TY  - CONF
AU  - Nikolić, Nataša
AU  - Porobić, Slavica
AU  - Tadić, Julijana
AU  - Vujčić, Ivica
AU  - Kojić, Marija
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12230
AB  - Polymeric materials are widely used in the chemical and optical industries, the packaging materials industry, and biomedicine. New technologies and the search for innovative and sustainable solutions have contributed to the development of polymer sensors and smart materials. Poly(vinyl-alcohol) (PVA) is a thermoplastic polymer soluble in water. It belongs to the group of non-toxic and completely biodegradable polymers, with excellent thermal and mechanical properties. Polymer-colored films have great potential as sensor systems, primarily due to their visual color change, which makes them easy to use. Azo dyes, which are used for coloring polymer films, represent the most important class of synthetic dyes, and their exceptional properties are reflected in high extinction coefficients, as well as excellent fastness to light and wet processing. Traditionally, azo dyes are used in the food and cosmetic industries, and are also used as pH indicators. In this work, in addition to the synthesis of azo pyridone dyes, polymeric films were also synthesized. The first series of films were synthesized based on PVA and newly synthesized azo dyes, and the sensory properties of the new films were tested. The second series of films were synthesized in order to test the films as dosimeters for γ-radiation, and for this reason, TTC was added to their synthesis. The dye used in the experiments were characterized by ATR-FTIR, NMR and UV-Vis spectra. The chemical structure of the synthesized films was analyzed by ATR-FTIR spectroscopy. The sensory properties of the film were tested in solutions of different pH values, while the possibility for application in dosimetry was tested at different doses of γ-radiation at the 60Co source. Changes in the color of the films were monitored spectrophotometrically by recording reflection spectra.
PB  - Niš : RAD Centre
C3  - RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts
T1  - Sensory properties of new films based on poly(vinyl-alcohol) and pyridone azo dyes
SP  - 180
EP  - 180
DO  - 10.21175/rad.abstr.book.2023.32.10
ER  - 

@conference{
author = "Nikolić, Nataša and Porobić, Slavica and Tadić, Julijana and Vujčić, Ivica and Kojić, Marija and Lađarević, Jelena and Mijin, Dušan",
year = "2023",
abstract = "Polymeric materials are widely used in the chemical and optical industries, the packaging materials industry, and biomedicine. New technologies and the search for innovative and sustainable solutions have contributed to the development of polymer sensors and smart materials. Poly(vinyl-alcohol) (PVA) is a thermoplastic polymer soluble in water. It belongs to the group of non-toxic and completely biodegradable polymers, with excellent thermal and mechanical properties. Polymer-colored films have great potential as sensor systems, primarily due to their visual color change, which makes them easy to use. Azo dyes, which are used for coloring polymer films, represent the most important class of synthetic dyes, and their exceptional properties are reflected in high extinction coefficients, as well as excellent fastness to light and wet processing. Traditionally, azo dyes are used in the food and cosmetic industries, and are also used as pH indicators. In this work, in addition to the synthesis of azo pyridone dyes, polymeric films were also synthesized. The first series of films were synthesized based on PVA and newly synthesized azo dyes, and the sensory properties of the new films were tested. The second series of films were synthesized in order to test the films as dosimeters for γ-radiation, and for this reason, TTC was added to their synthesis. The dye used in the experiments were characterized by ATR-FTIR, NMR and UV-Vis spectra. The chemical structure of the synthesized films was analyzed by ATR-FTIR spectroscopy. The sensory properties of the film were tested in solutions of different pH values, while the possibility for application in dosimetry was tested at different doses of γ-radiation at the 60Co source. Changes in the color of the films were monitored spectrophotometrically by recording reflection spectra.",
publisher = "Niš : RAD Centre",
journal = "RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts",
title = "Sensory properties of new films based on poly(vinyl-alcohol) and pyridone azo dyes",
pages = "180-180",
doi = "10.21175/rad.abstr.book.2023.32.10"
}

Nikolić, N., Porobić, S., Tadić, J., Vujčić, I., Kojić, M., Lađarević, J.,& Mijin, D.. (2023). Sensory properties of new films based on poly(vinyl-alcohol) and pyridone azo dyes. in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts
Niš : RAD Centre., 180-180.
https://doi.org/10.21175/rad.abstr.book.2023.32.10

Nikolić N, Porobić S, Tadić J, Vujčić I, Kojić M, Lađarević J, Mijin D. Sensory properties of new films based on poly(vinyl-alcohol) and pyridone azo dyes. in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts. 2023;:180-180.
doi:10.21175/rad.abstr.book.2023.32.10 .

