TY  - JOUR
AU  - Batinić, Petar M.
AU  - Đorđević, Verica B.
AU  - Obradović, Nataša
AU  - Krstić, Aleksandar D.
AU  - Stevanović, Sanja I.
AU  - Balanč, Bojana
AU  - Marković, Smilja
AU  - Pjanović, Rada V.
AU  - Mijin, Dušan Ž.
AU  - Bugarski, Branko M.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10851
AB  - Liposome-encapsulated folic acid is incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of CMC and solagum (9:1 w/w) using the film-forming cast solution method. Histidine is used to increase solubility for folic acid in liposomes (1–5 mg mL−1), and propylene glycol is used as a film plasticizer (2.6 mas%). The obtained films (50–60 µm tick) containing 3.12–20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films are scrutinized. Folic acid gives yellow color to the films and contributes to stronger chemical bonds which result in improved strength of the film. Liposomes prolong the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degrade homogeneity of the films, which can be ascribed to its agglomeration within the film matrix as revealed by atomic force microscopy. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg mL−1 liposome-encapsulated folic acid is recommended. Practical Application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide.
T2  - European Journal of Lipid Science and Technology
T1  - Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid
SP  - 2200169
DO  - 10.1002/ejlt.202200169
ER  - 

@article{
author = "Batinić, Petar M. and Đorđević, Verica B. and Obradović, Nataša and Krstić, Aleksandar D. and Stevanović, Sanja I. and Balanč, Bojana and Marković, Smilja and Pjanović, Rada V. and Mijin, Dušan Ž. and Bugarski, Branko M.",
year = "2023",
abstract = "Liposome-encapsulated folic acid is incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of CMC and solagum (9:1 w/w) using the film-forming cast solution method. Histidine is used to increase solubility for folic acid in liposomes (1–5 mg mL−1), and propylene glycol is used as a film plasticizer (2.6 mas%). The obtained films (50–60 µm tick) containing 3.12–20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films are scrutinized. Folic acid gives yellow color to the films and contributes to stronger chemical bonds which result in improved strength of the film. Liposomes prolong the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degrade homogeneity of the films, which can be ascribed to its agglomeration within the film matrix as revealed by atomic force microscopy. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg mL−1 liposome-encapsulated folic acid is recommended. Practical Application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide.",
journal = "European Journal of Lipid Science and Technology",
title = "Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid",
pages = "2200169",
doi = "10.1002/ejlt.202200169"
}

Batinić, P. M., Đorđević, V. B., Obradović, N., Krstić, A. D., Stevanović, S. I., Balanč, B., Marković, S., Pjanović, R. V., Mijin, D. Ž.,& Bugarski, B. M.. (2023). Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid. in European Journal of Lipid Science and Technology, 2200169.
https://doi.org/10.1002/ejlt.202200169

Batinić PM, Đorđević VB, Obradović N, Krstić AD, Stevanović SI, Balanč B, Marković S, Pjanović RV, Mijin DŽ, Bugarski BM. Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid. in European Journal of Lipid Science and Technology. 2023;:2200169.
doi:10.1002/ejlt.202200169 .

Batinić, Petar M., Đorđević, Verica B., Obradović, Nataša, Krstić, Aleksandar D., Stevanović, Sanja I., Balanč, Bojana, Marković, Smilja, Pjanović, Rada V., Mijin, Dušan Ž., Bugarski, Branko M., "Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid" in European Journal of Lipid Science and Technology (2023):2200169,
https://doi.org/10.1002/ejlt.202200169 . .

