TY  - JOUR
AU  - Rajković, Katarina M.
AU  - Đurašević, Mirjana
AU  - Markićević, Milan
AU  - Milanović, Zorana
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
AU  - Mirković, Marija
AU  - Mutić, Jelena
AU  - Obradović, Zorica
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13181
AB  - The aim of this work was to analyze the multi-elemental composition of the extracts of J. nigra husk, with an assessment of the possible influence of their microelements on biochemical, toxicological and radioprotective effects of in rats exposed to radiation from 99mTc-radiopharmaceuticals. The elements in extract were quantified: microelements (Zn>Al>Se>Cu>Sr>Cr>Ni>Mn>Ba>I>V) and toxic-elements (Pb>Hg>Cd>As). The use of extract in rats showed no clinical evidence of toxicity in terms of biochemical parameters. The results showed significant alteration in the organs accumulation of 99mTc-radiopharmaceuticals. The results showed that extract of J. nigra husk may act as a potential radioprotector of organ system.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - Roles of Junglas nigra husk extract microelements as radioprotectors: an in vivo model using 99mTc-radiopharmaceuticals
DO  - 10.1007/s10967-024-09464-z
ER  - 

@article{
author = "Rajković, Katarina M. and Đurašević, Mirjana and Markićević, Milan and Milanović, Zorana and Vranješ-Đurić, Sanja and Janković, Drina and Mirković, Marija and Mutić, Jelena and Obradović, Zorica",
year = "2024",
abstract = "The aim of this work was to analyze the multi-elemental composition of the extracts of J. nigra husk, with an assessment of the possible influence of their microelements on biochemical, toxicological and radioprotective effects of in rats exposed to radiation from 99mTc-radiopharmaceuticals. The elements in extract were quantified: microelements (Zn>Al>Se>Cu>Sr>Cr>Ni>Mn>Ba>I>V) and toxic-elements (Pb>Hg>Cd>As). The use of extract in rats showed no clinical evidence of toxicity in terms of biochemical parameters. The results showed significant alteration in the organs accumulation of 99mTc-radiopharmaceuticals. The results showed that extract of J. nigra husk may act as a potential radioprotector of organ system.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "Roles of Junglas nigra husk extract microelements as radioprotectors: an in vivo model using 99mTc-radiopharmaceuticals",
doi = "10.1007/s10967-024-09464-z"
}

Rajković, K. M., Đurašević, M., Markićević, M., Milanović, Z., Vranješ-Đurić, S., Janković, D., Mirković, M., Mutić, J.,& Obradović, Z.. (2024). Roles of Junglas nigra husk extract microelements as radioprotectors: an in vivo model using 99mTc-radiopharmaceuticals. in Journal of Radioanalytical and Nuclear Chemistry.
https://doi.org/10.1007/s10967-024-09464-z

Rajković KM, Đurašević M, Markićević M, Milanović Z, Vranješ-Đurić S, Janković D, Mirković M, Mutić J, Obradović Z. Roles of Junglas nigra husk extract microelements as radioprotectors: an in vivo model using 99mTc-radiopharmaceuticals. in Journal of Radioanalytical and Nuclear Chemistry. 2024;.
doi:10.1007/s10967-024-09464-z .

Rajković, Katarina M., Đurašević, Mirjana, Markićević, Milan, Milanović, Zorana, Vranješ-Đurić, Sanja, Janković, Drina, Mirković, Marija, Mutić, Jelena, Obradović, Zorica, "Roles of Junglas nigra husk extract microelements as radioprotectors: an in vivo model using 99mTc-radiopharmaceuticals" in Journal of Radioanalytical and Nuclear Chemistry (2024),
https://doi.org/10.1007/s10967-024-09464-z . .

TY  - JOUR
AU  - Rajković, Katarina M.
AU  - Đurašević, Mirjana
AU  - Markićević, Milan
AU  - Milanović, Zorana
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
AU  - Stanković, Dragana
AU  - Obradović, Zorica
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12239
AB  - J. nigra leaf contains mixture of various pharmacologically active compounds and it is assumed that they may have the potential radioprotective effect. The purpose of this work was to predict radioprotective doses by correlating changes in organ distribution of radiopharmaceuticals with extract dose levels and rat body weight using response surface methodology (RSM) based on a second-order polynomial equation. The extract was administered daily by oral gavage to rats at dose of 6.9, 10.3, or 13.7 mg kg−1 body weight (bw) day−1 for 10 days. On the eleventh day, 0.1 ml of the one radiopharmaceutical (Na99mTcO4, 99mTc-dimercaptosuccinic acid and 99mTc-tin colloid) was injected into the tail vein. The statistical parameters: the coefficient of determination (0.81–0.95), the coefficient of variation (3.05–11.1), the adequate precision (8.82–19.12) and the mean relative percentage deviation (± 2.3–8.2) were indicated the precision and reliability of RSM. Using RSM, the predicted daily dose of leaf extract ranging from 11.19 to 11.99 mg kg−1 bw may be considered as an optimal daily radiopotective dose for protection of organs from radiation in cases of planned radiation exposures.
T2  - Journal of Environmental Radioactivity
T1  - Optimization of radioprotective dose of Juglans nigra leaf extract using response surface methodology
VL  - 272
SP  - 107333
DO  - 10.1016/j.jenvrad.2023.107333
ER  - 