Nikolić, Nataša, Porobić, Slavica, Tadić, Julijana, Vujčić, Ivica, Kojić, Marija, Lađarević, Jelena, Mijin, Dušan, "Sensory properties of new films based on poly(vinyl-alcohol) and pyridone azo dyes" in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts (2023):180-180,
https://doi.org/10.21175/rad.abstr.book.2023.32.10 . .

TY  - JOUR
AU  - Tadić, Julijana D.
AU  - Lađarević, Jelena M.
AU  - Vitnik, Željko J.
AU  - Vitnik, Vesna D.
AU  - Stanojković, Tatjana P.
AU  - Matić, Ivana Z.
AU  - Mijin, Dušan Ž.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10890
AB  - Seven novel azo dyes with 2-pyridone and dihydropyrimidinone moieties have been synthesized and thoroughly characterized. The azo-hydrazone tautomerism has been investigated by experimental and theoretical approaches. The optimizations of geometries have been performed with density functional theory (DFT). The vibrational and NMR spectra were calculated and correlated with experimental ones. Furthermore, quantum chemical descriptors were calculated and MEP maps were plotted to determine biological reactivity of dyes. The antioxidant assay evinced that 5, 6 and 7 are promising antioxidant candidates. In vitro cytotoxic activity was studied against three malignant cell lines: prostate adenocarcinoma (PC-3), lung carcinoma (A549) and chronic myelogenous leukemia (K562), as well as against human normal lung fibroblasts (MRC-5), using MTT assay. Examination of cytotoxic effects on human cancer cell lines showed the concentration dependent cytotoxicity of all investigated compounds. The K562 cells were the most sensitive to the cytotoxicity of the compounds 3, 5 and 6, wherein compound 5 was particularly prominent and selective in cytotoxic action between K562 (24.97 μM) and PC-3 (48.98 μM) cancer cells, and normal MRC-5 (91.11 μM) cells. Moreover, the cell cycle analysis of compound 5 was examined in K562 cells, by flow cytometry, to study its mechanism of anticancer action. Finally, in silico evaluation of physicochemical parameters, druglikeness and ADME properties showed that investigated compounds are orally bioavailable with no permeation to the blood brain barrier.
T2  - Dyes and Pigments
T1  - Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity
VL  - 187
SP  - 109123
DO  - 10.1016/j.dyepig.2020.109123
ER  - 

@article{
author = "Tadić, Julijana D. and Lađarević, Jelena M. and Vitnik, Željko J. and Vitnik, Vesna D. and Stanojković, Tatjana P. and Matić, Ivana Z. and Mijin, Dušan Ž.",
year = "2021",
abstract = "Seven novel azo dyes with 2-pyridone and dihydropyrimidinone moieties have been synthesized and thoroughly characterized. The azo-hydrazone tautomerism has been investigated by experimental and theoretical approaches. The optimizations of geometries have been performed with density functional theory (DFT). The vibrational and NMR spectra were calculated and correlated with experimental ones. Furthermore, quantum chemical descriptors were calculated and MEP maps were plotted to determine biological reactivity of dyes. The antioxidant assay evinced that 5, 6 and 7 are promising antioxidant candidates. In vitro cytotoxic activity was studied against three malignant cell lines: prostate adenocarcinoma (PC-3), lung carcinoma (A549) and chronic myelogenous leukemia (K562), as well as against human normal lung fibroblasts (MRC-5), using MTT assay. Examination of cytotoxic effects on human cancer cell lines showed the concentration dependent cytotoxicity of all investigated compounds. The K562 cells were the most sensitive to the cytotoxicity of the compounds 3, 5 and 6, wherein compound 5 was particularly prominent and selective in cytotoxic action between K562 (24.97 μM) and PC-3 (48.98 μM) cancer cells, and normal MRC-5 (91.11 μM) cells. Moreover, the cell cycle analysis of compound 5 was examined in K562 cells, by flow cytometry, to study its mechanism of anticancer action. Finally, in silico evaluation of physicochemical parameters, druglikeness and ADME properties showed that investigated compounds are orally bioavailable with no permeation to the blood brain barrier.",
journal = "Dyes and Pigments",
title = "Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity",
volume = "187",
pages = "109123",
doi = "10.1016/j.dyepig.2020.109123"
}

