TY  - JOUR
AU  - Anderluh, Marko
AU  - Berti, Francesco
AU  - Bzducha-Wróbel, Anna
AU  - Chiodo, Fabrizio
AU  - Colombo, Cinzia
AU  - Compostella, Federica
AU  - Durlik, Katarzyna
AU  - Ferhati, Xhenti
AU  - Holmdahl, Rikard
AU  - Jovanović, Dragana J.
AU  - Kaca, Wieslaw
AU  - Lay, Luigi
AU  - Marinović-Cincović, Milena
AU  - Marradi, Marco
AU  - Ozil, Musa
AU  - Polito, Laura
AU  - Reina, Josè Juan
AU  - Reis, Celso A.
AU  - Sackstein, Robert
AU  - Silipo, Alba
AU  - Švajger, Urban
AU  - Vaněk, Ondřej
AU  - Yamamoto, Fumiichiro
AU  - Richichi, Barbara
AU  - van Vliet, Sandra J.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9834
AB  - Vaccination is one of the greatest achievements in biomedical research preventing death and morbidity in many infectious diseases through the induction of pathogen-specific humoral and cellular immune responses. Currently, no effective vaccines are available for pathogens with a highly variable antigenic load, such as the human immunodeficiency virus or to induce cellular T-cell immunity in the fight against cancer. The recent SARS-CoV-2 outbreak has reinforced the relevance of designing smart therapeutic vaccine modalities to ensure public health. Indeed, academic and private companies have ongoing joint efforts to develop novel vaccine prototypes for this virus. Many pathogens are covered by a dense glycan-coat, which form an attractive target for vaccine development. Moreover, many tumor types are characterized by altered glycosylation profiles that are known as “tumor-associated carbohydrate antigens”. Unfortunately, glycans do not provoke a vigorous immune response and generally serve as T-cell-independent antigens, not eliciting protective immunoglobulin G responses nor inducing immunological memory. A close and continuous crosstalk between glycochemists and glycoimmunologists is essential for the successful development of efficient immune modulators. It is clear that this is a key point for the discovery of novel approaches, which could significantly improve our understanding of the immune system. In this review, we discuss the latest advancements in development of vaccines against glycan epitopes to gain selective immune responses and to provide an overview on the role of different immunogenic constructs in improving glycovaccine efficacy.
T2  - The FEBS Journal
T1  - Recent advances on smart glycoconjugate vaccines in infections and cancer
VL  - 289
SP  - 4251
EP  - 4303
DO  - 10.1111/febs.15909
ER  - 

@article{
author = "Anderluh, Marko and Berti, Francesco and Bzducha-Wróbel, Anna and Chiodo, Fabrizio and Colombo, Cinzia and Compostella, Federica and Durlik, Katarzyna and Ferhati, Xhenti and Holmdahl, Rikard and Jovanović, Dragana J. and Kaca, Wieslaw and Lay, Luigi and Marinović-Cincović, Milena and Marradi, Marco and Ozil, Musa and Polito, Laura and Reina, Josè Juan and Reis, Celso A. and Sackstein, Robert and Silipo, Alba and Švajger, Urban and Vaněk, Ondřej and Yamamoto, Fumiichiro and Richichi, Barbara and van Vliet, Sandra J.",
year = "2021",
abstract = "Vaccination is one of the greatest achievements in biomedical research preventing death and morbidity in many infectious diseases through the induction of pathogen-specific humoral and cellular immune responses. Currently, no effective vaccines are available for pathogens with a highly variable antigenic load, such as the human immunodeficiency virus or to induce cellular T-cell immunity in the fight against cancer. The recent SARS-CoV-2 outbreak has reinforced the relevance of designing smart therapeutic vaccine modalities to ensure public health. Indeed, academic and private companies have ongoing joint efforts to develop novel vaccine prototypes for this virus. Many pathogens are covered by a dense glycan-coat, which form an attractive target for vaccine development. Moreover, many tumor types are characterized by altered glycosylation profiles that are known as “tumor-associated carbohydrate antigens”. Unfortunately, glycans do not provoke a vigorous immune response and generally serve as T-cell-independent antigens, not eliciting protective immunoglobulin G responses nor inducing immunological memory. A close and continuous crosstalk between glycochemists and glycoimmunologists is essential for the successful development of efficient immune modulators. It is clear that this is a key point for the discovery of novel approaches, which could significantly improve our understanding of the immune system. In this review, we discuss the latest advancements in development of vaccines against glycan epitopes to gain selective immune responses and to provide an overview on the role of different immunogenic constructs in improving glycovaccine efficacy.",
journal = "The FEBS Journal",
title = "Recent advances on smart glycoconjugate vaccines in infections and cancer",
volume = "289",
pages = "4251-4303",
doi = "10.1111/febs.15909"
}

Anderluh, M., Berti, F., Bzducha-Wróbel, A., Chiodo, F., Colombo, C., Compostella, F., Durlik, K., Ferhati, X., Holmdahl, R., Jovanović, D. J., Kaca, W., Lay, L., Marinović-Cincović, M., Marradi, M., Ozil, M., Polito, L., Reina, J. J., Reis, C. A., Sackstein, R., Silipo, A., Švajger, U., Vaněk, O., Yamamoto, F., Richichi, B.,& van Vliet, S. J.. (2021). Recent advances on smart glycoconjugate vaccines in infections and cancer. in The FEBS Journal, 289, 4251-4303.
https://doi.org/10.1111/febs.15909

Anderluh M, Berti F, Bzducha-Wróbel A, Chiodo F, Colombo C, Compostella F, Durlik K, Ferhati X, Holmdahl R, Jovanović DJ, Kaca W, Lay L, Marinović-Cincović M, Marradi M, Ozil M, Polito L, Reina JJ, Reis CA, Sackstein R, Silipo A, Švajger U, Vaněk O, Yamamoto F, Richichi B, van Vliet SJ. Recent advances on smart glycoconjugate vaccines in infections and cancer. in The FEBS Journal. 2021;289:4251-4303.
doi:10.1111/febs.15909 .

Anderluh, Marko, Berti, Francesco, Bzducha-Wróbel, Anna, Chiodo, Fabrizio, Colombo, Cinzia, Compostella, Federica, Durlik, Katarzyna, Ferhati, Xhenti, Holmdahl, Rikard, Jovanović, Dragana J., Kaca, Wieslaw, Lay, Luigi, Marinović-Cincović, Milena, Marradi, Marco, Ozil, Musa, Polito, Laura, Reina, Josè Juan, Reis, Celso A., Sackstein, Robert, Silipo, Alba, Švajger, Urban, Vaněk, Ondřej, Yamamoto, Fumiichiro, Richichi, Barbara, van Vliet, Sandra J., "Recent advances on smart glycoconjugate vaccines in infections and cancer" in The FEBS Journal, 289 (2021):4251-4303,
https://doi.org/10.1111/febs.15909 . .