TY  - JOUR
AU  - Popović, Nataša M.
AU  - Ruždijić, Sabera
AU  - Kanazir, Dušan T.
AU  - Nićiforović, Ana
AU  - Adžić, Miroslav
AU  - Paraskevopoulou, Elissavet
AU  - Pantelidou, Constantia
AU  - Radojčić, Marija
AU  - Demonacos, Constantinos
AU  - Krstić-Demonacos, Marija
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3999
AB  - The glucocorticoid receptor (GR) signal transduction and transcriptional regulation are efficiently recapitulated when GR is expressed in Saccharomyces cerevisiae. In this report we demonstrate that the in vivo GR phosphorylation pattern, hormone dependency and interdependency of phosphorylation events were similar in yeast and mammalian cells. GR phosphorylation at S246 exhibited inhibitory effect on S224 and S232 phosphorylation, suggesting the conservation of molecular mechanisms that control this interdependence between yeast and mammalian cells. To assess the effects of GR phosphorylation the mutated GR derivatives T171A, S224A, S232A, S246A were overexpressed and their transcriptional activity was analysed. These receptor derivatives displayed significant hormone inducible transcription when overexpressed in S. cerevisiae. We have established an inducible methionine expression system, which allows the close regulation of the receptor protein levels to analyse the dependence of GR function on its phosphorylation and protein abundance. Using this system we observed that GR S246A mutation increased its activity across all of the GR concentrations tested. The activity of the S224A and S246A mutants was mostly independent of GR protein levels, whereas the WT, T171A and S232A mediated transcription diminished with declining GR protein levels. Our results suggest that GR phosphorylation at specific residues affects its transcriptional functions in a site selective manner and these effects were directly linked to GR dosage. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.
T2  - Steroids
T1  - Site-specific and dose-dependent effects of glucocorticoid receptor phosphorylation in yeast Saccharomyces cerevisiae
VL  - 75
IS  - 6
SP  - 457
EP  - 465
DO  - 10.1016/j.steroids.2010.03.001
ER  - 

@article{
author = "Popović, Nataša M. and Ruždijić, Sabera and Kanazir, Dušan T. and Nićiforović, Ana and Adžić, Miroslav and Paraskevopoulou, Elissavet and Pantelidou, Constantia and Radojčić, Marija and Demonacos, Constantinos and Krstić-Demonacos, Marija",
year = "2010",
abstract = "The glucocorticoid receptor (GR) signal transduction and transcriptional regulation are efficiently recapitulated when GR is expressed in Saccharomyces cerevisiae. In this report we demonstrate that the in vivo GR phosphorylation pattern, hormone dependency and interdependency of phosphorylation events were similar in yeast and mammalian cells. GR phosphorylation at S246 exhibited inhibitory effect on S224 and S232 phosphorylation, suggesting the conservation of molecular mechanisms that control this interdependence between yeast and mammalian cells. To assess the effects of GR phosphorylation the mutated GR derivatives T171A, S224A, S232A, S246A were overexpressed and their transcriptional activity was analysed. These receptor derivatives displayed significant hormone inducible transcription when overexpressed in S. cerevisiae. We have established an inducible methionine expression system, which allows the close regulation of the receptor protein levels to analyse the dependence of GR function on its phosphorylation and protein abundance. Using this system we observed that GR S246A mutation increased its activity across all of the GR concentrations tested. The activity of the S224A and S246A mutants was mostly independent of GR protein levels, whereas the WT, T171A and S232A mediated transcription diminished with declining GR protein levels. Our results suggest that GR phosphorylation at specific residues affects its transcriptional functions in a site selective manner and these effects were directly linked to GR dosage. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.",
journal = "Steroids",
title = "Site-specific and dose-dependent effects of glucocorticoid receptor phosphorylation in yeast Saccharomyces cerevisiae",
volume = "75",
number = "6",
pages = "457-465",
doi = "10.1016/j.steroids.2010.03.001"
}

Popović, N. M., Ruždijić, S., Kanazir, D. T., Nićiforović, A., Adžić, M., Paraskevopoulou, E., Pantelidou, C., Radojčić, M., Demonacos, C.,& Krstić-Demonacos, M.. (2010). Site-specific and dose-dependent effects of glucocorticoid receptor phosphorylation in yeast Saccharomyces cerevisiae. in Steroids, 75(6), 457-465.
https://doi.org/10.1016/j.steroids.2010.03.001

Popović NM, Ruždijić S, Kanazir DT, Nićiforović A, Adžić M, Paraskevopoulou E, Pantelidou C, Radojčić M, Demonacos C, Krstić-Demonacos M. Site-specific and dose-dependent effects of glucocorticoid receptor phosphorylation in yeast Saccharomyces cerevisiae. in Steroids. 2010;75(6):457-465.
doi:10.1016/j.steroids.2010.03.001 .

Popović, Nataša M., Ruždijić, Sabera, Kanazir, Dušan T., Nićiforović, Ana, Adžić, Miroslav, Paraskevopoulou, Elissavet, Pantelidou, Constantia, Radojčić, Marija, Demonacos, Constantinos, Krstić-Demonacos, Marija, "Site-specific and dose-dependent effects of glucocorticoid receptor phosphorylation in yeast Saccharomyces cerevisiae" in Steroids, 75, no. 6 (2010):457-465,
https://doi.org/10.1016/j.steroids.2010.03.001 . .

TY  - JOUR
AU  - Terzić, N
AU  - Vujčić, Miroslava T.
AU  - Ristić-Fira, Aleksandra
AU  - Krstić-Demonacos, Marija
AU  - Milanovic, D
AU  - Kanazir, Dušan T.
AU  - Ruždijić, Sabera
PY  - 2003
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2623
AB  - The effect of dexamethasone (DEX) on glucocorticoid receptor (GR)-mediated gene expression was examined in the brain of young and aged rats. Electrophoretic mobility shift assays showed that DEX treatment led to an increase of glucocorticoid response element (GRE) binding activity in aged rats, whereas in young animals GRE binding activity was decreased. Western blot analysis and reverse transcriptase polymerase chain reaction confirmed that, in aged animals, the GR mRNA and the GR protein levels were increased on DEX treatment. The binding activity of GRE activating protein-1 (AP-1) site and cross-competition analysis demonstrated specific pattern of expression during the ageing and DEX treatment, suggesting that GR modulates the activity of transcription factors AP-1 (Fos/Jun proteins) through protein-protein interaction. On the basis of these results, it can be concluded that the composition of transcriptional complexes that bind to GRE and AP-I regulatory elements changes upon DEX treatment in an age-specific manner.
T2  - Journals of Gerontology. Series A: Biological Sciences and Medical Sciences
T1  - Effects of age and dexamethasone treatment on glucocorticoid response element and activating protein-1 binding activity in rat brain
VL  - 58
IS  - 4
SP  - 297
EP  - 303
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2623
ER  - 

