Bogdanovic, Gordana M.

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  • Bogdanovic, Gordana M. (2)
Projects

Author's Bibliography

Fullerenol nanoparticles as a new delivery system for doxorubicin

Jović, Danica S.; Seke, Mariana; Đorđević, Aleksandar N.; Mrđanović, Jasminka Ž.; Aleksić, Lidija D.; Bogdanovic, Gordana M.; Pavić, Aleksandar B.; Plavec, Janez

(2016)

TY  - JOUR
AU  - Jović, Danica S.
AU  - Seke, Mariana
AU  - Đorđević, Aleksandar N.
AU  - Mrđanović, Jasminka Ž.
AU  - Aleksić, Lidija D.
AU  - Bogdanovic, Gordana M.
AU  - Pavić, Aleksandar B.
AU  - Plavec, Janez
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1042
AB  - Doxorubicin is a very potent chemotherapeutic drug, however its side effects limit its clinical use. The aim of this research was to investigate the properties of a fullerenol/doxorubicin nanocomposite, its potentially cytotoxic and genotoxic effects on malignant cell lines, as well as its toxicity towards zebra fish embryos. Chromatographic, NMR and mass spectral analysis of the nanocomposite imply that interactions between doxorubicin and fullerenol are non-covalent bonds. The stability of the nanocomposite was confirmed by the use of atomic force microscopy, dynamic light scattering and transmission electron microscopy. The nanocomposite, compared to the free doxorubicin at equivalent concentrations, significantly decreased the viability of MCF-7 and MDA-MB-231 cells. The flow cytometry results indicated that doxorubicin-loaded fullerenol could remarkably increase the uptake of doxorubicin suggesting that fullerenol might be a promising intracellular targeting carrier for the efficient delivery of antitumor drugs into tumor cells. The nanocomposite also affected cell cycle distribution. A genotoxicity test showed that the nanocomposite at all examined concentrations on MCF-7 and at lower concentrations on MDA-MB-231 cells caused DNA damage. Consequently, cell proliferation was notably reduced when compared with controls. Results of the zebrafish embryotoxicity assay showed a decreased overall toxicity, particularly cardiotoxicity and increased safety of the nanocomposite in comparison to doxorubicin alone, as manifested by a higher survival of embryos and less pericardial edema.
T2  - RSC Advances
T1  - Fullerenol nanoparticles as a new delivery system for doxorubicin
VL  - 6
IS  - 45
SP  - 38563
EP  - 38578
DO  - 10.1039/c6ra03879d
ER  - 
@article{
author = "Jović, Danica S. and Seke, Mariana and Đorđević, Aleksandar N. and Mrđanović, Jasminka Ž. and Aleksić, Lidija D. and Bogdanovic, Gordana M. and Pavić, Aleksandar B. and Plavec, Janez",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1042",
abstract = "Doxorubicin is a very potent chemotherapeutic drug, however its side effects limit its clinical use. The aim of this research was to investigate the properties of a fullerenol/doxorubicin nanocomposite, its potentially cytotoxic and genotoxic effects on malignant cell lines, as well as its toxicity towards zebra fish embryos. Chromatographic, NMR and mass spectral analysis of the nanocomposite imply that interactions between doxorubicin and fullerenol are non-covalent bonds. The stability of the nanocomposite was confirmed by the use of atomic force microscopy, dynamic light scattering and transmission electron microscopy. The nanocomposite, compared to the free doxorubicin at equivalent concentrations, significantly decreased the viability of MCF-7 and MDA-MB-231 cells. The flow cytometry results indicated that doxorubicin-loaded fullerenol could remarkably increase the uptake of doxorubicin suggesting that fullerenol might be a promising intracellular targeting carrier for the efficient delivery of antitumor drugs into tumor cells. The nanocomposite also affected cell cycle distribution. A genotoxicity test showed that the nanocomposite at all examined concentrations on MCF-7 and at lower concentrations on MDA-MB-231 cells caused DNA damage. Consequently, cell proliferation was notably reduced when compared with controls. Results of the zebrafish embryotoxicity assay showed a decreased overall toxicity, particularly cardiotoxicity and increased safety of the nanocomposite in comparison to doxorubicin alone, as manifested by a higher survival of embryos and less pericardial edema.",
journal = "RSC Advances",
title = "Fullerenol nanoparticles as a new delivery system for doxorubicin",
volume = "6",
number = "45",
pages = "38563-38578",
doi = "10.1039/c6ra03879d"
}
Jović, D. S., Seke, M., Đorđević, A. N., Mrđanović, J. Ž., Aleksić, L. D., Bogdanovic, G. M., Pavić, A. B.,& Plavec, J. (2016). Fullerenol nanoparticles as a new delivery system for doxorubicin.
RSC Advances, 6(45), 38563-38578.
https://doi.org/10.1039/c6ra03879d
Jović DS, Seke M, Đorđević AN, Mrđanović JŽ, Aleksić LD, Bogdanovic GM, Pavić AB, Plavec J. Fullerenol nanoparticles as a new delivery system for doxorubicin. RSC Advances. 2016;6(45):38563-38578
Jović Danica S., Seke Mariana, Đorđević Aleksandar N., Mrđanović Jasminka Ž., Aleksić Lidija D., Bogdanovic Gordana M., Pavić Aleksandar B., Plavec Janez, "Fullerenol nanoparticles as a new delivery system for doxorubicin" RSC Advances, 6, no. 45 (2016):38563-38578,
https://doi.org/10.1039/c6ra03879d .
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Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes

