TY  - CONF
AU  - Čolović, Mirjana B.
AU  - Vasić, Vesna M.
AU  - Avramović, Nataša
AU  - Đurić, Dragan M.
AU  - Krstić, Danijela Z.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9189
AB  - Toxic effects of diazinon and its degradation products, diazoxon and 2- isopropyl-6-methyl-4-pyrimidinol (IMP), were investigated in vitro by determining the inhibition of acetylcholinesterase (AChE), Na+ /K+ -ATPase and ecto-ATPase activity in rat brain synaptosomes after 1 hour exposure toward varying concentrations. Dose-dependent AChE and Na+ /K+ -ATPase inhibition was obtained in the presence of diazinon, while diazinon concentrations below 0.1 mM did not noticeably affect ecto-ATPase activity. Diazinon oxidation product, diazoxon was found as the most toxic investigated compound. Diazoxon induced dose-dependent and almost complete inhibition of AChE, Na+ /K+ -ATPase and ecto-ATPase at the highest investigated concentration (0.1 mM), while hydrolysis product of diazinon, IMP did not remarkably influence their activities.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
T1  - In vitro evaluation of diazinon and its degradation products neurotoxicity potential in rat brain synaptosomes
VL  - F-05-P
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9189
ER  - 

@conference{
author = "Čolović, Mirjana B. and Vasić, Vesna M. and Avramović, Nataša and Đurić, Dragan M. and Krstić, Danijela Z.",
year = "2014",
abstract = "Toxic effects of diazinon and its degradation products, diazoxon and 2- isopropyl-6-methyl-4-pyrimidinol (IMP), were investigated in vitro by determining the inhibition of acetylcholinesterase (AChE), Na+ /K+ -ATPase and ecto-ATPase activity in rat brain synaptosomes after 1 hour exposure toward varying concentrations. Dose-dependent AChE and Na+ /K+ -ATPase inhibition was obtained in the presence of diazinon, while diazinon concentrations below 0.1 mM did not noticeably affect ecto-ATPase activity. Diazinon oxidation product, diazoxon was found as the most toxic investigated compound. Diazoxon induced dose-dependent and almost complete inhibition of AChE, Na+ /K+ -ATPase and ecto-ATPase at the highest investigated concentration (0.1 mM), while hydrolysis product of diazinon, IMP did not remarkably influence their activities.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry",
title = "In vitro evaluation of diazinon and its degradation products neurotoxicity potential in rat brain synaptosomes",
volume = "F-05-P",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9189"
}

Čolović, M. B., Vasić, V. M., Avramović, N., Đurić, D. M.,& Krstić, D. Z.. (2014). In vitro evaluation of diazinon and its degradation products neurotoxicity potential in rat brain synaptosomes. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
Society of Physical Chemists of Serbia., F-05-P.
https://hdl.handle.net/21.15107/rcub_vinar_9189

Čolović MB, Vasić VM, Avramović N, Đurić DM, Krstić DZ. In vitro evaluation of diazinon and its degradation products neurotoxicity potential in rat brain synaptosomes. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;F-05-P.
https://hdl.handle.net/21.15107/rcub_vinar_9189 .

Čolović, Mirjana B., Vasić, Vesna M., Avramović, Nataša, Đurić, Dragan M., Krstić, Danijela Z., "In vitro evaluation of diazinon and its degradation products neurotoxicity potential in rat brain synaptosomes" in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, F-05-P (2014),
https://hdl.handle.net/21.15107/rcub_vinar_9189 .

TY  - CONF
AU  - Čolović, Mirjana B.
AU  - Vasić, Vesna M.
AU  - Avramović, Nataša
AU  - Đurić, Dragan M.
AU  - Krstić, Danijela Z.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9195
AB  - In vitro evaluation of oxidative stress responses to various concentrations of diazinon and its degradation products, diazoxon and 2-isopropyl-6-methyl- 4-pyrimidinol (IMP) was investigated by determining antioxidant enzymes activity (catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)) and lipid peroxidation level in rat brain synaptosomes. Diazinon showed negligible prooxidative properties causing increase in antioxidant enzymes activity and lipid peroxidation level up to 10%. Increasing concentrations of diazinon oxidation product, diazoxon activated CAT (up to 20%), SOD (up to 50%), GPx (up to 25%), and significantly increased the content of lipid peroxidation indicator (up to 50%). The investigated hydrolysis product of diazinon, IMP did not remarkably influence the activity of CAT, GPx and lipid peroxidation level (up to 10%), while it induced SOD stimulation up to 30%.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
T1  - The effects of diazinon and its degradation products on oxidative stress parameters in rat brain synaptosomes
VL  - F-24-P
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9195
ER  - 

@conference{
author = "Čolović, Mirjana B. and Vasić, Vesna M. and Avramović, Nataša and Đurić, Dragan M. and Krstić, Danijela Z.",
year = "2014",
abstract = "In vitro evaluation of oxidative stress responses to various concentrations of diazinon and its degradation products, diazoxon and 2-isopropyl-6-methyl- 4-pyrimidinol (IMP) was investigated by determining antioxidant enzymes activity (catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)) and lipid peroxidation level in rat brain synaptosomes. Diazinon showed negligible prooxidative properties causing increase in antioxidant enzymes activity and lipid peroxidation level up to 10%. Increasing concentrations of diazinon oxidation product, diazoxon activated CAT (up to 20%), SOD (up to 50%), GPx (up to 25%), and significantly increased the content of lipid peroxidation indicator (up to 50%). The investigated hydrolysis product of diazinon, IMP did not remarkably influence the activity of CAT, GPx and lipid peroxidation level (up to 10%), while it induced SOD stimulation up to 30%.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry",
title = "The effects of diazinon and its degradation products on oxidative stress parameters in rat brain synaptosomes",
volume = "F-24-P",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9195"
}

Čolović, M. B., Vasić, V. M., Avramović, N., Đurić, D. M.,& Krstić, D. Z.. (2014). The effects of diazinon and its degradation products on oxidative stress parameters in rat brain synaptosomes. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
Society of Physical Chemists of Serbia., F-24-P.
https://hdl.handle.net/21.15107/rcub_vinar_9195

Čolović MB, Vasić VM, Avramović N, Đurić DM, Krstić DZ. The effects of diazinon and its degradation products on oxidative stress parameters in rat brain synaptosomes. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;F-24-P.
https://hdl.handle.net/21.15107/rcub_vinar_9195 .

Čolović, Mirjana B., Vasić, Vesna M., Avramović, Nataša, Đurić, Dragan M., Krstić, Danijela Z., "The effects of diazinon and its degradation products on oxidative stress parameters in rat brain synaptosomes" in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, F-24-P (2014),
https://hdl.handle.net/21.15107/rcub_vinar_9195 .