TY  - CONF
AU  - Đurić, Dragan
AU  - Krstić, Danijela
AU  - Čolović, Mirjana
AU  - Jakovljević, Jovana
AU  - Jakovljević, Vladimir
AU  - Tasić, Nebojša
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12983
AB  - L-methionine, the principal sulfur-containing amino acid in proteins, has important roles in cell physiology as an antioxidant, and in the breakdown of fats and heavy metals. Methionine is the precursor of homocysteine, and participates in the methylation and transsulfuration pathways. Elevated total plasma homocysteine (hyperhomocysteinemia) is associated with atherosclerosis, thromboembolic disease and cancer. Whether homocysteine per se or a coincident metabolic abnormality (homocysteine-related compounds, thiolactone metabolites) causes vascular disease is still an open question. Animals with genetic hyperhomocysteinemia have so far not displayed atheromatous lesions. However, when methionine-rich diets are used to induce hyperhomocysteinemia, vascular pathology is often observed. Such studies have not distinguished the effects of excess dietary methionine from those of hyperhomocysteinemia. It is known that high methionine diet, not only red meat for example lamb, beef, pork but also chicken meat can induce cardiovascular dysfunction but the mechanisms are unclear. It has been hypothesized that a diet rich in methionine can malfunction the cardiovascular system in three ways: (1) by augmenting oxidative stress, (2) by inflammatory manifestations, and (3) by matrix/vascular remodeling. However, some evidence indicates that an excess of methionine can be harmful for other systems, and can increase the risk of developing type-2 diabetes, certain types of cancer, brain alterations such as schizophrenia, and memory impairment. However this is still controversial because previous studies suggesting the use of L-methionine as a treatment for depression and other diseases indicate that it might also improve memory (role in brain function). Thus, the direction of our research is to further elucidate mechanisms of cardiovascular and neural effects of homocysteine vs. methionine overload.
PB  - Kragujevac : Medical Faculty
C3  - Serbian Journal of Experimental and Clinical Research
T1  - Methionine versus homocysteine: future directions in cardiovascular research
VL  - 18
IS  - 1
SP  - 39
EP  - 39
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12983
ER  - 

@conference{
author = "Đurić, Dragan and Krstić, Danijela and Čolović, Mirjana and Jakovljević, Jovana and Jakovljević, Vladimir and Tasić, Nebojša",
year = "2016",
abstract = "L-methionine, the principal sulfur-containing amino acid in proteins, has important roles in cell physiology as an antioxidant, and in the breakdown of fats and heavy metals. Methionine is the precursor of homocysteine, and participates in the methylation and transsulfuration pathways. Elevated total plasma homocysteine (hyperhomocysteinemia) is associated with atherosclerosis, thromboembolic disease and cancer. Whether homocysteine per se or a coincident metabolic abnormality (homocysteine-related compounds, thiolactone metabolites) causes vascular disease is still an open question. Animals with genetic hyperhomocysteinemia have so far not displayed atheromatous lesions. However, when methionine-rich diets are used to induce hyperhomocysteinemia, vascular pathology is often observed. Such studies have not distinguished the effects of excess dietary methionine from those of hyperhomocysteinemia. It is known that high methionine diet, not only red meat for example lamb, beef, pork but also chicken meat can induce cardiovascular dysfunction but the mechanisms are unclear. It has been hypothesized that a diet rich in methionine can malfunction the cardiovascular system in three ways: (1) by augmenting oxidative stress, (2) by inflammatory manifestations, and (3) by matrix/vascular remodeling. However, some evidence indicates that an excess of methionine can be harmful for other systems, and can increase the risk of developing type-2 diabetes, certain types of cancer, brain alterations such as schizophrenia, and memory impairment. However this is still controversial because previous studies suggesting the use of L-methionine as a treatment for depression and other diseases indicate that it might also improve memory (role in brain function). Thus, the direction of our research is to further elucidate mechanisms of cardiovascular and neural effects of homocysteine vs. methionine overload.",
publisher = "Kragujevac : Medical Faculty",
journal = "Serbian Journal of Experimental and Clinical Research",
title = "Methionine versus homocysteine: future directions in cardiovascular research",
volume = "18",
number = "1",
pages = "39-39",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12983"
}

Đurić, D., Krstić, D., Čolović, M., Jakovljević, J., Jakovljević, V.,& Tasić, N.. (2016). Methionine versus homocysteine: future directions in cardiovascular research. in Serbian Journal of Experimental and Clinical Research
Kragujevac : Medical Faculty., 18(1), 39-39.
https://hdl.handle.net/21.15107/rcub_vinar_12983

Đurić D, Krstić D, Čolović M, Jakovljević J, Jakovljević V, Tasić N. Methionine versus homocysteine: future directions in cardiovascular research. in Serbian Journal of Experimental and Clinical Research. 2016;18(1):39-39.
https://hdl.handle.net/21.15107/rcub_vinar_12983 .

Đurić, Dragan, Krstić, Danijela, Čolović, Mirjana, Jakovljević, Jovana, Jakovljević, Vladimir, Tasić, Nebojša, "Methionine versus homocysteine: future directions in cardiovascular research" in Serbian Journal of Experimental and Clinical Research, 18, no. 1 (2016):39-39,
https://hdl.handle.net/21.15107/rcub_vinar_12983 .