TY  - JOUR
AU  - Stanković, Aleksandra
AU  - Živković, Maja
AU  - Kostić, Mirjana M.
AU  - Atanackovic, Jasmina
AU  - Krstić, Zoran
AU  - Alavantić, Dragan
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3873
AB  - Objectives: Congenital anomalies of the kidney and urinary tract (CAKUT) are common causes of chronic renal failure in children. The angiotensin II receptor type 2 (AT2R) is one of proposed candidate genes for CAKUT, but the expression was never explored in humans. The aim was to establish the AM gene expression in human CAKUT concerning -1332A/G polymorphism, which might affect alternative splicing. Design and methods: Forty-eight patients with CAKUT constitute the basis of this study. Genotyping for -1332A/G, RT-PCR for AT2R gene expression and confirmation sequencing were performed. Results: The expression of Ex 1/2/3 and Ex 1/3 transcript splice variants of the AT2R mRNA were detected in human CAKUT tissue. The pattern was observed independently of A to G transition. Conclusions: The expression of AT2R mRNA in human CAKUT was established for the first time and was not affected by -1332A/G polymorphism in children with CAKUT. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
T2  - Clinical Biochemistry
T1  - Expression profiling of the AT2R mRNA in affected tissue from children with CAKUT
VL  - 43
IS  - 1-2
SP  - 71
EP  - 75
DO  - 10.1016/j.clinbiochem.2009.09.009
ER  - 

@article{
author = "Stanković, Aleksandra and Živković, Maja and Kostić, Mirjana M. and Atanackovic, Jasmina and Krstić, Zoran and Alavantić, Dragan",
year = "2010",
abstract = "Objectives: Congenital anomalies of the kidney and urinary tract (CAKUT) are common causes of chronic renal failure in children. The angiotensin II receptor type 2 (AT2R) is one of proposed candidate genes for CAKUT, but the expression was never explored in humans. The aim was to establish the AM gene expression in human CAKUT concerning -1332A/G polymorphism, which might affect alternative splicing. Design and methods: Forty-eight patients with CAKUT constitute the basis of this study. Genotyping for -1332A/G, RT-PCR for AT2R gene expression and confirmation sequencing were performed. Results: The expression of Ex 1/2/3 and Ex 1/3 transcript splice variants of the AT2R mRNA were detected in human CAKUT tissue. The pattern was observed independently of A to G transition. Conclusions: The expression of AT2R mRNA in human CAKUT was established for the first time and was not affected by -1332A/G polymorphism in children with CAKUT. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.",
journal = "Clinical Biochemistry",
title = "Expression profiling of the AT2R mRNA in affected tissue from children with CAKUT",
volume = "43",
number = "1-2",
pages = "71-75",
doi = "10.1016/j.clinbiochem.2009.09.009"
}

Stanković, A., Živković, M., Kostić, M. M., Atanackovic, J., Krstić, Z.,& Alavantić, D.. (2010). Expression profiling of the AT2R mRNA in affected tissue from children with CAKUT. in Clinical Biochemistry, 43(1-2), 71-75.
https://doi.org/10.1016/j.clinbiochem.2009.09.009

Stanković A, Živković M, Kostić MM, Atanackovic J, Krstić Z, Alavantić D. Expression profiling of the AT2R mRNA in affected tissue from children with CAKUT. in Clinical Biochemistry. 2010;43(1-2):71-75.
doi:10.1016/j.clinbiochem.2009.09.009 .

Stanković, Aleksandra, Živković, Maja, Kostić, Mirjana M., Atanackovic, Jasmina, Krstić, Zoran, Alavantić, Dragan, "Expression profiling of the AT2R mRNA in affected tissue from children with CAKUT" in Clinical Biochemistry, 43, no. 1-2 (2010):71-75,
https://doi.org/10.1016/j.clinbiochem.2009.09.009 . .