Tadić, J. D., Lađarević, J. M., Vitnik, Ž. J., Vitnik, V. D., Stanojković, T. P., Matić, I. Z.,& Mijin, D. Ž.. (2021). Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity. in Dyes and Pigments, 187, 109123.
https://doi.org/10.1016/j.dyepig.2020.109123

Tadić JD, Lađarević JM, Vitnik ŽJ, Vitnik VD, Stanojković TP, Matić IZ, Mijin DŽ. Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity. in Dyes and Pigments. 2021;187:109123.
doi:10.1016/j.dyepig.2020.109123 .

Tadić, Julijana D., Lađarević, Jelena M., Vitnik, Željko J., Vitnik, Vesna D., Stanojković, Tatjana P., Matić, Ivana Z., Mijin, Dušan Ž., "Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity" in Dyes and Pigments, 187 (2021):109123,
https://doi.org/10.1016/j.dyepig.2020.109123 . .

TY  - CONF
AU  - Porobić, Slavica
AU  - Lađarević, Jelena
AU  - Kojić, Marija
AU  - Katnić, Đurica
AU  - Marinović-Cincović, Milena
AU  - Tadić, Julijana
AU  - Mijin, Dušan
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11426
AB  - A new heterocyclic azo dye 5-(2,6-dimethylphenyl)-6-hydroxy-4-methyl-2-oxo-1,2- dihydropyridine-3-carboxamide was synthesized and structurally characterized by elemental analysis, FTIR, 1H and 13C NMR spectroscopy techniques. These analysis have confirmed that synthesized dye exists in the tinctorial strongest tautomeric form, hydrazone form. The dye is characterized by reflection spectrum, while absorption and emisson spectra are recorded in nine different solvents. The antioxidant activity of the synthesized dye has been chemically tested and has been shown to have great potential as an antioxidant molecule.
PB  - Szeged : University of Szeged
C3  - 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
T1  - Optical and Antioxidative Properties of 5-(2,6-dimethylphenyl)- 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
SP  - 281
EP  - 285
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11426
ER  - 

@conference{
author = "Porobić, Slavica and Lađarević, Jelena and Kojić, Marija and Katnić, Đurica and Marinović-Cincović, Milena and Tadić, Julijana and Mijin, Dušan",
year = "2021",
abstract = "A new heterocyclic azo dye 5-(2,6-dimethylphenyl)-6-hydroxy-4-methyl-2-oxo-1,2- dihydropyridine-3-carboxamide was synthesized and structurally characterized by elemental analysis, FTIR, 1H and 13C NMR spectroscopy techniques. These analysis have confirmed that synthesized dye exists in the tinctorial strongest tautomeric form, hydrazone form. The dye is characterized by reflection spectrum, while absorption and emisson spectra are recorded in nine different solvents. The antioxidant activity of the synthesized dye has been chemically tested and has been shown to have great potential as an antioxidant molecule.",
publisher = "Szeged : University of Szeged",
journal = "27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary",
title = "Optical and Antioxidative Properties of 5-(2,6-dimethylphenyl)- 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide",
pages = "281-285",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11426"
}

Porobić, S., Lađarević, J., Kojić, M., Katnić, Đ., Marinović-Cincović, M., Tadić, J.,& Mijin, D.. (2021). Optical and Antioxidative Properties of 5-(2,6-dimethylphenyl)- 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
Szeged : University of Szeged., 281-285.
https://hdl.handle.net/21.15107/rcub_vinar_11426

Porobić S, Lađarević J, Kojić M, Katnić Đ, Marinović-Cincović M, Tadić J, Mijin D. Optical and Antioxidative Properties of 5-(2,6-dimethylphenyl)- 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary. 2021;:281-285.
https://hdl.handle.net/21.15107/rcub_vinar_11426 .

