TY  - JOUR
AU  - Rašić-Marković, Aleksandra
AU  - Hrnčić, Dragan
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Djuric, E.
AU  - Rankov-Petrovic, B.
AU  - Šušić, Veselinka
AU  - Stanojlović, Olivera
AU  - Đurić, Dragan M.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7114
AB  - The aim of the present study was to examine the effect of subchronic co-administration of folic acid (F) and L-arginine (A) on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone (H) induced seizures in adult rats. The activity of membrane ATPases in different brain regions were also investigated. Rats were treated with F, A, or vehicle for 15 days (regimen: F 5 mg/kg + A 500 mg/kg (F5A500); F 10 mg/kg + A 300 mg/kg (F10A300)). Seizures were elicited by convulsive dose of H (H, F5A500H, F10A300H) Subchronic supplementation with F and A did not affect seizure incidence, number of seizure episodes, and severity in F5A500H and F10A300H groups vs. H group. However, a tendency to increase latency and decrease the number of seizure episodes was noticed in the F10A300H group. EEG mean spectral power densities during ictal periods were significantly lower in F10A300H vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased in almost all examined structures in rats treated with F and A. We can conclude that subchronic supplementation with folic acid and L-arginine has an antiepileptic effect in DL homocysteine thiolactone induced epilepsy.
T2  - Canadian Journal of Physiology and Pharmacology
T1  - The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures
VL  - 94
IS  - 10
SP  - 1083
EP  - 1089
DO  - 10.1139/cjpp-2016-0076
ER  - 

@article{
author = "Rašić-Marković, Aleksandra and Hrnčić, Dragan and Krstić, Danijela Z. and Čolović, Mirjana B. and Djuric, E. and Rankov-Petrovic, B. and Šušić, Veselinka and Stanojlović, Olivera and Đurić, Dragan M.",
year = "2016",
abstract = "The aim of the present study was to examine the effect of subchronic co-administration of folic acid (F) and L-arginine (A) on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone (H) induced seizures in adult rats. The activity of membrane ATPases in different brain regions were also investigated. Rats were treated with F, A, or vehicle for 15 days (regimen: F 5 mg/kg + A 500 mg/kg (F5A500); F 10 mg/kg + A 300 mg/kg (F10A300)). Seizures were elicited by convulsive dose of H (H, F5A500H, F10A300H) Subchronic supplementation with F and A did not affect seizure incidence, number of seizure episodes, and severity in F5A500H and F10A300H groups vs. H group. However, a tendency to increase latency and decrease the number of seizure episodes was noticed in the F10A300H group. EEG mean spectral power densities during ictal periods were significantly lower in F10A300H vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased in almost all examined structures in rats treated with F and A. We can conclude that subchronic supplementation with folic acid and L-arginine has an antiepileptic effect in DL homocysteine thiolactone induced epilepsy.",
journal = "Canadian Journal of Physiology and Pharmacology",
title = "The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures",
volume = "94",
number = "10",
pages = "1083-1089",
doi = "10.1139/cjpp-2016-0076"
}

Rašić-Marković, A., Hrnčić, D., Krstić, D. Z., Čolović, M. B., Djuric, E., Rankov-Petrovic, B., Šušić, V., Stanojlović, O.,& Đurić, D. M.. (2016). The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures. in Canadian Journal of Physiology and Pharmacology, 94(10), 1083-1089.
https://doi.org/10.1139/cjpp-2016-0076

Rašić-Marković A, Hrnčić D, Krstić DZ, Čolović MB, Djuric E, Rankov-Petrovic B, Šušić V, Stanojlović O, Đurić DM. The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures. in Canadian Journal of Physiology and Pharmacology. 2016;94(10):1083-1089.
doi:10.1139/cjpp-2016-0076 .

Rašić-Marković, Aleksandra, Hrnčić, Dragan, Krstić, Danijela Z., Čolović, Mirjana B., Djuric, E., Rankov-Petrovic, B., Šušić, Veselinka, Stanojlović, Olivera, Đurić, Dragan M., "The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures" in Canadian Journal of Physiology and Pharmacology, 94, no. 10 (2016):1083-1089,
https://doi.org/10.1139/cjpp-2016-0076 . .

