TY  - CONF
AU  - Spasojević-Tišma, V.
AU  - Jeremić, M.
AU  - Pejić, Snežana
AU  - Drakulić, Dunja R.
AU  - Stanković, S.
AU  - Košutić, D.
AU  - Todorović, Ana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12865
AB  - BACKGROUND-AIM Differentiated thyroid cancer (DTC) is the most rapidly diagnosed cancer worldwide and the most frequent endocrinemalignancy, comprised of differentiated subtypes, specifically papillary and follicular thyroid cancer. Thyroidectomyis currently the preferred treatment for DTC. However, adjuvant therapy in the form of radioactive iodine (131I) is oftenadministered to reduce the risk of tumor recurrence and to facilitate future cancer surveillance. As 131I treatmentadditionally might upregulate oxidative stress regularly observed in thyroid cancer patients, the aim of our study wasto investigate the alterations in the levels of glutathione (GSH), superoxide anion (O2-), nitric oxide (NO) and activityof superoxide dismutase (SOD) in blood of DTC patients treated with 131I. METHODS All investigated parameters were determined with well-established spectrophotometric methods in blood samples ofthyroidectomized DTC patients obtained 0 (before), 3, 7 and 30 days after the 131I treatment. The treatment was orallyadministered once in the dose of 3.7 GBq. RESULTS Our results showed that, compared to the values before the therapy, SOD activity was significantly increased on the3th and 30th day after the 131I treatment alongwith the levels of GSH on 7th day. Other investigated oxidative stressindicators were unchanged. According to obtained data, in the blood of thyroidectomized DTC patients during the first30 days after the therapy, increased antioxidative capacity, reflected through upregulated SOD activity and GSH levels,might be sufficient to prevent the increase of O2- and NO and, in general, suppress the oxidative stress. CONCLUSIONS Our findings provide a better insight into individual antioxidant parameters fluctuations, thus contribute to a betterunderstanding of the redox mechanisms critical for 131I treatment outcomes, since an increase in the oxidative stressin the early stages of therapy can affect later health concerns and may represent a potential risk factor for cancerprogression in DTC patients.
PB  - Berlin ; Boston : Walter de Gruyter
C3  - Clinical chemistry and laboratory medicine
T1  - Oxidative Stress in Differentiated Thyroid Cancer Patients After Radioiodine Treatment
VL  - 61
IS  - Special Supplement
SP  - S1416
EP  - S1416
DO  - 10.1515/cclm-2023-7051
ER  - 

@conference{
author = "Spasojević-Tišma, V. and Jeremić, M. and Pejić, Snežana and Drakulić, Dunja R. and Stanković, S. and Košutić, D. and Todorović, Ana",
year = "2023",
abstract = "BACKGROUND-AIM Differentiated thyroid cancer (DTC) is the most rapidly diagnosed cancer worldwide and the most frequent endocrinemalignancy, comprised of differentiated subtypes, specifically papillary and follicular thyroid cancer. Thyroidectomyis currently the preferred treatment for DTC. However, adjuvant therapy in the form of radioactive iodine (131I) is oftenadministered to reduce the risk of tumor recurrence and to facilitate future cancer surveillance. As 131I treatmentadditionally might upregulate oxidative stress regularly observed in thyroid cancer patients, the aim of our study wasto investigate the alterations in the levels of glutathione (GSH), superoxide anion (O2-), nitric oxide (NO) and activityof superoxide dismutase (SOD) in blood of DTC patients treated with 131I. METHODS All investigated parameters were determined with well-established spectrophotometric methods in blood samples ofthyroidectomized DTC patients obtained 0 (before), 3, 7 and 30 days after the 131I treatment. The treatment was orallyadministered once in the dose of 3.7 GBq. RESULTS Our results showed that, compared to the values before the therapy, SOD activity was significantly increased on the3th and 30th day after the 131I treatment alongwith the levels of GSH on 7th day. Other investigated oxidative stressindicators were unchanged. According to obtained data, in the blood of thyroidectomized DTC patients during the first30 days after the therapy, increased antioxidative capacity, reflected through upregulated SOD activity and GSH levels,might be sufficient to prevent the increase of O2- and NO and, in general, suppress the oxidative stress. CONCLUSIONS Our findings provide a better insight into individual antioxidant parameters fluctuations, thus contribute to a betterunderstanding of the redox mechanisms critical for 131I treatment outcomes, since an increase in the oxidative stressin the early stages of therapy can affect later health concerns and may represent a potential risk factor for cancerprogression in DTC patients.",
publisher = "Berlin ; Boston : Walter de Gruyter",
journal = "Clinical chemistry and laboratory medicine",
title = "Oxidative Stress in Differentiated Thyroid Cancer Patients After Radioiodine Treatment",
volume = "61",
number = "Special Supplement",
pages = "S1416-S1416",
doi = "10.1515/cclm-2023-7051"
}

