TY  - JOUR
AU  - Sakata, Dousatsu
AU  - Hirayama, Ryoichi
AU  - Shin, Wook-Geun
AU  - Belli, Mauro
AU  - Tabocchini, Maria A
AU  - Stewart, Robert D
AU  - Belov, Oleg
AU  - Bernal, Mario A
AU  - Bordage, Marie-Claude
AU  - Brown, Jeremy M.C.
AU  - Đorđević, Miloš
AU  - Emfietzoglou, Dimitris
AU  - Francis, Ziad
AU  - Guatelli, Susanna
AU  - Inaniwa, Taku
AU  - Ivanchenko, Vladimir
AU  - Karamitros, Mathieu
AU  - Kyriakou, Ioanna
AU  - Lampe, Nathanael
AU  - Li, Zhuxin
AU  - Meylan, Sylvain
AU  - Michelet, Claire
AU  - Nieminen, Petteri
AU  - Perrot, Yann
AU  - Petrović, Ivan M.
AU  - Ramos-Mendez, Jose
AU  - Ristić-Fira, Aleksandra
AU  - Santin, Giovanni
AU  - Schuemann, Jan
AU  - Tran, Hoang N
AU  - Villagrasa, Carmen
AU  - Incerti, Sebastien
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10573
AB  - Purpose: Track structure Monte Carlo (MC) codes have achieved successful outcomes in the quantitative investigation of radiation-induced initial DNA damage. The aim of the present study is to extend a Geant4-DNA radiobiological application by incorporating a feature allowing for the prediction of DNA rejoining kinetics and corresponding cell surviving fraction along time after irradiation, for a Chinese hamster V79 cell line, which is one of the most popular and widely investigated cell lines in radiobiology. Methods: We implemented the Two-Lesion Kinetics (TLK) model, originally proposed by Stewart, which allows for simulations to calculate residual DNA damage and surviving fraction along time via the number of initial DNA damage and its complexity as inputs. Results: By optimizing the model parameters of the TLK model in accordance to the experimental data on V79, we were able to predict both DNA rejoining kinetics at low linear energy transfers (LET) and cell surviving fraction. Conclusion: This is the first study to demonstrate the implementation of both the cell surviving fraction and the DNA rejoining kinetics with the estimated initial DNA damage, in a realistic cell geometrical model simulated by full track structure MC simulations at DNA level and for various LET. These simulation and model make the link between mechanistic physical/chemical damage processes and these two specific biological endpoints.
T2  - Physica Medica
T1  - Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA
VL  - 105
SP  - 102508
DO  - 10.1016/j.ejmp.2022.11.012
ER  - 

@article{
author = "Sakata, Dousatsu and Hirayama, Ryoichi and Shin, Wook-Geun and Belli, Mauro and Tabocchini, Maria A and Stewart, Robert D and Belov, Oleg and Bernal, Mario A and Bordage, Marie-Claude and Brown, Jeremy M.C. and Đorđević, Miloš and Emfietzoglou, Dimitris and Francis, Ziad and Guatelli, Susanna and Inaniwa, Taku and Ivanchenko, Vladimir and Karamitros, Mathieu and Kyriakou, Ioanna and Lampe, Nathanael and Li, Zhuxin and Meylan, Sylvain and Michelet, Claire and Nieminen, Petteri and Perrot, Yann and Petrović, Ivan M. and Ramos-Mendez, Jose and Ristić-Fira, Aleksandra and Santin, Giovanni and Schuemann, Jan and Tran, Hoang N and Villagrasa, Carmen and Incerti, Sebastien",
year = "2023",
abstract = "Purpose: Track structure Monte Carlo (MC) codes have achieved successful outcomes in the quantitative investigation of radiation-induced initial DNA damage. The aim of the present study is to extend a Geant4-DNA radiobiological application by incorporating a feature allowing for the prediction of DNA rejoining kinetics and corresponding cell surviving fraction along time after irradiation, for a Chinese hamster V79 cell line, which is one of the most popular and widely investigated cell lines in radiobiology. Methods: We implemented the Two-Lesion Kinetics (TLK) model, originally proposed by Stewart, which allows for simulations to calculate residual DNA damage and surviving fraction along time via the number of initial DNA damage and its complexity as inputs. Results: By optimizing the model parameters of the TLK model in accordance to the experimental data on V79, we were able to predict both DNA rejoining kinetics at low linear energy transfers (LET) and cell surviving fraction. Conclusion: This is the first study to demonstrate the implementation of both the cell surviving fraction and the DNA rejoining kinetics with the estimated initial DNA damage, in a realistic cell geometrical model simulated by full track structure MC simulations at DNA level and for various LET. These simulation and model make the link between mechanistic physical/chemical damage processes and these two specific biological endpoints.",
journal = "Physica Medica",
title = "Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA",
volume = "105",
pages = "102508",
doi = "10.1016/j.ejmp.2022.11.012"
}