TY  - JOUR
AU  - Rašić-Marković, Aleksandra
AU  - Rankov-Petrović, B.
AU  - Hrnčić, Dragan
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Macut, Dj
AU  - Đurić, Dragan M.
AU  - Stanojlović, Olivera
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/619
AB  - Influence of folic acid on the CNS is still unclear. Folate has a neuroprotective effect, while on the other hand excess folate can exacerbate seizures in epileptics. The aim of the present study was to examine the effect of subchronic administration of folic acid on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone induced seizures in adult rats. The activity of Na+/K+-ATPase and Mg2+-ATPase in different brain regions was investigated. Adult male Wistar rats were divided into groups: 1. Controls (C, 0.9% NaCl); 2. DL homocysteine-thiolactone 8.0 mmol/kg (H); 3. Subchronic supplementation with folic acid 5 mg/kg for 7 days (F) and 4. Subchronic supplementation with F + single dose of H (FH). Seizure behaviour was assessed by incidence, latency, number and intensity of seizure episodes. Seizure severity was described by a descriptive scale with grades 0-4. For EEG recordings, three gold-plated recording electrodes were implanted into the skull. Subchronic supplementation with folic acid did not affect seizure incidence, median number of seizure episodes and severity in FH, comparison with H (p GT 0.05). The majority of seizure episodes in all groups were of grade 2. There were no significant differences in lethal outcomes at 24 h upon H injection in the FH vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased in almost all examined structures in the FH vs. H group. Subchronic folic acid administration did not exacerbate H induced seizures and completely recovered the activity of ATPases.
T2  - Acta Physiologica Hungarica
T1  - The effect of subchronic supplementation with folic acid on homocysteine induced seizures
VL  - 102
IS  - 2
SP  - 151
EP  - 162
DO  - 10.1556/036.102.2015.2.6
ER  - 

@article{
author = "Rašić-Marković, Aleksandra and Rankov-Petrović, B. and Hrnčić, Dragan and Krstić, Danijela Z. and Čolović, Mirjana B. and Macut, Dj and Đurić, Dragan M. and Stanojlović, Olivera",
year = "2015",
abstract = "Influence of folic acid on the CNS is still unclear. Folate has a neuroprotective effect, while on the other hand excess folate can exacerbate seizures in epileptics. The aim of the present study was to examine the effect of subchronic administration of folic acid on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone induced seizures in adult rats. The activity of Na+/K+-ATPase and Mg2+-ATPase in different brain regions was investigated. Adult male Wistar rats were divided into groups: 1. Controls (C, 0.9% NaCl); 2. DL homocysteine-thiolactone 8.0 mmol/kg (H); 3. Subchronic supplementation with folic acid 5 mg/kg for 7 days (F) and 4. Subchronic supplementation with F + single dose of H (FH). Seizure behaviour was assessed by incidence, latency, number and intensity of seizure episodes. Seizure severity was described by a descriptive scale with grades 0-4. For EEG recordings, three gold-plated recording electrodes were implanted into the skull. Subchronic supplementation with folic acid did not affect seizure incidence, median number of seizure episodes and severity in FH, comparison with H (p GT 0.05). The majority of seizure episodes in all groups were of grade 2. There were no significant differences in lethal outcomes at 24 h upon H injection in the FH vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased in almost all examined structures in the FH vs. H group. Subchronic folic acid administration did not exacerbate H induced seizures and completely recovered the activity of ATPases.",
journal = "Acta Physiologica Hungarica",
title = "The effect of subchronic supplementation with folic acid on homocysteine induced seizures",
volume = "102",
number = "2",
pages = "151-162",
doi = "10.1556/036.102.2015.2.6"
}

Rašić-Marković, A., Rankov-Petrović, B., Hrnčić, D., Krstić, D. Z., Čolović, M. B., Macut, D., Đurić, D. M.,& Stanojlović, O.. (2015). The effect of subchronic supplementation with folic acid on homocysteine induced seizures. in Acta Physiologica Hungarica, 102(2), 151-162.
https://doi.org/10.1556/036.102.2015.2.6

Rašić-Marković A, Rankov-Petrović B, Hrnčić D, Krstić DZ, Čolović MB, Macut D, Đurić DM, Stanojlović O. The effect of subchronic supplementation with folic acid on homocysteine induced seizures. in Acta Physiologica Hungarica. 2015;102(2):151-162.
doi:10.1556/036.102.2015.2.6 .

Rašić-Marković, Aleksandra, Rankov-Petrović, B., Hrnčić, Dragan, Krstić, Danijela Z., Čolović, Mirjana B., Macut, Dj, Đurić, Dragan M., Stanojlović, Olivera, "The effect of subchronic supplementation with folic acid on homocysteine induced seizures" in Acta Physiologica Hungarica, 102, no. 2 (2015):151-162,
https://doi.org/10.1556/036.102.2015.2.6 . .

