TY  - JOUR
AU  - Dražić, Branka
AU  - Antonijević-Nikolić, Mirjana
AU  - Marinović-Cincović, Milena
AU  - Živković-Radovanović, Vukosava
AU  - Borović, Branka
AU  - Tanasković, Slađana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10365
AB  - Two new cationic Cu(II) complexes of cyclam (1,4,8,11-tetraazacyclotetradecane) and aminocarboxylate coligands glycine or alanine have been synthesized. The complexes were characterized by elemental analysis (C, H and N), molar electrical conductivity, magnetic susceptibility measurement at room temperature, spectral methods (UV/Vis and Fourier transform infrared), as well as by thermogravimetric (TG) and differential thermal analysis (DTA). The analytical data of the complexes show the formation of mononuclear complexes with general formula [Cu(L)cyc](ClO4)2·nH2O, A) L = glycine, n = 1.5 and B) L = alanine, n = 2.5. The tetradentate ligand cyclam was coordinated to metals through four N donors. The spectroscopic data suggested that the amino carboxylate ligands coordinated via their carboxylate ion moieties. The six- -coordinate octahedral geometry around Cu(II) in both complexes was presumed. TG-DTA analysis indicated that complex B decomposed exothermally in a single step in the range of 310–400°C. The cytotoxic activity of Cu(II) complexes and the starting ligands were tested against human cervix adenocarcinoma cell line (HeLa), human melanoma (FemX) and human colon carcinoma (LS174). The IC50 values for the Cu(II) complexes were from 48.35–82.25 μM. Both complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.
T2  - Journal of the Serbian Chemical Society
T1  - New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies
VL  - 87
IS  - 4
SP  - 451
EP  - 464
DO  - 10.2298/JSC211107026D
ER  - 

@article{
author = "Dražić, Branka and Antonijević-Nikolić, Mirjana and Marinović-Cincović, Milena and Živković-Radovanović, Vukosava and Borović, Branka and Tanasković, Slađana",
year = "2022",
abstract = "Two new cationic Cu(II) complexes of cyclam (1,4,8,11-tetraazacyclotetradecane) and aminocarboxylate coligands glycine or alanine have been synthesized. The complexes were characterized by elemental analysis (C, H and N), molar electrical conductivity, magnetic susceptibility measurement at room temperature, spectral methods (UV/Vis and Fourier transform infrared), as well as by thermogravimetric (TG) and differential thermal analysis (DTA). The analytical data of the complexes show the formation of mononuclear complexes with general formula [Cu(L)cyc](ClO4)2·nH2O, A) L = glycine, n = 1.5 and B) L = alanine, n = 2.5. The tetradentate ligand cyclam was coordinated to metals through four N donors. The spectroscopic data suggested that the amino carboxylate ligands coordinated via their carboxylate ion moieties. The six- -coordinate octahedral geometry around Cu(II) in both complexes was presumed. TG-DTA analysis indicated that complex B decomposed exothermally in a single step in the range of 310–400°C. The cytotoxic activity of Cu(II) complexes and the starting ligands were tested against human cervix adenocarcinoma cell line (HeLa), human melanoma (FemX) and human colon carcinoma (LS174). The IC50 values for the Cu(II) complexes were from 48.35–82.25 μM. Both complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.",
journal = "Journal of the Serbian Chemical Society",
title = "New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies",
volume = "87",
number = "4",
pages = "451-464",
doi = "10.2298/JSC211107026D"
}

Dražić, B., Antonijević-Nikolić, M., Marinović-Cincović, M., Živković-Radovanović, V., Borović, B.,& Tanasković, S.. (2022). New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies. in Journal of the Serbian Chemical Society, 87(4), 451-464.
https://doi.org/10.2298/JSC211107026D

Dražić B, Antonijević-Nikolić M, Marinović-Cincović M, Živković-Radovanović V, Borović B, Tanasković S. New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies. in Journal of the Serbian Chemical Society. 2022;87(4):451-464.
doi:10.2298/JSC211107026D .

Dražić, Branka, Antonijević-Nikolić, Mirjana, Marinović-Cincović, Milena, Živković-Radovanović, Vukosava, Borović, Branka, Tanasković, Slađana, "New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies" in Journal of the Serbian Chemical Society, 87, no. 4 (2022):451-464,
https://doi.org/10.2298/JSC211107026D . .

