TY  - JOUR
AU  - Nićiforović, Ana
AU  - Đorđević, Jelena D.
AU  - Adžić, Miroslav
AU  - Vučić, Vesna
AU  - Mitrasinovic, Petar M.
AU  - Radojčić, Marija
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3404
AB  - Molecular mechanisms for the gamma-ionizing radiation (IR) resistance of human prostate cancer cells, PC-3, are not quite clear. Since the low-LET-IR effects are primarily manifested by the generation of reactive oxygen species (ROS), the IR-induced expressions both of ROS-metabolizing antioxidant enzymes, such as Mn- and CuZn superoxide dismutases (SODs) and catalase (Cat), and of the transcriptional nuclear factor-kappaB (NF-kappa B) were explored. A substantial increase in the concentrations of SODs was observed in the cells irradiated by 10 and 20 Gy relative to those irradiated by 0 and 2 Gy, while the Cat and NF-kappa B expressions were found to be fairly stable. A system biology model was developed to shed more light on how MnSOD affects the biological state of cells depending upon the production of H2O2. By raising the initial presence of MnSOD in the 0.7-10 mu M concentration range, the time-dependent concentrations of H2O2 for various initial levels of MnSOD were contrasted. The radioresistance of PC-3 cells is suggested to be associated with the positive, feed-forward vicious circle established between the H2O2-mediated elevation of MnSOD expression.
T2  - Annals of Biomedical Engineering
T1  - Experimental and systems biology studies of the molecular basis for the radioresistance of prostate carcinoma cells
VL  - 36
IS  - 5
SP  - 831
EP  - 838
DO  - 10.1007/s10439-008-9457-4
ER  - 

@article{
author = "Nićiforović, Ana and Đorđević, Jelena D. and Adžić, Miroslav and Vučić, Vesna and Mitrasinovic, Petar M. and Radojčić, Marija",
year = "2008",
abstract = "Molecular mechanisms for the gamma-ionizing radiation (IR) resistance of human prostate cancer cells, PC-3, are not quite clear. Since the low-LET-IR effects are primarily manifested by the generation of reactive oxygen species (ROS), the IR-induced expressions both of ROS-metabolizing antioxidant enzymes, such as Mn- and CuZn superoxide dismutases (SODs) and catalase (Cat), and of the transcriptional nuclear factor-kappaB (NF-kappa B) were explored. A substantial increase in the concentrations of SODs was observed in the cells irradiated by 10 and 20 Gy relative to those irradiated by 0 and 2 Gy, while the Cat and NF-kappa B expressions were found to be fairly stable. A system biology model was developed to shed more light on how MnSOD affects the biological state of cells depending upon the production of H2O2. By raising the initial presence of MnSOD in the 0.7-10 mu M concentration range, the time-dependent concentrations of H2O2 for various initial levels of MnSOD were contrasted. The radioresistance of PC-3 cells is suggested to be associated with the positive, feed-forward vicious circle established between the H2O2-mediated elevation of MnSOD expression.",
journal = "Annals of Biomedical Engineering",
title = "Experimental and systems biology studies of the molecular basis for the radioresistance of prostate carcinoma cells",
volume = "36",
number = "5",
pages = "831-838",
doi = "10.1007/s10439-008-9457-4"
}

Nićiforović, A., Đorđević, J. D., Adžić, M., Vučić, V., Mitrasinovic, P. M.,& Radojčić, M.. (2008). Experimental and systems biology studies of the molecular basis for the radioresistance of prostate carcinoma cells. in Annals of Biomedical Engineering, 36(5), 831-838.
https://doi.org/10.1007/s10439-008-9457-4

Nićiforović A, Đorđević JD, Adžić M, Vučić V, Mitrasinovic PM, Radojčić M. Experimental and systems biology studies of the molecular basis for the radioresistance of prostate carcinoma cells. in Annals of Biomedical Engineering. 2008;36(5):831-838.
doi:10.1007/s10439-008-9457-4 .

Nićiforović, Ana, Đorđević, Jelena D., Adžić, Miroslav, Vučić, Vesna, Mitrasinovic, Petar M., Radojčić, Marija, "Experimental and systems biology studies of the molecular basis for the radioresistance of prostate carcinoma cells" in Annals of Biomedical Engineering, 36, no. 5 (2008):831-838,
https://doi.org/10.1007/s10439-008-9457-4 . .