TY  - JOUR
AU  - Hrnčić, Dragan
AU  - Rašić-Marković, Aleksandra
AU  - Lekovic, J.
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Macut, D.
AU  - Šušić, Veselinka
AU  - Đurić, Dragan M.
AU  - Stanojlović, Olivera
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6049
AB  - The aim of the study was to examine the effects of chronic exercise training on seizures induced by homocysteine thiolactone (HCT) in adult rats. Rats were assigned to: sedentary control; exercise control; sedentary +HCT; exercise + HCT group. Animals in the exercise groups ran 30 min daily on a treadmill for 30 consecutive days (belt speed 20 m/min), while sedentary rats spent the same time on the treadmill (speed 0 m/min). On the 31st day, the HCT groups received HCT (8.0 mmol/kg), while the control groups received vehicle. Afterwards, convulsive behavior and EEG activity were registered. Lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) activity were ascertained in the rat hippocampus. No signs of seizures were registered in sedentary and exercise control rats. Seizure latency was increased, while number of seizure episodes and spike-and-wave discharges (SWD) in EEG were decreased in the exercise + HCT compared to the sedentary +HCT group. Seizure incidence, the severity thereof and duration of SWDs were not significantly different between these groups. Exercise partly prevented increase of lipid peroxidation and decrease of the SOD and CAT activity after HCT administration. These results indicate beneficial effects of exercise in model of HCT induced seizures in rats, what could be, at least in part, a consequence of improved antioxidant enzymes activity.
T2  - International Journal of Sports Medicine
T1  - Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress
VL  - 35
IS  - 7
SP  - 544
EP  - 550
DO  - 10.1055/s-0033-1357162
ER  - 

@article{
author = "Hrnčić, Dragan and Rašić-Marković, Aleksandra and Lekovic, J. and Krstić, Danijela Z. and Čolović, Mirjana B. and Macut, D. and Šušić, Veselinka and Đurić, Dragan M. and Stanojlović, Olivera",
year = "2014",
abstract = "The aim of the study was to examine the effects of chronic exercise training on seizures induced by homocysteine thiolactone (HCT) in adult rats. Rats were assigned to: sedentary control; exercise control; sedentary +HCT; exercise + HCT group. Animals in the exercise groups ran 30 min daily on a treadmill for 30 consecutive days (belt speed 20 m/min), while sedentary rats spent the same time on the treadmill (speed 0 m/min). On the 31st day, the HCT groups received HCT (8.0 mmol/kg), while the control groups received vehicle. Afterwards, convulsive behavior and EEG activity were registered. Lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) activity were ascertained in the rat hippocampus. No signs of seizures were registered in sedentary and exercise control rats. Seizure latency was increased, while number of seizure episodes and spike-and-wave discharges (SWD) in EEG were decreased in the exercise + HCT compared to the sedentary +HCT group. Seizure incidence, the severity thereof and duration of SWDs were not significantly different between these groups. Exercise partly prevented increase of lipid peroxidation and decrease of the SOD and CAT activity after HCT administration. These results indicate beneficial effects of exercise in model of HCT induced seizures in rats, what could be, at least in part, a consequence of improved antioxidant enzymes activity.",
journal = "International Journal of Sports Medicine",
title = "Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress",
volume = "35",
number = "7",
pages = "544-550",
doi = "10.1055/s-0033-1357162"
}

Hrnčić, D., Rašić-Marković, A., Lekovic, J., Krstić, D. Z., Čolović, M. B., Macut, D., Šušić, V., Đurić, D. M.,& Stanojlović, O.. (2014). Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress. in International Journal of Sports Medicine, 35(7), 544-550.
https://doi.org/10.1055/s-0033-1357162

Hrnčić D, Rašić-Marković A, Lekovic J, Krstić DZ, Čolović MB, Macut D, Šušić V, Đurić DM, Stanojlović O. Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress. in International Journal of Sports Medicine. 2014;35(7):544-550.
doi:10.1055/s-0033-1357162 .

Hrnčić, Dragan, Rašić-Marković, Aleksandra, Lekovic, J., Krstić, Danijela Z., Čolović, Mirjana B., Macut, D., Šušić, Veselinka, Đurić, Dragan M., Stanojlović, Olivera, "Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress" in International Journal of Sports Medicine, 35, no. 7 (2014):544-550,
https://doi.org/10.1055/s-0033-1357162 . .

