Borišev, Ivana

Link to this page

Authority KeyName Variants
2aa6c7f6-9a6f-422a-a588-655fe067d523
  • Borišev, Ivana (4)
Projects

Author's Bibliography

The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity

Jović, Danica; Jaćević, Vesna; Kuča, Kamil; Borišev, Ivana; Mrđanović, Jasminka; Petrović, Danijela; Seke, Mariana; Đorđević, Aleksandar

(2020)

TY  - JOUR
AU  - Jović, Danica
AU  - Jaćević, Vesna
AU  - Kuča, Kamil
AU  - Borišev, Ivana
AU  - Mrđanović, Jasminka
AU  - Petrović, Danijela
AU  - Seke, Mariana
AU  - Đorđević, Aleksandar
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9120
AB  - Being a member of the nanofamily, carbon nanomaterials exhibit specific properties that mostly arise from their small size. They have proved to be very promising for application in the technical and biomedical field. A wide spectrum of use implies the inevitable presence of carbon nanomaterials in the environment, thus potentially endangering their whole nature. Although scientists worldwide have conducted research investigating the impact of these materials, it is evident that there are still significant gaps concerning the knowledge of their mechanisms, as well as the prolonged and chronic exposure and effects. This manuscript summarizes the most prominent representatives of carbon nanomaterial groups, giving a brief review of their general physico-chemical properties, the most common use, and toxicity profiles. Toxicity was presented through genotoxicity and the activation of the cell signaling pathways, both including in vitro and in vivo models, mechanisms, and the consequential outcomes. Moreover, the acute toxicity of fullerenol, as one of the most commonly investigated members, was briefly presented in the final part of this review. Thinking small can greatly help us improve our lives, but also obliges us to deeply and comprehensively investigate all the possible consequences that could arise from our pure-hearted scientific ambitions and work.
T2  - Nanomaterials
T1  - The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity
VL  - 10
IS  - 8
SP  - 1508
DO  - 10.3390/nano10081508
ER  - 
@article{
author = "Jović, Danica and Jaćević, Vesna and Kuča, Kamil and Borišev, Ivana and Mrđanović, Jasminka and Petrović, Danijela and Seke, Mariana and Đorđević, Aleksandar",
year = "2020",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9120",
abstract = "Being a member of the nanofamily, carbon nanomaterials exhibit specific properties that mostly arise from their small size. They have proved to be very promising for application in the technical and biomedical field. A wide spectrum of use implies the inevitable presence of carbon nanomaterials in the environment, thus potentially endangering their whole nature. Although scientists worldwide have conducted research investigating the impact of these materials, it is evident that there are still significant gaps concerning the knowledge of their mechanisms, as well as the prolonged and chronic exposure and effects. This manuscript summarizes the most prominent representatives of carbon nanomaterial groups, giving a brief review of their general physico-chemical properties, the most common use, and toxicity profiles. Toxicity was presented through genotoxicity and the activation of the cell signaling pathways, both including in vitro and in vivo models, mechanisms, and the consequential outcomes. Moreover, the acute toxicity of fullerenol, as one of the most commonly investigated members, was briefly presented in the final part of this review. Thinking small can greatly help us improve our lives, but also obliges us to deeply and comprehensively investigate all the possible consequences that could arise from our pure-hearted scientific ambitions and work.",
journal = "Nanomaterials",
title = "The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity",
volume = "10",
number = "8",
pages = "1508",
doi = "10.3390/nano10081508"
}
Jović, D., Jaćević, V., Kuča, K., Borišev, I., Mrđanović, J., Petrović, D., Seke, M.,& Đorđević, A. (2020). The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity.
Nanomaterials, 10(8), 1508.
https://doi.org/10.3390/nano10081508
Jović D, Jaćević V, Kuča K, Borišev I, Mrđanović J, Petrović D, Seke M, Đorđević A. The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity. Nanomaterials. 2020;10(8):1508
Jović Danica, Jaćević Vesna, Kuča Kamil, Borišev Ivana, Mrđanović Jasminka, Petrović Danijela, Seke Mariana, Đorđević Aleksandar, "The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity" Nanomaterials, 10, no. 8 (2020):1508,
https://doi.org/10.3390/nano10081508 .
1
11
7

Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats

Petrović, Danijela; Seke, Mariana; Labudović-Borović, Milica; Jović, Danica S.; Borišev, Ivana; Srđenović, Branislava U.; Rakočević, Zlatko Lj.; Pavlović, Vladimir B.; Đorđević, Aleksandar N.

