TY  - JOUR
AU  - Bajić, Vladan P.
AU  - Spremo-Potparević, Biljana
AU  - Živković, Lada
AU  - Čabarkapa, Andrea
AU  - Kotur-Stevuljevic, Jelena
AU  - Isenović, Esma R.
AU  - Sredojević, Dušan
AU  - Vukoje, Ivana D.
AU  - Lazić, Vesna M.
AU  - Ahrenkiel, Scott Phillip
AU  - Nedeljković, Jovan
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1607
AB  - The antigenotoxic and antioxidative properties of surface-modified TiO2 nanoparticles (NPs) with ascorbic acid (AA) were compared with those of constituents (free AA and bare TiO2 NPs). Colloids consisting of the TiO2 NPs with anatase crystal structure were prepared by acidic hydrolysis of TiCl4. The synthesized TiO2 NPs were characterized using transmission electron microscopy and X-ray diffraction analysis. The charge transfer (CT) complex formation between surface Ti atoms and AA is indicated by immediate appearance of red color. Composition and stability constants of CT complex were determined using Jobs method and Banesi-Hildebrand analysis, respectively. The surface structure of CT complex was determined from infra-red spectra of free and bound AA to the surface Ti atoms. The experimental data were supported with quantum chemical calculations based on density functional theory (DFT). The antigenotoxic potential of CT complex was evaluated in leukocytes of whole blood cells in vitro by comet assay method. For evaluation of antioxidant properties, total antioxidant status (TAS) and total oxidant status (TOS) were determined in human serum pool in vitro. The presented results indicate that bare TiO2 NPs have more pronounced antigenotoxic effects in comparison with either surface-modified TiO2 NPs with AA or free AA. No significant differences between the antigenotoxic and antioxidative properties of free and bound AA on the TiO2 NPs were noticed in the investigated concentration range. It seems that surface-modified TiO2 NPs with AA and/or similar compounds can be used to maintain its beneficial activities. (C) 2017 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces. B: Biointerfaces
T1  - Surface-modified TiO2 nanoparticles with ascorbic acid: Antioxidant properties and efficiency against DNA damage in vitro
VL  - 155
SP  - 323
EP  - 331
DO  - 10.1016/j.colsurfb.2017.04.032
ER  - 

@article{
author = "Bajić, Vladan P. and Spremo-Potparević, Biljana and Živković, Lada and Čabarkapa, Andrea and Kotur-Stevuljevic, Jelena and Isenović, Esma R. and Sredojević, Dušan and Vukoje, Ivana D. and Lazić, Vesna M. and Ahrenkiel, Scott Phillip and Nedeljković, Jovan",
year = "2017",
abstract = "The antigenotoxic and antioxidative properties of surface-modified TiO2 nanoparticles (NPs) with ascorbic acid (AA) were compared with those of constituents (free AA and bare TiO2 NPs). Colloids consisting of the TiO2 NPs with anatase crystal structure were prepared by acidic hydrolysis of TiCl4. The synthesized TiO2 NPs were characterized using transmission electron microscopy and X-ray diffraction analysis. The charge transfer (CT) complex formation between surface Ti atoms and AA is indicated by immediate appearance of red color. Composition and stability constants of CT complex were determined using Jobs method and Banesi-Hildebrand analysis, respectively. The surface structure of CT complex was determined from infra-red spectra of free and bound AA to the surface Ti atoms. The experimental data were supported with quantum chemical calculations based on density functional theory (DFT). The antigenotoxic potential of CT complex was evaluated in leukocytes of whole blood cells in vitro by comet assay method. For evaluation of antioxidant properties, total antioxidant status (TAS) and total oxidant status (TOS) were determined in human serum pool in vitro. The presented results indicate that bare TiO2 NPs have more pronounced antigenotoxic effects in comparison with either surface-modified TiO2 NPs with AA or free AA. No significant differences between the antigenotoxic and antioxidative properties of free and bound AA on the TiO2 NPs were noticed in the investigated concentration range. It seems that surface-modified TiO2 NPs with AA and/or similar compounds can be used to maintain its beneficial activities. (C) 2017 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces. B: Biointerfaces",
title = "Surface-modified TiO2 nanoparticles with ascorbic acid: Antioxidant properties and efficiency against DNA damage in vitro",
volume = "155",
pages = "323-331",
doi = "10.1016/j.colsurfb.2017.04.032"
}