TY  - CONF
AU  - Antonijević-Nikolić, Mirjana
AU  - Marinović-Cincović, Milena
AU  - Tanasković, Slađana
AU  - Dražić, Branka
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11665
AB  - The aim of this study was to investigate thermal behavior of the new complex with formula [Cu(ala)cyc](ClO4)2∙2.5H2O. The complex was isolated and previously characterized by: elemental analysis (C, H, N), molar conductivity, UV/Vis and FTIR spectroscopy and magnetic measurements at room temperature. The sixcoordinate octahedral geometry around Cu(II) complexes was proposed. The experimental data suggested that the tetradentate ligand cyclam was coordinated to metals through four N donors and the amino carboxylate ligand coordinated via carboxylate ion. Investigate of thermal stability can be crucial in confirming the structure as well as in assessing the applicability of new compounds. The thermal properties of these complex have been investigated by thermogravimetric (TG) and differential thermal analysis (DTA). Therefore, TG-DTA analysis indicates that investigated complex decomposes exothermally in a single step in the range of 310 - 400 °C.
PB  - University in Banjaluka : Faculty of Technology
C3  - 14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska
T1  - Thermal stability of new Copper(II) cyclam complex with
aminocarboxylate Co-ligand
SP  - 25
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11665
ER  - 

@conference{
author = "Antonijević-Nikolić, Mirjana and Marinović-Cincović, Milena and Tanasković, Slađana and Dražić, Branka",
year = "2022",
abstract = "The aim of this study was to investigate thermal behavior of the new complex with formula [Cu(ala)cyc](ClO4)2∙2.5H2O. The complex was isolated and previously characterized by: elemental analysis (C, H, N), molar conductivity, UV/Vis and FTIR spectroscopy and magnetic measurements at room temperature. The sixcoordinate octahedral geometry around Cu(II) complexes was proposed. The experimental data suggested that the tetradentate ligand cyclam was coordinated to metals through four N donors and the amino carboxylate ligand coordinated via carboxylate ion. Investigate of thermal stability can be crucial in confirming the structure as well as in assessing the applicability of new compounds. The thermal properties of these complex have been investigated by thermogravimetric (TG) and differential thermal analysis (DTA). Therefore, TG-DTA analysis indicates that investigated complex decomposes exothermally in a single step in the range of 310 - 400 °C.",
publisher = "University in Banjaluka : Faculty of Technology",
journal = "14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska",
title = "Thermal stability of new Copper(II) cyclam complex with
aminocarboxylate Co-ligand",
pages = "25",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11665"
}

Antonijević-Nikolić, M., Marinović-Cincović, M., Tanasković, S.,& Dražić, B.. (2022). Thermal stability of new Copper(II) cyclam complex with
aminocarboxylate Co-ligand. in 14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska
University in Banjaluka : Faculty of Technology., 25.
https://hdl.handle.net/21.15107/rcub_vinar_11665

Antonijević-Nikolić M, Marinović-Cincović M, Tanasković S, Dražić B. Thermal stability of new Copper(II) cyclam complex with
aminocarboxylate Co-ligand. in 14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska. 2022;:25.
https://hdl.handle.net/21.15107/rcub_vinar_11665 .

Antonijević-Nikolić, Mirjana, Marinović-Cincović, Milena, Tanasković, Slađana, Dražić, Branka, "Thermal stability of new Copper(II) cyclam complex with
aminocarboxylate Co-ligand" in 14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska (2022):25,
https://hdl.handle.net/21.15107/rcub_vinar_11665 .