@article{
author = "Terzić, N and Vujčić, Miroslava T. and Ristić-Fira, Aleksandra and Krstić-Demonacos, Marija and Milanovic, D and Kanazir, Dušan T. and Ruždijić, Sabera",
year = "2003",
abstract = "The effect of dexamethasone (DEX) on glucocorticoid receptor (GR)-mediated gene expression was examined in the brain of young and aged rats. Electrophoretic mobility shift assays showed that DEX treatment led to an increase of glucocorticoid response element (GRE) binding activity in aged rats, whereas in young animals GRE binding activity was decreased. Western blot analysis and reverse transcriptase polymerase chain reaction confirmed that, in aged animals, the GR mRNA and the GR protein levels were increased on DEX treatment. The binding activity of GRE activating protein-1 (AP-1) site and cross-competition analysis demonstrated specific pattern of expression during the ageing and DEX treatment, suggesting that GR modulates the activity of transcription factors AP-1 (Fos/Jun proteins) through protein-protein interaction. On the basis of these results, it can be concluded that the composition of transcriptional complexes that bind to GRE and AP-I regulatory elements changes upon DEX treatment in an age-specific manner.",
journal = "Journals of Gerontology. Series A: Biological Sciences and Medical Sciences",
title = "Effects of age and dexamethasone treatment on glucocorticoid response element and activating protein-1 binding activity in rat brain",
volume = "58",
number = "4",
pages = "297-303",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2623"
}

Terzić, N., Vujčić, M. T., Ristić-Fira, A., Krstić-Demonacos, M., Milanovic, D., Kanazir, D. T.,& Ruždijić, S.. (2003). Effects of age and dexamethasone treatment on glucocorticoid response element and activating protein-1 binding activity in rat brain. in Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 58(4), 297-303.
https://hdl.handle.net/21.15107/rcub_vinar_2623

Terzić N, Vujčić MT, Ristić-Fira A, Krstić-Demonacos M, Milanovic D, Kanazir DT, Ruždijić S. Effects of age and dexamethasone treatment on glucocorticoid response element and activating protein-1 binding activity in rat brain. in Journals of Gerontology. Series A: Biological Sciences and Medical Sciences. 2003;58(4):297-303.
https://hdl.handle.net/21.15107/rcub_vinar_2623 .

Terzić, N, Vujčić, Miroslava T., Ristić-Fira, Aleksandra, Krstić-Demonacos, Marija, Milanovic, D, Kanazir, Dušan T., Ruždijić, Sabera, "Effects of age and dexamethasone treatment on glucocorticoid response element and activating protein-1 binding activity in rat brain" in Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 58, no. 4 (2003):297-303,
https://hdl.handle.net/21.15107/rcub_vinar_2623 .

TY  - JOUR
AU  - Ristić-Fira, Aleksandra
AU  - Todorović, Danijela V.
AU  - Petrović, Ivan M.
AU  - Ruzvdijic, S
AU  - Raffaele, L
AU  - Sabini, MG
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cuttone, Giacomo
AU  - Farruggia, G
AU  - Masotti, L
AU  - Kanazir, Dušan T.
PY  - 2001
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6321
AB  - The aim of this work is the in vitro study of human melanoma cell growth modulation after irradiation with protons. Confluent cell monolayers were irradiated with single doses ranging from 1 to 20 Gy, using proton beams having energy of 22.6 MeV at the target. 48 hours after irradiation, cell growth, cell cycle analyses and initiation of cell death were followed. The obtained results were compared with the effects of glucocorticoid hormones. The inhibition of melanoma cell growth was observed, especially after single application of 12 and 16 Gy. Cell cycle analyses of melanomas after proton irradiation, have shown the G2/M arrest of irradiated cells corresponding with the increase of applied dose. The flow cytometric analysis has shown presence of apoptotic nuclei. Glucocorticoid treatment has shown modest melanoma cell growth inhibition, cell cycle arrest in G2/M phase and ladder pattern on agarose gel electrophoresis.
T2  - Physica Medica
T1  - Inhibition of human melanoma cell growth by proton irradiation
VL  - 17
SP  - 71
EP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_vinar_6321
ER  - 

@article{
author = "Ristić-Fira, Aleksandra and Todorović, Danijela V. and Petrović, Ivan M. and Ruzvdijic, S and Raffaele, L and Sabini, MG and Cirrone, Giuseppe Antonio Pablo and Cuttone, Giacomo and Farruggia, G and Masotti, L and Kanazir, Dušan T.",
year = "2001",
abstract = "The aim of this work is the in vitro study of human melanoma cell growth modulation after irradiation with protons. Confluent cell monolayers were irradiated with single doses ranging from 1 to 20 Gy, using proton beams having energy of 22.6 MeV at the target. 48 hours after irradiation, cell growth, cell cycle analyses and initiation of cell death were followed. The obtained results were compared with the effects of glucocorticoid hormones. The inhibition of melanoma cell growth was observed, especially after single application of 12 and 16 Gy. Cell cycle analyses of melanomas after proton irradiation, have shown the G2/M arrest of irradiated cells corresponding with the increase of applied dose. The flow cytometric analysis has shown presence of apoptotic nuclei. Glucocorticoid treatment has shown modest melanoma cell growth inhibition, cell cycle arrest in G2/M phase and ladder pattern on agarose gel electrophoresis.",
journal = "Physica Medica",
title = "Inhibition of human melanoma cell growth by proton irradiation",
volume = "17",
pages = "71-75",
url = "https://hdl.handle.net/21.15107/rcub_vinar_6321"
}

Ristić-Fira, A., Todorović, D. V., Petrović, I. M., Ruzvdijic, S., Raffaele, L., Sabini, M., Cirrone, G. A. P., Cuttone, G., Farruggia, G., Masotti, L.,& Kanazir, D. T.. (2001). Inhibition of human melanoma cell growth by proton irradiation. in Physica Medica, 17, 71-75.
https://hdl.handle.net/21.15107/rcub_vinar_6321

Ristić-Fira A, Todorović DV, Petrović IM, Ruzvdijic S, Raffaele L, Sabini M, Cirrone GAP, Cuttone G, Farruggia G, Masotti L, Kanazir DT. Inhibition of human melanoma cell growth by proton irradiation. in Physica Medica. 2001;17:71-75.
https://hdl.handle.net/21.15107/rcub_vinar_6321 .

