TY  - CONF
AU  - Keta, Otilija D.
AU  - Petković, Vladana
AU  - Đorđević, Neda O.
AU  - Đorđević, Miloš
AU  - Ivković, Branka
AU  - Dobričić, Vladimir
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12088
AB  - Given the well-established potential of chalcones in modulating the response of cancer cells to therapeutic interventions, coupled with the growing imperative to enhance their biological attributes, the objective of this study was to synthesize a methoxy-substituted chalcone (OCH3) and assess its capacity to amplify the inhibitory effects of radiation in melanoma cells known for their resistance to radiotherapy. The A375 melanoma cells were subjected to a clinically relevant dose of 2 Gy gamma irradiation. OCH3 was employed either as a standalone treatment or in conjunction with irradiation. The obtained results unveiled the substantial radiosensitizing potential of OCH3 within this specific cell line. Our subsequent investigations will be designed to investigate the underlying mechanisms that contribute to the radiosensitizing properties of OCH3. Moreover, we intend to evaluate the efficacy of OCH3 against other types of radioresistant cancer cells. The presented data not only illuminates the enhanced therapeutic possibilities offered by OCH3 but also highlights its potential as a valuable agent in addressing a wider array of challenging malignancies.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays
SP  - 471
EP  - 474
DO  - 10.46793/ICCBI23.471K
ER  - 

@conference{
author = "Keta, Otilija D. and Petković, Vladana and Đorđević, Neda O. and Đorđević, Miloš and Ivković, Branka and Dobričić, Vladimir",
year = "2023",
abstract = "Given the well-established potential of chalcones in modulating the response of cancer cells to therapeutic interventions, coupled with the growing imperative to enhance their biological attributes, the objective of this study was to synthesize a methoxy-substituted chalcone (OCH3) and assess its capacity to amplify the inhibitory effects of radiation in melanoma cells known for their resistance to radiotherapy. The A375 melanoma cells were subjected to a clinically relevant dose of 2 Gy gamma irradiation. OCH3 was employed either as a standalone treatment or in conjunction with irradiation. The obtained results unveiled the substantial radiosensitizing potential of OCH3 within this specific cell line. Our subsequent investigations will be designed to investigate the underlying mechanisms that contribute to the radiosensitizing properties of OCH3. Moreover, we intend to evaluate the efficacy of OCH3 against other types of radioresistant cancer cells. The presented data not only illuminates the enhanced therapeutic possibilities offered by OCH3 but also highlights its potential as a valuable agent in addressing a wider array of challenging malignancies.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays",
pages = "471-474",
doi = "10.46793/ICCBI23.471K"
}

Keta, O. D., Petković, V., Đorđević, N. O., Đorđević, M., Ivković, B.,& Dobričić, V.. (2023). The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 471-474.
https://doi.org/10.46793/ICCBI23.471K

Keta OD, Petković V, Đorđević NO, Đorđević M, Ivković B, Dobričić V. The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:471-474.
doi:10.46793/ICCBI23.471K .

Keta, Otilija D., Petković, Vladana, Đorđević, Neda O., Đorđević, Miloš, Ivković, Branka, Dobričić, Vladimir, "The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):471-474,
https://doi.org/10.46793/ICCBI23.471K . .

TY  - CONF
AU  - Keta, Otilija D.
AU  - Bošković, Jelena
AU  - Petković, Vladana
AU  - Đorđević, Neda O.
AU  - Dobričić, Vladimir
AU  - Čudina, Olivera
AU  - Pajović, Snežana B.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12089
AB  - Among novel cancer chemotherapy approaches, the use of cyclooxygenases (COXs) and lipoxygenases (LOXs) inhibitors represents a promising mean for cancer treatment showing lesser toxicity comparing to the currently used cytotoxic drugs. This study detailed the synthesis of three novel compounds: 1ME, BHTK-AA, and IBU-Ac, each with the capability to concurrently inhibit both COX-2 and 5-LOX. Subsequently, we assessed their effectiveness in inhibiting the proliferation of HeLa cervical and MIA PaCa-2 pancreatic cancer cells. The IC50 values for both examined cell lines were approximately 40 μM, indicating the promising inhibitory potential of the IBU-Ac compound in both types of cancer cells. This finding is positioned to stimulate further investigation into the potential application of IBU-Ac against these particular types of cancers, while also advocating its use in combination with standard anti-cancer protocols, i.e., chemoterapeutics or radiation therapy. The results of this work are also advocating the development and refinement of dual COX-2 and 5-LOX inhibitors, thus improving their efficacy and safety.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines
SP  - 503
EP  - 506
DO  - 10.46793/ICCBI23.503K
ER  - 

@conference{
author = "Keta, Otilija D. and Bošković, Jelena and Petković, Vladana and Đorđević, Neda O. and Dobričić, Vladimir and Čudina, Olivera and Pajović, Snežana B.",
year = "2023",
abstract = "Among novel cancer chemotherapy approaches, the use of cyclooxygenases (COXs) and lipoxygenases (LOXs) inhibitors represents a promising mean for cancer treatment showing lesser toxicity comparing to the currently used cytotoxic drugs. This study detailed the synthesis of three novel compounds: 1ME, BHTK-AA, and IBU-Ac, each with the capability to concurrently inhibit both COX-2 and 5-LOX. Subsequently, we assessed their effectiveness in inhibiting the proliferation of HeLa cervical and MIA PaCa-2 pancreatic cancer cells. The IC50 values for both examined cell lines were approximately 40 μM, indicating the promising inhibitory potential of the IBU-Ac compound in both types of cancer cells. This finding is positioned to stimulate further investigation into the potential application of IBU-Ac against these particular types of cancers, while also advocating its use in combination with standard anti-cancer protocols, i.e., chemoterapeutics or radiation therapy. The results of this work are also advocating the development and refinement of dual COX-2 and 5-LOX inhibitors, thus improving their efficacy and safety.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines",
pages = "503-506",
doi = "10.46793/ICCBI23.503K"
}

Keta, O. D., Bošković, J., Petković, V., Đorđević, N. O., Dobričić, V., Čudina, O.,& Pajović, S. B.. (2023). Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 503-506.
https://doi.org/10.46793/ICCBI23.503K

Keta OD, Bošković J, Petković V, Đorđević NO, Dobričić V, Čudina O, Pajović SB. Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:503-506.
doi:10.46793/ICCBI23.503K .

Keta, Otilija D., Bošković, Jelena, Petković, Vladana, Đorđević, Neda O., Dobričić, Vladimir, Čudina, Olivera, Pajović, Snežana B., "Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):503-506,
https://doi.org/10.46793/ICCBI23.503K . .