TY  - JOUR
AU  - Fani, M
AU  - Vranješ, Sanja
AU  - Archimandritis, Spyridon
AU  - Potamianos, S
AU  - Xanthopoulos, S
AU  - Bouziotis, Penelope
AU  - Varvarigou, AD
PY  - 2002
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2557
AB  - The labeling of a monoclonal (anti-CEA) and a polyclonal (IgG) antibody with Sm-153 has been investigated, using the bicyclic anhydride of DTPA (cDTPAa) as the chelating agent. The radiochemical study was performed using a combination of radioanalytical techniques (gel filtration, HPLC, ITLC-SG and SDS-PAGE). Optimization of factors affecting labeling (pH, Ab, Ab-DTPA concentration, etc.) leads to a labeling yield higher than 90%. Biodistribution studies in normal mice showed slow blood clearance and high uptake into the liver, kidney and lungs. (C) 2002 Elsevier Science Ltd. All rights reserved.
T2  - Applied Radiation and Isotopes
T1  - Labeling of monoclonal antibodies with Sm-153 for potential use in radioimmunotherapy
VL  - 57
IS  - 5
SP  - 665
EP  - 674
DO  - 10.1016/S0969-8043(02)00181-1
ER  - 

@article{
author = "Fani, M and Vranješ, Sanja and Archimandritis, Spyridon and Potamianos, S and Xanthopoulos, S and Bouziotis, Penelope and Varvarigou, AD",
year = "2002",
abstract = "The labeling of a monoclonal (anti-CEA) and a polyclonal (IgG) antibody with Sm-153 has been investigated, using the bicyclic anhydride of DTPA (cDTPAa) as the chelating agent. The radiochemical study was performed using a combination of radioanalytical techniques (gel filtration, HPLC, ITLC-SG and SDS-PAGE). Optimization of factors affecting labeling (pH, Ab, Ab-DTPA concentration, etc.) leads to a labeling yield higher than 90%. Biodistribution studies in normal mice showed slow blood clearance and high uptake into the liver, kidney and lungs. (C) 2002 Elsevier Science Ltd. All rights reserved.",
journal = "Applied Radiation and Isotopes",
title = "Labeling of monoclonal antibodies with Sm-153 for potential use in radioimmunotherapy",
volume = "57",
number = "5",
pages = "665-674",
doi = "10.1016/S0969-8043(02)00181-1"
}

Fani, M., Vranješ, S., Archimandritis, S., Potamianos, S., Xanthopoulos, S., Bouziotis, P.,& Varvarigou, A.. (2002). Labeling of monoclonal antibodies with Sm-153 for potential use in radioimmunotherapy. in Applied Radiation and Isotopes, 57(5), 665-674.
https://doi.org/10.1016/S0969-8043(02)00181-1

Fani M, Vranješ S, Archimandritis S, Potamianos S, Xanthopoulos S, Bouziotis P, Varvarigou A. Labeling of monoclonal antibodies with Sm-153 for potential use in radioimmunotherapy. in Applied Radiation and Isotopes. 2002;57(5):665-674.
doi:10.1016/S0969-8043(02)00181-1 .

Fani, M, Vranješ, Sanja, Archimandritis, Spyridon, Potamianos, S, Xanthopoulos, S, Bouziotis, Penelope, Varvarigou, AD, "Labeling of monoclonal antibodies with Sm-153 for potential use in radioimmunotherapy" in Applied Radiation and Isotopes, 57, no. 5 (2002):665-674,
https://doi.org/10.1016/S0969-8043(02)00181-1 . .