TY  - JOUR
AU  - Kaluđerović, Branka V.
AU  - Jovanovic, Vladislava M.
AU  - Stevanović, Sanja I.
AU  - Bogdanov, Žarko
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5837
AB  - An ultrasonic irradiation was applied for the impregnation by chemical agents in the chemical activation process of new type of active carbon precursor. Plane tree seed, due to the unique fibrous structure and low cost is a promising eco-friendly raw material for the preparation of activated carbon materials. Ultrasonic irradiation was used for the impregnation step allowing the chemical activation by different agents: potassium or sodium hydroxide, hydrogen peroxide and pyrogallol. The porous structures were examined by nitrogen adsorption/desorption isotherms at 77 K and electrochemically by cyclic voltammetry. The textures of these materials were observed by scanning electron microscopy. The application of ultrasonic irradiation in the impregnation step increased surface area of the final material more than two times in comparison to the material which impregnation in the activation process was by conventional stirring. Ultrasonic irradiation enhances the chemical activation process and the activated carbon fibrous materials with nanoporous structure were obtained by impregnation of seeds with alkaline hydroxides. Total surface areas of these samples were 976 m(2) g(-1), and 1130 m(2) g(-1). These fibers have total specific capacitance as high as 125 F g(-1) and 53 F g(-1) which major fraction in both cases originate from internal micropores structure. (C) 2013 Elsevier B.V. All rights reserved.
T2  - Ultrasonics Sonochemistry
T1  - Characterization of nanoporous carbon fibrous materials obtained by chemical activation of plane tree seed under ultrasonic irradiation
VL  - 21
IS  - 2
SP  - 782
EP  - 789
DO  - 10.1016/j.ultsonch.2013.09.004
ER  - 

@article{
author = "Kaluđerović, Branka V. and Jovanovic, Vladislava M. and Stevanović, Sanja I. and Bogdanov, Žarko",
year = "2014",
abstract = "An ultrasonic irradiation was applied for the impregnation by chemical agents in the chemical activation process of new type of active carbon precursor. Plane tree seed, due to the unique fibrous structure and low cost is a promising eco-friendly raw material for the preparation of activated carbon materials. Ultrasonic irradiation was used for the impregnation step allowing the chemical activation by different agents: potassium or sodium hydroxide, hydrogen peroxide and pyrogallol. The porous structures were examined by nitrogen adsorption/desorption isotherms at 77 K and electrochemically by cyclic voltammetry. The textures of these materials were observed by scanning electron microscopy. The application of ultrasonic irradiation in the impregnation step increased surface area of the final material more than two times in comparison to the material which impregnation in the activation process was by conventional stirring. Ultrasonic irradiation enhances the chemical activation process and the activated carbon fibrous materials with nanoporous structure were obtained by impregnation of seeds with alkaline hydroxides. Total surface areas of these samples were 976 m(2) g(-1), and 1130 m(2) g(-1). These fibers have total specific capacitance as high as 125 F g(-1) and 53 F g(-1) which major fraction in both cases originate from internal micropores structure. (C) 2013 Elsevier B.V. All rights reserved.",
journal = "Ultrasonics Sonochemistry",
title = "Characterization of nanoporous carbon fibrous materials obtained by chemical activation of plane tree seed under ultrasonic irradiation",
volume = "21",
number = "2",
pages = "782-789",
doi = "10.1016/j.ultsonch.2013.09.004"
}

Kaluđerović, B. V., Jovanovic, V. M., Stevanović, S. I.,& Bogdanov, Ž.. (2014). Characterization of nanoporous carbon fibrous materials obtained by chemical activation of plane tree seed under ultrasonic irradiation. in Ultrasonics Sonochemistry, 21(2), 782-789.
https://doi.org/10.1016/j.ultsonch.2013.09.004

Kaluđerović BV, Jovanovic VM, Stevanović SI, Bogdanov Ž. Characterization of nanoporous carbon fibrous materials obtained by chemical activation of plane tree seed under ultrasonic irradiation. in Ultrasonics Sonochemistry. 2014;21(2):782-789.
doi:10.1016/j.ultsonch.2013.09.004 .

Kaluđerović, Branka V., Jovanovic, Vladislava M., Stevanović, Sanja I., Bogdanov, Žarko, "Characterization of nanoporous carbon fibrous materials obtained by chemical activation of plane tree seed under ultrasonic irradiation" in Ultrasonics Sonochemistry, 21, no. 2 (2014):782-789,
https://doi.org/10.1016/j.ultsonch.2013.09.004 . .