(2018)

TY  - JOUR
AU  - Petrović, Danijela
AU  - Seke, Mariana
AU  - Labudović-Borović, Milica
AU  - Jović, Danica S.
AU  - Borišev, Ivana
AU  - Srđenović, Branislava U.
AU  - Rakočević, Zlatko Lj.
AU  - Pavlović, Vladimir B.
AU  - Đorđević, Aleksandar N.
PY  - 2018
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0014480017305890
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7688
AB  - In our recent studies we have designed fullerenol/doxorubicin nanocomposite (FNP/DOX) as the new drug nanocarrier. This research has demonstrated that this novel nanocomposite has had better implications on the liver tissue in vivo (Wistar rats treated intraperitoneally), than treatment based only on DOX. FNP/DOX has been characterised by DLS, TEM and AFM measurements which have shown that DOX loaded onto FNP did not influence fullerenol nanoparticle's size. FNP/DOX affected oxidative status in blood causing a significant decrease of catalase and SOD activity in comparison to DOX, implicating the reduction in oxidative stress. qRT-PCR results on the mRNA level of antioxidative enzymes (catalase and MnSOD) revealed that the effect of oxidative stress is significantly reduced by the treatment with FNP/DOX (p <.05). The ultrastructural analysis of the liver tissue has revealed that FNP/DOX nanocomposite generated considerably less damage in the liver tissue, than DOX applied at the same dose. Hence, our results have indicated that FNP, within FNP/DOX nanocomposite, exhibits protective effects to the liver tissue of the healthy rats.
T2  - Experimental and Molecular Pathology
T1  - Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats
VL  - 104
IS  - 3
SP  - 199
EP  - 211
DO  - 10.1016/j.yexmp.2018.04.005
ER  - 
@article{
author = "Petrović, Danijela and Seke, Mariana and Labudović-Borović, Milica and Jović, Danica S. and Borišev, Ivana and Srđenović, Branislava U. and Rakočević, Zlatko Lj. and Pavlović, Vladimir B. and Đorđević, Aleksandar N.",
year = "2018",
url = "http://linkinghub.elsevier.com/retrieve/pii/S0014480017305890, http://vinar.vin.bg.ac.rs/handle/123456789/7688",
abstract = "In our recent studies we have designed fullerenol/doxorubicin nanocomposite (FNP/DOX) as the new drug nanocarrier. This research has demonstrated that this novel nanocomposite has had better implications on the liver tissue in vivo (Wistar rats treated intraperitoneally), than treatment based only on DOX. FNP/DOX has been characterised by DLS, TEM and AFM measurements which have shown that DOX loaded onto FNP did not influence fullerenol nanoparticle's size. FNP/DOX affected oxidative status in blood causing a significant decrease of catalase and SOD activity in comparison to DOX, implicating the reduction in oxidative stress. qRT-PCR results on the mRNA level of antioxidative enzymes (catalase and MnSOD) revealed that the effect of oxidative stress is significantly reduced by the treatment with FNP/DOX (p <.05). The ultrastructural analysis of the liver tissue has revealed that FNP/DOX nanocomposite generated considerably less damage in the liver tissue, than DOX applied at the same dose. Hence, our results have indicated that FNP, within FNP/DOX nanocomposite, exhibits protective effects to the liver tissue of the healthy rats.",
journal = "Experimental and Molecular Pathology",
title = "Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats",
volume = "104",
number = "3",
pages = "199-211",
doi = "10.1016/j.yexmp.2018.04.005"
}
Petrović, D., Seke, M., Labudović-Borović, M., Jović, D. S., Borišev, I., Srđenović, B. U., Rakočević, Z. Lj., Pavlović, V. B.,& Đorđević, A. N. (2018). Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats.
Experimental and Molecular Pathology, 104(3), 199-211.
https://doi.org/10.1016/j.yexmp.2018.04.005
Petrović D, Seke M, Labudović-Borović M, Jović DS, Borišev I, Srđenović BU, Rakočević ZL, Pavlović VB, Đorđević AN. Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats. Experimental and Molecular Pathology. 2018;104(3):199-211
Petrović Danijela, Seke Mariana, Labudović-Borović Milica, Jović Danica S., Borišev Ivana, Srđenović Branislava U., Rakočević Zlatko Lj., Pavlović Vladimir B., Đorđević Aleksandar N., "Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats" Experimental and Molecular Pathology, 104, no. 3 (2018):199-211,
https://doi.org/10.1016/j.yexmp.2018.04.005 .
10
8
9