Bajić, V. P., Spremo-Potparević, B., Živković, L., Čabarkapa, A., Kotur-Stevuljevic, J., Isenović, E. R., Sredojević, D., Vukoje, I. D., Lazić, V. M., Ahrenkiel, S. P.,& Nedeljković, J.. (2017). Surface-modified TiO2 nanoparticles with ascorbic acid: Antioxidant properties and efficiency against DNA damage in vitro. in Colloids and Surfaces. B: Biointerfaces, 155, 323-331.
https://doi.org/10.1016/j.colsurfb.2017.04.032

Bajić VP, Spremo-Potparević B, Živković L, Čabarkapa A, Kotur-Stevuljevic J, Isenović ER, Sredojević D, Vukoje ID, Lazić VM, Ahrenkiel SP, Nedeljković J. Surface-modified TiO2 nanoparticles with ascorbic acid: Antioxidant properties and efficiency against DNA damage in vitro. in Colloids and Surfaces. B: Biointerfaces. 2017;155:323-331.
doi:10.1016/j.colsurfb.2017.04.032 .

Bajić, Vladan P., Spremo-Potparević, Biljana, Živković, Lada, Čabarkapa, Andrea, Kotur-Stevuljevic, Jelena, Isenović, Esma R., Sredojević, Dušan, Vukoje, Ivana D., Lazić, Vesna M., Ahrenkiel, Scott Phillip, Nedeljković, Jovan, "Surface-modified TiO2 nanoparticles with ascorbic acid: Antioxidant properties and efficiency against DNA damage in vitro" in Colloids and Surfaces. B: Biointerfaces, 155 (2017):323-331,
https://doi.org/10.1016/j.colsurfb.2017.04.032 . .

TY  - JOUR
AU  - Baralic, Ivana
AU  - Đorđević, Brižita
AU  - Dikic, Nenad
AU  - Kotur-Stevuljevic, Jelena
AU  - Spasic, Slavica
AU  - Jelić-Ivanović, Zorana
AU  - Radivojevic, Nenad
AU  - Anđelković, Marija
AU  - Pejić, Snežana
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5713
AB  - The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p LT 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p LT 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p LT 0.05; training, p LT 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p LT 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p LT 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright (c) 2012 John Wiley and Sons, Ltd.
T2  - Phytotherapy Research
T1  - Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players
VL  - 27
IS  - 10
SP  - 1536
EP  - 1542
DO  - 10.1002/ptr.4898
ER  - 

@article{
author = "Baralic, Ivana and Đorđević, Brižita and Dikic, Nenad and Kotur-Stevuljevic, Jelena and Spasic, Slavica and Jelić-Ivanović, Zorana and Radivojevic, Nenad and Anđelković, Marija and Pejić, Snežana",
year = "2013",
abstract = "The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p LT 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p LT 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p LT 0.05; training, p LT 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p LT 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p LT 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright (c) 2012 John Wiley and Sons, Ltd.",
journal = "Phytotherapy Research",
title = "Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players",
volume = "27",
number = "10",
pages = "1536-1542",
doi = "10.1002/ptr.4898"
}

Baralic, I., Đorđević, B., Dikic, N., Kotur-Stevuljevic, J., Spasic, S., Jelić-Ivanović, Z., Radivojevic, N., Anđelković, M.,& Pejić, S.. (2013). Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players. in Phytotherapy Research, 27(10), 1536-1542.
https://doi.org/10.1002/ptr.4898

Baralic I, Đorđević B, Dikic N, Kotur-Stevuljevic J, Spasic S, Jelić-Ivanović Z, Radivojevic N, Anđelković M, Pejić S. Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players. in Phytotherapy Research. 2013;27(10):1536-1542.
doi:10.1002/ptr.4898 .

