TY  - JOUR
AU  - Vasović, Dolika D.
AU  - Ivković, Sanja
AU  - Živanović, Ana
AU  - Major, Tamara
AU  - Milašin, Jelena M.
AU  - Nikolić, Nađa S.
AU  - Simonović, Jelena
AU  - Šutulović, Nikola
AU  - Hrnčić, Dragan
AU  - Stanojlović, Olivera
AU  - Vesković, Milena
AU  - Rašić, Dejan M.
AU  - Mladenović, Dušan
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13177
AB  - Diabetic retinopathy is not cured efficiently and changes of lifestyle measures may delay early retinal injury indiabetes. The aim of our study was to investigate the effects of reduced daily light exposure on retinal vascularchanges in streptozotocin (STZ)-induced model of DM with emphasis on inflammation, Aqp4 expression, visualcycle and cholesterol metabolism-related gene expression in rat retina and RPE. Male Wistar rats were dividedinto the following groups: 1. control; 2. diabetic group (DM) treated with streptozotocin (100 mg/kg); 3. groupexposed to light/dark cycle 6/18 h (6/18); 4. diabetic group exposed to light/dark cycle 6/18 h (DM+6/18).Retinal vascular abnormalities were estimated based on lectin staining, while the expression of genes involved inthe visual cycle, cholesterol metabolism, and inflammation was determined by qRT-PCR. Reduced light exposurealleviated vasculopathy, gliosis and the expression of IL-1 and TNF-α in the retina with increased perivascularAqp4 expression. The expression of genes involved in visual cycle and cholesterol metabolism was significantlyup-regulated in RPE in DM+6/18 vs. DM group. In the retina only the expression of APOE was significantlyhigher in DM+6/18 vs. DM group. Reduced light exposure mitigates vascular changes and gliosis in DM via itsanti-inflammatory effect, increased retinal cholesterol turnover and perivascular Aqp4 expression.
T2  - Chemico-Biological Interactions
T1  - Reduced light exposure mitigates streptozotocin-induced vascular changes and gliosis in diabetic retina by an anti-inflammatory effect and increased retinal cholesterol turnover
VL  - 394
SP  - 110996
DO  - 10.1016/j.cbi.2024.110996
ER  - 

@article{
author = "Vasović, Dolika D. and Ivković, Sanja and Živanović, Ana and Major, Tamara and Milašin, Jelena M. and Nikolić, Nađa S. and Simonović, Jelena and Šutulović, Nikola and Hrnčić, Dragan and Stanojlović, Olivera and Vesković, Milena and Rašić, Dejan M. and Mladenović, Dušan",
year = "2024",
abstract = "Diabetic retinopathy is not cured efficiently and changes of lifestyle measures may delay early retinal injury indiabetes. The aim of our study was to investigate the effects of reduced daily light exposure on retinal vascularchanges in streptozotocin (STZ)-induced model of DM with emphasis on inflammation, Aqp4 expression, visualcycle and cholesterol metabolism-related gene expression in rat retina and RPE. Male Wistar rats were dividedinto the following groups: 1. control; 2. diabetic group (DM) treated with streptozotocin (100 mg/kg); 3. groupexposed to light/dark cycle 6/18 h (6/18); 4. diabetic group exposed to light/dark cycle 6/18 h (DM+6/18).Retinal vascular abnormalities were estimated based on lectin staining, while the expression of genes involved inthe visual cycle, cholesterol metabolism, and inflammation was determined by qRT-PCR. Reduced light exposurealleviated vasculopathy, gliosis and the expression of IL-1 and TNF-α in the retina with increased perivascularAqp4 expression. The expression of genes involved in visual cycle and cholesterol metabolism was significantlyup-regulated in RPE in DM+6/18 vs. DM group. In the retina only the expression of APOE was significantlyhigher in DM+6/18 vs. DM group. Reduced light exposure mitigates vascular changes and gliosis in DM via itsanti-inflammatory effect, increased retinal cholesterol turnover and perivascular Aqp4 expression.",
journal = "Chemico-Biological Interactions",
title = "Reduced light exposure mitigates streptozotocin-induced vascular changes and gliosis in diabetic retina by an anti-inflammatory effect and increased retinal cholesterol turnover",
volume = "394",
pages = "110996",
doi = "10.1016/j.cbi.2024.110996"
}