Nanoformulations of doxorubicin: How far have we come and where do we go from here?

Borišev, Ivana; Mrđanović, Jasminka Ž.; Petrović, Danijela; Seke, Mariana; Jović, Danica S.; Srđenović, Branislava U.; Latinović, Nataša; Đorđević, Aleksandar N.

(2018)

TY  - JOUR
AU  - Borišev, Ivana
AU  - Mrđanović, Jasminka Ž.
AU  - Petrović, Danijela
AU  - Seke, Mariana
AU  - Jović, Danica S.
AU  - Srđenović, Branislava U.
AU  - Latinović, Nataša
AU  - Đorđević, Aleksandar N.
PY  - 2018
UR  - http://stacks.iop.org/0957-4484/29/i=33/a=332002?key=crossref.4804877570e2609bf6333877ee495ab3
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7751
AB  - Nanotechnology, focused on discovery and development of new pharmaceutical products is known as nanopharmacology, and one research area this branch is engaged in are nanopharmaceuticals. The importance of being nano has been particularly emphasized in scientific areas dealing with nanomedicine and nanopharmaceuticals. Nanopharmaceuticals, their routes of administration, obstacles and solutions concerning their improved application and enhanced efficacy have been briefly yet comprehensively described. Cancer is one of the leading causes of death worldwide and evergrowing number of scientific research on the topic only confirms that the needs have not been completed yet and that there is a wide platform for improvement. This is undoubtedly true for nanoformulations of an anticancer drug doxorubicin, where various nanocarrriers were given an important role to reduce the drug toxicity, while the efficacy of the drug was supposed to be retained or preferably enhanced. Therefore, we present an interdisciplinary comprehensive overview of interdisciplinary nature on nanopharmaceuticals based on doxorubicin and its nanoformulations with valuable information concerning trends, obstacles and prospective of nanopharmaceuticals development, mode of activity of sole drug doxorubicin and its nanoformulations based on different nanocarriers, their brief descriptions of biological activity through assessing in vitro and in vivo behavior.
T2  - Nanotechnology
T1  - Nanoformulations of doxorubicin: How far have we come and where do we go from here?
VL  - 29
IS  - 33
SP  - 332002
DO  - 10.1088/1361-6528/aac7dd
ER  - 
@article{
author = "Borišev, Ivana and Mrđanović, Jasminka Ž. and Petrović, Danijela and Seke, Mariana and Jović, Danica S. and Srđenović, Branislava U. and Latinović, Nataša and Đorđević, Aleksandar N.",
year = "2018",
url = "http://stacks.iop.org/0957-4484/29/i=33/a=332002?key=crossref.4804877570e2609bf6333877ee495ab3, http://vinar.vin.bg.ac.rs/handle/123456789/7751",
abstract = "Nanotechnology, focused on discovery and development of new pharmaceutical products is known as nanopharmacology, and one research area this branch is engaged in are nanopharmaceuticals. The importance of being nano has been particularly emphasized in scientific areas dealing with nanomedicine and nanopharmaceuticals. Nanopharmaceuticals, their routes of administration, obstacles and solutions concerning their improved application and enhanced efficacy have been briefly yet comprehensively described. Cancer is one of the leading causes of death worldwide and evergrowing number of scientific research on the topic only confirms that the needs have not been completed yet and that there is a wide platform for improvement. This is undoubtedly true for nanoformulations of an anticancer drug doxorubicin, where various nanocarrriers were given an important role to reduce the drug toxicity, while the efficacy of the drug was supposed to be retained or preferably enhanced. Therefore, we present an interdisciplinary comprehensive overview of interdisciplinary nature on nanopharmaceuticals based on doxorubicin and its nanoformulations with valuable information concerning trends, obstacles and prospective of nanopharmaceuticals development, mode of activity of sole drug doxorubicin and its nanoformulations based on different nanocarriers, their brief descriptions of biological activity through assessing in vitro and in vivo behavior.",
journal = "Nanotechnology",
title = "Nanoformulations of doxorubicin: How far have we come and where do we go from here?",
volume = "29",
number = "33",
pages = "332002",
doi = "10.1088/1361-6528/aac7dd"
}
Borišev, I., Mrđanović, J. Ž., Petrović, D., Seke, M., Jović, D. S., Srđenović, B. U., Latinović, N.,& Đorđević, A. N. (2018). Nanoformulations of doxorubicin: How far have we come and where do we go from here?.
Nanotechnology, 29(33), 332002.
https://doi.org/10.1088/1361-6528/aac7dd
Borišev I, Mrđanović JŽ, Petrović D, Seke M, Jović DS, Srđenović BU, Latinović N, Đorđević AN. Nanoformulations of doxorubicin: How far have we come and where do we go from here?. Nanotechnology. 2018;29(33):332002
Borišev Ivana, Mrđanović Jasminka Ž., Petrović Danijela, Seke Mariana, Jović Danica S., Srđenović Branislava U., Latinović Nataša, Đorđević Aleksandar N., "Nanoformulations of doxorubicin: How far have we come and where do we go from here?" Nanotechnology, 29, no. 33 (2018):332002,
https://doi.org/10.1088/1361-6528/aac7dd .
15
10
13

