TY  - JOUR
AU  - Keta, Otilija D.
AU  - Todorović, Danijela V.
AU  - Bulat, Tanja M.
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Romano, Francesco
AU  - Cuttone, Giacomo
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1573
AB  - The aim of this study was to investigate effects of irradiations with the therapeutic proton and carbon ion beams in two non-small cell lung cancers, CRL5876 adenocarcinoma and HTB177 large cell lung carcinoma. The DNA damage response dynamics, cell cycle regulation, and cell death pathway activation were followed. Viability of both cell lines was lower after carbon ions compared to the therapeutic proton irradiations. HTB177 cells showed higher recovery than CRL5876 cells seven days following the treatments, but the survival rates of both cell lines were lower after exposure to carbon ions with respect to therapeutic protons. When analyzing cell cycle distribution of both CRL5876 and HTB177 cells, it was noticed that therapeutic protons predominantly induced G1 arrest, while the cells after carbon ions were arrested in G2/M phase. The results illustrated that differences in the levels of phosphorylated H2AX, a double-strand break marker, exist after therapeutic proton and carbon ion irradiations. We also observed dose- and time-dependent increase in the p53 and p21 levels after applied irradiations. Carbon ions caused larger increase in the quantity of p53 and p21 compared to therapeutic protons. These results suggested that various repair mechanisms were induced in the treated cells. Considering the fact that we have not observed any distinct change in the Bax/Bcl-2 ratio following irradiations, it seemed that different types of cell death were involved in the response to the two types of irradiations that were applied.
T2  - Experimental Biology and Medicine
T1  - Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions
VL  - 242
IS  - 10
SP  - 1015
EP  - 1024
DO  - 10.1177/1535370216669611
ER  - 

@article{
author = "Keta, Otilija D. and Todorović, Danijela V. and Bulat, Tanja M. and Cirrone, Giuseppe Antonio Pablo and Romano, Francesco and Cuttone, Giacomo and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2017",
abstract = "The aim of this study was to investigate effects of irradiations with the therapeutic proton and carbon ion beams in two non-small cell lung cancers, CRL5876 adenocarcinoma and HTB177 large cell lung carcinoma. The DNA damage response dynamics, cell cycle regulation, and cell death pathway activation were followed. Viability of both cell lines was lower after carbon ions compared to the therapeutic proton irradiations. HTB177 cells showed higher recovery than CRL5876 cells seven days following the treatments, but the survival rates of both cell lines were lower after exposure to carbon ions with respect to therapeutic protons. When analyzing cell cycle distribution of both CRL5876 and HTB177 cells, it was noticed that therapeutic protons predominantly induced G1 arrest, while the cells after carbon ions were arrested in G2/M phase. The results illustrated that differences in the levels of phosphorylated H2AX, a double-strand break marker, exist after therapeutic proton and carbon ion irradiations. We also observed dose- and time-dependent increase in the p53 and p21 levels after applied irradiations. Carbon ions caused larger increase in the quantity of p53 and p21 compared to therapeutic protons. These results suggested that various repair mechanisms were induced in the treated cells. Considering the fact that we have not observed any distinct change in the Bax/Bcl-2 ratio following irradiations, it seemed that different types of cell death were involved in the response to the two types of irradiations that were applied.",
journal = "Experimental Biology and Medicine",
title = "Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions",
volume = "242",
number = "10",
pages = "1015-1024",
doi = "10.1177/1535370216669611"
}

Keta, O. D., Todorović, D. V., Bulat, T. M., Cirrone, G. A. P., Romano, F., Cuttone, G., Petrović, I. M.,& Ristić-Fira, A.. (2017). Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions. in Experimental Biology and Medicine, 242(10), 1015-1024.
https://doi.org/10.1177/1535370216669611

Keta OD, Todorović DV, Bulat TM, Cirrone GAP, Romano F, Cuttone G, Petrović IM, Ristić-Fira A. Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions. in Experimental Biology and Medicine. 2017;242(10):1015-1024.
doi:10.1177/1535370216669611 .

Keta, Otilija D., Todorović, Danijela V., Bulat, Tanja M., Cirrone, Giuseppe Antonio Pablo, Romano, Francesco, Cuttone, Giacomo, Petrović, Ivan M., Ristić-Fira, Aleksandra, "Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions" in Experimental Biology and Medicine, 242, no. 10 (2017):1015-1024,
https://doi.org/10.1177/1535370216669611 . .

TY  - JOUR
AU  - Žakula, Jelena
AU  - Korićanac, Lela
AU  - Keta, Otilija D.
AU  - Todorović, Danijela V.
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Romano, Francesco
AU  - Cuttone, Giacomo
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1290
AB  - Background and objectives: The main goal when treating malignancies with radiation is to deprive tumour cells of their reproductive potential. One approach is to induce tumour cell apoptosis. This study was conducted to evaluate the ability of carbon ions (C-12) to induce apoptosis and cell cycle arrest in human HTB140 melanoma cells. Methods: In this in vitro study, human melanoma HTB140 cells were irradiated with the 62 MeV/n carbon (C-12) ion beam, having two different linear energy transfer (LET) values: 197 and 382 keV/mu m. The dose range was 2 to 16 Gy. Cell viability was estimated by the sulforhodamine B assay seven days after irradiation. The cell cycle and apoptosis were evaluated 48 h after irradiation using flow cytometry. At the same time point, protein and gene expression of apoptotic regulators were estimated using the Western blot and q-PCR methods, respectively. Results: Cell viability experiments indicated strong anti-tumour effects of C-12 ions. The analysis of cell cycle showed that C-12 ions blocked HTB140 cells in G2 phase and induced the dose dependent increase of apoptosis. The maximum value of 21.8 per cent was attained after irradiation with LET of 197 keV/mu m at the dose level of 16 Gy. Pro-apoptotic effects of C-12 ions were confirmed by changes of key apoptotic molecules: the p53, Bax, Bcl-2, poly ADP ribose polymerase (PARP) as well as nuclear factor kappa B (NF kappa B). At the level of protein expression, the results indicated significant increases of p53, NF kappa B and Bax/Bcl-2 ratio and PARP cleavage. The Bax/Bcl-2 mRNA ratio was also increased, while no change was detected in the level of NF kappa B mRNA. Interpretation and conclusions: The present results indicated that anti-tumour effects of C-12 ions in human melanoma HTB140 cells were accomplished through induction of the mitochondrial apoptotic pathway as well as G2 arrest.
T2  - Indian Journal of Medical Research
T1  - Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells
VL  - 143
SP  - 120
EP  - 128
DO  - 10.4103/0971-5916.191811
ER  - 