Ristić-Fira, Aleksandra, Todorović, Danijela V., Petrović, Ivan M., Ruzvdijic, S, Raffaele, L, Sabini, MG, Cirrone, Giuseppe Antonio Pablo, Cuttone, Giacomo, Farruggia, G, Masotti, L, Kanazir, Dušan T., "Inhibition of human melanoma cell growth by proton irradiation" in Physica Medica, 17 (2001):71-75,
https://hdl.handle.net/21.15107/rcub_vinar_6321 .

TY  - JOUR
AU  - Horvat, Anica
AU  - Nikezie, G
AU  - Petrović, S
AU  - Kanazir, Dušan T.
PY  - 2001
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2430
AB  - The subsynaptosomal distribution and specific binding of 17 beta -estradiol in vitro to mitochondria isolated from presynaptic nerve endings of female rat brain were examined. 17 beta -Estradiol is (i) distributed unequally in synaptosomes and mitochondria posses the highest capacity to bind estradiol with respect to the available amount of the hormone. (ii) Estradiol binds specifically to isolated synaptosomal mitochondria. A Michaelis-Menten plot of specific binding was sigmoidal within a concentration range of 0.1-5 nM of added estradiol, with a saturation plateau at 3 nM. Binding of higher estradiol concentrations demonstrated an exponential Michaelis-Menten plot, indicating non-specific binding to mitochondria. V-max, and K-m for the sigmoidal-shape range were estimated as 46 +/- 6 fmol of estradiol/mg of mitochondrial proteins and 0.46 +/- 0.07 nM free estradiol respectively. (iii) Esstradiol binding is not affected by the removal of ovaries. The results show that inhibition of Na-dependent Ca2+ efflux from mitochondria by estradiol occurs according to an affinity change of the translocator for Na+, at the same estradiol concentrations that show specific binding to mitochondrial membranes. These data imply that physiological concentrations of estradiol, acting on mitochondrial membrane properties, extragenomically modulate the mitochondrial, and consequently the synaptosomal content of Ca2+, and in that way exert a significant change in nerve cell homeostasis.
T2  - Cellular and Molecular Life Sciences / CMLS
T1  - Binding of estradiol to synaptosomal mitochondria: physiological significance
VL  - 58
IS  - 4
SP  - 636
EP  - 644
DO  - 10.1007/PL00000886
ER  - 

@article{
author = "Horvat, Anica and Nikezie, G and Petrović, S and Kanazir, Dušan T.",
year = "2001",
abstract = "The subsynaptosomal distribution and specific binding of 17 beta -estradiol in vitro to mitochondria isolated from presynaptic nerve endings of female rat brain were examined. 17 beta -Estradiol is (i) distributed unequally in synaptosomes and mitochondria posses the highest capacity to bind estradiol with respect to the available amount of the hormone. (ii) Estradiol binds specifically to isolated synaptosomal mitochondria. A Michaelis-Menten plot of specific binding was sigmoidal within a concentration range of 0.1-5 nM of added estradiol, with a saturation plateau at 3 nM. Binding of higher estradiol concentrations demonstrated an exponential Michaelis-Menten plot, indicating non-specific binding to mitochondria. V-max, and K-m for the sigmoidal-shape range were estimated as 46 +/- 6 fmol of estradiol/mg of mitochondrial proteins and 0.46 +/- 0.07 nM free estradiol respectively. (iii) Esstradiol binding is not affected by the removal of ovaries. The results show that inhibition of Na-dependent Ca2+ efflux from mitochondria by estradiol occurs according to an affinity change of the translocator for Na+, at the same estradiol concentrations that show specific binding to mitochondrial membranes. These data imply that physiological concentrations of estradiol, acting on mitochondrial membrane properties, extragenomically modulate the mitochondrial, and consequently the synaptosomal content of Ca2+, and in that way exert a significant change in nerve cell homeostasis.",
journal = "Cellular and Molecular Life Sciences / CMLS",
title = "Binding of estradiol to synaptosomal mitochondria: physiological significance",
volume = "58",
number = "4",
pages = "636-644",
doi = "10.1007/PL00000886"
}

Horvat, A., Nikezie, G., Petrović, S.,& Kanazir, D. T.. (2001). Binding of estradiol to synaptosomal mitochondria: physiological significance. in Cellular and Molecular Life Sciences / CMLS, 58(4), 636-644.
https://doi.org/10.1007/PL00000886

Horvat A, Nikezie G, Petrović S, Kanazir DT. Binding of estradiol to synaptosomal mitochondria: physiological significance. in Cellular and Molecular Life Sciences / CMLS. 2001;58(4):636-644.
doi:10.1007/PL00000886 .

Horvat, Anica, Nikezie, G, Petrović, S, Kanazir, Dušan T., "Binding of estradiol to synaptosomal mitochondria: physiological significance" in Cellular and Molecular Life Sciences / CMLS, 58, no. 4 (2001):636-644,
https://doi.org/10.1007/PL00000886 . .

TY  - JOUR
AU  - Ristić-Fira, Aleksandra
AU  - Nikolic, D
AU  - Petrović, Ivan M.
AU  - Ruždijić, Sabera
AU  - Raffaele, L
AU  - Sabini, MG
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cuttone, Giacomo
AU  - Farruggia, G
AU  - Masotti, L
AU  - Kanazir, Dušan T.
PY  - 2001
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2426
AB  - The aim of this work is the in vitro study of the late effects of single proton irradiation on HTB63 human melanoma cell growth, cell cycle and cell death. The experimental conditions were focused on analyzing the effects of irradiation on the periphery of tumour that can be, in clinical practice, close to critical organs. Confluent cell monolayers were irradiated with single doses ranging from 1 - 20 Gy, using proton beams having an energy of 22.6 MeV at the target. Antiproliferative effect of protons, cell cycle analysis and initiation of cell death, were followed 48 hours after irradiation. The inhibition of melanoma cell growth was observed, especially after single application of 12 and 16 Gy. Cell cycle analysis and cell viability have shown the G2/M and G1/G0 arrest of irradiated cells correlating with the increase of the applied dose. The flow cytometric analysis has shown presence of apoptotic nuclei. These data demonstrate that irradiation with protons, under the chosen experimental conditions, have significant effects on melanoma cell growth inhibition being dose dependent, G2/M cell cycle arrest and appearance of apoptotic nuclei, even 48 hours after irradiation. The results obtained may help the understanding of the relationship between cell proliferation, death and cell cycle regulation of melanomas after proton irradiation.
T2  - Journal of Experimental and Clinical Cancer Research
T1  - The late effects of proton irradiation on cell growth, cell cycle arrest and apoptosis in a human melanoma cell line
VL  - 20
IS  - 1
SP  - 135
EP  - 143
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2426
ER  - 