TY  - CONF
AU  - Nićiforović, Ana
AU  - Đorđević, Jelena D.
AU  - Adžić, Miroslav
AU  - Vučić, Vesna
AU  - Mitrasinovic, Petar M.
AU  - Radojčić, Marija
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6410
C3  - Abstracts of Papers of the American Chemical Society
T1  - MEDI 314-Experimental and systems biology studies of the radioresistance of prostate carcinoma cells
VL  - 234
UR  - https://hdl.handle.net/21.15107/rcub_vinar_6410
ER  - 

@conference{
author = "Nićiforović, Ana and Đorđević, Jelena D. and Adžić, Miroslav and Vučić, Vesna and Mitrasinovic, Petar M. and Radojčić, Marija",
year = "2007",
journal = "Abstracts of Papers of the American Chemical Society",
title = "MEDI 314-Experimental and systems biology studies of the radioresistance of prostate carcinoma cells",
volume = "234",
url = "https://hdl.handle.net/21.15107/rcub_vinar_6410"
}

Nićiforović, A., Đorđević, J. D., Adžić, M., Vučić, V., Mitrasinovic, P. M.,& Radojčić, M.. (2007). MEDI 314-Experimental and systems biology studies of the radioresistance of prostate carcinoma cells. in Abstracts of Papers of the American Chemical Society, 234.
https://hdl.handle.net/21.15107/rcub_vinar_6410

Nićiforović A, Đorđević JD, Adžić M, Vučić V, Mitrasinovic PM, Radojčić M. MEDI 314-Experimental and systems biology studies of the radioresistance of prostate carcinoma cells. in Abstracts of Papers of the American Chemical Society. 2007;234.
https://hdl.handle.net/21.15107/rcub_vinar_6410 .

Nićiforović, Ana, Đorđević, Jelena D., Adžić, Miroslav, Vučić, Vesna, Mitrasinovic, Petar M., Radojčić, Marija, "MEDI 314-Experimental and systems biology studies of the radioresistance of prostate carcinoma cells" in Abstracts of Papers of the American Chemical Society, 234 (2007),
https://hdl.handle.net/21.15107/rcub_vinar_6410 .

TY  - CONF
AU  - Nićiforović, Ana
AU  - Đorđević, Jelena D.
AU  - Adžić, Miroslav
AU  - Vučić, Vesna
AU  - Mitrasinovic, Petar M.
AU  - Radojčić, Marija
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6409
C3  - Abstracts of Papers of the American Chemical Society
T1  - BIOL 165-A kinetic study of the radioresistance of prostate carcinoma cells
VL  - 234
UR  - https://hdl.handle.net/21.15107/rcub_vinar_6409
ER  - 

@conference{
author = "Nićiforović, Ana and Đorđević, Jelena D. and Adžić, Miroslav and Vučić, Vesna and Mitrasinovic, Petar M. and Radojčić, Marija",
year = "2007",
journal = "Abstracts of Papers of the American Chemical Society",
title = "BIOL 165-A kinetic study of the radioresistance of prostate carcinoma cells",
volume = "234",
url = "https://hdl.handle.net/21.15107/rcub_vinar_6409"
}

Nićiforović, A., Đorđević, J. D., Adžić, M., Vučić, V., Mitrasinovic, P. M.,& Radojčić, M.. (2007). BIOL 165-A kinetic study of the radioresistance of prostate carcinoma cells. in Abstracts of Papers of the American Chemical Society, 234.
https://hdl.handle.net/21.15107/rcub_vinar_6409

Nićiforović A, Đorđević JD, Adžić M, Vučić V, Mitrasinovic PM, Radojčić M. BIOL 165-A kinetic study of the radioresistance of prostate carcinoma cells. in Abstracts of Papers of the American Chemical Society. 2007;234.
https://hdl.handle.net/21.15107/rcub_vinar_6409 .

Nićiforović, Ana, Đorđević, Jelena D., Adžić, Miroslav, Vučić, Vesna, Mitrasinovic, Petar M., Radojčić, Marija, "BIOL 165-A kinetic study of the radioresistance of prostate carcinoma cells" in Abstracts of Papers of the American Chemical Society, 234 (2007),
https://hdl.handle.net/21.15107/rcub_vinar_6409 .