Bundalo, Maja M.

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orcid::0000-0002-0589-2672
  • Bundalo, Maja M. (13)
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Author's Bibliography

Estradiol ameliorates antioxidant axis SIRT1-FoxO3a-MnSOD/catalase in the heart of fructose-fed ovariectomized rats

Bošković, Maja; Bundalo, Maja M.; Živković, Maja; Stanišić, Jelena; Kostić, Milan; Korićanac, Goran; Stanković, Aleksandra

(2019)

TY  - JOUR
AU  - Bošković, Maja
AU  - Bundalo, Maja M.
AU  - Živković, Maja
AU  - Stanišić, Jelena
AU  - Kostić, Milan
AU  - Korićanac, Goran
AU  - Stanković, Aleksandra
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7984
AB  - Harmful effects of fructose-rich diet (FRD) were predominantly observed in males, suggesting protective effects of estrogens. Little is known about AMPK/sirtuin-1 (SIRT1)/forkhead box O3 (FoxO3a)/manganese superoxide dismutase (MnSOD)/catalase signaling in the heart in state of metabolic syndrome and oxidative stress induced by fructose over-consumption. We investigated the effect of 10% FRD on expression of AMPK-SIRT1-FoxO3a-MnSOD/catalase axis in myocardium and potentially beneficial effect of 17β-estradiol replacement. The expression of NADPH oxidase 4 (Nox4) and miRNA-155, unfavorable regulators of this axis, were also investigated. FRD significantly increased AMPK and decreased FoxO3a activity, decreased SIRT1, MnSOD and Nox4 protein expression while E2 reverted these changes, except for Nox4, and increased catalase protein level. E2 diminished Nox4 and MnSOD mRNA level in FRD ovariectomized rats. These results suggest independent response of AMPK and SIRT to FRD treatment. The proposed signaling in the heart should be further investigated in the prooxidative and antioxidative milieu.
T2  - Journal of Functional Foods
T1  - Estradiol ameliorates antioxidant axis SIRT1-FoxO3a-MnSOD/catalase in the heart of fructose-fed ovariectomized rats
VL  - 52
SP  - 690
EP  - 698
DO  - 10.1016/j.jff.2018.11.053
ER  - 
@article{
author = "Bošković, Maja and Bundalo, Maja M. and Živković, Maja and Stanišić, Jelena and Kostić, Milan and Korićanac, Goran and Stanković, Aleksandra",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7984",
abstract = "Harmful effects of fructose-rich diet (FRD) were predominantly observed in males, suggesting protective effects of estrogens. Little is known about AMPK/sirtuin-1 (SIRT1)/forkhead box O3 (FoxO3a)/manganese superoxide dismutase (MnSOD)/catalase signaling in the heart in state of metabolic syndrome and oxidative stress induced by fructose over-consumption. We investigated the effect of 10% FRD on expression of AMPK-SIRT1-FoxO3a-MnSOD/catalase axis in myocardium and potentially beneficial effect of 17β-estradiol replacement. The expression of NADPH oxidase 4 (Nox4) and miRNA-155, unfavorable regulators of this axis, were also investigated. FRD significantly increased AMPK and decreased FoxO3a activity, decreased SIRT1, MnSOD and Nox4 protein expression while E2 reverted these changes, except for Nox4, and increased catalase protein level. E2 diminished Nox4 and MnSOD mRNA level in FRD ovariectomized rats. These results suggest independent response of AMPK and SIRT to FRD treatment. The proposed signaling in the heart should be further investigated in the prooxidative and antioxidative milieu.",
journal = "Journal of Functional Foods",
title = "Estradiol ameliorates antioxidant axis SIRT1-FoxO3a-MnSOD/catalase in the heart of fructose-fed ovariectomized rats",
volume = "52",
pages = "690-698",
doi = "10.1016/j.jff.2018.11.053"
}
Bošković, M., Bundalo, M. M., Živković, M., Stanišić, J., Kostić, M., Korićanac, G.,& Stanković, A. (2019). Estradiol ameliorates antioxidant axis SIRT1-FoxO3a-MnSOD/catalase in the heart of fructose-fed ovariectomized rats.
Journal of Functional Foods, 52, 690-698.
https://doi.org/10.1016/j.jff.2018.11.053
Bošković M, Bundalo MM, Živković M, Stanišić J, Kostić M, Korićanac G, Stanković A. Estradiol ameliorates antioxidant axis SIRT1-FoxO3a-MnSOD/catalase in the heart of fructose-fed ovariectomized rats. Journal of Functional Foods. 2019;52:690-698
Bošković Maja, Bundalo Maja M., Živković Maja, Stanišić Jelena, Kostić Milan, Korićanac Goran, Stanković Aleksandra, "Estradiol ameliorates antioxidant axis SIRT1-FoxO3a-MnSOD/catalase in the heart of fructose-fed ovariectomized rats" Journal of Functional Foods, 52 (2019):690-698,
https://doi.org/10.1016/j.jff.2018.11.053 .
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Fructose-rich diet differently affects angiotensin II receptor content in the nucleus and a plasma membrane fraction of visceral adipose tissue

Bundalo, Maja M.; Đorđević, Ana D.; Bursac, Biljana; Živković, Maja; Korićanac, Goran; Stanković, Aleksandra

(2017)