Vasović, D. D., Ivković, S., Živanović, A., Major, T., Milašin, J. M., Nikolić, N. S., Simonović, J., Šutulović, N., Hrnčić, D., Stanojlović, O., Vesković, M., Rašić, D. M.,& Mladenović, D.. (2024). Reduced light exposure mitigates streptozotocin-induced vascular changes and gliosis in diabetic retina by an anti-inflammatory effect and increased retinal cholesterol turnover. in Chemico-Biological Interactions, 394, 110996.
https://doi.org/10.1016/j.cbi.2024.110996

Vasović DD, Ivković S, Živanović A, Major T, Milašin JM, Nikolić NS, Simonović J, Šutulović N, Hrnčić D, Stanojlović O, Vesković M, Rašić DM, Mladenović D. Reduced light exposure mitigates streptozotocin-induced vascular changes and gliosis in diabetic retina by an anti-inflammatory effect and increased retinal cholesterol turnover. in Chemico-Biological Interactions. 2024;394:110996.
doi:10.1016/j.cbi.2024.110996 .

Vasović, Dolika D., Ivković, Sanja, Živanović, Ana, Major, Tamara, Milašin, Jelena M., Nikolić, Nađa S., Simonović, Jelena, Šutulović, Nikola, Hrnčić, Dragan, Stanojlović, Olivera, Vesković, Milena, Rašić, Dejan M., Mladenović, Dušan, "Reduced light exposure mitigates streptozotocin-induced vascular changes and gliosis in diabetic retina by an anti-inflammatory effect and increased retinal cholesterol turnover" in Chemico-Biological Interactions, 394 (2024):110996,
https://doi.org/10.1016/j.cbi.2024.110996 . .

TY  - JOUR
AU  - Gandara, Meriene
AU  - Mladenović, Dušan
AU  - Oliveira Martins, Marta de Jesus
AU  - Rakočević, Lazar
AU  - Kruszynski de Assis, João Marcos
AU  - Šljukić, Biljana
AU  - Sarmento Gonçalves, Emerson
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13098
AB  - In search for novel materials to replace noble metal-based electrocatalysts in electrochemical energy conversion and storage devices, special attention is given to a distinct class of materials, MAX phase that combines advantages of ceramic and metallic properties. Herein, Nb4AlC3 MAX phase is prepared by a solid-state mixing reaction and characterized morphologically and structurally by transmission and scanning electron microscopy with energy-dispersive X-ray spectroscopy, nitrogen-sorption, X-ray diffraction analysis, X-ray photoelectron and Raman spectroscopy. Electrochemical performance of Nb4AlC3 in terms of capacitance as well as for oxygen reduction reaction (ORR) and hydrogen evolution reaction (HER) is evaluated in different electrolytes. The specific capacitance Cs of 66.4, 55.0, and 46.0 F g−1 at 5 mV s−1 is determined for acidic, neutral and alkaline medium, respectively. Continuous cycling reveals high capacitance retention in three electrolyte media; moreover, increase of capacitance is observed in acidic and neutral media. The electrochemical impedance spectroscopy showed a low charge transfer resistance of 64.76 Ω cm2 that resulted in better performance for HER in acidic medium (Tafel slope of 60 mV dec−1). In alkaline media, the charge storage value in the double layer is 360 mF cm−2 (0.7 V versus reversible hydrogen electrode) and the best ORR performance of the Nb4AlC3 is achieved in this medium (Tafel slope of 126 mV dec−1).
T2  - Small
T1  - MAX Phase (Nb4AlC3) For Electrocatalysis Applications
DO  - 10.1002/smll.202310576
ER  - 