TY  - CONF
AU  - Đurić, Dragan M.
AU  - Stanojlović, Olivera
AU  - Hrnčić, Dragan
AU  - Puškaš, Nela
AU  - Rašić-Marković, Aleksandra
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Bjekić, J. M.
AU  - Grubač, Željko
AU  - Šutulović, Nikola
AU  - Šušić, Veselinka
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/72
PB  - Wiley
C3  - Acta Physiologica
T1  - Effects of methionine-enriched diet on the rat heart and aorta
VL  - 211
IS  - SI
SP  - 78
EP  - 78
DO  - 10.1111/apha.12362
ER  - 

@conference{
author = "Đurić, Dragan M. and Stanojlović, Olivera and Hrnčić, Dragan and Puškaš, Nela and Rašić-Marković, Aleksandra and Čolović, Mirjana B. and Krstić, Danijela Z. and Bjekić, J. M. and Grubač, Željko and Šutulović, Nikola and Šušić, Veselinka",
year = "2014",
publisher = "Wiley",
journal = "Acta Physiologica",
title = "Effects of methionine-enriched diet on the rat heart and aorta",
volume = "211",
number = "SI",
pages = "78-78",
doi = "10.1111/apha.12362"
}

Đurić, D. M., Stanojlović, O., Hrnčić, D., Puškaš, N., Rašić-Marković, A., Čolović, M. B., Krstić, D. Z., Bjekić, J. M., Grubač, Ž., Šutulović, N.,& Šušić, V.. (2014). Effects of methionine-enriched diet on the rat heart and aorta. in Acta Physiologica
Wiley., 211(SI), 78-78.
https://doi.org/10.1111/apha.12362

Đurić DM, Stanojlović O, Hrnčić D, Puškaš N, Rašić-Marković A, Čolović MB, Krstić DZ, Bjekić JM, Grubač Ž, Šutulović N, Šušić V. Effects of methionine-enriched diet on the rat heart and aorta. in Acta Physiologica. 2014;211(SI):78-78.
doi:10.1111/apha.12362 .

Đurić, Dragan M., Stanojlović, Olivera, Hrnčić, Dragan, Puškaš, Nela, Rašić-Marković, Aleksandra, Čolović, Mirjana B., Krstić, Danijela Z., Bjekić, J. M., Grubač, Željko, Šutulović, Nikola, Šušić, Veselinka, "Effects of methionine-enriched diet on the rat heart and aorta" in Acta Physiologica, 211, no. SI (2014):78-78,
https://doi.org/10.1111/apha.12362 . .

TY  - JOUR
AU  - Mladenovic, D.
AU  - Hrnčić, Dragan
AU  - Rašić-Marković, Aleksandra
AU  - Puškaš, Nela
AU  - Petrovic, S.
AU  - Stanojlović, Olivera
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5226
AB  - Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT 0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans.
T2  - Human and Experimental Toxicology
T1  - Spectral analysis of thioacetamide-induced electroencephalographic changes in rats
VL  - 32
IS  - 1
SP  - 90
EP  - 100
DO  - 10.1177/0960327112456312
ER  - 

@article{
author = "Mladenovic, D. and Hrnčić, Dragan and Rašić-Marković, Aleksandra and Puškaš, Nela and Petrovic, S. and Stanojlović, Olivera",
year = "2013",
abstract = "Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT 0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans.",
journal = "Human and Experimental Toxicology",
title = "Spectral analysis of thioacetamide-induced electroencephalographic changes in rats",
volume = "32",
number = "1",
pages = "90-100",
doi = "10.1177/0960327112456312"
}

Mladenovic, D., Hrnčić, D., Rašić-Marković, A., Puškaš, N., Petrovic, S.,& Stanojlović, O.. (2013). Spectral analysis of thioacetamide-induced electroencephalographic changes in rats. in Human and Experimental Toxicology, 32(1), 90-100.
https://doi.org/10.1177/0960327112456312

Mladenovic D, Hrnčić D, Rašić-Marković A, Puškaš N, Petrovic S, Stanojlović O. Spectral analysis of thioacetamide-induced electroencephalographic changes in rats. in Human and Experimental Toxicology. 2013;32(1):90-100.
doi:10.1177/0960327112456312 .

Mladenovic, D., Hrnčić, Dragan, Rašić-Marković, Aleksandra, Puškaš, Nela, Petrovic, S., Stanojlović, Olivera, "Spectral analysis of thioacetamide-induced electroencephalographic changes in rats" in Human and Experimental Toxicology, 32, no. 1 (2013):90-100,
https://doi.org/10.1177/0960327112456312 . .