@article{
author = "Žakula, Jelena and Korićanac, Lela and Keta, Otilija D. and Todorović, Danijela V. and Cirrone, Giuseppe Antonio Pablo and Romano, Francesco and Cuttone, Giacomo and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2016",
abstract = "Background and objectives: The main goal when treating malignancies with radiation is to deprive tumour cells of their reproductive potential. One approach is to induce tumour cell apoptosis. This study was conducted to evaluate the ability of carbon ions (C-12) to induce apoptosis and cell cycle arrest in human HTB140 melanoma cells. Methods: In this in vitro study, human melanoma HTB140 cells were irradiated with the 62 MeV/n carbon (C-12) ion beam, having two different linear energy transfer (LET) values: 197 and 382 keV/mu m. The dose range was 2 to 16 Gy. Cell viability was estimated by the sulforhodamine B assay seven days after irradiation. The cell cycle and apoptosis were evaluated 48 h after irradiation using flow cytometry. At the same time point, protein and gene expression of apoptotic regulators were estimated using the Western blot and q-PCR methods, respectively. Results: Cell viability experiments indicated strong anti-tumour effects of C-12 ions. The analysis of cell cycle showed that C-12 ions blocked HTB140 cells in G2 phase and induced the dose dependent increase of apoptosis. The maximum value of 21.8 per cent was attained after irradiation with LET of 197 keV/mu m at the dose level of 16 Gy. Pro-apoptotic effects of C-12 ions were confirmed by changes of key apoptotic molecules: the p53, Bax, Bcl-2, poly ADP ribose polymerase (PARP) as well as nuclear factor kappa B (NF kappa B). At the level of protein expression, the results indicated significant increases of p53, NF kappa B and Bax/Bcl-2 ratio and PARP cleavage. The Bax/Bcl-2 mRNA ratio was also increased, while no change was detected in the level of NF kappa B mRNA. Interpretation and conclusions: The present results indicated that anti-tumour effects of C-12 ions in human melanoma HTB140 cells were accomplished through induction of the mitochondrial apoptotic pathway as well as G2 arrest.",
journal = "Indian Journal of Medical Research",
title = "Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells",
volume = "143",
pages = "120-128",
doi = "10.4103/0971-5916.191811"
}

Žakula, J., Korićanac, L., Keta, O. D., Todorović, D. V., Cirrone, G. A. P., Romano, F., Cuttone, G., Petrović, I. M.,& Ristić-Fira, A.. (2016). Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells. in Indian Journal of Medical Research, 143, 120-128.
https://doi.org/10.4103/0971-5916.191811

Žakula J, Korićanac L, Keta OD, Todorović DV, Cirrone GAP, Romano F, Cuttone G, Petrović IM, Ristić-Fira A. Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells. in Indian Journal of Medical Research. 2016;143:120-128.
doi:10.4103/0971-5916.191811 .

Žakula, Jelena, Korićanac, Lela, Keta, Otilija D., Todorović, Danijela V., Cirrone, Giuseppe Antonio Pablo, Romano, Francesco, Cuttone, Giacomo, Petrović, Ivan M., Ristić-Fira, Aleksandra, "Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells" in Indian Journal of Medical Research, 143 (2016):120-128,
https://doi.org/10.4103/0971-5916.191811 . .

TY  - JOUR
AU  - Allison, John
AU  - Amako, Katsuya
AU  - Apostolakis, John
AU  - Arce, Pedro
AU  - Asai, Makoto
AU  - Aso, Tsukasa
AU  - Bagli, Enrico
AU  - Bagulya, Alexander V.
AU  - Banerjee, S
AU  - Barrand, Guy C.
AU  - Beck, Bret R.
AU  - Bogdanov, Aleksei G.
AU  - Brandt, Daniel
AU  - Brown, Jeremy Michael Cooney
AU  - Burkhardt, Helmut
AU  - Canal, Philippe
AU  - Cano-Ott, Daniel
AU  - Chauvie, S
AU  - Cho, Kihyeon
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cooperman, Gene D.
AU  - Cortés-Giraldo, Miguel Antonio
AU  - Cosmo, Gabriele
AU  - Cuttone, Giacomo
AU  - Depaola, Gerardo O.
AU  - Desorgher, Laurent
AU  - Dong, Xin
AU  - Dotti, Andrea
AU  - Elvira, Daniel V.
AU  - Folger, Gunter
AU  - Francis, Ziad
AU  - Galoyan, Aida S.
AU  - Garnier, Laurent
AU  - Gayer, Marek
AU  - Genser, K.L.
AU  - Grichine, V.M.
AU  - Guatelli, S
AU  - Gueye, Paul L.J.
AU  - Gumplinger, Peter
AU  - Howard, Alexander S.
AU  - Hrivnacova, Ivana
AU  - Hwang, Soonwook
AU  - Incerti, Sebastien
AU  - Ivanchenko, A.
AU  - Ivanchenko, Vladimir
AU  - Jones, F.W.
AU  - Jun, S.Y.
AU  - Kaitaniemi, Pekka
AU  - Karakatsanis, Nicolas
AU  - Karamitros, M
AU  - Kelsey, M
AU  - Kimura, Akinori
AU  - Koi, Tatsumi
AU  - Kurashige, Hisaya
AU  - Lechner, Anton
AU  - Lee, Sebyeong
AU  - Longo, F
AU  - Maire, M
AU  - Mancusi, Davide
AU  - Mantero, Alfonso
AU  - Mendoza, Emilio
AU  - Morgan, Ben
AU  - Murakami, Kouichi
AU  - Nikitina, Tatiana
AU  - Pandola, Luciano
AU  - Paprocki, P
AU  - Perl, Joseph M.
AU  - Petrović, Ivan M.
AU  - Pia, Maria Grazia
AU  - Pokorski, Witold
AU  - Quesada Molina, Jose Manuel
AU  - Raine, Melanie
AU  - Reis, M.A.
AU  - Ribon, A
AU  - Ristić-Fira, Aleksandra
AU  - Romano, Francesco
AU  - Russo, Giorgio
AU  - Santin, G
AU  - Sasaki, Takashi
AU  - Sawkey, Daren L.
AU  - Shin, Jae-ik
AU  - Strakovsky, Igor I.
AU  - Taborda, Ana
AU  - Tanaka, Satoshi
AU  - Tomé, B
AU  - Toshito, T
AU  - Tran, H.N.
AU  - Truscott, Peter R.
AU  - Urban, Laszlo
AU  - Uzhinsky, Vladimir V.
AU  - Verbeke, Jerome M.
AU  - Verderi, Marc
AU  - Wendt, Brycen L.
AU  - Wenzel, Hans Joachim
AU  - Wright, Dennis Herbert
AU  - Wright, Douglas M.
AU  - Yamashita, Tomohiro
AU  - Yarba, Julia V.
AU  - Yoshida, Hajime
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8645
AB  - Geant4 is a software toolkit for the simulation of the passage of particles through matter. It is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection. Over the past several years, major changes have been made to the toolkit in order to accommodate the needs of these user communities, and to efficiently exploit the growth of computing power made available by advances in technology. The adaptation of Geant4 to multithreading, advances in physics, detector modeling and visualization, extensions to the toolkit, including biasing and reverse Monte Carlo, and tools for physics and release validation are discussed here.
T2  - Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
T1  - Recent developments in Geant4
VL  - 835
SP  - 186
EP  - 225
DO  - 10.1016/j.nima.2016.06.125
ER  - 

