TY  - JOUR
AU  - Nilsson, Robert
AU  - Antic, Ruza
AU  - Berni, Andrea
AU  - Dallner, Gustav
AU  - Dettbarn, Gerhard
AU  - Gromadzinska, Jolanta
AU  - Joksić, Gordana
AU  - Lundin, Cecilia
AU  - Palitti, Fabrizio
AU  - Prochazka, Gabriela
AU  - Rydzynski, Konrad
AU  - Segerback, Dan
AU  - Soucek, Pavel
AU  - Tekle, Michael
AU  - Seidel, Albrecht
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5310
AB  - Exposure of the general population to polycyclic aromatic hydrocarbons (PAH) is ubiquitous. The aim of this study was to analyze biomarkers associated with the uptake of PAH in 428 non-smoking women from Lodz (Poland), Viterbo (Italy), Belgrade (Serbia) and from the Pancevo area, where the petrochemical complex was destroyed by the air raids in 1999. Urinary excretion of PAH metabolites was lowest in Italian women, intermediary for Serbian and highest in Polish women, who predominantly excreted hydroxy phenanthrenes as metabolites of phenanthrene. Bulky DNA adduct levels were highest in Italian and Polish women. Genotype or PAH ambient air levels could not explain the dissimilarities between the study groups with respect to biomarker patterns, which probably reflected differences in life style-associated factors.
T2  - Biomarkers
T1  - Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia and Italy - relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project)
VL  - 18
IS  - 2
SP  - 165
EP  - 173
DO  - 10.3109/1354750X.2012.762807
ER  - 

@article{
author = "Nilsson, Robert and Antic, Ruza and Berni, Andrea and Dallner, Gustav and Dettbarn, Gerhard and Gromadzinska, Jolanta and Joksić, Gordana and Lundin, Cecilia and Palitti, Fabrizio and Prochazka, Gabriela and Rydzynski, Konrad and Segerback, Dan and Soucek, Pavel and Tekle, Michael and Seidel, Albrecht",
year = "2013",
abstract = "Exposure of the general population to polycyclic aromatic hydrocarbons (PAH) is ubiquitous. The aim of this study was to analyze biomarkers associated with the uptake of PAH in 428 non-smoking women from Lodz (Poland), Viterbo (Italy), Belgrade (Serbia) and from the Pancevo area, where the petrochemical complex was destroyed by the air raids in 1999. Urinary excretion of PAH metabolites was lowest in Italian women, intermediary for Serbian and highest in Polish women, who predominantly excreted hydroxy phenanthrenes as metabolites of phenanthrene. Bulky DNA adduct levels were highest in Italian and Polish women. Genotype or PAH ambient air levels could not explain the dissimilarities between the study groups with respect to biomarker patterns, which probably reflected differences in life style-associated factors.",
journal = "Biomarkers",
title = "Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia and Italy - relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project)",
volume = "18",
number = "2",
pages = "165-173",
doi = "10.3109/1354750X.2012.762807"
}

Nilsson, R., Antic, R., Berni, A., Dallner, G., Dettbarn, G., Gromadzinska, J., Joksić, G., Lundin, C., Palitti, F., Prochazka, G., Rydzynski, K., Segerback, D., Soucek, P., Tekle, M.,& Seidel, A.. (2013). Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia and Italy - relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project). in Biomarkers, 18(2), 165-173.
https://doi.org/10.3109/1354750X.2012.762807

Nilsson R, Antic R, Berni A, Dallner G, Dettbarn G, Gromadzinska J, Joksić G, Lundin C, Palitti F, Prochazka G, Rydzynski K, Segerback D, Soucek P, Tekle M, Seidel A. Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia and Italy - relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project). in Biomarkers. 2013;18(2):165-173.
doi:10.3109/1354750X.2012.762807 .

Nilsson, Robert, Antic, Ruza, Berni, Andrea, Dallner, Gustav, Dettbarn, Gerhard, Gromadzinska, Jolanta, Joksić, Gordana, Lundin, Cecilia, Palitti, Fabrizio, Prochazka, Gabriela, Rydzynski, Konrad, Segerback, Dan, Soucek, Pavel, Tekle, Michael, Seidel, Albrecht, "Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia and Italy - relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project)" in Biomarkers, 18, no. 2 (2013):165-173,
https://doi.org/10.3109/1354750X.2012.762807 . .