TY  - JOUR
AU  - Bundalo, Maja M.
AU  - Đorđević, Ana D.
AU  - Bursac, Biljana
AU  - Živković, Maja
AU  - Korićanac, Goran
AU  - Stanković, Aleksandra
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1839
AB  - The adipose tissue renin-angiotensin system (RAS) is proposed to be a pathophysiological link between adipose tissue dysregulation and metabolic disorders induced by a fructose-rich diet (FRD). RAS can act intracellularly. We hypothesized that adipocyte nuclear membranes possess angiotensin receptor types 1 and 2 (AT1R and AT2R), which couple to nuclear signaling pathways and regulate oxidative gene expression under FRD conditions. We analyzed the effect of consumption of 10% fructose solution for 9 weeks on biochemical parameters, adipocyte morphology, and expression of AT1R, AT2R, AT1R-associated protein (ATRAP), NADPH oxidase 4 (NOX4), matrix metalloproteinase-9 (MMP-9), and manganese superoxide dismutase (MnSOD) in adipose tissue of Wistar rats. We detected AT1R and AT2R in the nuclear fraction. FRD reduced the level of angiotensin receptors in the nucleus, while increased AT1R and decreased AT2R levels were observed in the plasma membrane. FRD increased the ATRAP mRNA level and decreased MnSOD mRNA and protein levels. No significant differences were observed for MMP-9 and NOX4 mRNA levels. These findings coincided with hyperleptinemia, elevated blood pressure and triglycerides, and unchanged visceral adipose tissue mass and morphology in FRD rats. Besides providing evidence for nuclear localization of angiotensin receptors in visceral adipose tissue, this study demonstrates the different effects of FRD on AT1R expression in different cellular compartments. Elevated blood pressure and decreased antioxidant capacity in visceral fat of fructose-fed rats were accompanied by an increased AT1R level in the plasma membrane, while upregulation of ATRAP and a decrease of nuclear membrane AT1R suggest an increased capacity for attenuation of excessive AT1R signaling and visceral adiposity.
T2  - Applied Physiology Nutrition and Metabolism
T1  - Fructose-rich diet differently affects angiotensin II receptor content in the nucleus and a plasma membrane fraction of visceral adipose tissue
VL  - 42
IS  - 12
SP  - 1254
EP  - 1263
DO  - 10.1139/apnm-2016-0725
ER  - 
@article{
author = "Bundalo, Maja M. and Đorđević, Ana D. and Bursac, Biljana and Živković, Maja and Korićanac, Goran and Stanković, Aleksandra",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1839",
abstract = "The adipose tissue renin-angiotensin system (RAS) is proposed to be a pathophysiological link between adipose tissue dysregulation and metabolic disorders induced by a fructose-rich diet (FRD). RAS can act intracellularly. We hypothesized that adipocyte nuclear membranes possess angiotensin receptor types 1 and 2 (AT1R and AT2R), which couple to nuclear signaling pathways and regulate oxidative gene expression under FRD conditions. We analyzed the effect of consumption of 10% fructose solution for 9 weeks on biochemical parameters, adipocyte morphology, and expression of AT1R, AT2R, AT1R-associated protein (ATRAP), NADPH oxidase 4 (NOX4), matrix metalloproteinase-9 (MMP-9), and manganese superoxide dismutase (MnSOD) in adipose tissue of Wistar rats. We detected AT1R and AT2R in the nuclear fraction. FRD reduced the level of angiotensin receptors in the nucleus, while increased AT1R and decreased AT2R levels were observed in the plasma membrane. FRD increased the ATRAP mRNA level and decreased MnSOD mRNA and protein levels. No significant differences were observed for MMP-9 and NOX4 mRNA levels. These findings coincided with hyperleptinemia, elevated blood pressure and triglycerides, and unchanged visceral adipose tissue mass and morphology in FRD rats. Besides providing evidence for nuclear localization of angiotensin receptors in visceral adipose tissue, this study demonstrates the different effects of FRD on AT1R expression in different cellular compartments. Elevated blood pressure and decreased antioxidant capacity in visceral fat of fructose-fed rats were accompanied by an increased AT1R level in the plasma membrane, while upregulation of ATRAP and a decrease of nuclear membrane AT1R suggest an increased capacity for attenuation of excessive AT1R signaling and visceral adiposity.",
journal = "Applied Physiology Nutrition and Metabolism",
title = "Fructose-rich diet differently affects angiotensin II receptor content in the nucleus and a plasma membrane fraction of visceral adipose tissue",
volume = "42",
number = "12",
pages = "1254-1263",
doi = "10.1139/apnm-2016-0725"
}
Bundalo, M. M., Đorđević, A. D., Bursac, B., Živković, M., Korićanac, G.,& Stanković, A. (2017). Fructose-rich diet differently affects angiotensin II receptor content in the nucleus and a plasma membrane fraction of visceral adipose tissue.
Applied Physiology Nutrition and Metabolism, 42(12), 1254-1263.
https://doi.org/10.1139/apnm-2016-0725
Bundalo MM, Đorđević AD, Bursac B, Živković M, Korićanac G, Stanković A. Fructose-rich diet differently affects angiotensin II receptor content in the nucleus and a plasma membrane fraction of visceral adipose tissue. Applied Physiology Nutrition and Metabolism. 2017;42(12):1254-1263
Bundalo Maja M., Đorđević Ana D., Bursac Biljana, Živković Maja, Korićanac Goran, Stanković Aleksandra, "Fructose-rich diet differently affects angiotensin II receptor content in the nucleus and a plasma membrane fraction of visceral adipose tissue" Applied Physiology Nutrition and Metabolism, 42, no. 12 (2017):1254-1263,
https://doi.org/10.1139/apnm-2016-0725 .
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Fructose-rich diet and insulin action in female rat heart: Estradiol friend or foe?

Bundalo, Maja M.; Romić, Snježana Đ.; Tepavčević, Snežana; Stojiljković, Mojca D.; Stanković, Aleksandra; Živković, Maja; Korićanac, Goran

(2017)

TY  - JOUR
AU  - Bundalo, Maja M.
AU  - Romić, Snježana Đ.
AU  - Tepavčević, Snežana
AU  - Stojiljković, Mojca D.
AU  - Stanković, Aleksandra
AU  - Živković, Maja
AU  - Korićanac, Goran
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1726
AB  - Increased intake of fructose in humans and laboratory animals is demonstrated to be a risk factor for development of metabolic disorders (insulin resistance, metabolic syndrome, type 2 diabetes) and cardiovascular diseases. On the other hand, estradiol is emphasized as a cardioprotective agent. The main goal of this review is to summarize recent findings on damaging cardiac effects of fructose-rich diet in females, mostly experimental animals, and to evaluate protective capacity of estradiol. Published results of our and other research groups indicate mostly detrimental effects of fructose-rich diet on cardiac insulin signaling molecules, glucose and fatty acid metabolism, nitric oxide production and ion transport, as well as renin-angiotensin system and inflammation. Some of these processes are involved in cardiac insulin signal transmission, others are regulated by insulin or have an influence on insulin action. Administration of estradiol to ovariectomized female rats, exposed to increased intake of fructose, was mostly beneficial to the heart, but sometimes it was ineffective or even detrimental, depending on the particular processes. We believe that these data, carefully translated to human population, could be useful for clinicians dealing with postmenopausal women susceptible to metabolic diseases and hormone replacement therapy.
T2  - European Journal of Pharmacology
T1  - Fructose-rich diet and insulin action in female rat heart: Estradiol friend or foe?
VL  - 811
SP  - 141
EP  - 147
DO  - 10.1016/j.ejphar.2017.06.003
ER  - 
@article{
author = "Bundalo, Maja M. and Romić, Snježana Đ. and Tepavčević, Snežana and Stojiljković, Mojca D. and Stanković, Aleksandra and Živković, Maja and Korićanac, Goran",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1726",
abstract = "Increased intake of fructose in humans and laboratory animals is demonstrated to be a risk factor for development of metabolic disorders (insulin resistance, metabolic syndrome, type 2 diabetes) and cardiovascular diseases. On the other hand, estradiol is emphasized as a cardioprotective agent. The main goal of this review is to summarize recent findings on damaging cardiac effects of fructose-rich diet in females, mostly experimental animals, and to evaluate protective capacity of estradiol. Published results of our and other research groups indicate mostly detrimental effects of fructose-rich diet on cardiac insulin signaling molecules, glucose and fatty acid metabolism, nitric oxide production and ion transport, as well as renin-angiotensin system and inflammation. Some of these processes are involved in cardiac insulin signal transmission, others are regulated by insulin or have an influence on insulin action. Administration of estradiol to ovariectomized female rats, exposed to increased intake of fructose, was mostly beneficial to the heart, but sometimes it was ineffective or even detrimental, depending on the particular processes. We believe that these data, carefully translated to human population, could be useful for clinicians dealing with postmenopausal women susceptible to metabolic diseases and hormone replacement therapy.",
journal = "European Journal of Pharmacology",
title = "Fructose-rich diet and insulin action in female rat heart: Estradiol friend or foe?",
volume = "811",
pages = "141-147",
doi = "10.1016/j.ejphar.2017.06.003"
}
Bundalo, M. M., Romić, S. Đ., Tepavčević, S., Stojiljković, M. D., Stanković, A., Živković, M.,& Korićanac, G. (2017). Fructose-rich diet and insulin action in female rat heart: Estradiol friend or foe?.
European Journal of Pharmacology, 811, 141-147.
https://doi.org/10.1016/j.ejphar.2017.06.003
Bundalo MM, Romić SĐ, Tepavčević S, Stojiljković MD, Stanković A, Živković M, Korićanac G. Fructose-rich diet and insulin action in female rat heart: Estradiol friend or foe?. European Journal of Pharmacology. 2017;811:141-147
Bundalo Maja M., Romić Snježana Đ., Tepavčević Snežana, Stojiljković Mojca D., Stanković Aleksandra, Živković Maja, Korićanac Goran, "Fructose-rich diet and insulin action in female rat heart: Estradiol friend or foe?" European Journal of Pharmacology, 811 (2017):141-147,
https://doi.org/10.1016/j.ejphar.2017.06.003 .
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Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia

Cvetković, Mirjana; Živković, Maja; Bundalo, Maja M.; Gojković, Ivana; Spasojević-Dimitrijeva, Brankica; Stanković, Aleksandra; Kostić, Mirjana M.