@article{
author = "Allison, John and Amako, Katsuya and Apostolakis, John and Arce, Pedro and Asai, Makoto and Aso, Tsukasa and Bagli, Enrico and Bagulya, Alexander V. and Banerjee, S and Barrand, Guy C. and Beck, Bret R. and Bogdanov, Aleksei G. and Brandt, Daniel and Brown, Jeremy Michael Cooney and Burkhardt, Helmut and Canal, Philippe and Cano-Ott, Daniel and Chauvie, S and Cho, Kihyeon and Cirrone, Giuseppe Antonio Pablo and Cooperman, Gene D. and Cortés-Giraldo, Miguel Antonio and Cosmo, Gabriele and Cuttone, Giacomo and Depaola, Gerardo O. and Desorgher, Laurent and Dong, Xin and Dotti, Andrea and Elvira, Daniel V. and Folger, Gunter and Francis, Ziad and Galoyan, Aida S. and Garnier, Laurent and Gayer, Marek and Genser, K.L. and Grichine, V.M. and Guatelli, S and Gueye, Paul L.J. and Gumplinger, Peter and Howard, Alexander S. and Hrivnacova, Ivana and Hwang, Soonwook and Incerti, Sebastien and Ivanchenko, A. and Ivanchenko, Vladimir and Jones, F.W. and Jun, S.Y. and Kaitaniemi, Pekka and Karakatsanis, Nicolas and Karamitros, M and Kelsey, M and Kimura, Akinori and Koi, Tatsumi and Kurashige, Hisaya and Lechner, Anton and Lee, Sebyeong and Longo, F and Maire, M and Mancusi, Davide and Mantero, Alfonso and Mendoza, Emilio and Morgan, Ben and Murakami, Kouichi and Nikitina, Tatiana and Pandola, Luciano and Paprocki, P and Perl, Joseph M. and Petrović, Ivan M. and Pia, Maria Grazia and Pokorski, Witold and Quesada Molina, Jose Manuel and Raine, Melanie and Reis, M.A. and Ribon, A and Ristić-Fira, Aleksandra and Romano, Francesco and Russo, Giorgio and Santin, G and Sasaki, Takashi and Sawkey, Daren L. and Shin, Jae-ik and Strakovsky, Igor I. and Taborda, Ana and Tanaka, Satoshi and Tomé, B and Toshito, T and Tran, H.N. and Truscott, Peter R. and Urban, Laszlo and Uzhinsky, Vladimir V. and Verbeke, Jerome M. and Verderi, Marc and Wendt, Brycen L. and Wenzel, Hans Joachim and Wright, Dennis Herbert and Wright, Douglas M. and Yamashita, Tomohiro and Yarba, Julia V. and Yoshida, Hajime",
year = "2016",
abstract = "Geant4 is a software toolkit for the simulation of the passage of particles through matter. It is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection. Over the past several years, major changes have been made to the toolkit in order to accommodate the needs of these user communities, and to efficiently exploit the growth of computing power made available by advances in technology. The adaptation of Geant4 to multithreading, advances in physics, detector modeling and visualization, extensions to the toolkit, including biasing and reverse Monte Carlo, and tools for physics and release validation are discussed here.",
journal = "Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment",
title = "Recent developments in Geant4",
volume = "835",
pages = "186-225",
doi = "10.1016/j.nima.2016.06.125"
}

Allison, J., Amako, K., Apostolakis, J., Arce, P., Asai, M., Aso, T., Bagli, E., Bagulya, A. V., Banerjee, S., Barrand, G. C., Beck, B. R., Bogdanov, A. G., Brandt, D., Brown, J. M. C., Burkhardt, H., Canal, P., Cano-Ott, D., Chauvie, S., Cho, K., Cirrone, G. A. P., Cooperman, G. D., Cortés-Giraldo, M. A., Cosmo, G., Cuttone, G., Depaola, G. O., Desorgher, L., Dong, X., Dotti, A., Elvira, D. V., Folger, G., Francis, Z., Galoyan, A. S., Garnier, L., Gayer, M., Genser, K.L., Grichine, V.M., Guatelli, S., Gueye, P. L.J., Gumplinger, P., Howard, A. S., Hrivnacova, I., Hwang, S., Incerti, S., Ivanchenko, A., Ivanchenko, V., Jones, F.W., Jun, S.Y., Kaitaniemi, P., Karakatsanis, N., Karamitros, M., Kelsey, M., Kimura, A., Koi, T., Kurashige, H., Lechner, A., Lee, S., Longo, F., Maire, M., Mancusi, D., Mantero, A., Mendoza, E., Morgan, B., Murakami, K., Nikitina, T., Pandola, L., Paprocki, P., Perl, J. M., Petrović, I. M., Pia, M. G., Pokorski, W., Quesada Molina, J. M., Raine, M., Reis, M.A., Ribon, A., Ristić-Fira, A., Romano, F., Russo, G., Santin, G., Sasaki, T., Sawkey, D. L., Shin, J., Strakovsky, I. I., Taborda, A., Tanaka, S., Tomé, B., Toshito, T., Tran, H.N., Truscott, P. R., Urban, L., Uzhinsky, V. V., Verbeke, J. M., Verderi, M., Wendt, B. L., Wenzel, H. J., Wright, D. H., Wright, D. M., Yamashita, T., Yarba, J. V.,& Yoshida, H.. (2016). Recent developments in Geant4. in Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 835, 186-225.
https://doi.org/10.1016/j.nima.2016.06.125

Allison J, Amako K, Apostolakis J, Arce P, Asai M, Aso T, Bagli E, Bagulya AV, Banerjee S, Barrand GC, Beck BR, Bogdanov AG, Brandt D, Brown JMC, Burkhardt H, Canal P, Cano-Ott D, Chauvie S, Cho K, Cirrone GAP, Cooperman GD, Cortés-Giraldo MA, Cosmo G, Cuttone G, Depaola GO, Desorgher L, Dong X, Dotti A, Elvira DV, Folger G, Francis Z, Galoyan AS, Garnier L, Gayer M, Genser K, Grichine V, Guatelli S, Gueye PL, Gumplinger P, Howard AS, Hrivnacova I, Hwang S, Incerti S, Ivanchenko A, Ivanchenko V, Jones F, Jun S, Kaitaniemi P, Karakatsanis N, Karamitros M, Kelsey M, Kimura A, Koi T, Kurashige H, Lechner A, Lee S, Longo F, Maire M, Mancusi D, Mantero A, Mendoza E, Morgan B, Murakami K, Nikitina T, Pandola L, Paprocki P, Perl JM, Petrović IM, Pia MG, Pokorski W, Quesada Molina JM, Raine M, Reis M, Ribon A, Ristić-Fira A, Romano F, Russo G, Santin G, Sasaki T, Sawkey DL, Shin J, Strakovsky II, Taborda A, Tanaka S, Tomé B, Toshito T, Tran H, Truscott PR, Urban L, Uzhinsky VV, Verbeke JM, Verderi M, Wendt BL, Wenzel HJ, Wright DH, Wright DM, Yamashita T, Yarba JV, Yoshida H. Recent developments in Geant4. in Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2016;835:186-225.
doi:10.1016/j.nima.2016.06.125 .