@article{
author = "Ristić-Fira, Aleksandra and Nikolic, D and Petrović, Ivan M. and Ruždijić, Sabera and Raffaele, L and Sabini, MG and Cirrone, Giuseppe Antonio Pablo and Cuttone, Giacomo and Farruggia, G and Masotti, L and Kanazir, Dušan T.",
year = "2001",
abstract = "The aim of this work is the in vitro study of the late effects of single proton irradiation on HTB63 human melanoma cell growth, cell cycle and cell death. The experimental conditions were focused on analyzing the effects of irradiation on the periphery of tumour that can be, in clinical practice, close to critical organs. Confluent cell monolayers were irradiated with single doses ranging from 1 - 20 Gy, using proton beams having an energy of 22.6 MeV at the target. Antiproliferative effect of protons, cell cycle analysis and initiation of cell death, were followed 48 hours after irradiation. The inhibition of melanoma cell growth was observed, especially after single application of 12 and 16 Gy. Cell cycle analysis and cell viability have shown the G2/M and G1/G0 arrest of irradiated cells correlating with the increase of the applied dose. The flow cytometric analysis has shown presence of apoptotic nuclei. These data demonstrate that irradiation with protons, under the chosen experimental conditions, have significant effects on melanoma cell growth inhibition being dose dependent, G2/M cell cycle arrest and appearance of apoptotic nuclei, even 48 hours after irradiation. The results obtained may help the understanding of the relationship between cell proliferation, death and cell cycle regulation of melanomas after proton irradiation.",
journal = "Journal of Experimental and Clinical Cancer Research",
title = "The late effects of proton irradiation on cell growth, cell cycle arrest and apoptosis in a human melanoma cell line",
volume = "20",
number = "1",
pages = "135-143",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2426"
}

Ristić-Fira, A., Nikolic, D., Petrović, I. M., Ruždijić, S., Raffaele, L., Sabini, M., Cirrone, G. A. P., Cuttone, G., Farruggia, G., Masotti, L.,& Kanazir, D. T.. (2001). The late effects of proton irradiation on cell growth, cell cycle arrest and apoptosis in a human melanoma cell line. in Journal of Experimental and Clinical Cancer Research, 20(1), 135-143.
https://hdl.handle.net/21.15107/rcub_vinar_2426

Ristić-Fira A, Nikolic D, Petrović IM, Ruždijić S, Raffaele L, Sabini M, Cirrone GAP, Cuttone G, Farruggia G, Masotti L, Kanazir DT. The late effects of proton irradiation on cell growth, cell cycle arrest and apoptosis in a human melanoma cell line. in Journal of Experimental and Clinical Cancer Research. 2001;20(1):135-143.
https://hdl.handle.net/21.15107/rcub_vinar_2426 .

Ristić-Fira, Aleksandra, Nikolic, D, Petrović, Ivan M., Ruždijić, Sabera, Raffaele, L, Sabini, MG, Cirrone, Giuseppe Antonio Pablo, Cuttone, Giacomo, Farruggia, G, Masotti, L, Kanazir, Dušan T., "The late effects of proton irradiation on cell growth, cell cycle arrest and apoptosis in a human melanoma cell line" in Journal of Experimental and Clinical Cancer Research, 20, no. 1 (2001):135-143,
https://hdl.handle.net/21.15107/rcub_vinar_2426 .

TY  - JOUR
AU  - Nedeljković, N.
AU  - Đorđević, V.
AU  - Horvat, Anica
AU  - Nikezić, Gordana S.
AU  - Kanazir, Dušan T.
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2376
AB  - Abundant evidence indicates that ATP and adenosine act as neurotransmitters or co-transmitters, influencing nerve cell physiology in various ways. Therefore, regulation of ATP-metabolizing enzymes is essential for the normal development and function of neuronal tissue. In the present study we have examined the effect of gonadal (OVX) or adrenal (ADX) steroid hormone deprivation on the activity and expression of synaptic membrane ecto-ATPase in three extrahypothalamic brain areas of female rats, primarily not associated with reproductive function. It was shown that OVX significantly increased ecto-ATPase activity and the relative abundance of this enzyme in the hippocampal (Hip) and caudate nucleus (CN), but not in brain stem (BS) membrane preparations. ADX was followed by an upregulation of the enzyme activity and its relative abundance in all the brain areas investigated. The highest enzyme activity and the most profound effects of OVX and ADX were detected in the CN. The results obtained indicate that ADX and OVX upregulate the expression of ecto-ATPase, potentiating the production of adenosine in synaptic cleft thus modulating the activity of numerous neurotransmitter systems in distinct areas of the CNS.
T2  - Physiological Research
T1  - Effect of steroid hormone deprivation on the expression of ecto-ATPase in distinct brain regions of female rats
VL  - 49
IS  - 4
SP  - 419
EP  - 426
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2376
ER  - 

@article{
author = "Nedeljković, N. and Đorđević, V. and Horvat, Anica and Nikezić, Gordana S. and Kanazir, Dušan T.",
year = "2000",
abstract = "Abundant evidence indicates that ATP and adenosine act as neurotransmitters or co-transmitters, influencing nerve cell physiology in various ways. Therefore, regulation of ATP-metabolizing enzymes is essential for the normal development and function of neuronal tissue. In the present study we have examined the effect of gonadal (OVX) or adrenal (ADX) steroid hormone deprivation on the activity and expression of synaptic membrane ecto-ATPase in three extrahypothalamic brain areas of female rats, primarily not associated with reproductive function. It was shown that OVX significantly increased ecto-ATPase activity and the relative abundance of this enzyme in the hippocampal (Hip) and caudate nucleus (CN), but not in brain stem (BS) membrane preparations. ADX was followed by an upregulation of the enzyme activity and its relative abundance in all the brain areas investigated. The highest enzyme activity and the most profound effects of OVX and ADX were detected in the CN. The results obtained indicate that ADX and OVX upregulate the expression of ecto-ATPase, potentiating the production of adenosine in synaptic cleft thus modulating the activity of numerous neurotransmitter systems in distinct areas of the CNS.",
journal = "Physiological Research",
title = "Effect of steroid hormone deprivation on the expression of ecto-ATPase in distinct brain regions of female rats",
volume = "49",
number = "4",
pages = "419-426",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2376"
}