(2017)

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Živković, Maja
AU  - Bundalo, Maja M.
AU  - Gojković, Ivana
AU  - Spasojević-Dimitrijeva, Brankica
AU  - Stanković, Aleksandra
AU  - Kostić, Mirjana M.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1918
AB  - Background: The interindividual variability of cyclosporin A (CsA) pharmacokinetics might be explained by heterogeneity in the cytochrome P450 3A (CYP3A) subfamily. Altered CYP3A enzyme activity was associated with variant allele of P450 oxidoreductase gene (POR*28). The aim of this study was to assess the impact of age, CYP3A5*3, CYP3A4*22, and POR*28 alleles on CsA pharmacokinetics in pediatric renal transplant recipients. Methods: Renal transplant patients receiving CsA (n = 47) were genotyped for CYP3A5*3, CYP3A4*22, and POR*28. Results: CYP3A5 nonexpressers had higher overall dose-adjusted predose concentration (C0/dose; ng/mL per mg/kg) compared with expressers (31.48 +/- 12.75 versus 22.44 +/- 7.12, P = 0.01). CY-P3A5 nonexpressers carrying POR*28 allele had a lower overall dose-adjusted concentration (C2/dose) than those with POR*1/*1 genotype (165.54 +/- 70.40 versus 210.55 +/- 79.98, P = 0.02), with age as covariate. Children aged 6 years and younger had a lower overall C0/dose (18.82 +/- 4.72 versus 34.19 +/- 11.89, P = 0.001) and C2/dose (106.75 +/- 26.99 versus 209.20 +/- 71.57, P LT 0.001) compared with older children. Carriers of CYP3A5*3 allele aged LT = 6 years required higher dose of CsA and achieved lower C0/dose and C2/dose, at most time points, than older carriers of this allele. Carriers of POR*28 allele aged # 6 years required higher doses of CsA, whereas they achieved lower C0/dose and C2/dose, at most time points, in comparison to older carriers of this allele. The significant effect of age (P LT 0.002) and CYP3A5 variation (P, 0.02) was shown for overall C0/dose, whereas age (P LT 0.00001) and POR variation (P = 0.05) showed significant effect on C2/dose. Regression summary for overall C2/dose in patients aged 6 years younger showed a significant effect of both CYP3A5 and POR variations (P LT 0.016). Conclusions: Younger age, POR*28 allele, and CYP3A5*3 allele were associated with higher CsA dosing requirements and lower concentration/dose ratio. Pretransplant screening of relevant polymorphisms in accordance with age should be considered to adjust therapy.
T2  - Therapeutic Drug Monitoring
T1  - Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia
VL  - 39
IS  - 6
SP  - 589
EP  - 595
DO  - 10.1097/FTD.0000000000000442
ER  - 
@article{
author = "Cvetković, Mirjana and Živković, Maja and Bundalo, Maja M. and Gojković, Ivana and Spasojević-Dimitrijeva, Brankica and Stanković, Aleksandra and Kostić, Mirjana M.",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1918",
abstract = "Background: The interindividual variability of cyclosporin A (CsA) pharmacokinetics might be explained by heterogeneity in the cytochrome P450 3A (CYP3A) subfamily. Altered CYP3A enzyme activity was associated with variant allele of P450 oxidoreductase gene (POR*28). The aim of this study was to assess the impact of age, CYP3A5*3, CYP3A4*22, and POR*28 alleles on CsA pharmacokinetics in pediatric renal transplant recipients. Methods: Renal transplant patients receiving CsA (n = 47) were genotyped for CYP3A5*3, CYP3A4*22, and POR*28. Results: CYP3A5 nonexpressers had higher overall dose-adjusted predose concentration (C0/dose; ng/mL per mg/kg) compared with expressers (31.48 +/- 12.75 versus 22.44 +/- 7.12, P = 0.01). CY-P3A5 nonexpressers carrying POR*28 allele had a lower overall dose-adjusted concentration (C2/dose) than those with POR*1/*1 genotype (165.54 +/- 70.40 versus 210.55 +/- 79.98, P = 0.02), with age as covariate. Children aged 6 years and younger had a lower overall C0/dose (18.82 +/- 4.72 versus 34.19 +/- 11.89, P = 0.001) and C2/dose (106.75 +/- 26.99 versus 209.20 +/- 71.57, P LT 0.001) compared with older children. Carriers of CYP3A5*3 allele aged LT = 6 years required higher dose of CsA and achieved lower C0/dose and C2/dose, at most time points, than older carriers of this allele. Carriers of POR*28 allele aged # 6 years required higher doses of CsA, whereas they achieved lower C0/dose and C2/dose, at most time points, in comparison to older carriers of this allele. The significant effect of age (P LT 0.002) and CYP3A5 variation (P, 0.02) was shown for overall C0/dose, whereas age (P LT 0.00001) and POR variation (P = 0.05) showed significant effect on C2/dose. Regression summary for overall C2/dose in patients aged 6 years younger showed a significant effect of both CYP3A5 and POR variations (P LT 0.016). Conclusions: Younger age, POR*28 allele, and CYP3A5*3 allele were associated with higher CsA dosing requirements and lower concentration/dose ratio. Pretransplant screening of relevant polymorphisms in accordance with age should be considered to adjust therapy.",
journal = "Therapeutic Drug Monitoring",
title = "Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia",
volume = "39",
number = "6",
pages = "589-595",
doi = "10.1097/FTD.0000000000000442"
}
Cvetković, M., Živković, M., Bundalo, M. M., Gojković, I., Spasojević-Dimitrijeva, B., Stanković, A.,& Kostić, M. M. (2017). Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia.
Therapeutic Drug Monitoring, 39(6), 589-595.
https://doi.org/10.1097/FTD.0000000000000442
Cvetković M, Živković M, Bundalo MM, Gojković I, Spasojević-Dimitrijeva B, Stanković A, Kostić MM. Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia. Therapeutic Drug Monitoring. 2017;39(6):589-595
Cvetković Mirjana, Živković Maja, Bundalo Maja M., Gojković Ivana, Spasojević-Dimitrijeva Brankica, Stanković Aleksandra, Kostić Mirjana M., "Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia" Therapeutic Drug Monitoring, 39, no. 6 (2017):589-595,
https://doi.org/10.1097/FTD.0000000000000442 .
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Estradiol Protects Ovariectomized Female Rats Against Fructose-Rich Diet Induced Oxidative Stress

Bošković, Maja; Bundalo, Maja M.; Stojiljković, Mojca D.; Kostić, Milan; Živković, Maja; Korićanac, Goran; Stanković, Aleksandra; Životić, Ivan

(2017)

TY  - CONF
AU  - Bošković, Maja
AU  - Bundalo, Maja M.
AU  - Stojiljković, Mojca D.
AU  - Kostić, Milan
AU  - Živković, Maja
AU  - Korićanac, Goran
AU  - Stanković, Aleksandra
AU  - Životić, Ivan
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7179
C3  - Atherosclerosis
T1  - Estradiol Protects Ovariectomized Female Rats Against Fructose-Rich Diet Induced Oxidative Stress
VL  - 263
SP  - E192
EP  - E192
DO  - 10.1016/j.atherosclerosis.2017.06.616
ER  - 
@conference{
author = "Bošković, Maja and Bundalo, Maja M. and Stojiljković, Mojca D. and Kostić, Milan and Živković, Maja and Korićanac, Goran and Stanković, Aleksandra and Životić, Ivan",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7179",
journal = "Atherosclerosis",
title = "Estradiol Protects Ovariectomized Female Rats Against Fructose-Rich Diet Induced Oxidative Stress",
volume = "263",
pages = "E192-E192",
doi = "10.1016/j.atherosclerosis.2017.06.616"
}
Bošković, M., Bundalo, M. M., Stojiljković, M. D., Kostić, M., Živković, M., Korićanac, G., Stanković, A.,& Životić, I. (2017). Estradiol Protects Ovariectomized Female Rats Against Fructose-Rich Diet Induced Oxidative Stress.
Atherosclerosis, 263, E192-E192.
https://doi.org/10.1016/j.atherosclerosis.2017.06.616
Bošković M, Bundalo MM, Stojiljković MD, Kostić M, Živković M, Korićanac G, Stanković A, Životić I. Estradiol Protects Ovariectomized Female Rats Against Fructose-Rich Diet Induced Oxidative Stress. Atherosclerosis. 2017;263:E192-E192
Bošković Maja, Bundalo Maja M., Stojiljković Mojca D., Kostić Milan, Živković Maja, Korićanac Goran, Stanković Aleksandra, Životić Ivan, "Estradiol Protects Ovariectomized Female Rats Against Fructose-Rich Diet Induced Oxidative Stress" Atherosclerosis, 263 (2017):E192-E192,
https://doi.org/10.1016/j.atherosclerosis.2017.06.616 .