@article{
author = "Rajković, Katarina M. and Đurašević, Mirjana and Markićević, Milan and Milanović, Zorana and Vranješ-Đurić, Sanja and Janković, Drina and Stanković, Dragana and Obradović, Zorica",
year = "2024",
abstract = "J. nigra leaf contains mixture of various pharmacologically active compounds and it is assumed that they may have the potential radioprotective effect. The purpose of this work was to predict radioprotective doses by correlating changes in organ distribution of radiopharmaceuticals with extract dose levels and rat body weight using response surface methodology (RSM) based on a second-order polynomial equation. The extract was administered daily by oral gavage to rats at dose of 6.9, 10.3, or 13.7 mg kg−1 body weight (bw) day−1 for 10 days. On the eleventh day, 0.1 ml of the one radiopharmaceutical (Na99mTcO4, 99mTc-dimercaptosuccinic acid and 99mTc-tin colloid) was injected into the tail vein. The statistical parameters: the coefficient of determination (0.81–0.95), the coefficient of variation (3.05–11.1), the adequate precision (8.82–19.12) and the mean relative percentage deviation (± 2.3–8.2) were indicated the precision and reliability of RSM. Using RSM, the predicted daily dose of leaf extract ranging from 11.19 to 11.99 mg kg−1 bw may be considered as an optimal daily radiopotective dose for protection of organs from radiation in cases of planned radiation exposures.",
journal = "Journal of Environmental Radioactivity",
title = "Optimization of radioprotective dose of Juglans nigra leaf extract using response surface methodology",
volume = "272",
pages = "107333",
doi = "10.1016/j.jenvrad.2023.107333"
}

Rajković, K. M., Đurašević, M., Markićević, M., Milanović, Z., Vranješ-Đurić, S., Janković, D., Stanković, D.,& Obradović, Z.. (2024). Optimization of radioprotective dose of Juglans nigra leaf extract using response surface methodology. in Journal of Environmental Radioactivity, 272, 107333.
https://doi.org/10.1016/j.jenvrad.2023.107333

Rajković KM, Đurašević M, Markićević M, Milanović Z, Vranješ-Đurić S, Janković D, Stanković D, Obradović Z. Optimization of radioprotective dose of Juglans nigra leaf extract using response surface methodology. in Journal of Environmental Radioactivity. 2024;272:107333.
doi:10.1016/j.jenvrad.2023.107333 .

Rajković, Katarina M., Đurašević, Mirjana, Markićević, Milan, Milanović, Zorana, Vranješ-Đurić, Sanja, Janković, Drina, Stanković, Dragana, Obradović, Zorica, "Optimization of radioprotective dose of Juglans nigra leaf extract using response surface methodology" in Journal of Environmental Radioactivity, 272 (2024):107333,
https://doi.org/10.1016/j.jenvrad.2023.107333 . .

TY  - CONF
AU  - Rajković, Katarina M.
AU  - Đurašević, Mirjana
AU  - Obradović, Zorica
AU  - Milanović, Zorana
AU  - Vukadinović, Aleksandar
AU  - Perić, Marko
AU  - Stanković, Dragana
AU  - Janković, Drina
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12184
AB  - Tc-99m-radiofarmaceutici se koriste u različitim dijagnostičkim procedurama u nuklearnoj medicini. Da bi se minimizirali štetni efekti jonizujućeg zračenja na zdrava tkiva, intenzivno se istražuju radioprotektivne osobine biljnih ekstrakata. Ljuska ploda crnog oraha sadrži mešavinu različitih farmakološki aktivnih jedinjenja kojа imaju antioksidativno dejstvo i za koje se pretpostavlja da mogu imati i potencijalno radioprotektivno dejstvo. U tom kontekstu, cilj rada je bio da se proceni radioprotektivni efekat ekstrakta ljuske ploda crnog oraha. U ovoj studiji primenjen je eksperimentalni model koji se zasnivao na proceni uticaja ekstrakta na biodistribuciju Tc-99m-radiofarmaceutika po organima eksperimentalnih životinja (pacovi). Ekstrakt ljuske crnog oraha doveo je do smanjenognakupljanja Tc-99m-radiofarmaceutika u pojedinim organimapacova. Rezultati dobijeni na osnovu eksperimentalnog modela sugerišu moguću upotrebu ekstrakta ljuske ploda crnog oraha kao radioprotektivnog sredstva u slučajevima planiranog izlaganja jonizujućem zračenju u nuklearnoj medicini.
AB  - Tc-99m-radiopharmaceuticals are used in various diagnostic procedures in nuclear medicine. In order to minimize the harmful effects of ionizing radiation on healthy tissues, the radioprotective properties of plant extracts are intensively researched. J. nigra husk contains a mixture of various pharmacologically active compounds that have an antioxidant effect and which are assumed to have a potential radioprotective effect. In this context, the aim of the work was to evaluate the radioprotective effect of black walnut husk extract. In this study, an experimental model was applied, which was based on the assessment of the effect of the extract on the biodistribution of Tc-99m-radiopharmaceuticals in the organs of experimental animals (rats). Black walnut husk extract led to a decrease in the accumulation of Tc-99m-radiopharmaceutical in certain organs of rats. The results obtained on the basis of the experimental model suggest that it is possible to use black walnut husk extract as a radioprotective agent in cases of planned exposure to ionizing radiation in diagnosticsnuclear medicine.
PB  - Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"
PB  - Društvo za zaštitu od zračenja Srbije i Crne Gore
C3  - 32. simpozijum DZZSCG : zbornik radova
T1  - Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta
T1  - Experimental Model for Assessing the Possible Radioprotective Effect of Plant Extract
SP  - 321
EP  - 327
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12184
ER  - 

