TY  - JOUR
AU  - Glišić, Sanja
AU  - Arrigo, Patrizio
AU  - Alavantić, Dragan
AU  - Perović, Vladimir R.
AU  - Prljić, Jelena
AU  - Veljković, Nevena V.
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3356
AB  - Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism. Decrease of the LPL enzymatic activity leads to elevated triglycerides (TG) and reduced high-density lipoprotein (HDL-C levels), both risk factors for cardiovascular disease (CVD). Therefore, mutations, which decrease the LPL activity, may confer susceptibility to CVD. Here, the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of nucleotide and protein sequences, is applied for identification of evolutionary highly conserved information encoded by the primary structure of LPL. It was demonstrated that mutations, which alter the LPL enzymatic activity also alter this information. On the basis of this finding, an efficient an simple bioinformatics criterion for assessment of the pathogenic effect of LPL nonsynonymous single nucleotide substitution as a risk factor of CVD has been proposed.
T2  - Proteins: Structure Function and Bioinformatics
T1  - Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease
VL  - 70
IS  - 3
SP  - 855
EP  - 862
DO  - 10.1002/prot.21581
ER  - 

@article{
author = "Glišić, Sanja and Arrigo, Patrizio and Alavantić, Dragan and Perović, Vladimir R. and Prljić, Jelena and Veljković, Nevena V.",
year = "2008",
abstract = "Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism. Decrease of the LPL enzymatic activity leads to elevated triglycerides (TG) and reduced high-density lipoprotein (HDL-C levels), both risk factors for cardiovascular disease (CVD). Therefore, mutations, which decrease the LPL activity, may confer susceptibility to CVD. Here, the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of nucleotide and protein sequences, is applied for identification of evolutionary highly conserved information encoded by the primary structure of LPL. It was demonstrated that mutations, which alter the LPL enzymatic activity also alter this information. On the basis of this finding, an efficient an simple bioinformatics criterion for assessment of the pathogenic effect of LPL nonsynonymous single nucleotide substitution as a risk factor of CVD has been proposed.",
journal = "Proteins: Structure Function and Bioinformatics",
title = "Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease",
volume = "70",
number = "3",
pages = "855-862",
doi = "10.1002/prot.21581"
}

Glišić, S., Arrigo, P., Alavantić, D., Perović, V. R., Prljić, J.,& Veljković, N. V.. (2008). Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease. in Proteins: Structure Function and Bioinformatics, 70(3), 855-862.
https://doi.org/10.1002/prot.21581

Glišić S, Arrigo P, Alavantić D, Perović VR, Prljić J, Veljković NV. Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease. in Proteins: Structure Function and Bioinformatics. 2008;70(3):855-862.
doi:10.1002/prot.21581 .

Glišić, Sanja, Arrigo, Patrizio, Alavantić, Dragan, Perović, Vladimir R., Prljić, Jelena, Veljković, Nevena V., "Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease" in Proteins: Structure Function and Bioinformatics, 70, no. 3 (2008):855-862,
https://doi.org/10.1002/prot.21581 . .