Nedeljković, N., Đorđević, V., Horvat, A., Nikezić, G. S.,& Kanazir, D. T.. (2000). Effect of steroid hormone deprivation on the expression of ecto-ATPase in distinct brain regions of female rats. in Physiological Research, 49(4), 419-426.
https://hdl.handle.net/21.15107/rcub_vinar_2376

Nedeljković N, Đorđević V, Horvat A, Nikezić GS, Kanazir DT. Effect of steroid hormone deprivation on the expression of ecto-ATPase in distinct brain regions of female rats. in Physiological Research. 2000;49(4):419-426.
https://hdl.handle.net/21.15107/rcub_vinar_2376 .

Nedeljković, N., Đorđević, V., Horvat, Anica, Nikezić, Gordana S., Kanazir, Dušan T., "Effect of steroid hormone deprivation on the expression of ecto-ATPase in distinct brain regions of female rats" in Physiological Research, 49, no. 4 (2000):419-426,
https://hdl.handle.net/21.15107/rcub_vinar_2376 .

TY  - JOUR
AU  - Joksić, Gordana
AU  - Pajović, Snežana B.
AU  - Stankovic, M
AU  - Pejić, Snežana
AU  - Kasapović, Jelena
AU  - Cuttone, Giacomo
AU  - Calonghi, N
AU  - Masotti, L
AU  - Kanazir, Dušan T.
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2358
AB  - The goal of this study was to provide data on the dose-dependent production of dicentrics and micronuclei in human lymphocytes irradiated with 22.6 MeV protons and to estimate the possible contribution of intracellular superoxide dismutases (SOD) to the relative biological effectiveness (RBE) of protons. For the dose-response study, heparinized whole blood of a healthy volunteer was irradiated with protons and Xrays employing radiation doses of 0.5-4 Gy. Three biological endpoints were analyzed: chromosomal aberrations, micronuclei, and specific activity of cytosolic (CuZnSOD) and mitochondrial (MnSOD) superoxide dismutases in harvested human blood cells. Dicentric dose-response curves fit a linear-quadratic form (alpha = 0.094 +/- 0.006, beta = 0.032 +/- 0.001) induced with X-rays and (alpha = 0.119 +/- 0.057, beta = 0.029 +/- 0.014) for 22.6 MeV protons. Protons were more effective than X-rays in producing exchanges, particularly at 0.5 and 1 Gy. In contrast to X-ray irradiated samples where a significant increase in the specific activity of MnSOD was recorded (up to a radiation dose of 1 Gy), irradiation with protons markedly reduced its activity. As a consequence of the reduced activity of MnSOD, the chromosomal dose-response curve became quadratic. The RBE for dicentrics varies with dose (from 2.2 to 1.01) and reduced activity of MnSOD is an important contributor to the RBE of protons. SODs, particularly MnSOD, play an important role in defending DNA from reactive oxygen species. A reduced activity of SOD, particularly MnSOD, is an important contributor to the RBE of protons.
T2  - Cellular and Molecular Life Sciences / CMLS
T1  - Chromosome aberrations, micronuclei, and activity of superoxide dismutases in human lymphocytes after irradiation in vitro
VL  - 57
IS  - 5
SP  - 842
EP  - 850
DO  - 10.1007/s000180050046
ER  - 

@article{
author = "Joksić, Gordana and Pajović, Snežana B. and Stankovic, M and Pejić, Snežana and Kasapović, Jelena and Cuttone, Giacomo and Calonghi, N and Masotti, L and Kanazir, Dušan T.",
year = "2000",
abstract = "The goal of this study was to provide data on the dose-dependent production of dicentrics and micronuclei in human lymphocytes irradiated with 22.6 MeV protons and to estimate the possible contribution of intracellular superoxide dismutases (SOD) to the relative biological effectiveness (RBE) of protons. For the dose-response study, heparinized whole blood of a healthy volunteer was irradiated with protons and Xrays employing radiation doses of 0.5-4 Gy. Three biological endpoints were analyzed: chromosomal aberrations, micronuclei, and specific activity of cytosolic (CuZnSOD) and mitochondrial (MnSOD) superoxide dismutases in harvested human blood cells. Dicentric dose-response curves fit a linear-quadratic form (alpha = 0.094 +/- 0.006, beta = 0.032 +/- 0.001) induced with X-rays and (alpha = 0.119 +/- 0.057, beta = 0.029 +/- 0.014) for 22.6 MeV protons. Protons were more effective than X-rays in producing exchanges, particularly at 0.5 and 1 Gy. In contrast to X-ray irradiated samples where a significant increase in the specific activity of MnSOD was recorded (up to a radiation dose of 1 Gy), irradiation with protons markedly reduced its activity. As a consequence of the reduced activity of MnSOD, the chromosomal dose-response curve became quadratic. The RBE for dicentrics varies with dose (from 2.2 to 1.01) and reduced activity of MnSOD is an important contributor to the RBE of protons. SODs, particularly MnSOD, play an important role in defending DNA from reactive oxygen species. A reduced activity of SOD, particularly MnSOD, is an important contributor to the RBE of protons.",
journal = "Cellular and Molecular Life Sciences / CMLS",
title = "Chromosome aberrations, micronuclei, and activity of superoxide dismutases in human lymphocytes after irradiation in vitro",
volume = "57",
number = "5",
pages = "842-850",
doi = "10.1007/s000180050046"
}

Joksić, G., Pajović, S. B., Stankovic, M., Pejić, S., Kasapović, J., Cuttone, G., Calonghi, N., Masotti, L.,& Kanazir, D. T.. (2000). Chromosome aberrations, micronuclei, and activity of superoxide dismutases in human lymphocytes after irradiation in vitro. in Cellular and Molecular Life Sciences / CMLS, 57(5), 842-850.
https://doi.org/10.1007/s000180050046

Joksić G, Pajović SB, Stankovic M, Pejić S, Kasapović J, Cuttone G, Calonghi N, Masotti L, Kanazir DT. Chromosome aberrations, micronuclei, and activity of superoxide dismutases in human lymphocytes after irradiation in vitro. in Cellular and Molecular Life Sciences / CMLS. 2000;57(5):842-850.
doi:10.1007/s000180050046 .