Sakata, D., Hirayama, R., Shin, W., Belli, M., Tabocchini, M. A., Stewart, R. D., Belov, O., Bernal, M. A., Bordage, M., Brown, J. M.C., Đorđević, M., Emfietzoglou, D., Francis, Z., Guatelli, S., Inaniwa, T., Ivanchenko, V., Karamitros, M., Kyriakou, I., Lampe, N., Li, Z., Meylan, S., Michelet, C., Nieminen, P., Perrot, Y., Petrović, I. M., Ramos-Mendez, J., Ristić-Fira, A., Santin, G., Schuemann, J., Tran, H. N., Villagrasa, C.,& Incerti, S.. (2023). Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA. in Physica Medica, 105, 102508.
https://doi.org/10.1016/j.ejmp.2022.11.012

Sakata D, Hirayama R, Shin W, Belli M, Tabocchini MA, Stewart RD, Belov O, Bernal MA, Bordage M, Brown JM, Đorđević M, Emfietzoglou D, Francis Z, Guatelli S, Inaniwa T, Ivanchenko V, Karamitros M, Kyriakou I, Lampe N, Li Z, Meylan S, Michelet C, Nieminen P, Perrot Y, Petrović IM, Ramos-Mendez J, Ristić-Fira A, Santin G, Schuemann J, Tran HN, Villagrasa C, Incerti S. Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA. in Physica Medica. 2023;105:102508.
doi:10.1016/j.ejmp.2022.11.012 .

Sakata, Dousatsu, Hirayama, Ryoichi, Shin, Wook-Geun, Belli, Mauro, Tabocchini, Maria A, Stewart, Robert D, Belov, Oleg, Bernal, Mario A, Bordage, Marie-Claude, Brown, Jeremy M.C., Đorđević, Miloš, Emfietzoglou, Dimitris, Francis, Ziad, Guatelli, Susanna, Inaniwa, Taku, Ivanchenko, Vladimir, Karamitros, Mathieu, Kyriakou, Ioanna, Lampe, Nathanael, Li, Zhuxin, Meylan, Sylvain, Michelet, Claire, Nieminen, Petteri, Perrot, Yann, Petrović, Ivan M., Ramos-Mendez, Jose, Ristić-Fira, Aleksandra, Santin, Giovanni, Schuemann, Jan, Tran, Hoang N, Villagrasa, Carmen, Incerti, Sebastien, "Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA" in Physica Medica, 105 (2023):102508,
https://doi.org/10.1016/j.ejmp.2022.11.012 . .

TY  - JOUR
AU  - Ivanchenko, Vladimir
AU  - Apostolakis, John
AU  - Bagulya, Alexander V.
AU  - Abdelouahed, Haifa Ben
AU  - Black, Rachel
AU  - Bogdanov, Alexey
AU  - Burkhard, Helmut
AU  - Chauvie, Stéphane
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cuttone, Giacomo
AU  - Depaola, Gerardo O.
AU  - Di Rosa, Francesco
AU  - Elles, Sabine
AU  - Francis, Ziad
AU  - Grichine, Vladimir
AU  - Gumplinger, Peter
AU  - Gueye, Paul
AU  - Incerti, Sebastien
AU  - Ivanchenko, Anton
AU  - Jacquemier, Jean
AU  - Lechner, Anton
AU  - Longo, Francesco
AU  - Kadri, Omrane
AU  - Karakatsanis, Nicolas
AU  - Karamitros, Mathieu
AU  - Kokoulin, Rostislav
AU  - Kurashige, Hisaya
AU  - Maire, Michel
AU  - Mantero, Alfonso
AU  - Mascialino, Barbara
AU  - Moscicki, Jakub
AU  - Pandola, Luciano
AU  - Perl, Joseph M.
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Romano, Francesco
AU  - Russo, Giorgio
AU  - Santin, Giovanni
AU  - Schaelicke, Andreas
AU  - Toshito, Toshiyuki
AU  - Tran, Hoang
AU  - Urban, Laszlo
AU  - Yamashita, Tomohiro
AU  - Zacharatou, Christina
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8641
AB  - An overview of the electromagnetic (EM) physics of the Geant4 toolkit is presented Two sets of EM models are available: the 'Standard' initially focused on high energy physics (HEP) while the 'Low-energy' was developed for medical, space and other applications The 'Standard' models provide a faster computation but are less accurate for keV energies, the 'Low-energy' models are more CPU time consuming A common interface to EM physics models has been developed allowing a natural combination of ultra-relativistic, relativistic and low-energy models for the same run providing both precision and CPU performance Due to this migration additional capabilities become available The new developments include relativistic models for bremsstrahlung and e+e- pair production, models of multiple and single scattering, hadron/ion ionization, microdosimetry for very low energies and also improvements in existing Geant4 models In parallel, validation suites and benchmarks have been intensively developed (author)
T2  - Progress in Nuclear Science and Technology
T1  - Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces
VL  - 2
SP  - 898
EP  - 903
DO  - 10.15669/pnst.2.898
ER  - 