Uticaj ishrane bogate fruktozom na ekspresiju komponenti renin-angiotenzin sistema i inflamacije u tkivu srca pacova: polno specifične razlike

Bundalo, Maja M.

(Универзитет у Београду, Биолошки факултет, 2016)

TY  - BOOK
AU  - Bundalo, Maja M.
PY  - 2016
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=3043
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:11284/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1025057202
UR  - http://nardus.mpn.gov.rs/123456789/5664
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7279
AB  - Ishrana bogata fruktozom predstavlja bitan faktor u razvoju metaboličkogsindroma koji je povezan sa povećanim rizikom za nastanak kardiovaskularnih bolesti.Smatra se da hronična inflamacija ima bitnu ulogu u njegovoj patogenezi. Ženke suzaštićene od ishranom izazvanih metaboličkih poremećaja i hipertenzije ureproduktivnom periodu. Estrogen, koji utiče na normalno funkcionisanjekardiovaskularnog sistema, bi mogao doprinositi uočenim polno specifičnim razlikama unastanku simptoma metaboličkog sindroma. Proteinske komponente renin-angiotenzinsistema (RAS) imaju bitnu ulogu u nastanku inflamacije, hipertenzije i insulinskerezistencije i na njihovu ekspresiju utiče estradiol. Ova doktorska disertacija je za ciljimala da ispita da li pol i estradiol doprinose promenama u ekspresiji komponenti RAS-a[angiotenzin konvertujućeg enzima (ACE), angiotenzin konvertujućeg enzima 2 (ACE2),angiotenzinskog receptora tipa 1 (AT1R), angiotenzinskog receptora tipa 2 (AT2R) ikolektrina] i medijatora inflamacije i remodelovanja tkiva srca [nuklearnog faktora κB(NFκB), matriks metaloproteinaze-9 (MMP-9) i liganda 16 iz familije hemokina CXC(CXCL16)] kod animalnog modela metaboličkog sindroma.Mužjaci i ženke pacova koji su pili 10% rastvor fruktoze umesto vode u trajanjuod 9 nedelja predstavljali su animalni model metaboličkog sindroma korišćen u ovojstudiji. Radi ispitivanja efekata estradiola jedan deo ženki pacova je ovarijektomisan ipodeljen u tri grupe pri čemi je jedna grupa pored standardne laboratorijske hrane pilavodu, druga grupa je pila 10% rastvor fruktoze, a treća grupa je pored rasvora fruktozeprimala i supstitucionu terapiju estradiolom. Ishrana bogata fruktozom je uzrokovalapovećanje krvnog pritiska samo kod mužjaka pacova. Ovaj tip ishrane nije doveo dopromena u masi srca niti u odnosu masa srca/masa tela ni kod jednog pola, kao ni kodovarijektomisanih životinja što ukazuje da se hipertrofija srca nije razvila...
AB  - Fructose rich diet (FRD) represents an important factor in the development ofmetabolic syndrome. Metabolic syndrome is associated with increased risk forcardiovascular diseases occurrence and chronic inflammation has a major role in itspathogenesis. Females are protected from diet-induced metabolic disturbances andhypertension in their reproductive period. Estrogen, which influences the cardiovascularsystem, could contribute to the observed gender-specific differences in the onset ofmetabolic syndrome. Components of the renin-angiotensin system (RAS), the synthesisof which is mediated by estrogen, have an important role in the inflammatory processes,hypertension and insulin resistance. Almost all of the components of metabolic syndromeincrease the activity of RAS, which finally results in increased oxidative stress andinflammation. The aim of this doctoral dissertation was to investigate sex specific changesand role of estradiol in the expression of RAS components [angiotensin convertingenzyme (ACE), angiotensin converting enzyme 2 (ACE2), angiotensin receptor type 1(AT1R), angiotensin receptor type 2 (AT2R) and collectrin], as well as mediators ofinflammation and remodeling of heart tissue [nuclear faktor κB (NFκB), matrixmetalloproteinse-9 (MMP-9) and CXCL16 chemokine] in the animal model of metabolicsyndrome.Male and female rats, which consumed 10% fructose solution instead of water for9 weeks, represent an animal model of metabolic syndrome that was used in this study. Inorder to examine the effects of estradiol in the context of FRD, female rats wereovariectomized and divided in three groups: fed normal diet, fed FRD, and fed FRD andsubjected to estradiol replacement therapy. FRD increased blood pressure only in malerats. This diet regime didn't cause heart hypertrophy neither in intact males and females,nor in ovariectomized females...
PB  - Универзитет у Београду, Биолошки факултет
T2  - Универзитет у Београду
T1  - Uticaj ishrane bogate fruktozom na ekspresiju komponenti renin-angiotenzin sistema i inflamacije u tkivu srca pacova: polno specifične razlike
T1  - The effect of fructose rich diet on the expression of renin-angiostensin system components and inflamatory molecules in the rat heart: sex specific differences
ER  - 
@phdthesis{
author = "Bundalo, Maja M.",
year = "2016",
url = "http://eteze.bg.ac.rs/application/showtheses?thesesId=3043, https://fedorabg.bg.ac.rs/fedora/get/o:11284/bdef:Content/download, http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1025057202, http://nardus.mpn.gov.rs/123456789/5664, http://vinar.vin.bg.ac.rs/handle/123456789/7279",
abstract = "Ishrana bogata fruktozom predstavlja bitan faktor u razvoju metaboličkogsindroma koji je povezan sa povećanim rizikom za nastanak kardiovaskularnih bolesti.Smatra se da hronična inflamacija ima bitnu ulogu u njegovoj patogenezi. Ženke suzaštićene od ishranom izazvanih metaboličkih poremećaja i hipertenzije ureproduktivnom periodu. Estrogen, koji utiče na normalno funkcionisanjekardiovaskularnog sistema, bi mogao doprinositi uočenim polno specifičnim razlikama unastanku simptoma metaboličkog sindroma. Proteinske komponente renin-angiotenzinsistema (RAS) imaju bitnu ulogu u nastanku inflamacije, hipertenzije i insulinskerezistencije i na njihovu ekspresiju utiče estradiol. Ova doktorska disertacija je za ciljimala da ispita da li pol i estradiol doprinose promenama u ekspresiji komponenti RAS-a[angiotenzin konvertujućeg enzima (ACE), angiotenzin konvertujućeg enzima 2 (ACE2),angiotenzinskog receptora tipa 1 (AT1R), angiotenzinskog receptora tipa 2 (AT2R) ikolektrina] i medijatora inflamacije i remodelovanja tkiva srca [nuklearnog faktora κB(NFκB), matriks metaloproteinaze-9 (MMP-9) i liganda 16 iz familije hemokina CXC(CXCL16)] kod animalnog modela metaboličkog sindroma.Mužjaci i ženke pacova koji su pili 10% rastvor fruktoze umesto vode u trajanjuod 9 nedelja predstavljali su animalni model metaboličkog sindroma korišćen u ovojstudiji. Radi ispitivanja efekata estradiola jedan deo ženki pacova je ovarijektomisan ipodeljen u tri grupe pri čemi je jedna grupa pored standardne laboratorijske hrane pilavodu, druga grupa je pila 10% rastvor fruktoze, a treća grupa je pored rasvora fruktozeprimala i supstitucionu terapiju estradiolom. Ishrana bogata fruktozom je uzrokovalapovećanje krvnog pritiska samo kod mužjaka pacova. Ovaj tip ishrane nije doveo dopromena u masi srca niti u odnosu masa srca/masa tela ni kod jednog pola, kao ni kodovarijektomisanih životinja što ukazuje da se hipertrofija srca nije razvila..., Fructose rich diet (FRD) represents an important factor in the development ofmetabolic syndrome. Metabolic syndrome is associated with increased risk forcardiovascular diseases occurrence and chronic inflammation has a major role in itspathogenesis. Females are protected from diet-induced metabolic disturbances andhypertension in their reproductive period. Estrogen, which influences the cardiovascularsystem, could contribute to the observed gender-specific differences in the onset ofmetabolic syndrome. Components of the renin-angiotensin system (RAS), the synthesisof which is mediated by estrogen, have an important role in the inflammatory processes,hypertension and insulin resistance. Almost all of the components of metabolic syndromeincrease the activity of RAS, which finally results in increased oxidative stress andinflammation. The aim of this doctoral dissertation was to investigate sex specific changesand role of estradiol in the expression of RAS components [angiotensin convertingenzyme (ACE), angiotensin converting enzyme 2 (ACE2), angiotensin receptor type 1(AT1R), angiotensin receptor type 2 (AT2R) and collectrin], as well as mediators ofinflammation and remodeling of heart tissue [nuclear faktor κB (NFκB), matrixmetalloproteinse-9 (MMP-9) and CXCL16 chemokine] in the animal model of metabolicsyndrome.Male and female rats, which consumed 10% fructose solution instead of water for9 weeks, represent an animal model of metabolic syndrome that was used in this study. Inorder to examine the effects of estradiol in the context of FRD, female rats wereovariectomized and divided in three groups: fed normal diet, fed FRD, and fed FRD andsubjected to estradiol replacement therapy. FRD increased blood pressure only in malerats. This diet regime didn't cause heart hypertrophy neither in intact males and females,nor in ovariectomized females...",
publisher = "Универзитет у Београду, Биолошки факултет",
journal = "Универзитет у Београду",
title = "Uticaj ishrane bogate fruktozom na ekspresiju komponenti renin-angiotenzin sistema i inflamacije u tkivu srca pacova: polno specifične razlike, The effect of fructose rich diet on the expression of renin-angiostensin system components and inflamatory molecules in the rat heart: sex specific differences"
}
Bundalo, M. M. (2016). The effect of fructose rich diet on the expression of renin-angiostensin system components and inflamatory molecules in the rat heart: sex specific differences.
Универзитет у Београду
Универзитет у Београду, Биолошки факултет..
Bundalo MM. The effect of fructose rich diet on the expression of renin-angiostensin system components and inflamatory molecules in the rat heart: sex specific differences. Универзитет у Београду. 2016;
Bundalo Maja M., "The effect of fructose rich diet on the expression of renin-angiostensin system components and inflamatory molecules in the rat heart: sex specific differences" Универзитет у Београду (2016)