Joksić, Gordana, Pajović, Snežana B., Stankovic, M, Pejić, Snežana, Kasapović, Jelena, Cuttone, Giacomo, Calonghi, N, Masotti, L, Kanazir, Dušan T., "Chromosome aberrations, micronuclei, and activity of superoxide dismutases in human lymphocytes after irradiation in vitro" in Cellular and Molecular Life Sciences / CMLS, 57, no. 5 (2000):842-850,
https://doi.org/10.1007/s000180050046 . .

TY  - JOUR
AU  - Sevaljevic, L
AU  - Mačvanin, Mirjana
AU  - Žakula, Zorica
AU  - Kanazir, Dušan T.
AU  - Ribarac-Stepić, Nevena B.
PY  - 1998
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2189
AB  - Hormonal requirements for full hepatic expression of alpha(2)-macroglobulin (alpha(2)M), alpha(1)-acid glycoprotein (AGP), haptoglobin (Hp) and gamma-fibrinogen (Fb) were assessed at the level of mRNA. Prior to exposure to turpentine-induced inflammation, rats were either depleted of glucocorticoids by adrenalectomy or supplemented with an excess of dexamethasone. Adrenalectomy alone did not affect the basal level of acute phase protein (APP) expression except for alpha(2)M mRNA, the level of which was enhanced. In contrast, dexamethasone treatment alone promoted full induction of alpha(2)M, significant, but not maximal increase of AGP and Hp mRNAs and suppression of Fb. In adrenalectomized rats, acute phase (AP)-cytokines, released in response to inflammation, promoted full expression of Fb and Hp and increased the level of AGP mRNA whereas alpha(2)M mRNA remained at the basal level. Inflammation in dexamethasone pretreated rats elicited changes which, in comparison to mRNA values for dexamethasone unpretreated inflamed rats, were seen as overexpression of alpha(2)M, full expression of AGP and incomplete expression of Hp, whereas Fb mRNA remained at the basal level. These data suggest that glucocorticoids are the principal inducers of a(2)M and AP-cytokines of Fb. For full induction of AGP, additive actions of glucocorticoids and AP-cytokines are required whereas expression of Hp is predominantly controlled by AP-cytokines. (C) 1998 Elsevier Science Ltd. All rights reserved.
T2  - Journal of Steroid Biochemistry and Molecular Biology
T1  - Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver
VL  - 66
IS  - 5-6
SP  - 347
EP  - 353
DO  - 10.1016/S0960-0760(98)00060-0
ER  - 

@article{
author = "Sevaljevic, L and Mačvanin, Mirjana and Žakula, Zorica and Kanazir, Dušan T. and Ribarac-Stepić, Nevena B.",
year = "1998",
abstract = "Hormonal requirements for full hepatic expression of alpha(2)-macroglobulin (alpha(2)M), alpha(1)-acid glycoprotein (AGP), haptoglobin (Hp) and gamma-fibrinogen (Fb) were assessed at the level of mRNA. Prior to exposure to turpentine-induced inflammation, rats were either depleted of glucocorticoids by adrenalectomy or supplemented with an excess of dexamethasone. Adrenalectomy alone did not affect the basal level of acute phase protein (APP) expression except for alpha(2)M mRNA, the level of which was enhanced. In contrast, dexamethasone treatment alone promoted full induction of alpha(2)M, significant, but not maximal increase of AGP and Hp mRNAs and suppression of Fb. In adrenalectomized rats, acute phase (AP)-cytokines, released in response to inflammation, promoted full expression of Fb and Hp and increased the level of AGP mRNA whereas alpha(2)M mRNA remained at the basal level. Inflammation in dexamethasone pretreated rats elicited changes which, in comparison to mRNA values for dexamethasone unpretreated inflamed rats, were seen as overexpression of alpha(2)M, full expression of AGP and incomplete expression of Hp, whereas Fb mRNA remained at the basal level. These data suggest that glucocorticoids are the principal inducers of a(2)M and AP-cytokines of Fb. For full induction of AGP, additive actions of glucocorticoids and AP-cytokines are required whereas expression of Hp is predominantly controlled by AP-cytokines. (C) 1998 Elsevier Science Ltd. All rights reserved.",
journal = "Journal of Steroid Biochemistry and Molecular Biology",
title = "Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver",
volume = "66",
number = "5-6",
pages = "347-353",
doi = "10.1016/S0960-0760(98)00060-0"
}

Sevaljevic, L., Mačvanin, M., Žakula, Z., Kanazir, D. T.,& Ribarac-Stepić, N. B.. (1998). Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver. in Journal of Steroid Biochemistry and Molecular Biology, 66(5-6), 347-353.
https://doi.org/10.1016/S0960-0760(98)00060-0

Sevaljevic L, Mačvanin M, Žakula Z, Kanazir DT, Ribarac-Stepić NB. Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver. in Journal of Steroid Biochemistry and Molecular Biology. 1998;66(5-6):347-353.
doi:10.1016/S0960-0760(98)00060-0 .

Sevaljevic, L, Mačvanin, Mirjana, Žakula, Zorica, Kanazir, Dušan T., Ribarac-Stepić, Nevena B., "Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver" in Journal of Steroid Biochemistry and Molecular Biology, 66, no. 5-6 (1998):347-353,
https://doi.org/10.1016/S0960-0760(98)00060-0 . .