Allison, John, Amako, Katsuya, Apostolakis, John, Arce, Pedro, Asai, Makoto, Aso, Tsukasa, Bagli, Enrico, Bagulya, Alexander V., Banerjee, S, Barrand, Guy C., Beck, Bret R., Bogdanov, Aleksei G., Brandt, Daniel, Brown, Jeremy Michael Cooney, Burkhardt, Helmut, Canal, Philippe, Cano-Ott, Daniel, Chauvie, S, Cho, Kihyeon, Cirrone, Giuseppe Antonio Pablo, Cooperman, Gene D., Cortés-Giraldo, Miguel Antonio, Cosmo, Gabriele, Cuttone, Giacomo, Depaola, Gerardo O., Desorgher, Laurent, Dong, Xin, Dotti, Andrea, Elvira, Daniel V., Folger, Gunter, Francis, Ziad, Galoyan, Aida S., Garnier, Laurent, Gayer, Marek, Genser, K.L., Grichine, V.M., Guatelli, S, Gueye, Paul L.J., Gumplinger, Peter, Howard, Alexander S., Hrivnacova, Ivana, Hwang, Soonwook, Incerti, Sebastien, Ivanchenko, A., Ivanchenko, Vladimir, Jones, F.W., Jun, S.Y., Kaitaniemi, Pekka, Karakatsanis, Nicolas, Karamitros, M, Kelsey, M, Kimura, Akinori, Koi, Tatsumi, Kurashige, Hisaya, Lechner, Anton, Lee, Sebyeong, Longo, F, Maire, M, Mancusi, Davide, Mantero, Alfonso, Mendoza, Emilio, Morgan, Ben, Murakami, Kouichi, Nikitina, Tatiana, Pandola, Luciano, Paprocki, P, Perl, Joseph M., Petrović, Ivan M., Pia, Maria Grazia, Pokorski, Witold, Quesada Molina, Jose Manuel, Raine, Melanie, Reis, M.A., Ribon, A, Ristić-Fira, Aleksandra, Romano, Francesco, Russo, Giorgio, Santin, G, Sasaki, Takashi, Sawkey, Daren L., Shin, Jae-ik, Strakovsky, Igor I., Taborda, Ana, Tanaka, Satoshi, Tomé, B, Toshito, T, Tran, H.N., Truscott, Peter R., Urban, Laszlo, Uzhinsky, Vladimir V., Verbeke, Jerome M., Verderi, Marc, Wendt, Brycen L., Wenzel, Hans Joachim, Wright, Dennis Herbert, Wright, Douglas M., Yamashita, Tomohiro, Yarba, Julia V., Yoshida, Hajime, "Recent developments in Geant4" in Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 835 (2016):186-225,
https://doi.org/10.1016/j.nima.2016.06.125 . .

TY  - CONF
AU  - Schillaci, F.
AU  - Anzalone, A.
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Carpinelli, M.
AU  - Cuttone, Giacomo
AU  - Cutroneo, M.
AU  - De Martinis, C.
AU  - Giove, D.
AU  - Korn, G.
AU  - Maggiore, M.
AU  - Manti, L.
AU  - Margarone, D.
AU  - Musumarra, A.
AU  - Perozziello, F. M.
AU  - Petrović, Ivan M.
AU  - Pisciotta, P.
AU  - Renis, M.
AU  - Ristić-Fira, Aleksandra
AU  - Romano, Francesco
AU  - Romano, Francesco
AU  - Schettino, G.
AU  - Scuderi, V.
AU  - Torrisi, L.
AU  - Tramontana, A.
AU  - Tudisco, S.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7029
AB  - ELI-Beamlines is one of the pillars of the pan-European project ELI (Extreme Light Infrastructure). It will be an ultra high-intensity, high repetition-rate, femtosecond laser facility whose main goal is generation and applications of high-brightness X-ray sources and accelerated charged particles in different fields. Particular care will be devoted to the potential applicability of laser-driven ion beams for medical treatments of tumors. Indeed, such kind of beams show very interesting peculiarities and, moreover, laser-driven based accelerators can really represent a competitive alternative to conventional machines since they are expected to be more compact in size and less expensive. The ELIMED project was launched thanks to a collaboration established between FZU-ASCR (ELI-Beamlines) and INFN-LNS researchers. Several European institutes have already shown a great interest in the project aiming to explore the possibility to use laser-driven ion (mostly proton) beams for several applications with a particular regard for medical ones. To reach the project goal several tasks need to be fulfilled, starting from the optimization of laser-target interaction to dosimetric studies at the irradiation point at the end of a proper designed transport beam-line. Researchers from LNS have already developed and successfully tested a high-dispersive power Thomson Parabola Spectrometer, which is the first prototype of a more performing device to be used within the ELIMED project. Also a Magnetic Selection System able to produce a small pencil beam out of a wide energy distribution of ions produced in laser-target interaction has been realized and some preliminary work for its testing and characterization is in progress. In this contribution the status of the project will be reported together with a short description of the of the features of device recently developed.
C3  - Journal of Physics: Conference Series
T1  - ELIMED, MEDical and multidisciplinary applications at ELI-Beamlines
VL  - 508
DO  - 10.1088/1742-6596/508/1/012010
ER  - 

@conference{
author = "Schillaci, F. and Anzalone, A. and Cirrone, Giuseppe Antonio Pablo and Carpinelli, M. and Cuttone, Giacomo and Cutroneo, M. and De Martinis, C. and Giove, D. and Korn, G. and Maggiore, M. and Manti, L. and Margarone, D. and Musumarra, A. and Perozziello, F. M. and Petrović, Ivan M. and Pisciotta, P. and Renis, M. and Ristić-Fira, Aleksandra and Romano, Francesco and Romano, Francesco and Schettino, G. and Scuderi, V. and Torrisi, L. and Tramontana, A. and Tudisco, S.",
year = "2014",
abstract = "ELI-Beamlines is one of the pillars of the pan-European project ELI (Extreme Light Infrastructure). It will be an ultra high-intensity, high repetition-rate, femtosecond laser facility whose main goal is generation and applications of high-brightness X-ray sources and accelerated charged particles in different fields. Particular care will be devoted to the potential applicability of laser-driven ion beams for medical treatments of tumors. Indeed, such kind of beams show very interesting peculiarities and, moreover, laser-driven based accelerators can really represent a competitive alternative to conventional machines since they are expected to be more compact in size and less expensive. The ELIMED project was launched thanks to a collaboration established between FZU-ASCR (ELI-Beamlines) and INFN-LNS researchers. Several European institutes have already shown a great interest in the project aiming to explore the possibility to use laser-driven ion (mostly proton) beams for several applications with a particular regard for medical ones. To reach the project goal several tasks need to be fulfilled, starting from the optimization of laser-target interaction to dosimetric studies at the irradiation point at the end of a proper designed transport beam-line. Researchers from LNS have already developed and successfully tested a high-dispersive power Thomson Parabola Spectrometer, which is the first prototype of a more performing device to be used within the ELIMED project. Also a Magnetic Selection System able to produce a small pencil beam out of a wide energy distribution of ions produced in laser-target interaction has been realized and some preliminary work for its testing and characterization is in progress. In this contribution the status of the project will be reported together with a short description of the of the features of device recently developed.",
journal = "Journal of Physics: Conference Series",
title = "ELIMED, MEDical and multidisciplinary applications at ELI-Beamlines",
volume = "508",
doi = "10.1088/1742-6596/508/1/012010"
}