TY  - JOUR
AU  - Kljajević, Ljiljana M.
AU  - Jovanovic, Vladislava M.
AU  - Stevanović, Sanja I.
AU  - Bogdanov, Žarko
AU  - Kaluđerović, Branka V.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4515
AB  - Active carbon hollow fibers were prepared from regenerated polysulfone hollow fibers by chemical activation using: disodium hydrogen phosphate 2-hydrate, disodium tetraborate 10-hydrate, hydrogen peroxide, and diammonium hydrogen phosphate. After chemical activation fibers were carbonized in an inert atmosphere. The specific surface area and porosity of obtained carbons were studied by nitrogen adsorption-desorption isotherms at 77 K, while the structures were examined with scanning electron microscopy and X-ray diffraction. The activation process increases these adsorption properties of fibers being more pronounced for active carbon fibers obtained with disodium tetraborate 10-hydrate and hydrogen peroxide as activator. The obtained active hollow carbons are microporous with different pore size distribution. Chemical activation with phosphates produces active carbon material with small surface area but with both mesopores and micropores. X-ray diffraction shows that besides turbostratic structure typical for carbon materials, there are some peaks which indicate some intermediate reaction products when sodium salts were used as activating agent. Based on data from the electrochemical measurements the activity and porosity of the active fibers depend strongly on the oxidizing agent applied.
T2  - Journal of the Serbian Chemical Society
T1  - Influence of chemical agents on the surface area and porosity of active carbon hollow fibers
VL  - 76
IS  - 9
SP  - 1283
EP  - 1294
DO  - 10.2298/JSC100226112K
ER  - 

@article{
author = "Kljajević, Ljiljana M. and Jovanovic, Vladislava M. and Stevanović, Sanja I. and Bogdanov, Žarko and Kaluđerović, Branka V.",
year = "2011",
abstract = "Active carbon hollow fibers were prepared from regenerated polysulfone hollow fibers by chemical activation using: disodium hydrogen phosphate 2-hydrate, disodium tetraborate 10-hydrate, hydrogen peroxide, and diammonium hydrogen phosphate. After chemical activation fibers were carbonized in an inert atmosphere. The specific surface area and porosity of obtained carbons were studied by nitrogen adsorption-desorption isotherms at 77 K, while the structures were examined with scanning electron microscopy and X-ray diffraction. The activation process increases these adsorption properties of fibers being more pronounced for active carbon fibers obtained with disodium tetraborate 10-hydrate and hydrogen peroxide as activator. The obtained active hollow carbons are microporous with different pore size distribution. Chemical activation with phosphates produces active carbon material with small surface area but with both mesopores and micropores. X-ray diffraction shows that besides turbostratic structure typical for carbon materials, there are some peaks which indicate some intermediate reaction products when sodium salts were used as activating agent. Based on data from the electrochemical measurements the activity and porosity of the active fibers depend strongly on the oxidizing agent applied.",
journal = "Journal of the Serbian Chemical Society",
title = "Influence of chemical agents on the surface area and porosity of active carbon hollow fibers",
volume = "76",
number = "9",
pages = "1283-1294",
doi = "10.2298/JSC100226112K"
}

Kljajević, L. M., Jovanovic, V. M., Stevanović, S. I., Bogdanov, Ž.,& Kaluđerović, B. V.. (2011). Influence of chemical agents on the surface area and porosity of active carbon hollow fibers. in Journal of the Serbian Chemical Society, 76(9), 1283-1294.
https://doi.org/10.2298/JSC100226112K

Kljajević LM, Jovanovic VM, Stevanović SI, Bogdanov Ž, Kaluđerović BV. Influence of chemical agents on the surface area and porosity of active carbon hollow fibers. in Journal of the Serbian Chemical Society. 2011;76(9):1283-1294.
doi:10.2298/JSC100226112K .

Kljajević, Ljiljana M., Jovanovic, Vladislava M., Stevanović, Sanja I., Bogdanov, Žarko, Kaluđerović, Branka V., "Influence of chemical agents on the surface area and porosity of active carbon hollow fibers" in Journal of the Serbian Chemical Society, 76, no. 9 (2011):1283-1294,
https://doi.org/10.2298/JSC100226112K . .