TY  - JOUR
AU  - Radisavljevic, Maja
AU  - Kamceva, Tina
AU  - Bugarčić, Živadin D.
AU  - Petković, Marijana
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5583
AB  - This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)(2) Cl-2, and [Pt(dach)Cl-2] on the activity of porcine pancreatic phospholipase A(2) (PLA(2)). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl-2] with PLA(2) could not be detected under our experimental conditions.
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2
VL  - 28
IS  - 4
SP  - 651
EP  - 660
DO  - 10.3109/14756366.2012.666539
ER  - 

@article{
author = "Radisavljevic, Maja and Kamceva, Tina and Bugarčić, Živadin D. and Petković, Marijana",
year = "2013",
abstract = "This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)(2) Cl-2, and [Pt(dach)Cl-2] on the activity of porcine pancreatic phospholipase A(2) (PLA(2)). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl-2] with PLA(2) could not be detected under our experimental conditions.",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2",
volume = "28",
number = "4",
pages = "651-660",
doi = "10.3109/14756366.2012.666539"
}

Radisavljevic, M., Kamceva, T., Bugarčić, Ž. D.,& Petković, M.. (2013). Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2. in Journal of Enzyme Inhibition and Medicinal Chemistry, 28(4), 651-660.
https://doi.org/10.3109/14756366.2012.666539

Radisavljevic M, Kamceva T, Bugarčić ŽD, Petković M. Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2013;28(4):651-660.
doi:10.3109/14756366.2012.666539 .

Radisavljevic, Maja, Kamceva, Tina, Bugarčić, Živadin D., Petković, Marijana, "Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2" in Journal of Enzyme Inhibition and Medicinal Chemistry, 28, no. 4 (2013):651-660,
https://doi.org/10.3109/14756366.2012.666539 . .

TY  - JOUR
AU  - Radisavljevic, Maja
AU  - Kamceva, Tina
AU  - Vukićević, Iva A.
AU  - Nišavić, Marija
AU  - Milovanović, Milan
AU  - Petković, Marijana
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5605
AB  - We compare the quality and reliability of laser desorption and ionisation mass spectra of FeCl3 acquired without the assistance of the matrix with the spectra acquired with different organic matrix molecules. Generally, inorganic salts tend to form clusters upon laser irradiation, the signals of which can be easily distinguished from ions arising from the matrix. In the presence of a matrix, cluster ions are, however, mostly suppressed. We have compared the number of analyte signals, accuracy of determination of isotope composition of the analyte and the sensitivity of FeCl3 detection between different approaches. The results obtained imply that the sensitivity of mass spectrometric analysis of FeCl3 is somewhat higher when matrices are applied than in the matrix-free approach. Among all matrices tested in this work, F20TPP seems to be the most promising for further applications as a matrix for mass spectrometry of inorganic salts.
T2  - European Journal of Mass Spectrometry
T1  - Sensitivity and accuracy of organic matrix-assisted Laser desorption and ionisation mass spectrometry of FeCl3 is higher than in in matrix-free approach
VL  - 19
IS  - 2
SP  - 77
EP  - 89
DO  - 10.1255/ejms.1217
ER  - 

@article{
author = "Radisavljevic, Maja and Kamceva, Tina and Vukićević, Iva A. and Nišavić, Marija and Milovanović, Milan and Petković, Marijana",
year = "2013",
abstract = "We compare the quality and reliability of laser desorption and ionisation mass spectra of FeCl3 acquired without the assistance of the matrix with the spectra acquired with different organic matrix molecules. Generally, inorganic salts tend to form clusters upon laser irradiation, the signals of which can be easily distinguished from ions arising from the matrix. In the presence of a matrix, cluster ions are, however, mostly suppressed. We have compared the number of analyte signals, accuracy of determination of isotope composition of the analyte and the sensitivity of FeCl3 detection between different approaches. The results obtained imply that the sensitivity of mass spectrometric analysis of FeCl3 is somewhat higher when matrices are applied than in the matrix-free approach. Among all matrices tested in this work, F20TPP seems to be the most promising for further applications as a matrix for mass spectrometry of inorganic salts.",
journal = "European Journal of Mass Spectrometry",
title = "Sensitivity and accuracy of organic matrix-assisted Laser desorption and ionisation mass spectrometry of FeCl3 is higher than in in matrix-free approach",
volume = "19",
number = "2",
pages = "77-89",
doi = "10.1255/ejms.1217"
}

Radisavljevic, M., Kamceva, T., Vukićević, I. A., Nišavić, M., Milovanović, M.,& Petković, M.. (2013). Sensitivity and accuracy of organic matrix-assisted Laser desorption and ionisation mass spectrometry of FeCl3 is higher than in in matrix-free approach. in European Journal of Mass Spectrometry, 19(2), 77-89.
https://doi.org/10.1255/ejms.1217

Radisavljevic M, Kamceva T, Vukićević IA, Nišavić M, Milovanović M, Petković M. Sensitivity and accuracy of organic matrix-assisted Laser desorption and ionisation mass spectrometry of FeCl3 is higher than in in matrix-free approach. in European Journal of Mass Spectrometry. 2013;19(2):77-89.
doi:10.1255/ejms.1217 .

Radisavljevic, Maja, Kamceva, Tina, Vukićević, Iva A., Nišavić, Marija, Milovanović, Milan, Petković, Marijana, "Sensitivity and accuracy of organic matrix-assisted Laser desorption and ionisation mass spectrometry of FeCl3 is higher than in in matrix-free approach" in European Journal of Mass Spectrometry, 19, no. 2 (2013):77-89,
https://doi.org/10.1255/ejms.1217 . .