TY  - JOUR
AU  - Satarić, Miljko V.
AU  - Sekulić, Dalibor L.
AU  - Zdravković, Slobodan
AU  - Ralević, Nebojša M.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1560
AB  - It appears that so called post translational modifications of tubulin heterodimers are mostly focussed at positions of amino acid sequences of carboxy terminal tails. These changes have very profound effects on microtubule functions especially in connection with cellular traffic in terms of motor proteins. In this study, we elaborated the biophysical model aimed to explain the strategy governing these subtle interplays between structural and functional properties of microtubules. We relied onto Langevin equations including fluctuation dissipation processes. In that context we found out that small interaction between a charged motor neck domain and oppositely charged carboxy terminal tail of the a tubulin plays the decisive role in tuning kinesin-1 motor processivity along microtubules.
T2  - Journal of Theoretical Biology
T1  - A biophysical model of how alpha-tubulin carboxy-terminal tails tune kinesin-1 processivity along microtubule
VL  - 420
SP  - 152
EP  - 157
DO  - 10.1016/j.jtbi.2017.03.012
ER  - 

@article{
author = "Satarić, Miljko V. and Sekulić, Dalibor L. and Zdravković, Slobodan and Ralević, Nebojša M.",
year = "2017",
abstract = "It appears that so called post translational modifications of tubulin heterodimers are mostly focussed at positions of amino acid sequences of carboxy terminal tails. These changes have very profound effects on microtubule functions especially in connection with cellular traffic in terms of motor proteins. In this study, we elaborated the biophysical model aimed to explain the strategy governing these subtle interplays between structural and functional properties of microtubules. We relied onto Langevin equations including fluctuation dissipation processes. In that context we found out that small interaction between a charged motor neck domain and oppositely charged carboxy terminal tail of the a tubulin plays the decisive role in tuning kinesin-1 motor processivity along microtubules.",
journal = "Journal of Theoretical Biology",
title = "A biophysical model of how alpha-tubulin carboxy-terminal tails tune kinesin-1 processivity along microtubule",
volume = "420",
pages = "152-157",
doi = "10.1016/j.jtbi.2017.03.012"
}

Satarić, M. V., Sekulić, D. L., Zdravković, S.,& Ralević, N. M.. (2017). A biophysical model of how alpha-tubulin carboxy-terminal tails tune kinesin-1 processivity along microtubule. in Journal of Theoretical Biology, 420, 152-157.
https://doi.org/10.1016/j.jtbi.2017.03.012

Satarić MV, Sekulić DL, Zdravković S, Ralević NM. A biophysical model of how alpha-tubulin carboxy-terminal tails tune kinesin-1 processivity along microtubule. in Journal of Theoretical Biology. 2017;420:152-157.
doi:10.1016/j.jtbi.2017.03.012 .

Satarić, Miljko V., Sekulić, Dalibor L., Zdravković, Slobodan, Ralević, Nebojša M., "A biophysical model of how alpha-tubulin carboxy-terminal tails tune kinesin-1 processivity along microtubule" in Journal of Theoretical Biology, 420 (2017):152-157,
https://doi.org/10.1016/j.jtbi.2017.03.012 . .