TY  - JOUR
AU  - Veljković, Nevena V.
AU  - Branch, DR
AU  - Metlaš, Radmila
AU  - Prljić, Jelena
AU  - Vlahovicek, K
AU  - Pongor, S
AU  - Veljković, Veljko
PY  - 2003
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2693
AB  - It has been reported that the C-terminus of the second conserved region (C2) of the envelope glycoprotein gp120, encompassing peptide RSANFTDNAKTIIVQLNESVEIN (NTM), is important for infectivity and neutralization of the human immunodeficiency virus type 1 (HIV-1). It was also demonstrated that human natural anti-vasoactive intestinal peptide (VIP) antibodies reactive with this gp120 region play an important role in control of HIV disease progression. The bioinformatic analysis based on the time-frequency signal processing revealed non-obvious similarities between NTM and VIP. When tested against a battery of sera from 46 AIDS patients, these peptides, in spite of a significant difference in their primary structures, showed a similar reactivity profiles (r = 0.83). Presented results point out that similarity in the periodical pattern of some physicochemical properties in primary structures of peptides plays a significant role in determination of their immunological crossreactivity. Based on these findings, we propose this bioinformatic criterion be used for design of VIP/NTM peptide mimetics for prevention and treatment of HIV disease.
T2  - Journal of Peptide Research
T1  - Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease
VL  - 62
IS  - 4
SP  - 158
EP  - 166
DO  - 10.1034/j.1399-3011.2003.00081.x
ER  - 

@article{
author = "Veljković, Nevena V. and Branch, DR and Metlaš, Radmila and Prljić, Jelena and Vlahovicek, K and Pongor, S and Veljković, Veljko",
year = "2003",
abstract = "It has been reported that the C-terminus of the second conserved region (C2) of the envelope glycoprotein gp120, encompassing peptide RSANFTDNAKTIIVQLNESVEIN (NTM), is important for infectivity and neutralization of the human immunodeficiency virus type 1 (HIV-1). It was also demonstrated that human natural anti-vasoactive intestinal peptide (VIP) antibodies reactive with this gp120 region play an important role in control of HIV disease progression. The bioinformatic analysis based on the time-frequency signal processing revealed non-obvious similarities between NTM and VIP. When tested against a battery of sera from 46 AIDS patients, these peptides, in spite of a significant difference in their primary structures, showed a similar reactivity profiles (r = 0.83). Presented results point out that similarity in the periodical pattern of some physicochemical properties in primary structures of peptides plays a significant role in determination of their immunological crossreactivity. Based on these findings, we propose this bioinformatic criterion be used for design of VIP/NTM peptide mimetics for prevention and treatment of HIV disease.",
journal = "Journal of Peptide Research",
title = "Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease",
volume = "62",
number = "4",
pages = "158-166",
doi = "10.1034/j.1399-3011.2003.00081.x"
}

Veljković, N. V., Branch, D., Metlaš, R., Prljić, J., Vlahovicek, K., Pongor, S.,& Veljković, V.. (2003). Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease. in Journal of Peptide Research, 62(4), 158-166.
https://doi.org/10.1034/j.1399-3011.2003.00081.x

Veljković NV, Branch D, Metlaš R, Prljić J, Vlahovicek K, Pongor S, Veljković V. Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease. in Journal of Peptide Research. 2003;62(4):158-166.
doi:10.1034/j.1399-3011.2003.00081.x .

Veljković, Nevena V., Branch, DR, Metlaš, Radmila, Prljić, Jelena, Vlahovicek, K, Pongor, S, Veljković, Veljko, "Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease" in Journal of Peptide Research, 62, no. 4 (2003):158-166,
https://doi.org/10.1034/j.1399-3011.2003.00081.x . .