TY  - JOUR
AU  - Artiko, V
AU  - Davidovic, B
AU  - Nikolic, N
AU  - Petrović, M
AU  - Vlajkovic, M
AU  - Pesko, P
AU  - Knežević, S.
AU  - Dukić, V
AU  - Stefanovic, B
AU  - Tulic, C
AU  - Popovic, N
AU  - Milosavljevic, T
AU  - Obradović, V
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2874
AB  - Background/Aims: The aim of the study is detection and evaluation of the abdominal and gastrointestinal; infective foci using Tc-99m-ciprofloxacin (Laboratory for radioactive isotopes, Vinca). Methodology: In total 21 patients with clinical suspicion on abdominal or gastrointestinal infection were investigated. In all the patients, planar liver/spleen scintigraphy was performed. Ciprofloxacin chloride (3.5mg) was mixed with 555MBq of Tc-99m in 3mL of physiological solution and incubated for 20 min. After slow i.v. injection in a cubital vein, dynamic acquisition (1 f/min) was performed during the first 60 min in the position of interest, followed by static acquisition (500 000 imp) anterior and posterior view, abdomen and pelvis after 1 h and 4 h in all patients. When necessary, additional scintigrams were acquired after 24h. In all the patients with negative or equivocal findings of planar scintigraphy, emission computerized tomography (SPECT) was performed (60 positions, 6 degrees). Interpretation was made by three independent observers. Additional data were provided using clinical findings, ultrasonography, computed tomography and magnetic resonance imaging, laboratory analyses, and surgical or microbiological confirmation of infection. Results: There were eleven true-positive findings, seven true negative, two were false negative while one was false positive due to intestinal obstruction. Sensitivity was 79%, specificity 91%, positive predictive value 92%, negative predictive value 77% accuracy 84%. Conclusions: According to our results, scintigraphy with radiolabeled ciprofloxacin is a useful method for detection and assessment of exact localization of abdominal and gastrointestinal infections.
T2  - Hepato-gastroenterology
T1  - Detection of gastrointestinal and abdominal infections by, Tc-99m-ciprofloxacin
VL  - 52
IS  - 62
SP  - 491
EP  - 495
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2874
ER  - 

@article{
author = "Artiko, V and Davidovic, B and Nikolic, N and Petrović, M and Vlajkovic, M and Pesko, P and Knežević, S. and Dukić, V and Stefanovic, B and Tulic, C and Popovic, N and Milosavljevic, T and Obradović, V",
year = "2005",
abstract = "Background/Aims: The aim of the study is detection and evaluation of the abdominal and gastrointestinal; infective foci using Tc-99m-ciprofloxacin (Laboratory for radioactive isotopes, Vinca). Methodology: In total 21 patients with clinical suspicion on abdominal or gastrointestinal infection were investigated. In all the patients, planar liver/spleen scintigraphy was performed. Ciprofloxacin chloride (3.5mg) was mixed with 555MBq of Tc-99m in 3mL of physiological solution and incubated for 20 min. After slow i.v. injection in a cubital vein, dynamic acquisition (1 f/min) was performed during the first 60 min in the position of interest, followed by static acquisition (500 000 imp) anterior and posterior view, abdomen and pelvis after 1 h and 4 h in all patients. When necessary, additional scintigrams were acquired after 24h. In all the patients with negative or equivocal findings of planar scintigraphy, emission computerized tomography (SPECT) was performed (60 positions, 6 degrees). Interpretation was made by three independent observers. Additional data were provided using clinical findings, ultrasonography, computed tomography and magnetic resonance imaging, laboratory analyses, and surgical or microbiological confirmation of infection. Results: There were eleven true-positive findings, seven true negative, two were false negative while one was false positive due to intestinal obstruction. Sensitivity was 79%, specificity 91%, positive predictive value 92%, negative predictive value 77% accuracy 84%. Conclusions: According to our results, scintigraphy with radiolabeled ciprofloxacin is a useful method for detection and assessment of exact localization of abdominal and gastrointestinal infections.",
journal = "Hepato-gastroenterology",
title = "Detection of gastrointestinal and abdominal infections by, Tc-99m-ciprofloxacin",
volume = "52",
number = "62",
pages = "491-495",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2874"
}

Artiko, V., Davidovic, B., Nikolic, N., Petrović, M., Vlajkovic, M., Pesko, P., Knežević, S., Dukić, V., Stefanovic, B., Tulic, C., Popovic, N., Milosavljevic, T.,& Obradović, V.. (2005). Detection of gastrointestinal and abdominal infections by, Tc-99m-ciprofloxacin. in Hepato-gastroenterology, 52(62), 491-495.
https://hdl.handle.net/21.15107/rcub_vinar_2874

Artiko V, Davidovic B, Nikolic N, Petrović M, Vlajkovic M, Pesko P, Knežević S, Dukić V, Stefanovic B, Tulic C, Popovic N, Milosavljevic T, Obradović V. Detection of gastrointestinal and abdominal infections by, Tc-99m-ciprofloxacin. in Hepato-gastroenterology. 2005;52(62):491-495.
https://hdl.handle.net/21.15107/rcub_vinar_2874 .

Artiko, V, Davidovic, B, Nikolic, N, Petrović, M, Vlajkovic, M, Pesko, P, Knežević, S., Dukić, V, Stefanovic, B, Tulic, C, Popovic, N, Milosavljevic, T, Obradović, V, "Detection of gastrointestinal and abdominal infections by, Tc-99m-ciprofloxacin" in Hepato-gastroenterology, 52, no. 62 (2005):491-495,
https://hdl.handle.net/21.15107/rcub_vinar_2874 .

TY  - JOUR
AU  - Jovanović, Moma S.
AU  - Brborić, Jasmina
AU  - Vladimirov, Sote
AU  - Zmbova, B
AU  - Vuksanovic, LJ
AU  - Zivanov-Stakic, D
AU  - Obradović, V
PY  - 1999
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2246
AB  - A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging
VL  - 240
IS  - 1
SP  - 321
EP  - 324
DO  - 10.1007/BF02349171
ER  - 

@article{
author = "Jovanović, Moma S. and Brborić, Jasmina and Vladimirov, Sote and Zmbova, B and Vuksanovic, LJ and Zivanov-Stakic, D and Obradović, V",
year = "1999",
abstract = "A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging",
volume = "240",
number = "1",
pages = "321-324",
doi = "10.1007/BF02349171"
}

Jovanović, M. S., Brborić, J., Vladimirov, S., Zmbova, B., Vuksanovic, L., Zivanov-Stakic, D.,& Obradović, V.. (1999). New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry, 240(1), 321-324.
https://doi.org/10.1007/BF02349171

Jovanović MS, Brborić J, Vladimirov S, Zmbova B, Vuksanovic L, Zivanov-Stakic D, Obradović V. New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry. 1999;240(1):321-324.
doi:10.1007/BF02349171 .

Jovanović, Moma S., Brborić, Jasmina, Vladimirov, Sote, Zmbova, B, Vuksanovic, LJ, Zivanov-Stakic, D, Obradović, V, "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging" in Journal of Radioanalytical and Nuclear Chemistry, 240, no. 1 (1999):321-324,
https://doi.org/10.1007/BF02349171 . .