Fructose-rich diet induces gender-specific changes in expression of the renin-angiotensin system in rat heart and upregulates the ACE/AT1R axis in the male rat aorta

Bundalo, Maja M.; Živković, Maja; Romić, Snježana Đ.; Tepavčević, Snežana; Korićanac, Goran; Đurić, Tamara; Stanković, Aleksandra

(2016)

TY  - JOUR
AU  - Bundalo, Maja M.
AU  - Živković, Maja
AU  - Romić, Snježana Đ.
AU  - Tepavčević, Snežana
AU  - Korićanac, Goran
AU  - Đurić, Tamara
AU  - Stanković, Aleksandra
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1132
AB  - Introduction: The cardiovascular renin-angiotensin system (RAS) could be affected by gender and dietary regime. We hypothesized that male rats will be more susceptible to activation of RAS in the heart and aorta, as a response to a fructose-rich diet (FRD). Materials and methods: Both male and female Wistar rats were given a 10% (w/v) fructose solution for 9 weeks. We measured the biochemical parameters, blood pressure (BP) and heart rate. We used Western blot and real-time polymerase chain reaction (PCR) to quantify protein and gene expression. Results: In the male rats, the FRD elevated BP and expression of cardiac angiotensin-converting enzyme (ACE), while the expression of angiotensin-converting enzyme 2 (ACE2) and angiotensin II Type 2 receptor (AT(2)R) were significantly decreased. In female rats, there were no changes in cardiac RAS expression due to FRD. Furthermore, the ACE/AT(1)R axis was overexpressed in the FRD male rats aortae, while only AT(1)R was upregulated in the FRD female rats aortae. ACE2 expression remained unchanged in the aortae of both genders receiving the FRD. Conclusions: The FRD induced gender-specific changes in the expression of the RAS in the heart and aortae of male rats. Further investigations are required in order to get a comprehensive understanding of the underlying mechanisms of gender-specific fructose-induced cardiovascular pathologies.
T2  - Journal of the Renin-Angiotensin-Aldosterone System
T1  - Fructose-rich diet induces gender-specific changes in expression of the renin-angiotensin system in rat heart and upregulates the ACE/AT1R axis in the male rat aorta
VL  - 17
IS  - 2
DO  - 10.1177/1470320316642915
ER  - 
@article{
author = "Bundalo, Maja M. and Živković, Maja and Romić, Snježana Đ. and Tepavčević, Snežana and Korićanac, Goran and Đurić, Tamara and Stanković, Aleksandra",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1132",
abstract = "Introduction: The cardiovascular renin-angiotensin system (RAS) could be affected by gender and dietary regime. We hypothesized that male rats will be more susceptible to activation of RAS in the heart and aorta, as a response to a fructose-rich diet (FRD). Materials and methods: Both male and female Wistar rats were given a 10% (w/v) fructose solution for 9 weeks. We measured the biochemical parameters, blood pressure (BP) and heart rate. We used Western blot and real-time polymerase chain reaction (PCR) to quantify protein and gene expression. Results: In the male rats, the FRD elevated BP and expression of cardiac angiotensin-converting enzyme (ACE), while the expression of angiotensin-converting enzyme 2 (ACE2) and angiotensin II Type 2 receptor (AT(2)R) were significantly decreased. In female rats, there were no changes in cardiac RAS expression due to FRD. Furthermore, the ACE/AT(1)R axis was overexpressed in the FRD male rats aortae, while only AT(1)R was upregulated in the FRD female rats aortae. ACE2 expression remained unchanged in the aortae of both genders receiving the FRD. Conclusions: The FRD induced gender-specific changes in the expression of the RAS in the heart and aortae of male rats. Further investigations are required in order to get a comprehensive understanding of the underlying mechanisms of gender-specific fructose-induced cardiovascular pathologies.",
journal = "Journal of the Renin-Angiotensin-Aldosterone System",
title = "Fructose-rich diet induces gender-specific changes in expression of the renin-angiotensin system in rat heart and upregulates the ACE/AT1R axis in the male rat aorta",
volume = "17",
number = "2",
doi = "10.1177/1470320316642915"
}
Bundalo, M. M., Živković, M., Romić, S. Đ., Tepavčević, S., Korićanac, G., Đurić, T.,& Stanković, A. (2016). Fructose-rich diet induces gender-specific changes in expression of the renin-angiotensin system in rat heart and upregulates the ACE/AT1R axis in the male rat aorta.
Journal of the Renin-Angiotensin-Aldosterone System, 17(2).
https://doi.org/10.1177/1470320316642915
Bundalo MM, Živković M, Romić SĐ, Tepavčević S, Korićanac G, Đurić T, Stanković A. Fructose-rich diet induces gender-specific changes in expression of the renin-angiotensin system in rat heart and upregulates the ACE/AT1R axis in the male rat aorta. Journal of the Renin-Angiotensin-Aldosterone System. 2016;17(2)
Bundalo Maja M., Živković Maja, Romić Snježana Đ., Tepavčević Snežana, Korićanac Goran, Đurić Tamara, Stanković Aleksandra, "Fructose-rich diet induces gender-specific changes in expression of the renin-angiotensin system in rat heart and upregulates the ACE/AT1R axis in the male rat aorta" Journal of the Renin-Angiotensin-Aldosterone System, 17, no. 2 (2016),
https://doi.org/10.1177/1470320316642915 .
17
14
15

Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques

Stanković, Aleksandra; Kolaković, Ana; Živković, Maja; Đurić, Tamara; Bundalo, Maja M.; Končar, Igor; Davidovic, Lazar; Alavantić, Dragan

(2016)