TY  - JOUR
AU  - Kasapović, Jelena
AU  - Pajović, Snežana B.
AU  - Kanazir, Dušan T.
AU  - Martinović, Jelena
PY  - 1997
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2070
AB  - Activities of superoxide dismutases MnSOD and CuZnSOD were measured in appropriate subcellular fractions prepared from livers of intact and long-term gonadectomized (GX) rats of both sexes, and of GX female and male rats injected sc with a single dose of 5 mu g estradiol benzoate (EB) or 2 mg progesterone (P). In female livers, MnSOD activity did not vary significantly during the estrous cycle, declined after gonadectomy in comparison to proestrus, and was steady in GX females treated with EB or P. The activity of CuZnSOD was lowered at proestrus and elevated after removal of the ovaries in comparison to proestrus value. EB suppressed, and P elevated CuZnSOD activity in GX females. In the liver of male rats, MnSOD was not affected by gonadectomy nor by EB and P treatments. CuZnSOD activity was reduced following orchiectomy and enhanced in GX mates following treatment with P, while EB had no effect. These results suggest that P and EB modulate the activity of CuZnSOD and do not affect MnSOD in the rat liver. The modulatory effects are elicited by P in the males and by P and EB in the females. (C) 1997, Editrice Kurtis.
T2  - Journal of Endocrinological Investigation
T1  - Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the rat liver
VL  - 20
IS  - 4
SP  - 203
EP  - 206
DO  - 10.1007/BF03346903
ER  - 

@article{
author = "Kasapović, Jelena and Pajović, Snežana B. and Kanazir, Dušan T. and Martinović, Jelena",
year = "1997",
abstract = "Activities of superoxide dismutases MnSOD and CuZnSOD were measured in appropriate subcellular fractions prepared from livers of intact and long-term gonadectomized (GX) rats of both sexes, and of GX female and male rats injected sc with a single dose of 5 mu g estradiol benzoate (EB) or 2 mg progesterone (P). In female livers, MnSOD activity did not vary significantly during the estrous cycle, declined after gonadectomy in comparison to proestrus, and was steady in GX females treated with EB or P. The activity of CuZnSOD was lowered at proestrus and elevated after removal of the ovaries in comparison to proestrus value. EB suppressed, and P elevated CuZnSOD activity in GX females. In the liver of male rats, MnSOD was not affected by gonadectomy nor by EB and P treatments. CuZnSOD activity was reduced following orchiectomy and enhanced in GX mates following treatment with P, while EB had no effect. These results suggest that P and EB modulate the activity of CuZnSOD and do not affect MnSOD in the rat liver. The modulatory effects are elicited by P in the males and by P and EB in the females. (C) 1997, Editrice Kurtis.",
journal = "Journal of Endocrinological Investigation",
title = "Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the rat liver",
volume = "20",
number = "4",
pages = "203-206",
doi = "10.1007/BF03346903"
}

Kasapović, J., Pajović, S. B., Kanazir, D. T.,& Martinović, J.. (1997). Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the rat liver. in Journal of Endocrinological Investigation, 20(4), 203-206.
https://doi.org/10.1007/BF03346903

Kasapović J, Pajović SB, Kanazir DT, Martinović J. Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the rat liver. in Journal of Endocrinological Investigation. 1997;20(4):203-206.
doi:10.1007/BF03346903 .

Kasapović, Jelena, Pajović, Snežana B., Kanazir, Dušan T., Martinović, Jelena, "Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the rat liver" in Journal of Endocrinological Investigation, 20, no. 4 (1997):203-206,
https://doi.org/10.1007/BF03346903 . .

TY  - CONF
AU  - Isenović, Esma R.
AU  - Vulović, Mojca D.
AU  - Kanazir, Dušan T.
AU  - Ribarac-Stepić, Nevena B.
PY  - 1997
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/51
C3  - FASEB Journal
T1  - Effects of insulin on glucocorticoid receptors in adrenalectomy
VL  - 11
IS  - 9
SP  - A1049
EP  - A1049
UR  - https://hdl.handle.net/21.15107/rcub_vinar_51
ER  - 

@conference{
author = "Isenović, Esma R. and Vulović, Mojca D. and Kanazir, Dušan T. and Ribarac-Stepić, Nevena B.",
year = "1997",
journal = "FASEB Journal",
title = "Effects of insulin on glucocorticoid receptors in adrenalectomy",
volume = "11",
number = "9",
pages = "A1049-A1049",
url = "https://hdl.handle.net/21.15107/rcub_vinar_51"
}

Isenović, E. R., Vulović, M. D., Kanazir, D. T.,& Ribarac-Stepić, N. B.. (1997). Effects of insulin on glucocorticoid receptors in adrenalectomy. in FASEB Journal, 11(9), A1049-A1049.
https://hdl.handle.net/21.15107/rcub_vinar_51

Isenović ER, Vulović MD, Kanazir DT, Ribarac-Stepić NB. Effects of insulin on glucocorticoid receptors in adrenalectomy. in FASEB Journal. 1997;11(9):A1049-A1049.
https://hdl.handle.net/21.15107/rcub_vinar_51 .

Isenović, Esma R., Vulović, Mojca D., Kanazir, Dušan T., Ribarac-Stepić, Nevena B., "Effects of insulin on glucocorticoid receptors in adrenalectomy" in FASEB Journal, 11, no. 9 (1997):A1049-A1049,
https://hdl.handle.net/21.15107/rcub_vinar_51 .

TY  - CONF
AU  - Ribarac-Stepić, Nevena B.
AU  - Isenović, Esma R.
AU  - Korićanac, Goran
AU  - Kanazir, Dušan T.
PY  - 1997
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/50
AB  - The goal of this study was to examine the possible effects of the insulin on the functional properties of the glucocorticoid receptor (GR), in the rat liver, as well as its equilibrium binding constant (Kd) and number of binding sites (q), in order to contribute to elucidation of the molecular basis of the relationship between insulin and glucocorticoids in regulation of cell processes. Biological consequences of their interactions were judged on the basis of changes in GR as well as in the activity of Tryptophan oxygenase (TO). The experiments were perfomed on male nonadrenalectomized Wistar strain rats, treated by streptozotocin as well as adrenalectomized animals These group of animals were injected by insulin (25ug/100g b.w.) 18 hours before analysis. The obtained results have shown that the Kd in all experimental groups of animal was in the interval: 1.87-4.027nM. However, the injected insulin in all experimental groups increased the number of GR, while in streptozotocin treated rats, this increase was 1.5 fold, compared to the values obtained for corresponding controls. TO activity was increased (2-3 fold), in liver of insulin treated rats, except in the case of adrenalectomized animals, while the enzyme activity in streptozotocin treated rats was up to 3 fold, in respect to the appropriate control value. These evidences suggest that mechanisms of cooperative effects of insulin and glucocorticoid on regulation of cell function involve the modulation of hormone signals transmited through changes in number and functionality of GR proteins.
C3  - FASEB Journal
T1  - Glucocorticoid receptor and Tryptophan oxygenase activity in streptozotocin treated rats.
VL  - 11
IS  - 9
SP  - A1048
EP  - A1048
UR  - https://hdl.handle.net/21.15107/rcub_vinar_50
ER  - 