Schillaci, F., Anzalone, A., Cirrone, G. A. P., Carpinelli, M., Cuttone, G., Cutroneo, M., De Martinis, C., Giove, D., Korn, G., Maggiore, M., Manti, L., Margarone, D., Musumarra, A., Perozziello, F. M., Petrović, I. M., Pisciotta, P., Renis, M., Ristić-Fira, A., Romano, F., Romano, F., Schettino, G., Scuderi, V., Torrisi, L., Tramontana, A.,& Tudisco, S.. (2014). ELIMED, MEDical and multidisciplinary applications at ELI-Beamlines. in Journal of Physics: Conference Series, 508.
https://doi.org/10.1088/1742-6596/508/1/012010

Schillaci F, Anzalone A, Cirrone GAP, Carpinelli M, Cuttone G, Cutroneo M, De Martinis C, Giove D, Korn G, Maggiore M, Manti L, Margarone D, Musumarra A, Perozziello FM, Petrović IM, Pisciotta P, Renis M, Ristić-Fira A, Romano F, Romano F, Schettino G, Scuderi V, Torrisi L, Tramontana A, Tudisco S. ELIMED, MEDical and multidisciplinary applications at ELI-Beamlines. in Journal of Physics: Conference Series. 2014;508.
doi:10.1088/1742-6596/508/1/012010 .

Schillaci, F., Anzalone, A., Cirrone, Giuseppe Antonio Pablo, Carpinelli, M., Cuttone, Giacomo, Cutroneo, M., De Martinis, C., Giove, D., Korn, G., Maggiore, M., Manti, L., Margarone, D., Musumarra, A., Perozziello, F. M., Petrović, Ivan M., Pisciotta, P., Renis, M., Ristić-Fira, Aleksandra, Romano, Francesco, Romano, Francesco, Schettino, G., Scuderi, V., Torrisi, L., Tramontana, A., Tudisco, S., "ELIMED, MEDical and multidisciplinary applications at ELI-Beamlines" in Journal of Physics: Conference Series, 508 (2014),
https://doi.org/10.1088/1742-6596/508/1/012010 . .

TY  - JOUR
AU  - Romano, Francesco
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cuttone, Giacomo
AU  - Di Rosa, F.
AU  - Mazzaglia, S. E.
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Varisano, A.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6037
AB  - Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An open source application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.
T2  - Physics in Medicine and Biology
T1  - A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line
VL  - 59
IS  - 12
SP  - 2863
EP  - 2882
DO  - 10.1088/0031-9155/59/12/2863
ER  - 

@article{
author = "Romano, Francesco and Cirrone, Giuseppe Antonio Pablo and Cuttone, Giacomo and Di Rosa, F. and Mazzaglia, S. E. and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Varisano, A.",
year = "2014",
abstract = "Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An open source application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.",
journal = "Physics in Medicine and Biology",
title = "A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line",
volume = "59",
number = "12",
pages = "2863-2882",
doi = "10.1088/0031-9155/59/12/2863"
}

Romano, F., Cirrone, G. A. P., Cuttone, G., Di Rosa, F., Mazzaglia, S. E., Petrović, I. M., Ristić-Fira, A.,& Varisano, A.. (2014). A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line. in Physics in Medicine and Biology, 59(12), 2863-2882.
https://doi.org/10.1088/0031-9155/59/12/2863

Romano F, Cirrone GAP, Cuttone G, Di Rosa F, Mazzaglia SE, Petrović IM, Ristić-Fira A, Varisano A. A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line. in Physics in Medicine and Biology. 2014;59(12):2863-2882.
doi:10.1088/0031-9155/59/12/2863 .

Romano, Francesco, Cirrone, Giuseppe Antonio Pablo, Cuttone, Giacomo, Di Rosa, F., Mazzaglia, S. E., Petrović, Ivan M., Ristić-Fira, Aleksandra, Varisano, A., "A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line" in Physics in Medicine and Biology, 59, no. 12 (2014):2863-2882,
https://doi.org/10.1088/0031-9155/59/12/2863 . .

TY  - CONF
AU  - Ristić-Fira, Aleksandra
AU  - Bulat, Tanja M.
AU  - Keta, Otilija D.
AU  - Romano, Francesco
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cuttone, Giacomo
AU  - Petrović, Ivan M.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7005
AB  - The aim of this study is to investigate the behavior of radio-resistant human malignant cells, thus enabling better understanding of radiobiological effects of ions in such a case. Radiation sources such as accelerated continuous ion beams and laser technology-based ultra short radiation sources with energy of around 10 MeV will be used. The HTB140 melanoma cells are chosen since it has been shown that they represent the limit case of cellular radio-resistance among the studied tumour cell lines. These cells are particularly interesting as they provide data on the very edge of inactivation capacity of each beam line that is tested. After exposing the cell monolayers to continuous radiations of low (gamma-rays) and high (protons) linear energy transfer, the kinetics of disappearance of the phosphorylated histone H2AX (gamma-H2AX) foci per cell will be determined. The same procedure will be performed with the pulsed high dose rate protons. Detection and quantification of gamma-H2AX foci will be performed by immunohistochemical 3D time-dependent imaging analyses using laser scanning confocal microscopy. Immunoblotting will enable the follow-up of the relation between gamma-H2AX and cell cycle arrest via the p53/p21 pathway. In such a way the spatio-temporal changes on sub-cellular level will be visualized, quantified and compared. These results will show whether there is a difference in the effects on cells between continuous and pulsed irradiation mode. Therefore, they will contribute to the database that might promote pulsed sources for medical treatments of malignant growths.
C3  - AIP Conference Proceedings
T1  - Spatio-Temporal Radiation Biology with Conventionally or Laser-Accelerated Particles for ELIMED
VL  - 1546
SP  - 101
EP  - 104
DO  - 10.1063/1.4816616
ER  - 