TY  - JOUR
AU  - Stanković, Aleksandra
AU  - Kolaković, Ana
AU  - Živković, Maja
AU  - Đurić, Tamara
AU  - Bundalo, Maja M.
AU  - Končar, Igor
AU  - Davidovic, Lazar
AU  - Alavantić, Dragan
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1045
AB  - Background and Aims: The principal biologic effects of the renin-angiotensin system are mediated by activation of the AT1R receptor. The microRNA miR-155 regulates AT1R expression, with both its, and AT1Rs activity, linked to atherosclerosis. Target sites for miR-155 lie within the 3 UTR of the human AT1R gene, and include the AT1R A1166C polymorphism. Thus far, only levels of circulating miR-155 have been investigated with respect to A1166C genotypes. We hypothesized that the A1166C polymorphism could correlate with different, ultra-sonographically defined plaque phenotypes, as well as with an altered expression of AT1R mRNA and protein in human carotid plaques (CP), and altered expression of miR-155 in patients with advanced atherosclerosis. Methods: Our study cohort comprised 411 patients with advanced carotid atherosclerosis (298 hyperechoic; 113 hypoechoic plaques). PCR analyses identified A1166C genotypes; quantitative real-time PCR determined AT1R and miR-155 expression levels, with AT1R protein expression evaluated by western blot. Results: Genotypes containing the C allele bore a significant association with the hypoechoic plaque phenotype (adjusted OR 1.87, 95% CI 1.16-3.00, p = 0.01). The expression of AT1R mRNA and miR-155 were significantly up-regulated in the CPs of CC genotype carriers compared to the AA/AC genotypes (p = 0.032, p = 0.015, respectively). AT1R protein expression was also significantly higher for CC genotypes (p LT 0.01). Conclusion: Our results indicate that the AT1R A1166C polymorphism impacts an ultrasonographicallydefined human plaque phenotype, with intra-plaque AT1R and miR-155 expression altered in advanced carotid atherosclerosis. Validation and replication of these data should contribute to an improved personalized therapy with which to prevent carotid atherosclerosis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
T2  - Atherosclerosis
T1  - Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques
VL  - 248
SP  - 132
EP  - 139
DO  - 10.1016/j.atherosclerosis.2016.02.032
ER  - 
@article{
author = "Stanković, Aleksandra and Kolaković, Ana and Živković, Maja and Đurić, Tamara and Bundalo, Maja M. and Končar, Igor and Davidovic, Lazar and Alavantić, Dragan",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1045",
abstract = "Background and Aims: The principal biologic effects of the renin-angiotensin system are mediated by activation of the AT1R receptor. The microRNA miR-155 regulates AT1R expression, with both its, and AT1Rs activity, linked to atherosclerosis. Target sites for miR-155 lie within the 3 UTR of the human AT1R gene, and include the AT1R A1166C polymorphism. Thus far, only levels of circulating miR-155 have been investigated with respect to A1166C genotypes. We hypothesized that the A1166C polymorphism could correlate with different, ultra-sonographically defined plaque phenotypes, as well as with an altered expression of AT1R mRNA and protein in human carotid plaques (CP), and altered expression of miR-155 in patients with advanced atherosclerosis. Methods: Our study cohort comprised 411 patients with advanced carotid atherosclerosis (298 hyperechoic; 113 hypoechoic plaques). PCR analyses identified A1166C genotypes; quantitative real-time PCR determined AT1R and miR-155 expression levels, with AT1R protein expression evaluated by western blot. Results: Genotypes containing the C allele bore a significant association with the hypoechoic plaque phenotype (adjusted OR 1.87, 95% CI 1.16-3.00, p = 0.01). The expression of AT1R mRNA and miR-155 were significantly up-regulated in the CPs of CC genotype carriers compared to the AA/AC genotypes (p = 0.032, p = 0.015, respectively). AT1R protein expression was also significantly higher for CC genotypes (p LT 0.01). Conclusion: Our results indicate that the AT1R A1166C polymorphism impacts an ultrasonographicallydefined human plaque phenotype, with intra-plaque AT1R and miR-155 expression altered in advanced carotid atherosclerosis. Validation and replication of these data should contribute to an improved personalized therapy with which to prevent carotid atherosclerosis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.",
journal = "Atherosclerosis",
title = "Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques",
volume = "248",
pages = "132-139",
doi = "10.1016/j.atherosclerosis.2016.02.032"
}
Stanković, A., Kolaković, A., Živković, M., Đurić, T., Bundalo, M. M., Končar, I., Davidovic, L.,& Alavantić, D. (2016). Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques.
Atherosclerosis, 248, 132-139.
https://doi.org/10.1016/j.atherosclerosis.2016.02.032
Stanković A, Kolaković A, Živković M, Đurić T, Bundalo MM, Končar I, Davidovic L, Alavantić D. Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques. Atherosclerosis. 2016;248:132-139
Stanković Aleksandra, Kolaković Ana, Živković Maja, Đurić Tamara, Bundalo Maja M., Končar Igor, Davidovic Lazar, Alavantić Dragan, "Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques" Atherosclerosis, 248 (2016):132-139,
https://doi.org/10.1016/j.atherosclerosis.2016.02.032 .
1
6
5
4

Estradiol Protects Ovariectomized Female Rats Against Fructose Rich Diet Induced Cardiac Inflammation

Bundalo, Maja M.; Živković, Maja; Korićanac, Goran; Stanković, Aleksandra

(2016)

TY  - CONF
AU  - Bundalo, Maja M.
AU  - Živković, Maja
AU  - Korićanac, Goran
AU  - Stanković, Aleksandra
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7133
C3  - Atherosclerosis
T1  - Estradiol Protects Ovariectomized Female Rats Against Fructose Rich Diet Induced Cardiac Inflammation
VL  - 252
SP  - E207
EP  - E207
DO  - 10.1016/j.atherosclerosis.2016.07.139
ER  - 
@conference{
author = "Bundalo, Maja M. and Živković, Maja and Korićanac, Goran and Stanković, Aleksandra",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7133",
journal = "Atherosclerosis",
title = "Estradiol Protects Ovariectomized Female Rats Against Fructose Rich Diet Induced Cardiac Inflammation",
volume = "252",
pages = "E207-E207",
doi = "10.1016/j.atherosclerosis.2016.07.139"
}
Bundalo, M. M., Živković, M., Korićanac, G.,& Stanković, A. (2016). Estradiol Protects Ovariectomized Female Rats Against Fructose Rich Diet Induced Cardiac Inflammation.
Atherosclerosis, 252, E207-E207.
https://doi.org/10.1016/j.atherosclerosis.2016.07.139
Bundalo MM, Živković M, Korićanac G, Stanković A. Estradiol Protects Ovariectomized Female Rats Against Fructose Rich Diet Induced Cardiac Inflammation. Atherosclerosis. 2016;252:E207-E207
Bundalo Maja M., Živković Maja, Korićanac Goran, Stanković Aleksandra, "Estradiol Protects Ovariectomized Female Rats Against Fructose Rich Diet Induced Cardiac Inflammation" Atherosclerosis, 252 (2016):E207-E207,
https://doi.org/10.1016/j.atherosclerosis.2016.07.139 .