Spasojević-Tišma, V., Jeremić, M., Pejić, S., Drakulić, D. R., Stanković, S., Košutić, D.,& Todorović, A.. (2023). Oxidative Stress in Differentiated Thyroid Cancer Patients After Radioiodine Treatment. in Clinical chemistry and laboratory medicine
Berlin ; Boston : Walter de Gruyter., 61(Special Supplement), S1416-S1416.
https://doi.org/10.1515/cclm-2023-7051

Spasojević-Tišma V, Jeremić M, Pejić S, Drakulić DR, Stanković S, Košutić D, Todorović A. Oxidative Stress in Differentiated Thyroid Cancer Patients After Radioiodine Treatment. in Clinical chemistry and laboratory medicine. 2023;61(Special Supplement):S1416-S1416.
doi:10.1515/cclm-2023-7051 .

Spasojević-Tišma, V., Jeremić, M., Pejić, Snežana, Drakulić, Dunja R., Stanković, S., Košutić, D., Todorović, Ana, "Oxidative Stress in Differentiated Thyroid Cancer Patients After Radioiodine Treatment" in Clinical chemistry and laboratory medicine, 61, no. Special Supplement (2023):S1416-S1416,
https://doi.org/10.1515/cclm-2023-7051 . .

TY  - JOUR
AU  - Ciraj-Bjelac, Olivera
AU  - Kovačević, Milojko
AU  - Košutić, Duško D.
AU  - Stanković, Srboljub
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12155
AB  - X-rays are by far most significant contributor to total population dose from man-made sources of radiation. Diagnostic reference levels provide frameworks to reduce variability. The aim of this study is to establish, for the first time, a baseline for national diagnostic reference levels in Serbia for the most common X-ray examination types. Dose estimates are based on measurements of kerma-area product and Entrance surface air kerma for at least ten patients for each examination type, in each of 16 randomly selected hospitals in Serbia. Mean, median and third quartile values of patient doses are reported. Results have shown wide variation of mean hospital doses. Entrance surface doses were compared with previously published diagnostic reference levels. Doses for all studied examination types except chest radiography were within European DRL. The reasons for dose variation are discussed. The findings emphasize the importance of regular patient dose measurement to ensure that patient doses are kept as low as reasonable achievable.
AB  - Primena jonizuju}eg zračenja u dijagnostičkoj radiologiji je najznačajniji činilac u  ukupnom radijacionom optere}enju populacije. Dijagnostički referentni nivoi obezbedjuju  okvir za smanjenje varijabilnosti u ovoj oblasti. Cilj rada je da se odrede osnovne vrednosti  nacionalnih dijagnosti~kih referentnih nivoa u Srbiji za najfrekventnije procedure u konvencionalnoj   dijagnostičkoj radiologiji. Procena doza zasnovana je na merenju proizvoda kerme i površine (KAP) i   kerme na površini kože pacijenta (ESAK), za najmanje 10 pacijenata za svaku proceduru u 16 slučajno  odabranih bolnica u Srbiji. Odredjene srednje vrednosti pacijentnih doza, medijane i trećih kvartila   ukazuju na velike varijacije u izloženosti pacijenata u različitim bolnicama. Izmerene vrednosti ESAK   uporedjene su sa evropskim dijagnostičkim referentnim nivoima. Analizirani su uzroci varijacija pacijentnih  doza i mogućnosti za smanjenje radijacionog optere}enja populacije od dijagnostičke radiologije.  Rezultati ukazuju i na značaj redovnog merenja pacijentnih doza u dijagnostičkoj radiologiji.
T2  - Acta chirurgica Iugoslavica
T1  - Radijaciono opterećenje pacijenata u konvencionalnoj dijagnostičkoj radiologiji - analiza radiološke prakse u Srbiji
VL  - 54
IS  - 3
SP  - 93
EP  - 98
DO  - 10.2298/ACI0703093C
ER  - 