@article{
author = "Gandara, Meriene and Mladenović, Dušan and Oliveira Martins, Marta de Jesus and Rakočević, Lazar and Kruszynski de Assis, João Marcos and Šljukić, Biljana and Sarmento Gonçalves, Emerson",
year = "2024",
abstract = "In search for novel materials to replace noble metal-based electrocatalysts in electrochemical energy conversion and storage devices, special attention is given to a distinct class of materials, MAX phase that combines advantages of ceramic and metallic properties. Herein, Nb4AlC3 MAX phase is prepared by a solid-state mixing reaction and characterized morphologically and structurally by transmission and scanning electron microscopy with energy-dispersive X-ray spectroscopy, nitrogen-sorption, X-ray diffraction analysis, X-ray photoelectron and Raman spectroscopy. Electrochemical performance of Nb4AlC3 in terms of capacitance as well as for oxygen reduction reaction (ORR) and hydrogen evolution reaction (HER) is evaluated in different electrolytes. The specific capacitance Cs of 66.4, 55.0, and 46.0 F g−1 at 5 mV s−1 is determined for acidic, neutral and alkaline medium, respectively. Continuous cycling reveals high capacitance retention in three electrolyte media; moreover, increase of capacitance is observed in acidic and neutral media. The electrochemical impedance spectroscopy showed a low charge transfer resistance of 64.76 Ω cm2 that resulted in better performance for HER in acidic medium (Tafel slope of 60 mV dec−1). In alkaline media, the charge storage value in the double layer is 360 mF cm−2 (0.7 V versus reversible hydrogen electrode) and the best ORR performance of the Nb4AlC3 is achieved in this medium (Tafel slope of 126 mV dec−1).",
journal = "Small",
title = "MAX Phase (Nb4AlC3) For Electrocatalysis Applications",
doi = "10.1002/smll.202310576"
}

Gandara, M., Mladenović, D., Oliveira Martins, M. d. J., Rakočević, L., Kruszynski de Assis, J. M., Šljukić, B.,& Sarmento Gonçalves, E.. (2024). MAX Phase (Nb4AlC3) For Electrocatalysis Applications. in Small.
https://doi.org/10.1002/smll.202310576

Gandara M, Mladenović D, Oliveira Martins MDJ, Rakočević L, Kruszynski de Assis JM, Šljukić B, Sarmento Gonçalves E. MAX Phase (Nb4AlC3) For Electrocatalysis Applications. in Small. 2024;.
doi:10.1002/smll.202310576 .

Gandara, Meriene, Mladenović, Dušan, Oliveira Martins, Marta de Jesus, Rakočević, Lazar, Kruszynski de Assis, João Marcos, Šljukić, Biljana, Sarmento Gonçalves, Emerson, "MAX Phase (Nb4AlC3) For Electrocatalysis Applications" in Small (2024),
https://doi.org/10.1002/smll.202310576 . .

TY  - CONF
AU  - Vasović, Dolika V.
AU  - Ivković, Sanja
AU  - Jovanović Macura, Irena
AU  - Major, Tamara
AU  - Živanović, Ana
AU  - Milašin, Jelena
AU  - Nikolić, Nađa
AU  - Simonović, Jelena
AU  - Šutulović, Nikola
AU  - Hrnčić, Dragan
AU  - Stanojlović, Olivera
AU  - Mladenović, Dušan
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11056
AB  - Introduction: Diabetic retinopathy (DR) is not cured efficiently and changes of lifestyle measures may alleviate its course. The aim of our study was to investigate the effects of shortened daily photoperiod on inflammation and visual cycle in rat retina and retinal pigment epithelium (RPE) in DR. Methodology: Male Wistar rats were divided into the following groups: 1. control; 2. diabetic group (DM) treated with a single intraperitoneal injection of streptozotocin (100 mg/kg); 3. group exposed to light/dark cycle 6/18h for 3 months (6/18); 4. diabetic group exposed to light/dark cycle 6/18h (DM+6/18). Retinal blood vessel permeability was estimated immunohistochemically based on lectin staining, while the expression of genes involved in the visual cycle (SOX9, LRAT, RPE65, OTX2), and inflammation (IL-1, TNF-α) was determined by qRT-PCR in the retina and RPE. Results: Shortened photoperiod reduced neovascularisation and the expression of IL-1 and TNF-α in both retina and RPE. The expression of IL-1 and TNF-α genes in the retina was significantly higher in DM vs. control group (P=0.001). In contrast, retinal IL-1 and TNF-α expressions were significantly lower in DM+6/18 vs. DM group (P=0.001). The expression of IL-1 and TNF-α in RPE was significantly higher in DM vs. control group, however the expression of these genes was significantly lower in DM+6/18 vs. DM group (PIL-1=0.008 and PTNF-α=0.002). The expression of visual cycle genes was significantly up-regulated in RPE in DM+6/18 vs. DM group (P=0.001). Conclusion: Shortened daily photoperiod reduces blood vessel permeability in DR via its anti-inflammatory effect associated with accelerated visual cycle in the retina.
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - The effect of light/dark cycle changes on vascular permeability, inflammation and visual cycle in streptoyotocin-induced diabezic retinophaty in rats
SP  - 112
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11056
ER  - 