@article{
author = "Ivanchenko, Vladimir and Apostolakis, John and Bagulya, Alexander V. and Abdelouahed, Haifa Ben and Black, Rachel and Bogdanov, Alexey and Burkhard, Helmut and Chauvie, Stéphane and Cirrone, Giuseppe Antonio Pablo and Cuttone, Giacomo and Depaola, Gerardo O. and Di Rosa, Francesco and Elles, Sabine and Francis, Ziad and Grichine, Vladimir and Gumplinger, Peter and Gueye, Paul and Incerti, Sebastien and Ivanchenko, Anton and Jacquemier, Jean and Lechner, Anton and Longo, Francesco and Kadri, Omrane and Karakatsanis, Nicolas and Karamitros, Mathieu and Kokoulin, Rostislav and Kurashige, Hisaya and Maire, Michel and Mantero, Alfonso and Mascialino, Barbara and Moscicki, Jakub and Pandola, Luciano and Perl, Joseph M. and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Romano, Francesco and Russo, Giorgio and Santin, Giovanni and Schaelicke, Andreas and Toshito, Toshiyuki and Tran, Hoang and Urban, Laszlo and Yamashita, Tomohiro and Zacharatou, Christina",
year = "2011",
abstract = "An overview of the electromagnetic (EM) physics of the Geant4 toolkit is presented Two sets of EM models are available: the 'Standard' initially focused on high energy physics (HEP) while the 'Low-energy' was developed for medical, space and other applications The 'Standard' models provide a faster computation but are less accurate for keV energies, the 'Low-energy' models are more CPU time consuming A common interface to EM physics models has been developed allowing a natural combination of ultra-relativistic, relativistic and low-energy models for the same run providing both precision and CPU performance Due to this migration additional capabilities become available The new developments include relativistic models for bremsstrahlung and e+e- pair production, models of multiple and single scattering, hadron/ion ionization, microdosimetry for very low energies and also improvements in existing Geant4 models In parallel, validation suites and benchmarks have been intensively developed (author)",
journal = "Progress in Nuclear Science and Technology",
title = "Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces",
volume = "2",
pages = "898-903",
doi = "10.15669/pnst.2.898"
}

Ivanchenko, V., Apostolakis, J., Bagulya, A. V., Abdelouahed, H. B., Black, R., Bogdanov, A., Burkhard, H., Chauvie, S., Cirrone, G. A. P., Cuttone, G., Depaola, G. O., Di Rosa, F., Elles, S., Francis, Z., Grichine, V., Gumplinger, P., Gueye, P., Incerti, S., Ivanchenko, A., Jacquemier, J., Lechner, A., Longo, F., Kadri, O., Karakatsanis, N., Karamitros, M., Kokoulin, R., Kurashige, H., Maire, M., Mantero, A., Mascialino, B., Moscicki, J., Pandola, L., Perl, J. M., Petrović, I. M., Ristić-Fira, A., Romano, F., Russo, G., Santin, G., Schaelicke, A., Toshito, T., Tran, H., Urban, L., Yamashita, T.,& Zacharatou, C.. (2011). Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces. in Progress in Nuclear Science and Technology, 2, 898-903.
https://doi.org/10.15669/pnst.2.898

Ivanchenko V, Apostolakis J, Bagulya AV, Abdelouahed HB, Black R, Bogdanov A, Burkhard H, Chauvie S, Cirrone GAP, Cuttone G, Depaola GO, Di Rosa F, Elles S, Francis Z, Grichine V, Gumplinger P, Gueye P, Incerti S, Ivanchenko A, Jacquemier J, Lechner A, Longo F, Kadri O, Karakatsanis N, Karamitros M, Kokoulin R, Kurashige H, Maire M, Mantero A, Mascialino B, Moscicki J, Pandola L, Perl JM, Petrović IM, Ristić-Fira A, Romano F, Russo G, Santin G, Schaelicke A, Toshito T, Tran H, Urban L, Yamashita T, Zacharatou C. Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces. in Progress in Nuclear Science and Technology. 2011;2:898-903.
doi:10.15669/pnst.2.898 .

Ivanchenko, Vladimir, Apostolakis, John, Bagulya, Alexander V., Abdelouahed, Haifa Ben, Black, Rachel, Bogdanov, Alexey, Burkhard, Helmut, Chauvie, Stéphane, Cirrone, Giuseppe Antonio Pablo, Cuttone, Giacomo, Depaola, Gerardo O., Di Rosa, Francesco, Elles, Sabine, Francis, Ziad, Grichine, Vladimir, Gumplinger, Peter, Gueye, Paul, Incerti, Sebastien, Ivanchenko, Anton, Jacquemier, Jean, Lechner, Anton, Longo, Francesco, Kadri, Omrane, Karakatsanis, Nicolas, Karamitros, Mathieu, Kokoulin, Rostislav, Kurashige, Hisaya, Maire, Michel, Mantero, Alfonso, Mascialino, Barbara, Moscicki, Jakub, Pandola, Luciano, Perl, Joseph M., Petrović, Ivan M., Ristić-Fira, Aleksandra, Romano, Francesco, Russo, Giorgio, Santin, Giovanni, Schaelicke, Andreas, Toshito, Toshiyuki, Tran, Hoang, Urban, Laszlo, Yamashita, Tomohiro, Zacharatou, Christina, "Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces" in Progress in Nuclear Science and Technology, 2 (2011):898-903,
https://doi.org/10.15669/pnst.2.898 . .