@conference{
author = "Rajković, Katarina M. and Đurašević, Mirjana and Obradović, Zorica and Milanović, Zorana and Vukadinović, Aleksandar and Perić, Marko and Stanković, Dragana and Janković, Drina",
year = "2023",
abstract = "Tc-99m-radiofarmaceutici se koriste u različitim dijagnostičkim procedurama u nuklearnoj medicini. Da bi se minimizirali štetni efekti jonizujućeg zračenja na zdrava tkiva, intenzivno se istražuju radioprotektivne osobine biljnih ekstrakata. Ljuska ploda crnog oraha sadrži mešavinu različitih farmakološki aktivnih jedinjenja kojа imaju antioksidativno dejstvo i za koje se pretpostavlja da mogu imati i potencijalno radioprotektivno dejstvo. U tom kontekstu, cilj rada je bio da se proceni radioprotektivni efekat ekstrakta ljuske ploda crnog oraha. U ovoj studiji primenjen je eksperimentalni model koji se zasnivao na proceni uticaja ekstrakta na biodistribuciju Tc-99m-radiofarmaceutika po organima eksperimentalnih životinja (pacovi). Ekstrakt ljuske crnog oraha doveo je do smanjenognakupljanja Tc-99m-radiofarmaceutika u pojedinim organimapacova. Rezultati dobijeni na osnovu eksperimentalnog modela sugerišu moguću upotrebu ekstrakta ljuske ploda crnog oraha kao radioprotektivnog sredstva u slučajevima planiranog izlaganja jonizujućem zračenju u nuklearnoj medicini., Tc-99m-radiopharmaceuticals are used in various diagnostic procedures in nuclear medicine. In order to minimize the harmful effects of ionizing radiation on healthy tissues, the radioprotective properties of plant extracts are intensively researched. J. nigra husk contains a mixture of various pharmacologically active compounds that have an antioxidant effect and which are assumed to have a potential radioprotective effect. In this context, the aim of the work was to evaluate the radioprotective effect of black walnut husk extract. In this study, an experimental model was applied, which was based on the assessment of the effect of the extract on the biodistribution of Tc-99m-radiopharmaceuticals in the organs of experimental animals (rats). Black walnut husk extract led to a decrease in the accumulation of Tc-99m-radiopharmaceutical in certain organs of rats. The results obtained on the basis of the experimental model suggest that it is possible to use black walnut husk extract as a radioprotective agent in cases of planned exposure to ionizing radiation in diagnosticsnuclear medicine.",
publisher = "Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča", Društvo za zaštitu od zračenja Srbije i Crne Gore",
journal = "32. simpozijum DZZSCG : zbornik radova",
title = "Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta, Experimental Model for Assessing the Possible Radioprotective Effect of Plant Extract",
pages = "321-327",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12184"
}

Rajković, K. M., Đurašević, M., Obradović, Z., Milanović, Z., Vukadinović, A., Perić, M., Stanković, D.,& Janković, D.. (2023). Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta. in 32. simpozijum DZZSCG : zbornik radova
Beograd : Univerzitet u Beogradu, Institut za nuklearne nauke "Vinča"., 321-327.
https://hdl.handle.net/21.15107/rcub_vinar_12184

Rajković KM, Đurašević M, Obradović Z, Milanović Z, Vukadinović A, Perić M, Stanković D, Janković D. Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta. in 32. simpozijum DZZSCG : zbornik radova. 2023;:321-327.
https://hdl.handle.net/21.15107/rcub_vinar_12184 .

Rajković, Katarina M., Đurašević, Mirjana, Obradović, Zorica, Milanović, Zorana, Vukadinović, Aleksandar, Perić, Marko, Stanković, Dragana, Janković, Drina, "Eksperimentalni model za procenu mogućeg radioprotektivnog efekta biljnog ekstrakta" in 32. simpozijum DZZSCG : zbornik radova (2023):321-327,
https://hdl.handle.net/21.15107/rcub_vinar_12184 .