TY  - JOUR
AU  - Đorđević, Miloš
AU  - Fattori, Serena
AU  - Petringa, Giada
AU  - Ristić Fira, Aleksandra
AU  - Petrović, Ivan
AU  - Cuttone, Giacomo
AU  - Cirrone, G.A. Pablo
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12241
AB  - Purpose: The use of Monte Carlo (MC) simulations capable of reproducing radiobiological effects of ionising radiation on human cell lines is of great importance, especially for cases involving protons and heavier ion beams. In the latter, huge uncertainties can arise mainly related to the effects of the secondary particles produced in the beam-tissue interaction. This paper reports on a detailed MC study performed using Geant4-based approach on three cancer cell lines, the HTB-177, CRL-5876 and MCF-7, that were previously irradiated with therapeutic proton and carbon ion beams. Methods: A Geant4-based approach used jointly with analytical calculations has been developed to provide a more realistic estimation of the radiobiological damage produced by proton and carbon beams in tissues, reproducing available data obtained from in vitro cell irradiations. The MC “Hadrontherapy” Geant4 application and the Local Effect Model: LEM I, LEM II and LEM III coupled with the different numerical approaches: RapidRusso (RR) and RapidScholz (RS) were used in the study. Results: Experimental survival curves are compared with those evaluated using the highlighted Geant4 MC-based approach via chi-square statistical analysis, for the combinations of radiobiological models and numerical approaches, as outlined above. Conclusion: This study has presented a comparison of the survival data from MC simulations to experimental survival data for three cancer cell lines. An overall best level of agreement was obtained for the HTB-177 cells.
T2  - Physica Medica
T1  - Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams
VL  - 117
SP  - 103189
DO  - 10.1016/j.ejmp.2023.103189
ER  - 

@article{
author = "Đorđević, Miloš and Fattori, Serena and Petringa, Giada and Ristić Fira, Aleksandra and Petrović, Ivan and Cuttone, Giacomo and Cirrone, G.A. Pablo",
year = "2024",
abstract = "Purpose: The use of Monte Carlo (MC) simulations capable of reproducing radiobiological effects of ionising radiation on human cell lines is of great importance, especially for cases involving protons and heavier ion beams. In the latter, huge uncertainties can arise mainly related to the effects of the secondary particles produced in the beam-tissue interaction. This paper reports on a detailed MC study performed using Geant4-based approach on three cancer cell lines, the HTB-177, CRL-5876 and MCF-7, that were previously irradiated with therapeutic proton and carbon ion beams. Methods: A Geant4-based approach used jointly with analytical calculations has been developed to provide a more realistic estimation of the radiobiological damage produced by proton and carbon beams in tissues, reproducing available data obtained from in vitro cell irradiations. The MC “Hadrontherapy” Geant4 application and the Local Effect Model: LEM I, LEM II and LEM III coupled with the different numerical approaches: RapidRusso (RR) and RapidScholz (RS) were used in the study. Results: Experimental survival curves are compared with those evaluated using the highlighted Geant4 MC-based approach via chi-square statistical analysis, for the combinations of radiobiological models and numerical approaches, as outlined above. Conclusion: This study has presented a comparison of the survival data from MC simulations to experimental survival data for three cancer cell lines. An overall best level of agreement was obtained for the HTB-177 cells.",
journal = "Physica Medica",
title = "Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams",
volume = "117",
pages = "103189",
doi = "10.1016/j.ejmp.2023.103189"
}

Đorđević, M., Fattori, S., Petringa, G., Ristić Fira, A., Petrović, I., Cuttone, G.,& Cirrone, G.A. P.. (2024). Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams. in Physica Medica, 117, 103189.
https://doi.org/10.1016/j.ejmp.2023.103189

Đorđević M, Fattori S, Petringa G, Ristić Fira A, Petrović I, Cuttone G, Cirrone GP. Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams. in Physica Medica. 2024;117:103189.
doi:10.1016/j.ejmp.2023.103189 .

Đorđević, Miloš, Fattori, Serena, Petringa, Giada, Ristić Fira, Aleksandra, Petrović, Ivan, Cuttone, Giacomo, Cirrone, G.A. Pablo, "Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams" in Physica Medica, 117 (2024):103189,
https://doi.org/10.1016/j.ejmp.2023.103189 . .