TY  - JOUR
AU  - Joksić, Gordana
AU  - Spasojević-Tišma, Vera D.
AU  - Antic, Ruza
AU  - Nilsson, Robert
AU  - Rutqvist, Lars Erik
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4346
AB  - Background: Epidemiological studies suggest that smokeless tobacco in the form of Swedish snus has been used by many smokers in Scandinavia to quit smoking, but the efficacy of snus has so far not been evaluated in controlled clinical trials. Methods: We conducted a randomized, double-blind, placebo-controlled, clinical trial aimed at assessing the efficacy of snus to help adult cigarette smokers in Serbia to substantially reduce, and, eventually, completely stop smoking. The study enrolled 319 healthy smokers aged 20-65 years at two occupational health centers in Belgrade, Serbia. Most of them (81%) expressed an interest to quit rather than just reduce their smoking. Study products were used ad libitum throughout the 48-week study period. The main study objective during the first 24 weeks was smoking reduction. The primary end-point was defined as a biologically verified reduction of GT = 50% in the average number of smoked cigarettes per day during week 21-24 compared to baseline. During week 25-48 participants were actively instructed to stop smoking completely. Outcome measures of biologically verified, complete smoking cessation included 1-week point prevalence rates at clinical visits after 12, 24, 36, and 48 weeks, as well as 4-, 12- and 24-week continued cessation rates at the week 36 and 48 visits. Results: At the week 24 visit, the proportion of participants who achieved the protocol definition of a GT = 50% smoking reduction was similar in the two treatment groups. However, the proportion that reported more extreme reductions ( GT = 75%) was statistically significantly higher in the snus group than in the placebo group (p LT 0.01). The results for biologically verified complete cessation suggested that participants in the snus group were more likely to quit smoking completely than the controls; the odds ratio (snus versus placebo) for the protocol estimates of cessation varied between 1.9 to 3.4, but these ratios were of borderline significance with p-values ranging from 0.04-0.10. Snus was well tolerated and only 2/158 (1.3%) participants in the snus group discontinued treatment due to an adverse event (in both cases unrelated to snus). Conclusions: Swedish snus could promote smoking cessation among smokers in Serbia, that is, in a cultural setting without traditional use of oral, smokeless tobacco.
T2  - Harm Reduction Journal
T1  - Randomized, placebo-controlled, double-blind trial of Swedish snus for smoking reduction and cessation
VL  - 8
DO  - 10.1186/1477-7517-8-25
ER  - 

@article{
author = "Joksić, Gordana and Spasojević-Tišma, Vera D. and Antic, Ruza and Nilsson, Robert and Rutqvist, Lars Erik",
year = "2011",
abstract = "Background: Epidemiological studies suggest that smokeless tobacco in the form of Swedish snus has been used by many smokers in Scandinavia to quit smoking, but the efficacy of snus has so far not been evaluated in controlled clinical trials. Methods: We conducted a randomized, double-blind, placebo-controlled, clinical trial aimed at assessing the efficacy of snus to help adult cigarette smokers in Serbia to substantially reduce, and, eventually, completely stop smoking. The study enrolled 319 healthy smokers aged 20-65 years at two occupational health centers in Belgrade, Serbia. Most of them (81%) expressed an interest to quit rather than just reduce their smoking. Study products were used ad libitum throughout the 48-week study period. The main study objective during the first 24 weeks was smoking reduction. The primary end-point was defined as a biologically verified reduction of GT = 50% in the average number of smoked cigarettes per day during week 21-24 compared to baseline. During week 25-48 participants were actively instructed to stop smoking completely. Outcome measures of biologically verified, complete smoking cessation included 1-week point prevalence rates at clinical visits after 12, 24, 36, and 48 weeks, as well as 4-, 12- and 24-week continued cessation rates at the week 36 and 48 visits. Results: At the week 24 visit, the proportion of participants who achieved the protocol definition of a GT = 50% smoking reduction was similar in the two treatment groups. However, the proportion that reported more extreme reductions ( GT = 75%) was statistically significantly higher in the snus group than in the placebo group (p LT 0.01). The results for biologically verified complete cessation suggested that participants in the snus group were more likely to quit smoking completely than the controls; the odds ratio (snus versus placebo) for the protocol estimates of cessation varied between 1.9 to 3.4, but these ratios were of borderline significance with p-values ranging from 0.04-0.10. Snus was well tolerated and only 2/158 (1.3%) participants in the snus group discontinued treatment due to an adverse event (in both cases unrelated to snus). Conclusions: Swedish snus could promote smoking cessation among smokers in Serbia, that is, in a cultural setting without traditional use of oral, smokeless tobacco.",
journal = "Harm Reduction Journal",
title = "Randomized, placebo-controlled, double-blind trial of Swedish snus for smoking reduction and cessation",
volume = "8",
doi = "10.1186/1477-7517-8-25"
}

Joksić, G., Spasojević-Tišma, V. D., Antic, R., Nilsson, R.,& Rutqvist, L. E.. (2011). Randomized, placebo-controlled, double-blind trial of Swedish snus for smoking reduction and cessation. in Harm Reduction Journal, 8.
https://doi.org/10.1186/1477-7517-8-25

Joksić G, Spasojević-Tišma VD, Antic R, Nilsson R, Rutqvist LE. Randomized, placebo-controlled, double-blind trial of Swedish snus for smoking reduction and cessation. in Harm Reduction Journal. 2011;8.
doi:10.1186/1477-7517-8-25 .

Joksić, Gordana, Spasojević-Tišma, Vera D., Antic, Ruza, Nilsson, Robert, Rutqvist, Lars Erik, "Randomized, placebo-controlled, double-blind trial of Swedish snus for smoking reduction and cessation" in Harm Reduction Journal, 8 (2011),
https://doi.org/10.1186/1477-7517-8-25 . .