@conference{
author = "Ristić-Fira, Aleksandra and Bulat, Tanja M. and Keta, Otilija D. and Romano, Francesco and Cirrone, Giuseppe Antonio Pablo and Cuttone, Giacomo and Petrović, Ivan M.",
year = "2013",
abstract = "The aim of this study is to investigate the behavior of radio-resistant human malignant cells, thus enabling better understanding of radiobiological effects of ions in such a case. Radiation sources such as accelerated continuous ion beams and laser technology-based ultra short radiation sources with energy of around 10 MeV will be used. The HTB140 melanoma cells are chosen since it has been shown that they represent the limit case of cellular radio-resistance among the studied tumour cell lines. These cells are particularly interesting as they provide data on the very edge of inactivation capacity of each beam line that is tested. After exposing the cell monolayers to continuous radiations of low (gamma-rays) and high (protons) linear energy transfer, the kinetics of disappearance of the phosphorylated histone H2AX (gamma-H2AX) foci per cell will be determined. The same procedure will be performed with the pulsed high dose rate protons. Detection and quantification of gamma-H2AX foci will be performed by immunohistochemical 3D time-dependent imaging analyses using laser scanning confocal microscopy. Immunoblotting will enable the follow-up of the relation between gamma-H2AX and cell cycle arrest via the p53/p21 pathway. In such a way the spatio-temporal changes on sub-cellular level will be visualized, quantified and compared. These results will show whether there is a difference in the effects on cells between continuous and pulsed irradiation mode. Therefore, they will contribute to the database that might promote pulsed sources for medical treatments of malignant growths.",
journal = "AIP Conference Proceedings",
title = "Spatio-Temporal Radiation Biology with Conventionally or Laser-Accelerated Particles for ELIMED",
volume = "1546",
pages = "101-104",
doi = "10.1063/1.4816616"
}

Ristić-Fira, A., Bulat, T. M., Keta, O. D., Romano, F., Cirrone, G. A. P., Cuttone, G.,& Petrović, I. M.. (2013). Spatio-Temporal Radiation Biology with Conventionally or Laser-Accelerated Particles for ELIMED. in AIP Conference Proceedings, 1546, 101-104.
https://doi.org/10.1063/1.4816616

Ristić-Fira A, Bulat TM, Keta OD, Romano F, Cirrone GAP, Cuttone G, Petrović IM. Spatio-Temporal Radiation Biology with Conventionally or Laser-Accelerated Particles for ELIMED. in AIP Conference Proceedings. 2013;1546:101-104.
doi:10.1063/1.4816616 .

Ristić-Fira, Aleksandra, Bulat, Tanja M., Keta, Otilija D., Romano, Francesco, Cirrone, Giuseppe Antonio Pablo, Cuttone, Giacomo, Petrović, Ivan M., "Spatio-Temporal Radiation Biology with Conventionally or Laser-Accelerated Particles for ELIMED" in AIP Conference Proceedings, 1546 (2013):101-104,
https://doi.org/10.1063/1.4816616 . .

TY  - CONF
AU  - Ristić-Fira, Aleksandra
AU  - Petrović, Ivan M.
AU  - Todorović, Dragana
AU  - Korićanac, Lela
AU  - Keta, Otilija D.
AU  - Bulat, Tanja M.
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Romano, Francesco
AU  - Cuttone, Giacomo
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8642
C3  - Radiotherapy and Oncology
T1  - Response of human lung adenocarcinoma cells to proton radiation and erlotinib
VL  - 102
SP  - S106
EP  - S107
DO  - 10.1016/S0167-8140(12)70182-2
ER  - 

@conference{
author = "Ristić-Fira, Aleksandra and Petrović, Ivan M. and Todorović, Dragana and Korićanac, Lela and Keta, Otilija D. and Bulat, Tanja M. and Cirrone, Giuseppe Antonio Pablo and Romano, Francesco and Cuttone, Giacomo",
year = "2012",
journal = "Radiotherapy and Oncology",
title = "Response of human lung adenocarcinoma cells to proton radiation and erlotinib",
volume = "102",
pages = "S106-S107",
doi = "10.1016/S0167-8140(12)70182-2"
}

Ristić-Fira, A., Petrović, I. M., Todorović, D., Korićanac, L., Keta, O. D., Bulat, T. M., Cirrone, G. A. P., Romano, F.,& Cuttone, G.. (2012). Response of human lung adenocarcinoma cells to proton radiation and erlotinib. in Radiotherapy and Oncology, 102, S106-S107.
https://doi.org/10.1016/S0167-8140(12)70182-2

Ristić-Fira A, Petrović IM, Todorović D, Korićanac L, Keta OD, Bulat TM, Cirrone GAP, Romano F, Cuttone G. Response of human lung adenocarcinoma cells to proton radiation and erlotinib. in Radiotherapy and Oncology. 2012;102:S106-S107.
doi:10.1016/S0167-8140(12)70182-2 .

Ristić-Fira, Aleksandra, Petrović, Ivan M., Todorović, Dragana, Korićanac, Lela, Keta, Otilija D., Bulat, Tanja M., Cirrone, Giuseppe Antonio Pablo, Romano, Francesco, Cuttone, Giacomo, "Response of human lung adenocarcinoma cells to proton radiation and erlotinib" in Radiotherapy and Oncology, 102 (2012):S106-S107,
https://doi.org/10.1016/S0167-8140(12)70182-2 . .

TY  - CONF
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Todorović, Dragana
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Romano, Francesco
AU  - Cuttone, Giacomo
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8643
C3  - Radiotherapy and Oncology
T1  - Radio-resistant human malignant cells after irradiations with 1H and 12C ions of different LET
VL  - 102
SP  - S108
EP  - S109
DO  - 10.1016/S0167-8140(12)70185-8
ER  - 

@conference{
author = "Petrović, Ivan M. and Ristić-Fira, Aleksandra and Todorović, Dragana and Korićanac, Lela and Žakula, Jelena and Cirrone, Giuseppe Antonio Pablo and Romano, Francesco and Cuttone, Giacomo",
year = "2012",
journal = "Radiotherapy and Oncology",
title = "Radio-resistant human malignant cells after irradiations with 1H and 12C ions of different LET",
volume = "102",
pages = "S108-S109",
doi = "10.1016/S0167-8140(12)70185-8"
}

Petrović, I. M., Ristić-Fira, A., Todorović, D., Korićanac, L., Žakula, J., Cirrone, G. A. P., Romano, F.,& Cuttone, G.. (2012). Radio-resistant human malignant cells after irradiations with 1H and 12C ions of different LET. in Radiotherapy and Oncology, 102, S108-S109.
https://doi.org/10.1016/S0167-8140(12)70185-8

Petrović IM, Ristić-Fira A, Todorović D, Korićanac L, Žakula J, Cirrone GAP, Romano F, Cuttone G. Radio-resistant human malignant cells after irradiations with 1H and 12C ions of different LET. in Radiotherapy and Oncology. 2012;102:S108-S109.
doi:10.1016/S0167-8140(12)70185-8 .