@conference{
author = "Vasović, Dolika V. and Ivković, Sanja and Jovanović Macura, Irena and Major, Tamara and Živanović, Ana and Milašin, Jelena and Nikolić, Nađa and Simonović, Jelena and Šutulović, Nikola and Hrnčić, Dragan and Stanojlović, Olivera and Mladenović, Dušan",
year = "2023",
abstract = "Introduction: Diabetic retinopathy (DR) is not cured efficiently and changes of lifestyle measures may alleviate its course. The aim of our study was to investigate the effects of shortened daily photoperiod on inflammation and visual cycle in rat retina and retinal pigment epithelium (RPE) in DR. Methodology: Male Wistar rats were divided into the following groups: 1. control; 2. diabetic group (DM) treated with a single intraperitoneal injection of streptozotocin (100 mg/kg); 3. group exposed to light/dark cycle 6/18h for 3 months (6/18); 4. diabetic group exposed to light/dark cycle 6/18h (DM+6/18). Retinal blood vessel permeability was estimated immunohistochemically based on lectin staining, while the expression of genes involved in the visual cycle (SOX9, LRAT, RPE65, OTX2), and inflammation (IL-1, TNF-α) was determined by qRT-PCR in the retina and RPE. Results: Shortened photoperiod reduced neovascularisation and the expression of IL-1 and TNF-α in both retina and RPE. The expression of IL-1 and TNF-α genes in the retina was significantly higher in DM vs. control group (P=0.001). In contrast, retinal IL-1 and TNF-α expressions were significantly lower in DM+6/18 vs. DM group (P=0.001). The expression of IL-1 and TNF-α in RPE was significantly higher in DM vs. control group, however the expression of these genes was significantly lower in DM+6/18 vs. DM group (PIL-1=0.008 and PTNF-α=0.002). The expression of visual cycle genes was significantly up-regulated in RPE in DM+6/18 vs. DM group (P=0.001). Conclusion: Shortened daily photoperiod reduces blood vessel permeability in DR via its anti-inflammatory effect associated with accelerated visual cycle in the retina.",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "The effect of light/dark cycle changes on vascular permeability, inflammation and visual cycle in streptoyotocin-induced diabezic retinophaty in rats",
pages = "112",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11056"
}

Vasović, D. V., Ivković, S., Jovanović Macura, I., Major, T., Živanović, A., Milašin, J., Nikolić, N., Simonović, J., Šutulović, N., Hrnčić, D., Stanojlović, O.,& Mladenović, D.. (2023). The effect of light/dark cycle changes on vascular permeability, inflammation and visual cycle in streptoyotocin-induced diabezic retinophaty in rats. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 112.
https://hdl.handle.net/21.15107/rcub_vinar_11056

Vasović DV, Ivković S, Jovanović Macura I, Major T, Živanović A, Milašin J, Nikolić N, Simonović J, Šutulović N, Hrnčić D, Stanojlović O, Mladenović D. The effect of light/dark cycle changes on vascular permeability, inflammation and visual cycle in streptoyotocin-induced diabezic retinophaty in rats. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:112.
https://hdl.handle.net/21.15107/rcub_vinar_11056 .

Vasović, Dolika V., Ivković, Sanja, Jovanović Macura, Irena, Major, Tamara, Živanović, Ana, Milašin, Jelena, Nikolić, Nađa, Simonović, Jelena, Šutulović, Nikola, Hrnčić, Dragan, Stanojlović, Olivera, Mladenović, Dušan, "The effect of light/dark cycle changes on vascular permeability, inflammation and visual cycle in streptoyotocin-induced diabezic retinophaty in rats" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):112,
https://hdl.handle.net/21.15107/rcub_vinar_11056 .