@article{
author = "Ciraj-Bjelac, Olivera and Kovačević, Milojko and Košutić, Duško D. and Stanković, Srboljub",
year = "2007",
abstract = "X-rays are by far most significant contributor to total population dose from man-made sources of radiation. Diagnostic reference levels provide frameworks to reduce variability. The aim of this study is to establish, for the first time, a baseline for national diagnostic reference levels in Serbia for the most common X-ray examination types. Dose estimates are based on measurements of kerma-area product and Entrance surface air kerma for at least ten patients for each examination type, in each of 16 randomly selected hospitals in Serbia. Mean, median and third quartile values of patient doses are reported. Results have shown wide variation of mean hospital doses. Entrance surface doses were compared with previously published diagnostic reference levels. Doses for all studied examination types except chest radiography were within European DRL. The reasons for dose variation are discussed. The findings emphasize the importance of regular patient dose measurement to ensure that patient doses are kept as low as reasonable achievable., Primena jonizuju}eg zračenja u dijagnostičkoj radiologiji je najznačajniji činilac u  ukupnom radijacionom optere}enju populacije. Dijagnostički referentni nivoi obezbedjuju  okvir za smanjenje varijabilnosti u ovoj oblasti. Cilj rada je da se odrede osnovne vrednosti  nacionalnih dijagnosti~kih referentnih nivoa u Srbiji za najfrekventnije procedure u konvencionalnoj   dijagnostičkoj radiologiji. Procena doza zasnovana je na merenju proizvoda kerme i površine (KAP) i   kerme na površini kože pacijenta (ESAK), za najmanje 10 pacijenata za svaku proceduru u 16 slučajno  odabranih bolnica u Srbiji. Odredjene srednje vrednosti pacijentnih doza, medijane i trećih kvartila   ukazuju na velike varijacije u izloženosti pacijenata u različitim bolnicama. Izmerene vrednosti ESAK   uporedjene su sa evropskim dijagnostičkim referentnim nivoima. Analizirani su uzroci varijacija pacijentnih  doza i mogućnosti za smanjenje radijacionog optere}enja populacije od dijagnostičke radiologije.  Rezultati ukazuju i na značaj redovnog merenja pacijentnih doza u dijagnostičkoj radiologiji.",
journal = "Acta chirurgica Iugoslavica",
title = "Radijaciono opterećenje pacijenata u konvencionalnoj dijagnostičkoj radiologiji - analiza radiološke prakse u Srbiji",
volume = "54",
number = "3",
pages = "93-98",
doi = "10.2298/ACI0703093C"
}

Ciraj-Bjelac, O., Kovačević, M., Košutić, D. D.,& Stanković, S.. (2007). Radijaciono opterećenje pacijenata u konvencionalnoj dijagnostičkoj radiologiji - analiza radiološke prakse u Srbiji. in Acta chirurgica Iugoslavica, 54(3), 93-98.
https://doi.org/10.2298/ACI0703093C

Ciraj-Bjelac O, Kovačević M, Košutić DD, Stanković S. Radijaciono opterećenje pacijenata u konvencionalnoj dijagnostičkoj radiologiji - analiza radiološke prakse u Srbiji. in Acta chirurgica Iugoslavica. 2007;54(3):93-98.
doi:10.2298/ACI0703093C .

Ciraj-Bjelac, Olivera, Kovačević, Milojko, Košutić, Duško D., Stanković, Srboljub, "Radijaciono opterećenje pacijenata u konvencionalnoj dijagnostičkoj radiologiji - analiza radiološke prakse u Srbiji" in Acta chirurgica Iugoslavica, 54, no. 3 (2007):93-98,
https://doi.org/10.2298/ACI0703093C . .