TY  - JOUR
AU  - Jovanović-Ćupić, Snežana P.
AU  - Simonovic-Babic, Jasmina
AU  - Blagojevic, Jelena
AU  - Božić, Milena
AU  - Ješić, Rada
AU  - Nozic, D.
AU  - Stamenković, Gorana
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3752
AB  - Different types of interferon are widely used to treat hepatitis C virus (HCV) infection. Results obtained in vitro suggest that interferon inhibits internal ribosome entry site (IRES)-mediated translation of the HCV genome. To elucidate the possible effect of the nucleotide sequence of IRES on therapy outcome, we compared HCV isolates from patients with sustained response and non-response to interferon/ribavirin combination therapy. In 56 analyzed HCV isolates, nucleotide changes appeared strictly in the stem-loop IIIb region, the stem part from 243 nt to 248 nt, and the polypyrimidine-II region. The natural sequence variability of IRES in isolates of genotype 3a was significantly higher than in isolates of genotype 1b (p LT 0.05). The average number of nucleotide changes in genotype 3a correlated with response to therapy (p LT 0.05).
T2  - Archives of Biological Sciences
T1  - Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome
VL  - 61
IS  - 2
SP  - 205
EP  - 212
DO  - 10.2298/ABS0901205J
ER  - 

@article{
author = "Jovanović-Ćupić, Snežana P. and Simonovic-Babic, Jasmina and Blagojevic, Jelena and Božić, Milena and Ješić, Rada and Nozic, D. and Stamenković, Gorana",
year = "2009",
abstract = "Different types of interferon are widely used to treat hepatitis C virus (HCV) infection. Results obtained in vitro suggest that interferon inhibits internal ribosome entry site (IRES)-mediated translation of the HCV genome. To elucidate the possible effect of the nucleotide sequence of IRES on therapy outcome, we compared HCV isolates from patients with sustained response and non-response to interferon/ribavirin combination therapy. In 56 analyzed HCV isolates, nucleotide changes appeared strictly in the stem-loop IIIb region, the stem part from 243 nt to 248 nt, and the polypyrimidine-II region. The natural sequence variability of IRES in isolates of genotype 3a was significantly higher than in isolates of genotype 1b (p LT 0.05). The average number of nucleotide changes in genotype 3a correlated with response to therapy (p LT 0.05).",
journal = "Archives of Biological Sciences",
title = "Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome",
volume = "61",
number = "2",
pages = "205-212",
doi = "10.2298/ABS0901205J"
}

Jovanović-Ćupić, S. P., Simonovic-Babic, J., Blagojevic, J., Božić, M., Ješić, R., Nozic, D.,& Stamenković, G.. (2009). Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome. in Archives of Biological Sciences, 61(2), 205-212.
https://doi.org/10.2298/ABS0901205J

Jovanović-Ćupić SP, Simonovic-Babic J, Blagojevic J, Božić M, Ješić R, Nozic D, Stamenković G. Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome. in Archives of Biological Sciences. 2009;61(2):205-212.
doi:10.2298/ABS0901205J .

Jovanović-Ćupić, Snežana P., Simonovic-Babic, Jasmina, Blagojevic, Jelena, Božić, Milena, Ješić, Rada, Nozic, D., Stamenković, Gorana, "Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome" in Archives of Biological Sciences, 61, no. 2 (2009):205-212,
https://doi.org/10.2298/ABS0901205J . .