Petrović, Ivan M., Ristić-Fira, Aleksandra, Todorović, Dragana, Korićanac, Lela, Žakula, Jelena, Cirrone, Giuseppe Antonio Pablo, Romano, Francesco, Cuttone, Giacomo, "Radio-resistant human malignant cells after irradiations with 1H and 12C ions of different LET" in Radiotherapy and Oncology, 102 (2012):S108-S109,
https://doi.org/10.1016/S0167-8140(12)70185-8 . .

TY  - JOUR
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cuttone, Giacomo
AU  - Mazzaglia, Enrico S.
AU  - Romano, Francesco
AU  - Sardina, Daniele
AU  - Agodi, Clementina
AU  - Attili, Andrea
AU  - Blancato, A. Alessandra
AU  - De Napoli, Marzio
AU  - Di Rosa, Francesco
AU  - Kaitaniemi, Pekka
AU  - Marchetto, Flavio
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Shin, Jungwook
AU  - Tarnavsky, Nikolai
AU  - Tropea, Stefania
AU  - Zacharatou, Christina
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8640
AB  - Hadrontherapy is a C++, free and open source application developed using the Geant4 Monte Carlo libraries The basic version of Hadrontherapy is contained in the official Geant4 distribution (wwwcernch/Geant4/download), inside the category of the advanced examples This version permits the simulation of a typical proton/ion transport beam line and the calculation of dose and fluence distributions inside a test phantom A more complete version of the program is separately maintained and released by the authors and it offers a wider set of tools useful for Users interested in proton/ion-therapy studies It gives the possibility to retrieve ion stopping powers in arbitrary geometrical configuration, to calculate 3D distributions of fluences, dose deposited and LET of primary and of the generated secondary beams, to simulate typical nuclear physics experiments, to interactively switch between different implemented geometries, etc In this work the main characteristics of the actual full version of Hadrontherapy will be reported and results discussed and compared with the available experimental data For more information the reader can refer to the Hadrontherapy website (author)
T2  - Progress in Nuclear Science and Technology
T1  - Hadrontherapy: a Geant4-Based Tool for Proton/Ion-Therapy Studies
VL  - 2
SP  - 207
EP  - 212
DO  - 10.15669/pnst.2.207
ER  - 

@article{
author = "Cirrone, Giuseppe Antonio Pablo and Cuttone, Giacomo and Mazzaglia, Enrico S. and Romano, Francesco and Sardina, Daniele and Agodi, Clementina and Attili, Andrea and Blancato, A. Alessandra and De Napoli, Marzio and Di Rosa, Francesco and Kaitaniemi, Pekka and Marchetto, Flavio and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Shin, Jungwook and Tarnavsky, Nikolai and Tropea, Stefania and Zacharatou, Christina",
year = "2011",
abstract = "Hadrontherapy is a C++, free and open source application developed using the Geant4 Monte Carlo libraries The basic version of Hadrontherapy is contained in the official Geant4 distribution (wwwcernch/Geant4/download), inside the category of the advanced examples This version permits the simulation of a typical proton/ion transport beam line and the calculation of dose and fluence distributions inside a test phantom A more complete version of the program is separately maintained and released by the authors and it offers a wider set of tools useful for Users interested in proton/ion-therapy studies It gives the possibility to retrieve ion stopping powers in arbitrary geometrical configuration, to calculate 3D distributions of fluences, dose deposited and LET of primary and of the generated secondary beams, to simulate typical nuclear physics experiments, to interactively switch between different implemented geometries, etc In this work the main characteristics of the actual full version of Hadrontherapy will be reported and results discussed and compared with the available experimental data For more information the reader can refer to the Hadrontherapy website (author)",
journal = "Progress in Nuclear Science and Technology",
title = "Hadrontherapy: a Geant4-Based Tool for Proton/Ion-Therapy Studies",
volume = "2",
pages = "207-212",
doi = "10.15669/pnst.2.207"
}

Cirrone, G. A. P., Cuttone, G., Mazzaglia, E. S., Romano, F., Sardina, D., Agodi, C., Attili, A., Blancato, A. A., De Napoli, M., Di Rosa, F., Kaitaniemi, P., Marchetto, F., Petrović, I. M., Ristić-Fira, A., Shin, J., Tarnavsky, N., Tropea, S.,& Zacharatou, C.. (2011). Hadrontherapy: a Geant4-Based Tool for Proton/Ion-Therapy Studies. in Progress in Nuclear Science and Technology, 2, 207-212.
https://doi.org/10.15669/pnst.2.207

Cirrone GAP, Cuttone G, Mazzaglia ES, Romano F, Sardina D, Agodi C, Attili A, Blancato AA, De Napoli M, Di Rosa F, Kaitaniemi P, Marchetto F, Petrović IM, Ristić-Fira A, Shin J, Tarnavsky N, Tropea S, Zacharatou C. Hadrontherapy: a Geant4-Based Tool for Proton/Ion-Therapy Studies. in Progress in Nuclear Science and Technology. 2011;2:207-212.
doi:10.15669/pnst.2.207 .

Cirrone, Giuseppe Antonio Pablo, Cuttone, Giacomo, Mazzaglia, Enrico S., Romano, Francesco, Sardina, Daniele, Agodi, Clementina, Attili, Andrea, Blancato, A. Alessandra, De Napoli, Marzio, Di Rosa, Francesco, Kaitaniemi, Pekka, Marchetto, Flavio, Petrović, Ivan M., Ristić-Fira, Aleksandra, Shin, Jungwook, Tarnavsky, Nikolai, Tropea, Stefania, Zacharatou, Christina, "Hadrontherapy: a Geant4-Based Tool for Proton/Ion-Therapy Studies" in Progress in Nuclear Science and Technology, 2 (2011):207-212,
https://doi.org/10.15669/pnst.2.207 . .

