TY  - JOUR
AU  - Milanović, Zorana
AU  - Ilić Božović, Anja
AU  - Bojić-Trbojević, Žanka
AU  - Hajduković, Ljiljana
AU  - Francuski Andrić, Jelena
AU  - Kovačević Filipović, Milica
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12998
AB  - Acute B. canis infection can lead to an acute phase reaction (APR) in dogs. The parasite invades red blood cells causinganemia through immune-mediated hemolysis and possible erythropoietic suppression. A regenerative response of theerythroid lineage during the babesiosis has not been described in extension. This research examines hematologic parametersfocusing on the absolute reticulocyte count and apolipoprotein A I (ApoA I) level on the day of admission and 14 days aftertreatment with imidocarb-dipropionate in young (n=11) and adult (n=11) dogs naturally infected with B. canis. Metabolicand inflammatory processes were characterized by analyzing protein and lipid profiles, as well as ApoA I at specified timepoints. Automated analyzers were used to determine complete blood count and biochemical parameters, while ApoA I wasassessed using radioimmunoassay. The reticulocyte count was determined using a manual method by means of supravitalstaining. Both young and adult dogs with acute B. canis infection showed non-regenerative anemia without difference.Fourteen days after successful treatment with imidocarb-dipropionate, the anemia was corrected and a high reticulocytecount was observed (p<0.05). This indicates that the erythroid regenerative response was efficient in young and adult dogs,although vital signs, leukocyte count and triglyceride concentration suggest a more intense APR in young dogs. A decreasein ApoA I in both groups 14 days after treatment (p<0.01) confirmed that this lipoprotein acts as a positive acute-phaseprotein in acute B. canis infection in dogs, but further studies are needed to connect its role in erythroid lineage regeneration.
T2  - Macedonian Veterinary Review
T1  - Reticulocyte response in paired blood samples of Babesia canis infected young and adult dogs
VL  - 47
IS  - 1
SP  - i
EP  - ix
DO  - 10.2478/macvetrev-2024-0011
ER  - 

@article{
author = "Milanović, Zorana and Ilić Božović, Anja and Bojić-Trbojević, Žanka and Hajduković, Ljiljana and Francuski Andrić, Jelena and Kovačević Filipović, Milica",
year = "2024",
abstract = "Acute B. canis infection can lead to an acute phase reaction (APR) in dogs. The parasite invades red blood cells causinganemia through immune-mediated hemolysis and possible erythropoietic suppression. A regenerative response of theerythroid lineage during the babesiosis has not been described in extension. This research examines hematologic parametersfocusing on the absolute reticulocyte count and apolipoprotein A I (ApoA I) level on the day of admission and 14 days aftertreatment with imidocarb-dipropionate in young (n=11) and adult (n=11) dogs naturally infected with B. canis. Metabolicand inflammatory processes were characterized by analyzing protein and lipid profiles, as well as ApoA I at specified timepoints. Automated analyzers were used to determine complete blood count and biochemical parameters, while ApoA I wasassessed using radioimmunoassay. The reticulocyte count was determined using a manual method by means of supravitalstaining. Both young and adult dogs with acute B. canis infection showed non-regenerative anemia without difference.Fourteen days after successful treatment with imidocarb-dipropionate, the anemia was corrected and a high reticulocytecount was observed (p<0.05). This indicates that the erythroid regenerative response was efficient in young and adult dogs,although vital signs, leukocyte count and triglyceride concentration suggest a more intense APR in young dogs. A decreasein ApoA I in both groups 14 days after treatment (p<0.01) confirmed that this lipoprotein acts as a positive acute-phaseprotein in acute B. canis infection in dogs, but further studies are needed to connect its role in erythroid lineage regeneration.",
journal = "Macedonian Veterinary Review",
title = "Reticulocyte response in paired blood samples of Babesia canis infected young and adult dogs",
volume = "47",
number = "1",
pages = "i-ix",
doi = "10.2478/macvetrev-2024-0011"
}

Milanović, Z., Ilić Božović, A., Bojić-Trbojević, Ž., Hajduković, L., Francuski Andrić, J.,& Kovačević Filipović, M.. (2024). Reticulocyte response in paired blood samples of Babesia canis infected young and adult dogs. in Macedonian Veterinary Review, 47(1), i-ix.
https://doi.org/10.2478/macvetrev-2024-0011

Milanović Z, Ilić Božović A, Bojić-Trbojević Ž, Hajduković L, Francuski Andrić J, Kovačević Filipović M. Reticulocyte response in paired blood samples of Babesia canis infected young and adult dogs. in Macedonian Veterinary Review. 2024;47(1):i-ix.
doi:10.2478/macvetrev-2024-0011 .

Milanović, Zorana, Ilić Božović, Anja, Bojić-Trbojević, Žanka, Hajduković, Ljiljana, Francuski Andrić, Jelena, Kovačević Filipović, Milica, "Reticulocyte response in paired blood samples of Babesia canis infected young and adult dogs" in Macedonian Veterinary Review, 47, no. 1 (2024):i-ix,
https://doi.org/10.2478/macvetrev-2024-0011 . .