Fullerenol/iron nanocomposite modulates doxorubicin-induced cardiotoxicity

Seke, Mariana; Petrović, Danijela; Labudović-Borović, Milica; Jović, Danica S.; Borišev, Ivana; Kanacki, Z.; Zikic, D.; Đorđević, Aleksandar N.

(2017)

TY  - CONF
AU  - Seke, Mariana
AU  - Petrović, Danijela
AU  - Labudović-Borović, Milica
AU  - Jović, Danica S.
AU  - Borišev, Ivana
AU  - Kanacki, Z.
AU  - Zikic, D.
AU  - Đorđević, Aleksandar N.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7182
C3  - Annals of Oncology
T1  - Fullerenol/iron nanocomposite modulates doxorubicin-induced cardiotoxicity
VL  - 28
ER  - 
@conference{
author = "Seke, Mariana and Petrović, Danijela and Labudović-Borović, Milica and Jović, Danica S. and Borišev, Ivana and Kanacki, Z. and Zikic, D. and Đorđević, Aleksandar N.",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7182",
journal = "Annals of Oncology",
title = "Fullerenol/iron nanocomposite modulates doxorubicin-induced cardiotoxicity",
volume = "28"
}
Seke, M., Petrović, D., Labudović-Borović, M., Jović, D. S., Borišev, I., Kanacki, Z., Zikic, D.,& Đorđević, A. N. (2017). Fullerenol/iron nanocomposite modulates doxorubicin-induced cardiotoxicity.
Annals of Oncology, 28.
Seke M, Petrović D, Labudović-Borović M, Jović DS, Borišev I, Kanacki Z, Zikic D, Đorđević AN. Fullerenol/iron nanocomposite modulates doxorubicin-induced cardiotoxicity. Annals of Oncology. 2017;28
Seke Mariana, Petrović Danijela, Labudović-Borović Milica, Jović Danica S., Borišev Ivana, Kanacki Z., Zikic D., Đorđević Aleksandar N., "Fullerenol/iron nanocomposite modulates doxorubicin-induced cardiotoxicity" Annals of Oncology, 28 (2017)