@conference{
author = "Ribarac-Stepić, Nevena B. and Isenović, Esma R. and Korićanac, Goran and Kanazir, Dušan T.",
year = "1997",
abstract = "The goal of this study was to examine the possible effects of the insulin on the functional properties of the glucocorticoid receptor (GR), in the rat liver, as well as its equilibrium binding constant (Kd) and number of binding sites (q), in order to contribute to elucidation of the molecular basis of the relationship between insulin and glucocorticoids in regulation of cell processes. Biological consequences of their interactions were judged on the basis of changes in GR as well as in the activity of Tryptophan oxygenase (TO). The experiments were perfomed on male nonadrenalectomized Wistar strain rats, treated by streptozotocin as well as adrenalectomized animals These group of animals were injected by insulin (25ug/100g b.w.) 18 hours before analysis. The obtained results have shown that the Kd in all experimental groups of animal was in the interval: 1.87-4.027nM. However, the injected insulin in all experimental groups increased the number of GR, while in streptozotocin treated rats, this increase was 1.5 fold, compared to the values obtained for corresponding controls. TO activity was increased (2-3 fold), in liver of insulin treated rats, except in the case of adrenalectomized animals, while the enzyme activity in streptozotocin treated rats was up to 3 fold, in respect to the appropriate control value. These evidences suggest that mechanisms of cooperative effects of insulin and glucocorticoid on regulation of cell function involve the modulation of hormone signals transmited through changes in number and functionality of GR proteins.",
journal = "FASEB Journal",
title = "Glucocorticoid receptor and Tryptophan oxygenase activity in streptozotocin treated rats.",
volume = "11",
number = "9",
pages = "A1048-A1048",
url = "https://hdl.handle.net/21.15107/rcub_vinar_50"
}

Ribarac-Stepić, N. B., Isenović, E. R., Korićanac, G.,& Kanazir, D. T.. (1997). Glucocorticoid receptor and Tryptophan oxygenase activity in streptozotocin treated rats.. in FASEB Journal, 11(9), A1048-A1048.
https://hdl.handle.net/21.15107/rcub_vinar_50

Ribarac-Stepić NB, Isenović ER, Korićanac G, Kanazir DT. Glucocorticoid receptor and Tryptophan oxygenase activity in streptozotocin treated rats.. in FASEB Journal. 1997;11(9):A1048-A1048.
https://hdl.handle.net/21.15107/rcub_vinar_50 .

Ribarac-Stepić, Nevena B., Isenović, Esma R., Korićanac, Goran, Kanazir, Dušan T., "Glucocorticoid receptor and Tryptophan oxygenase activity in streptozotocin treated rats." in FASEB Journal, 11, no. 9 (1997):A1048-A1048,
https://hdl.handle.net/21.15107/rcub_vinar_50 .

TY  - JOUR
AU  - Počuča, Nataša
AU  - Krstić, M.
AU  - Kanazir, Dušan T.
PY  - 1996
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2032
T2  - Jugoslovenska Medicinska Biohemija
T1  - Detection and characterization of phosphoisoforms of glucocorticoid receptor expressed in bakers yeast (Saccharomyces cerevisiae)
VL  - 15
IS  - 4
SP  - 321
EP  - 322
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2032
ER  - 

@article{
author = "Počuča, Nataša and Krstić, M. and Kanazir, Dušan T.",
year = "1996",
journal = "Jugoslovenska Medicinska Biohemija",
title = "Detection and characterization of phosphoisoforms of glucocorticoid receptor expressed in bakers yeast (Saccharomyces cerevisiae)",
volume = "15",
number = "4",
pages = "321-322",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2032"
}

Počuča, N., Krstić, M.,& Kanazir, D. T.. (1996). Detection and characterization of phosphoisoforms of glucocorticoid receptor expressed in bakers yeast (Saccharomyces cerevisiae). in Jugoslovenska Medicinska Biohemija, 15(4), 321-322.
https://hdl.handle.net/21.15107/rcub_vinar_2032

Počuča N, Krstić M, Kanazir DT. Detection and characterization of phosphoisoforms of glucocorticoid receptor expressed in bakers yeast (Saccharomyces cerevisiae). in Jugoslovenska Medicinska Biohemija. 1996;15(4):321-322.
https://hdl.handle.net/21.15107/rcub_vinar_2032 .

Počuča, Nataša, Krstić, M., Kanazir, Dušan T., "Detection and characterization of phosphoisoforms of glucocorticoid receptor expressed in bakers yeast (Saccharomyces cerevisiae)" in Jugoslovenska Medicinska Biohemija, 15, no. 4 (1996):321-322,
https://hdl.handle.net/21.15107/rcub_vinar_2032 .

TY  - JOUR
AU  - Vujčić, Miroslava T.
AU  - Đorđević Marković, R.
AU  - Radić, Olivera
AU  - Krstić, M.
AU  - Kanazir, Dušan T.
PY  - 1996
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2030
T2  - Jugoslovenska Medicinska Biohemija
T1  - Analysis of kinase activity associated with corticosteroid binder IB
VL  - 15
IS  - 4
SP  - 319
EP  - 320
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2030
ER  - 

@article{
author = "Vujčić, Miroslava T. and Đorđević Marković, R. and Radić, Olivera and Krstić, M. and Kanazir, Dušan T.",
year = "1996",
journal = "Jugoslovenska Medicinska Biohemija",
title = "Analysis of kinase activity associated with corticosteroid binder IB",
volume = "15",
number = "4",
pages = "319-320",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2030"
}

Vujčić, M. T., Đorđević Marković, R., Radić, O., Krstić, M.,& Kanazir, D. T.. (1996). Analysis of kinase activity associated with corticosteroid binder IB. in Jugoslovenska Medicinska Biohemija, 15(4), 319-320.
https://hdl.handle.net/21.15107/rcub_vinar_2030

Vujčić MT, Đorđević Marković R, Radić O, Krstić M, Kanazir DT. Analysis of kinase activity associated with corticosteroid binder IB. in Jugoslovenska Medicinska Biohemija. 1996;15(4):319-320.
https://hdl.handle.net/21.15107/rcub_vinar_2030 .

Vujčić, Miroslava T., Đorđević Marković, R., Radić, Olivera, Krstić, M., Kanazir, Dušan T., "Analysis of kinase activity associated with corticosteroid binder IB" in Jugoslovenska Medicinska Biohemija, 15, no. 4 (1996):319-320,
https://hdl.handle.net/21.15107/rcub_vinar_2030 .