TY  - JOUR
AU  - Ivanchenko, Vladimir
AU  - Apostolakis, John
AU  - Bagulya, Alexander V.
AU  - Abdelouahed, Haifa Ben
AU  - Black, Rachel
AU  - Bogdanov, Alexey
AU  - Burkhard, Helmut
AU  - Chauvie, Stéphane
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cuttone, Giacomo
AU  - Depaola, Gerardo O.
AU  - Di Rosa, Francesco
AU  - Elles, Sabine
AU  - Francis, Ziad
AU  - Grichine, Vladimir
AU  - Gumplinger, Peter
AU  - Gueye, Paul
AU  - Incerti, Sebastien
AU  - Ivanchenko, Anton
AU  - Jacquemier, Jean
AU  - Lechner, Anton
AU  - Longo, Francesco
AU  - Kadri, Omrane
AU  - Karakatsanis, Nicolas
AU  - Karamitros, Mathieu
AU  - Kokoulin, Rostislav
AU  - Kurashige, Hisaya
AU  - Maire, Michel
AU  - Mantero, Alfonso
AU  - Mascialino, Barbara
AU  - Moscicki, Jakub
AU  - Pandola, Luciano
AU  - Perl, Joseph M.
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Romano, Francesco
AU  - Russo, Giorgio
AU  - Santin, Giovanni
AU  - Schaelicke, Andreas
AU  - Toshito, Toshiyuki
AU  - Tran, Hoang
AU  - Urban, Laszlo
AU  - Yamashita, Tomohiro
AU  - Zacharatou, Christina
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8641
AB  - An overview of the electromagnetic (EM) physics of the Geant4 toolkit is presented Two sets of EM models are available: the 'Standard' initially focused on high energy physics (HEP) while the 'Low-energy' was developed for medical, space and other applications The 'Standard' models provide a faster computation but are less accurate for keV energies, the 'Low-energy' models are more CPU time consuming A common interface to EM physics models has been developed allowing a natural combination of ultra-relativistic, relativistic and low-energy models for the same run providing both precision and CPU performance Due to this migration additional capabilities become available The new developments include relativistic models for bremsstrahlung and e+e- pair production, models of multiple and single scattering, hadron/ion ionization, microdosimetry for very low energies and also improvements in existing Geant4 models In parallel, validation suites and benchmarks have been intensively developed (author)
T2  - Progress in Nuclear Science and Technology
T1  - Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces
VL  - 2
SP  - 898
EP  - 903
DO  - 10.15669/pnst.2.898
ER  - 

@article{
author = "Ivanchenko, Vladimir and Apostolakis, John and Bagulya, Alexander V. and Abdelouahed, Haifa Ben and Black, Rachel and Bogdanov, Alexey and Burkhard, Helmut and Chauvie, Stéphane and Cirrone, Giuseppe Antonio Pablo and Cuttone, Giacomo and Depaola, Gerardo O. and Di Rosa, Francesco and Elles, Sabine and Francis, Ziad and Grichine, Vladimir and Gumplinger, Peter and Gueye, Paul and Incerti, Sebastien and Ivanchenko, Anton and Jacquemier, Jean and Lechner, Anton and Longo, Francesco and Kadri, Omrane and Karakatsanis, Nicolas and Karamitros, Mathieu and Kokoulin, Rostislav and Kurashige, Hisaya and Maire, Michel and Mantero, Alfonso and Mascialino, Barbara and Moscicki, Jakub and Pandola, Luciano and Perl, Joseph M. and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Romano, Francesco and Russo, Giorgio and Santin, Giovanni and Schaelicke, Andreas and Toshito, Toshiyuki and Tran, Hoang and Urban, Laszlo and Yamashita, Tomohiro and Zacharatou, Christina",
year = "2011",
abstract = "An overview of the electromagnetic (EM) physics of the Geant4 toolkit is presented Two sets of EM models are available: the 'Standard' initially focused on high energy physics (HEP) while the 'Low-energy' was developed for medical, space and other applications The 'Standard' models provide a faster computation but are less accurate for keV energies, the 'Low-energy' models are more CPU time consuming A common interface to EM physics models has been developed allowing a natural combination of ultra-relativistic, relativistic and low-energy models for the same run providing both precision and CPU performance Due to this migration additional capabilities become available The new developments include relativistic models for bremsstrahlung and e+e- pair production, models of multiple and single scattering, hadron/ion ionization, microdosimetry for very low energies and also improvements in existing Geant4 models In parallel, validation suites and benchmarks have been intensively developed (author)",
journal = "Progress in Nuclear Science and Technology",
title = "Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces",
volume = "2",
pages = "898-903",
doi = "10.15669/pnst.2.898"
}

Ivanchenko, V., Apostolakis, J., Bagulya, A. V., Abdelouahed, H. B., Black, R., Bogdanov, A., Burkhard, H., Chauvie, S., Cirrone, G. A. P., Cuttone, G., Depaola, G. O., Di Rosa, F., Elles, S., Francis, Z., Grichine, V., Gumplinger, P., Gueye, P., Incerti, S., Ivanchenko, A., Jacquemier, J., Lechner, A., Longo, F., Kadri, O., Karakatsanis, N., Karamitros, M., Kokoulin, R., Kurashige, H., Maire, M., Mantero, A., Mascialino, B., Moscicki, J., Pandola, L., Perl, J. M., Petrović, I. M., Ristić-Fira, A., Romano, F., Russo, G., Santin, G., Schaelicke, A., Toshito, T., Tran, H., Urban, L., Yamashita, T.,& Zacharatou, C.. (2011). Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces. in Progress in Nuclear Science and Technology, 2, 898-903.
https://doi.org/10.15669/pnst.2.898

Ivanchenko V, Apostolakis J, Bagulya AV, Abdelouahed HB, Black R, Bogdanov A, Burkhard H, Chauvie S, Cirrone GAP, Cuttone G, Depaola GO, Di Rosa F, Elles S, Francis Z, Grichine V, Gumplinger P, Gueye P, Incerti S, Ivanchenko A, Jacquemier J, Lechner A, Longo F, Kadri O, Karakatsanis N, Karamitros M, Kokoulin R, Kurashige H, Maire M, Mantero A, Mascialino B, Moscicki J, Pandola L, Perl JM, Petrović IM, Ristić-Fira A, Romano F, Russo G, Santin G, Schaelicke A, Toshito T, Tran H, Urban L, Yamashita T, Zacharatou C. Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces. in Progress in Nuclear Science and Technology. 2011;2:898-903.
doi:10.15669/pnst.2.898 .

Ivanchenko, Vladimir, Apostolakis, John, Bagulya, Alexander V., Abdelouahed, Haifa Ben, Black, Rachel, Bogdanov, Alexey, Burkhard, Helmut, Chauvie, Stéphane, Cirrone, Giuseppe Antonio Pablo, Cuttone, Giacomo, Depaola, Gerardo O., Di Rosa, Francesco, Elles, Sabine, Francis, Ziad, Grichine, Vladimir, Gumplinger, Peter, Gueye, Paul, Incerti, Sebastien, Ivanchenko, Anton, Jacquemier, Jean, Lechner, Anton, Longo, Francesco, Kadri, Omrane, Karakatsanis, Nicolas, Karamitros, Mathieu, Kokoulin, Rostislav, Kurashige, Hisaya, Maire, Michel, Mantero, Alfonso, Mascialino, Barbara, Moscicki, Jakub, Pandola, Luciano, Perl, Joseph M., Petrović, Ivan M., Ristić-Fira, Aleksandra, Romano, Francesco, Russo, Giorgio, Santin, Giovanni, Schaelicke, Andreas, Toshito, Toshiyuki, Tran, Hoang, Urban, Laszlo, Yamashita, Tomohiro, Zacharatou, Christina, "Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces" in Progress in Nuclear Science and Technology, 2 (2011):898-903,
https://doi.org/10.15669/pnst.2.898 . .