Oestradiol Treatment Counteracts the Effect of Fructose-Rich Diet on Matrix Metalloproteinase 9 Expression and NF kappa B Activation

Bundalo, Maja M.; Živković, Maja; Ćulafić, Tijana; Stojiljković, Mojca D.; Korićanac, Goran; Stanković, Aleksandra

(2015)

TY  - JOUR
AU  - Bundalo, Maja M.
AU  - Živković, Maja
AU  - Ćulafić, Tijana
AU  - Stojiljković, Mojca D.
AU  - Korićanac, Goran
AU  - Stanković, Aleksandra
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1112
AB  - Fructose-rich diet induces metabolic changes similar to those observed in metabolic syndrome. Among other matrix metalloproteinases, MMP-9 has an important role in adverse cardiac remodelling and might have a role in the development of cardiovascular disorders associated with metabolic syndrome. The changes of MMP-9 expression could be mediated via the NF kappa B pathway. In this study we investigated the effect of fructose-rich diet on MMP-9 expression in the heart of male and female rats, along with the effect of fructose-rich diet and oestradiol on MMP-9 expression in ovariectomized females. We further assessed the effect of fructose-rich diet and oestradiol on NF kappa B activation, measured as the level of p65 phosphorylation at Ser 276. The results showed that the diet regime did not affect the heart mass. Higher MMP-9 gene expression was found in cardiac tissue of male rats fed the fructose-rich diet than in females on the same diet regime. In ovariectomized females, fructose-rich diet upregulated MMP-9 protein and mRNA expression in the heart, as well as phosphorylation of the p65 subunit of NF kappa B at Ser 276. Oestradiol replacement therapy reverted these changes in the heart of ovariectomized females. This study has shown that oestradiol could revert the early molecular changes in MMP-9 expression induced by fructose-rich diet that occurred before cardiac hypertrophy development by decreasing phosphorylation of the NF kappa B p65 subunit at Ser 276.
T2  - Folia Biologica
T1  - Oestradiol Treatment Counteracts the Effect of Fructose-Rich Diet on Matrix Metalloproteinase 9 Expression and NF kappa B Activation
VL  - 61
IS  - 6
SP  - 233
EP  - 240
ER  - 
@article{
author = "Bundalo, Maja M. and Živković, Maja and Ćulafić, Tijana and Stojiljković, Mojca D. and Korićanac, Goran and Stanković, Aleksandra",
year = "2015",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1112",
abstract = "Fructose-rich diet induces metabolic changes similar to those observed in metabolic syndrome. Among other matrix metalloproteinases, MMP-9 has an important role in adverse cardiac remodelling and might have a role in the development of cardiovascular disorders associated with metabolic syndrome. The changes of MMP-9 expression could be mediated via the NF kappa B pathway. In this study we investigated the effect of fructose-rich diet on MMP-9 expression in the heart of male and female rats, along with the effect of fructose-rich diet and oestradiol on MMP-9 expression in ovariectomized females. We further assessed the effect of fructose-rich diet and oestradiol on NF kappa B activation, measured as the level of p65 phosphorylation at Ser 276. The results showed that the diet regime did not affect the heart mass. Higher MMP-9 gene expression was found in cardiac tissue of male rats fed the fructose-rich diet than in females on the same diet regime. In ovariectomized females, fructose-rich diet upregulated MMP-9 protein and mRNA expression in the heart, as well as phosphorylation of the p65 subunit of NF kappa B at Ser 276. Oestradiol replacement therapy reverted these changes in the heart of ovariectomized females. This study has shown that oestradiol could revert the early molecular changes in MMP-9 expression induced by fructose-rich diet that occurred before cardiac hypertrophy development by decreasing phosphorylation of the NF kappa B p65 subunit at Ser 276.",
journal = "Folia Biologica",
title = "Oestradiol Treatment Counteracts the Effect of Fructose-Rich Diet on Matrix Metalloproteinase 9 Expression and NF kappa B Activation",
volume = "61",
number = "6",
pages = "233-240"
}
Bundalo, M. M., Živković, M., Ćulafić, T., Stojiljković, M. D., Korićanac, G.,& Stanković, A. (2015). Oestradiol Treatment Counteracts the Effect of Fructose-Rich Diet on Matrix Metalloproteinase 9 Expression and NF kappa B Activation.
Folia Biologica, 61(6), 233-240.
Bundalo MM, Živković M, Ćulafić T, Stojiljković MD, Korićanac G, Stanković A. Oestradiol Treatment Counteracts the Effect of Fructose-Rich Diet on Matrix Metalloproteinase 9 Expression and NF kappa B Activation. Folia Biologica. 2015;61(6):233-240
Bundalo Maja M., Živković Maja, Ćulafić Tijana, Stojiljković Mojca D., Korićanac Goran, Stanković Aleksandra, "Oestradiol Treatment Counteracts the Effect of Fructose-Rich Diet on Matrix Metalloproteinase 9 Expression and NF kappa B Activation" Folia Biologica, 61, no. 6 (2015):233-240
7
6

Fructose-Rich Diet-Induced Changes in the Expression of the Renin Angiotensin System Molecules in the Heart of Ovariectomized Female Rats Could be Reversed by Estradiol

Bundalo, Maja M.; Živković, Maja; Tepavčević, Snežana; Ćulafić, Tijana; Korićanac, Goran; Stanković, Aleksandra

(2015)

TY  - JOUR
AU  - Bundalo, Maja M.
AU  - Živković, Maja
AU  - Tepavčević, Snežana
AU  - Ćulafić, Tijana
AU  - Korićanac, Goran
AU  - Stanković, Aleksandra
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/570
AB  - The renin-angiotensin system has been implicated in the development of metabolic syndrome and appears to be a key in the local tissue control of normal cardiac functions. Physiological concentrations of estrogens have been shown to be cardioprotective, especially against the damaging effects of fructose-rich diet. The aim of the study was to investigate the expression of the renin-angiotensin system molecules with potentially deleterious effect on the heart (angiotensin-converting enzyme and angiotensin II type 1 receptor) and those with potentially protective effects, (angiotensin-converting enzyme 2 and angiotensin II type 2 receptor), in ovariectomized fructose fed female rats with 17-estradiol replacement. Real-time PCR and Western blot analysis were used for quantification of gene and protein expression in the heart. Fructose diet increased the expression of angiotensin-converting enzyme and angiotensin II type 1 receptor and decreased the expression of angiotensin-converting enzyme 2 and angiotensin II type 2 receptor. On the other hand, estradiol replacement seems to undo fructose diet effects on cardiac renin-angiotensin system. Downregulation of angiotensin-converting enzyme and angiotensin II type 1 receptor, and reversion of expression of both potentially protective molecules, angiotensin-converting enzyme 2 and angiotensin II type 2 receptor, to the control level in cardiac tissue took place. Obtained results suggest that estradiol may reverse the harmful effect of fructose-rich diet on the expression of renin-angiotensin system molecules. These findings may also be important in further research of phenotypes like insulin resistance, metabolic syndrome, and following cardiovascular pathology in females.
T2  - Hormone and Metabolic Research
T1  - Fructose-Rich Diet-Induced Changes in the Expression of the Renin Angiotensin System Molecules in the Heart of Ovariectomized Female Rats Could be Reversed by Estradiol
VL  - 47
IS  - 7
SP  - 521
EP  - 527
DO  - 10.1055/s-0034-1394373
ER  - 
@article{
author = "Bundalo, Maja M. and Živković, Maja and Tepavčević, Snežana and Ćulafić, Tijana and Korićanac, Goran and Stanković, Aleksandra",
year = "2015",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/570",
abstract = "The renin-angiotensin system has been implicated in the development of metabolic syndrome and appears to be a key in the local tissue control of normal cardiac functions. Physiological concentrations of estrogens have been shown to be cardioprotective, especially against the damaging effects of fructose-rich diet. The aim of the study was to investigate the expression of the renin-angiotensin system molecules with potentially deleterious effect on the heart (angiotensin-converting enzyme and angiotensin II type 1 receptor) and those with potentially protective effects, (angiotensin-converting enzyme 2 and angiotensin II type 2 receptor), in ovariectomized fructose fed female rats with 17-estradiol replacement. Real-time PCR and Western blot analysis were used for quantification of gene and protein expression in the heart. Fructose diet increased the expression of angiotensin-converting enzyme and angiotensin II type 1 receptor and decreased the expression of angiotensin-converting enzyme 2 and angiotensin II type 2 receptor. On the other hand, estradiol replacement seems to undo fructose diet effects on cardiac renin-angiotensin system. Downregulation of angiotensin-converting enzyme and angiotensin II type 1 receptor, and reversion of expression of both potentially protective molecules, angiotensin-converting enzyme 2 and angiotensin II type 2 receptor, to the control level in cardiac tissue took place. Obtained results suggest that estradiol may reverse the harmful effect of fructose-rich diet on the expression of renin-angiotensin system molecules. These findings may also be important in further research of phenotypes like insulin resistance, metabolic syndrome, and following cardiovascular pathology in females.",
journal = "Hormone and Metabolic Research",
title = "Fructose-Rich Diet-Induced Changes in the Expression of the Renin Angiotensin System Molecules in the Heart of Ovariectomized Female Rats Could be Reversed by Estradiol",
volume = "47",
number = "7",
pages = "521-527",
doi = "10.1055/s-0034-1394373"
}
Bundalo, M. M., Živković, M., Tepavčević, S., Ćulafić, T., Korićanac, G.,& Stanković, A. (2015). Fructose-Rich Diet-Induced Changes in the Expression of the Renin Angiotensin System Molecules in the Heart of Ovariectomized Female Rats Could be Reversed by Estradiol.
Hormone and Metabolic Research, 47(7), 521-527.
https://doi.org/10.1055/s-0034-1394373
Bundalo MM, Živković M, Tepavčević S, Ćulafić T, Korićanac G, Stanković A. Fructose-Rich Diet-Induced Changes in the Expression of the Renin Angiotensin System Molecules in the Heart of Ovariectomized Female Rats Could be Reversed by Estradiol. Hormone and Metabolic Research. 2015;47(7):521-527
Bundalo Maja M., Živković Maja, Tepavčević Snežana, Ćulafić Tijana, Korićanac Goran, Stanković Aleksandra, "Fructose-Rich Diet-Induced Changes in the Expression of the Renin Angiotensin System Molecules in the Heart of Ovariectomized Female Rats Could be Reversed by Estradiol" Hormone and Metabolic Research, 47, no. 7 (2015):521-527,
https://doi.org/10.1055/s-0034-1394373 .
8
8
8