Mrđanović, Jasminka Ž.; Solajic, Slavica V.; Bogdanovic, Visnja V.; Đorđević, Aleksandar N.; Bogdanovic, Gordana M.; Injac, Rade D.; Rakočević, Zlatko Lj.

(2012)

TY  - JOUR
AU  - Mrđanović, Jasminka Ž.
AU  - Solajic, Slavica V.
AU  - Bogdanovic, Visnja V.
AU  - Đorđević, Aleksandar N.
AU  - Bogdanovic, Gordana M.
AU  - Injac, Rade D.
AU  - Rakočević, Zlatko Lj.
PY  - 2012
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/4935
AB  - Fullerenol C-60(OH)(24) nano particles (FNP) show various biological activities in different experimental models. We evaluated genotoxic and antigenotoxic effects of FNP on human peripheral blood lymphocytes (PBL) using two cytogenetic assays. The effects of FNP were evaluated on the frequency of chromosomal aberrations (CA) and micronuclei (MN) on undamaged and mitomycin C (MMC)-damaged PBL. FNP number distribution in a culture medium with serum showed that predominant particles were about 180 nm and 90 nm respectively. Cytogenetic assays showed that FNP decreased chromosomal aberrations and micronucleus frequency on the undamaged and the MMC- damaged human PBL at concentration range from 5.54 mu M to 221.60 mu M. Our research confirmed that FNP did not exhibit genotoxic but induced antigenotoxic effects at subcytotoxic concentrations on human lymphocytes.
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes
VL  - 7
IS  - 2
SP  - 673
EP  - 686
ER  - 
@article{
author = "Mrđanović, Jasminka Ž. and Solajic, Slavica V. and Bogdanovic, Visnja V. and Đorđević, Aleksandar N. and Bogdanovic, Gordana M. and Injac, Rade D. and Rakočević, Zlatko Lj.",
year = "2012",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/4935",
abstract = "Fullerenol C-60(OH)(24) nano particles (FNP) show various biological activities in different experimental models. We evaluated genotoxic and antigenotoxic effects of FNP on human peripheral blood lymphocytes (PBL) using two cytogenetic assays. The effects of FNP were evaluated on the frequency of chromosomal aberrations (CA) and micronuclei (MN) on undamaged and mitomycin C (MMC)-damaged PBL. FNP number distribution in a culture medium with serum showed that predominant particles were about 180 nm and 90 nm respectively. Cytogenetic assays showed that FNP decreased chromosomal aberrations and micronucleus frequency on the undamaged and the MMC- damaged human PBL at concentration range from 5.54 mu M to 221.60 mu M. Our research confirmed that FNP did not exhibit genotoxic but induced antigenotoxic effects at subcytotoxic concentrations on human lymphocytes.",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes",
volume = "7",
number = "2",
pages = "673-686"
}
Mrđanović, J. Ž., Solajic, S. V., Bogdanovic, V. V., Đorđević, A. N., Bogdanovic, G. M., Injac, R. D.,& Rakočević, Z. Lj. (2012). Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes.
Digest Journal of Nanomaterials and Biostructures, 7(2), 673-686.
Mrđanović JŽ, Solajic SV, Bogdanovic VV, Đorđević AN, Bogdanovic GM, Injac RD, Rakočević ZL. Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes. Digest Journal of Nanomaterials and Biostructures. 2012;7(2):673-686
Mrđanović Jasminka Ž., Solajic Slavica V., Bogdanovic Visnja V., Đorđević Aleksandar N., Bogdanovic Gordana M., Injac Rade D., Rakočević Zlatko Lj., "Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes" Digest Journal of Nanomaterials and Biostructures, 7, no. 2 (2012):673-686
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