Porobić, Slavica, Lađarević, Jelena, Kojić, Marija, Katnić, Đurica, Marinović-Cincović, Milena, Tadić, Julijana, Mijin, Dušan, "Optical and Antioxidative Properties of 5-(2,6-dimethylphenyl)- 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide" in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary (2021):281-285,
https://hdl.handle.net/21.15107/rcub_vinar_11426 .

TY  - CONF
AU  - Tadić, Julijana
AU  - Janković, Nenad
AU  - Lađarević, Jelena
AU  - Porobić, Slavica
AU  - Kojić, Marija
AU  - Marinović-Cincović, Milena
AU  - Mijin, Dušan
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11428
AB  - Molecular imaging is a relatively new research field, which has demonstrated great potential, especially in clinical oncology – from drug development to cancer early detection. The key of fluorescence imaging is the construction of fluorescent probe which is composed of two parts, the recognition groups to recognize cancer cells, and fluorophores to signal the recognition events. In this research, the structure of new fluorescent azo dye based on 2-oxo-1,2,3,4-tetrahydropyrimidin and 2-pyridone moieties has been reported. The absorption and emission properties of the investigated azo dye have been studied using UV-Vis and fluorescence spectroscopy. The obtained results suggest that studied dye meets the requirements for new green-emitting fluorescent probe, suitable for further application in biomedical researches.
PB  - Szeged : University of Szeged
C3  - 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
T1  - 2-oxo-1,2,3,4-tetrahydropyrimidine-azo-pyridone Dye: A Potential Application as New Green-Emitting Fluorescent Probe
SP  - 324
EP  - 326
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11428
ER  - 

@conference{
author = "Tadić, Julijana and Janković, Nenad and Lađarević, Jelena and Porobić, Slavica and Kojić, Marija and Marinović-Cincović, Milena and Mijin, Dušan",
year = "2021",
abstract = "Molecular imaging is a relatively new research field, which has demonstrated great potential, especially in clinical oncology – from drug development to cancer early detection. The key of fluorescence imaging is the construction of fluorescent probe which is composed of two parts, the recognition groups to recognize cancer cells, and fluorophores to signal the recognition events. In this research, the structure of new fluorescent azo dye based on 2-oxo-1,2,3,4-tetrahydropyrimidin and 2-pyridone moieties has been reported. The absorption and emission properties of the investigated azo dye have been studied using UV-Vis and fluorescence spectroscopy. The obtained results suggest that studied dye meets the requirements for new green-emitting fluorescent probe, suitable for further application in biomedical researches.",
publisher = "Szeged : University of Szeged",
journal = "27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary",
title = "2-oxo-1,2,3,4-tetrahydropyrimidine-azo-pyridone Dye: A Potential Application as New Green-Emitting Fluorescent Probe",
pages = "324-326",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11428"
}

Tadić, J., Janković, N., Lađarević, J., Porobić, S., Kojić, M., Marinović-Cincović, M.,& Mijin, D.. (2021). 2-oxo-1,2,3,4-tetrahydropyrimidine-azo-pyridone Dye: A Potential Application as New Green-Emitting Fluorescent Probe. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
Szeged : University of Szeged., 324-326.
https://hdl.handle.net/21.15107/rcub_vinar_11428

Tadić J, Janković N, Lađarević J, Porobić S, Kojić M, Marinović-Cincović M, Mijin D. 2-oxo-1,2,3,4-tetrahydropyrimidine-azo-pyridone Dye: A Potential Application as New Green-Emitting Fluorescent Probe. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary. 2021;:324-326.
https://hdl.handle.net/21.15107/rcub_vinar_11428 .

Tadić, Julijana, Janković, Nenad, Lađarević, Jelena, Porobić, Slavica, Kojić, Marija, Marinović-Cincović, Milena, Mijin, Dušan, "2-oxo-1,2,3,4-tetrahydropyrimidine-azo-pyridone Dye: A Potential Application as New Green-Emitting Fluorescent Probe" in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary (2021):324-326,
https://hdl.handle.net/21.15107/rcub_vinar_11428 .