TY  - JOUR
AU  - Spasojević, Nataša
AU  - Jovanović, Predrag
AU  - Stanisavljevic, D.
AU  - Stefanović, Bojana
AU  - Dronjak, Slađana
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5546
AB  - The brain monoamine systems play a crucial role in mediating social behaviors. In order to assess the effect of socially isolated rats on neurochemical substrates in hypothalamus we measured levels of tyrosine hydroxylase (TH), noradrenaline transporter (NET) and vesicular monoamine transporter 2 (VMAT 2). Our results show that 12 weeks of social isolation produced no significant changes in noradrenaline content in hypothalamus. The levels of TH and NET were elevated in these animals, whereas level of VMAT 2 was unchanged. The data suggests that both enhanced synthesis and reuptake may aid in the recovery of noradrenaline content in the hypothalamus. The adaptation of the hypothalamic noradrenaline to long period of stress may have great physiological importance and may represent mechanism designed to help the organism adapt to the deleterious effects of chronic indiviual housing.
T2  - Neurochemical Journal
T1  - Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing
VL  - 7
IS  - 2
SP  - 139
EP  - 143
DO  - 10.1134/S1819712413020050
ER  - 

@article{
author = "Spasojević, Nataša and Jovanović, Predrag and Stanisavljevic, D. and Stefanović, Bojana and Dronjak, Slađana",
year = "2013",
abstract = "The brain monoamine systems play a crucial role in mediating social behaviors. In order to assess the effect of socially isolated rats on neurochemical substrates in hypothalamus we measured levels of tyrosine hydroxylase (TH), noradrenaline transporter (NET) and vesicular monoamine transporter 2 (VMAT 2). Our results show that 12 weeks of social isolation produced no significant changes in noradrenaline content in hypothalamus. The levels of TH and NET were elevated in these animals, whereas level of VMAT 2 was unchanged. The data suggests that both enhanced synthesis and reuptake may aid in the recovery of noradrenaline content in the hypothalamus. The adaptation of the hypothalamic noradrenaline to long period of stress may have great physiological importance and may represent mechanism designed to help the organism adapt to the deleterious effects of chronic indiviual housing.",
journal = "Neurochemical Journal",
title = "Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing",
volume = "7",
number = "2",
pages = "139-143",
doi = "10.1134/S1819712413020050"
}

Spasojević, N., Jovanović, P., Stanisavljevic, D., Stefanović, B.,& Dronjak, S.. (2013). Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing. in Neurochemical Journal, 7(2), 139-143.
https://doi.org/10.1134/S1819712413020050

Spasojević N, Jovanović P, Stanisavljevic D, Stefanović B, Dronjak S. Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing. in Neurochemical Journal. 2013;7(2):139-143.
doi:10.1134/S1819712413020050 .

Spasojević, Nataša, Jovanović, Predrag, Stanisavljevic, D., Stefanović, Bojana, Dronjak, Slađana, "Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing" in Neurochemical Journal, 7, no. 2 (2013):139-143,
https://doi.org/10.1134/S1819712413020050 . .