The Ala/Ala Genotype of Ppary Pro12 Ala Polymorphism Is Associated with Late Onset of Multiple Sclerosis

Lukic, N.; Stanković, Aleksandra; Dinčić, Evica; Bundalo, Maja M.; Krsmanovic, Z.; Alavantić, Dragan; Živković, Maja

(2013)

TY  - JOUR
AU  - Lukic, N.
AU  - Stanković, Aleksandra
AU  - Dinčić, Evica
AU  - Bundalo, Maja M.
AU  - Krsmanovic, Z.
AU  - Alavantić, Dragan
AU  - Živković, Maja
PY  - 2013
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/5506
AB  - The function of peroxisome proliferator-activated receptor gamma (PPAR gamma) in immune regulation, as well as in anti-inflammatory and anti-proliferative actions towards T lymphocytes, has been reported. A potential role of PPARs in multiple sclerosis (MS) was suggested. The aim of this study was to investigate if there is an association of PPAR gamma-2 Pro12Ala polymorphism with MS in 361 patients from Serbia. The genotype and allele frequencies of Pro12Ala polymorphism were not significantly different between controls and patients, or between females and males. In contrast to controls, we detected a rare Ala/Ala genotype in patients with MS. We found that there is a significant association of Ala/Ala genotype with older age at onset (ANOVA, p=0.07; LSD post-hoc, Ala/Ala vs. Pro/Ala, p=0.03, Ala/Ala vs. Pro/Pro p=0.02). It would be useful to validate our results in other populations, as well as to perform follow-up of the disease progression in regard to PPAR gamma genotypes.
T2  - Archives of biological sciences
T1  - The Ala/Ala Genotype of Ppary Pro12 Ala Polymorphism Is Associated with Late Onset of Multiple Sclerosis
VL  - 65
IS  - 2
SP  - 447
EP  - 453
DO  - 10.2298/ABS1302447L
ER  - 
@article{
author = "Lukic, N. and Stanković, Aleksandra and Dinčić, Evica and Bundalo, Maja M. and Krsmanovic, Z. and Alavantić, Dragan and Živković, Maja",
year = "2013",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/5506",
abstract = "The function of peroxisome proliferator-activated receptor gamma (PPAR gamma) in immune regulation, as well as in anti-inflammatory and anti-proliferative actions towards T lymphocytes, has been reported. A potential role of PPARs in multiple sclerosis (MS) was suggested. The aim of this study was to investigate if there is an association of PPAR gamma-2 Pro12Ala polymorphism with MS in 361 patients from Serbia. The genotype and allele frequencies of Pro12Ala polymorphism were not significantly different between controls and patients, or between females and males. In contrast to controls, we detected a rare Ala/Ala genotype in patients with MS. We found that there is a significant association of Ala/Ala genotype with older age at onset (ANOVA, p=0.07; LSD post-hoc, Ala/Ala vs. Pro/Ala, p=0.03, Ala/Ala vs. Pro/Pro p=0.02). It would be useful to validate our results in other populations, as well as to perform follow-up of the disease progression in regard to PPAR gamma genotypes.",
journal = "Archives of biological sciences",
title = "The Ala/Ala Genotype of Ppary Pro12 Ala Polymorphism Is Associated with Late Onset of Multiple Sclerosis",
volume = "65",
number = "2",
pages = "447-453",
doi = "10.2298/ABS1302447L"
}
Lukic, N., Stanković, A., Dinčić, E., Bundalo, M. M., Krsmanovic, Z., Alavantić, D.,& Živković, M. (2013). The Ala/Ala Genotype of Ppary Pro12 Ala Polymorphism Is Associated with Late Onset of Multiple Sclerosis.
Archives of biological sciences, 65(2), 447-453.
https://doi.org/10.2298/ABS1302447L
Lukic N, Stanković A, Dinčić E, Bundalo MM, Krsmanovic Z, Alavantić D, Živković M. The Ala/Ala Genotype of Ppary Pro12 Ala Polymorphism Is Associated with Late Onset of Multiple Sclerosis. Archives of biological sciences. 2013;65(2):447-453
Lukic N., Stanković Aleksandra, Dinčić Evica, Bundalo Maja M., Krsmanovic Z., Alavantić Dragan, Živković Maja, "The Ala/Ala Genotype of Ppary Pro12 Ala Polymorphism Is Associated with Late Onset of Multiple Sclerosis" Archives of biological sciences, 65, no. 2 (2013):447-453,
https://doi.org/10.2298/ABS1302447L .
1
1

The Expression of Ace, Ace2, At1 and At2 Receptors in the Heart of Fructose Fed Ovariectomised Rats-Effect of Estradiol

Bundalo, Maja M.; Tepavčević, Snežana; Romić, Snježana Đ.; Korićanac, Goran; Živković, Maja; Stanković, Aleksandra

(2013)

TY  - CONF
AU  - Bundalo, Maja M.
AU  - Tepavčević, Snežana
AU  - Romić, Snježana Đ.
AU  - Korićanac, Goran
AU  - Živković, Maja
AU  - Stanković, Aleksandra
PY  - 2013
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/5741
C3  - Cardiology
T1  - The Expression of Ace, Ace2, At1 and At2 Receptors in the Heart of Fructose Fed Ovariectomised Rats-Effect of Estradiol
VL  - 126
SP  - 353
EP  - 353
ER  - 
@conference{
author = "Bundalo, Maja M. and Tepavčević, Snežana and Romić, Snježana Đ. and Korićanac, Goran and Živković, Maja and Stanković, Aleksandra",
year = "2013",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/5741",
journal = "Cardiology",
title = "The Expression of Ace, Ace2, At1 and At2 Receptors in the Heart of Fructose Fed Ovariectomised Rats-Effect of Estradiol",
volume = "126",
pages = "353-353"
}
Bundalo, M. M., Tepavčević, S., Romić, S. Đ., Korićanac, G., Živković, M.,& Stanković, A. (2013). The Expression of Ace, Ace2, At1 and At2 Receptors in the Heart of Fructose Fed Ovariectomised Rats-Effect of Estradiol.
Cardiology, 126, 353-353.
Bundalo MM, Tepavčević S, Romić SĐ, Korićanac G, Živković M, Stanković A. The Expression of Ace, Ace2, At1 and At2 Receptors in the Heart of Fructose Fed Ovariectomised Rats-Effect of Estradiol. Cardiology. 2013;126:353-353
Bundalo Maja M., Tepavčević Snežana, Romić Snježana Đ., Korićanac Goran, Živković Maja, Stanković Aleksandra, "The Expression of Ace, Ace2, At1 and At2 Receptors in the Heart of Fructose Fed Ovariectomised Rats-Effect of Estradiol" Cardiology, 126 (2013):353-353