž., Mandić-Rajčević, S., Sudar-Milovanović, E., Stojsavljević, A., Nikolić, G., Radojičić, O.,& Perović, M.. (2023). Does controlled ovarian stimulation during in vitro fertilization affect the level of nitric oxide a potential indicator of oocyte quality?. in Medical Hypotheses, 174, 111061.
https://doi.org/10.1016/j.mehy.2023.111061

Radaković-Ćosić J, Miković Ž, Mandić-Rajčević S, Sudar-Milovanović E, Stojsavljević A, Nikolić G, Radojičić O, Perović M. Does controlled ovarian stimulation during in vitro fertilization affect the level of nitric oxide a potential indicator of oocyte quality?. in Medical Hypotheses. 2023;174:111061.
doi:10.1016/j.mehy.2023.111061 .

Radaković-Ćosić, Jovana, Miković, Željko, Mandić-Rajčević, Stefan, Sudar-Milovanović, Emina, Stojsavljević, Aleksandar, Nikolić, Gorana, Radojičić, Ognjen, Perović, Milan, "Does controlled ovarian stimulation during in vitro fertilization affect the level of nitric oxide a potential indicator of oocyte quality?" in Medical Hypotheses, 174 (2023):111061,
https://doi.org/10.1016/j.mehy.2023.111061 . .

TY  - JOUR
AU  - Jeremić, Ana
AU  - Miković, Željko
AU  - Sudar-Milovanović, Emina
AU  - Isenović, Esma R.
AU  - Perović, Milan
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9971
AB  - Follicular and serum vitamin D are considered potential markers of the oocyte and embryos' quality and predictors of IVF outcomes.   Material and methods:  This retrospective cross-sectional study correlated vitamin D in sera and follicular fluid of women with unexplained...
T2  - Archives of Medical Science
T1  - Follicular and serum levels of vitamin D in women with unexplained infertility and their relationship with in vitro fertilization outcome: an observational pilot study
VL  - 17
IS  - 5
SP  - 1418
EP  - 1422
DO  - 10.5114/aoms/141185
ER  - 

@article{
author = "Jeremić, Ana and Miković, Željko and Sudar-Milovanović, Emina and Isenović, Esma R. and Perović, Milan",
year = "2021",
abstract = "Follicular and serum vitamin D are considered potential markers of the oocyte and embryos' quality and predictors of IVF outcomes.   Material and methods:  This retrospective cross-sectional study correlated vitamin D in sera and follicular fluid of women with unexplained...",
journal = "Archives of Medical Science",
title = "Follicular and serum levels of vitamin D in women with unexplained infertility and their relationship with in vitro fertilization outcome: an observational pilot study",
volume = "17",
number = "5",
pages = "1418-1422",
doi = "10.5114/aoms/141185"
}

Jeremić, A., Miković, Ž., Sudar-Milovanović, E., Isenović, E. R.,& Perović, M.. (2021). Follicular and serum levels of vitamin D in women with unexplained infertility and their relationship with in vitro fertilization outcome: an observational pilot study. in Archives of Medical Science, 17(5), 1418-1422.
https://doi.org/10.5114/aoms/141185

Jeremić A, Miković Ž, Sudar-Milovanović E, Isenović ER, Perović M. Follicular and serum levels of vitamin D in women with unexplained infertility and their relationship with in vitro fertilization outcome: an observational pilot study. in Archives of Medical Science. 2021;17(5):1418-1422.
doi:10.5114/aoms/141185 .

Jeremić, Ana, Miković, Željko, Sudar-Milovanović, Emina, Isenović, Esma R., Perović, Milan, "Follicular and serum levels of vitamin D in women with unexplained infertility and their relationship with in vitro fertilization outcome: an observational pilot study" in Archives of Medical Science, 17, no. 5 (2021):1418-1422,
https://doi.org/10.5114/aoms/141185 . .