TY  - JOUR
AU  - Antonijević-Nikolić, Mirjana
AU  - Szécsényi, Katalin Mészáros
AU  - Dražić, Branka
AU  - Rodić, Marko V.
AU  - Stanić, Vojislav
AU  - Tanasković, Slađana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9160
AB  - In vitro cytotoxic evaluation, formation constants and thermal stability of four mixed-ligand Co(II) complexes with tpmc = N,N',N",N'"-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane and carboxylate/dicarboxylate co-ligands of formulas [Co2(benz)2tpmc](ClO4)2•3H2O (1), benz– = benzoate anion; [Co2(L)tpmc](ClO4)2•nH2O, L = pht2– (phthalate dianion), n=2 (2), L = ipht2– (isophthalate dianion), n=4 (3) and L = tpht2–(terephthalate dianion), n=4 (4) are reported. The stoichiometric composition of the compounds in the solution were determined spectrophotometrically using Job's methods. Formation constants, K and Gibbs free energy, ΔG values were calculated. The thermal behavior of the complexes was investigated by simultaneous TG/DSC and TG – MS measurements. The cytotoxic effect of the complexes, the free ligands, the DMSO solvent and cis-platin, as referent cytostatic drug, was evaluated on Human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The IC50 values were between 12.7–42.3 μM. The first crystal structure determination of the Co(II) complex [Co2(µ-pht)tpmc](ClO4)2•H2O with boat conformation of tpmc ligand, was also done. The complex crystallizes in monoclinic crystal system, C2/c space group. The geometries around both Co(II) atoms are highly distorted octahedral. The Co(II) ions exhibit CoN4O2 coordination environments with the four nitrogen donor atoms of the tpmc ligand and two oxygen atoms belonging to the one carboxylate group of pht2− ligand. The carboxylate groups of pht2− are coordinated in an endo-bidentate mode. The tpmc ligand adopted a boat conformation in which the two coordinated Co(II) atoms are located on the same side of the ring, with Co•••Co distance amounting 5.4799(5) Å. © 2021
T2  - Journal of Molecular Structure
T1  - Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior
VL  - 1236
SP  - 130133
DO  - 10.1016/j.molstruc.2021.130133
ER  - 

@article{
author = "Antonijević-Nikolić, Mirjana and Szécsényi, Katalin Mészáros and Dražić, Branka and Rodić, Marko V. and Stanić, Vojislav and Tanasković, Slađana",
year = "2021",
abstract = "In vitro cytotoxic evaluation, formation constants and thermal stability of four mixed-ligand Co(II) complexes with tpmc = N,N',N",N'"-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane and carboxylate/dicarboxylate co-ligands of formulas [Co2(benz)2tpmc](ClO4)2•3H2O (1), benz– = benzoate anion; [Co2(L)tpmc](ClO4)2•nH2O, L = pht2– (phthalate dianion), n=2 (2), L = ipht2– (isophthalate dianion), n=4 (3) and L = tpht2–(terephthalate dianion), n=4 (4) are reported. The stoichiometric composition of the compounds in the solution were determined spectrophotometrically using Job's methods. Formation constants, K and Gibbs free energy, ΔG values were calculated. The thermal behavior of the complexes was investigated by simultaneous TG/DSC and TG – MS measurements. The cytotoxic effect of the complexes, the free ligands, the DMSO solvent and cis-platin, as referent cytostatic drug, was evaluated on Human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The IC50 values were between 12.7–42.3 μM. The first crystal structure determination of the Co(II) complex [Co2(µ-pht)tpmc](ClO4)2•H2O with boat conformation of tpmc ligand, was also done. The complex crystallizes in monoclinic crystal system, C2/c space group. The geometries around both Co(II) atoms are highly distorted octahedral. The Co(II) ions exhibit CoN4O2 coordination environments with the four nitrogen donor atoms of the tpmc ligand and two oxygen atoms belonging to the one carboxylate group of pht2− ligand. The carboxylate groups of pht2− are coordinated in an endo-bidentate mode. The tpmc ligand adopted a boat conformation in which the two coordinated Co(II) atoms are located on the same side of the ring, with Co•••Co distance amounting 5.4799(5) Å. © 2021",
journal = "Journal of Molecular Structure",
title = "Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior",
volume = "1236",
pages = "130133",
doi = "10.1016/j.molstruc.2021.130133"
}

Antonijević-Nikolić, M., Szécsényi, K. M., Dražić, B., Rodić, M. V., Stanić, V.,& Tanasković, S.. (2021). Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior. in Journal of Molecular Structure, 1236, 130133.
https://doi.org/10.1016/j.molstruc.2021.130133

Antonijević-Nikolić M, Szécsényi KM, Dražić B, Rodić MV, Stanić V, Tanasković S. Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior. in Journal of Molecular Structure. 2021;1236:130133.
doi:10.1016/j.molstruc.2021.130133 .

Antonijević-Nikolić, Mirjana, Szécsényi, Katalin Mészáros, Dražić, Branka, Rodić, Marko V., Stanić, Vojislav, Tanasković, Slađana, "Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior" in Journal of Molecular Structure, 1236 (2021):130133,
https://doi.org/10.1016/j.molstruc.2021.130133 . .