Baralic, Ivana, Đorđević, Brižita, Dikic, Nenad, Kotur-Stevuljevic, Jelena, Spasic, Slavica, Jelić-Ivanović, Zorana, Radivojevic, Nenad, Anđelković, Marija, Pejić, Snežana, "Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players" in Phytotherapy Research, 27, no. 10 (2013):1536-1542,
https://doi.org/10.1002/ptr.4898 . .

TY  - JOUR
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
AU  - Kotur-Stevuljevic, Jelena
AU  - Joksić, Jelena
AU  - Guć-Šćekić, Marija
AU  - Vujić, Dragana
AU  - Joksić, Gordana
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4379
AB  - Fanconi anemia (FA) is a rare cancer-prone genetic disorder characterized by progressive bone marrow failure, chromosomal instability and redox abnormalities. There is much biochemical and genetic data, which strongly suggest that FA cells experience increased oxidative stress. The present study was designed to elucidate if differences in oxidant state exist between control, idiopathic bone marrow failure (idBMF) and FA cells, and to analyze oxidant state of cells in FA heterozygous carriers as well. The results of the present study confirm an in vivo prooxidant state of FA cells and clearly indicate that FA patients can be distinguished from idBMF patients based on the oxidant state of cells. Female carriers of FA mutation also exhibited hallmarks of an in vivo prooxidant state behaving in a similar manner as FA patients. On the other hand, the oxidant state of cells in FA male carriers and idBMF families failed to show any significant difference vs. controls. We demonstrate that the altered oxidant state influences susceptibility of cells to apoptosis in both FA patients and female carriers. The results highlight the need for further research of the possible role of mitochondrial inheritance in the pathogenesis of FA.
T2  - Biological Chemistry
T1  - Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes
VL  - 392
IS  - 7
SP  - 625
EP  - 632
DO  - 10.1515/BC.2011.064
ER  - 

@article{
author = "Petrović, Sandra and Leskovac, Andreja and Kotur-Stevuljevic, Jelena and Joksić, Jelena and Guć-Šćekić, Marija and Vujić, Dragana and Joksić, Gordana",
year = "2011",
abstract = "Fanconi anemia (FA) is a rare cancer-prone genetic disorder characterized by progressive bone marrow failure, chromosomal instability and redox abnormalities. There is much biochemical and genetic data, which strongly suggest that FA cells experience increased oxidative stress. The present study was designed to elucidate if differences in oxidant state exist between control, idiopathic bone marrow failure (idBMF) and FA cells, and to analyze oxidant state of cells in FA heterozygous carriers as well. The results of the present study confirm an in vivo prooxidant state of FA cells and clearly indicate that FA patients can be distinguished from idBMF patients based on the oxidant state of cells. Female carriers of FA mutation also exhibited hallmarks of an in vivo prooxidant state behaving in a similar manner as FA patients. On the other hand, the oxidant state of cells in FA male carriers and idBMF families failed to show any significant difference vs. controls. We demonstrate that the altered oxidant state influences susceptibility of cells to apoptosis in both FA patients and female carriers. The results highlight the need for further research of the possible role of mitochondrial inheritance in the pathogenesis of FA.",
journal = "Biological Chemistry",
title = "Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes",
volume = "392",
number = "7",
pages = "625-632",
doi = "10.1515/BC.2011.064"
}

Petrović, S., Leskovac, A., Kotur-Stevuljevic, J., Joksić, J., Guć-Šćekić, M., Vujić, D.,& Joksić, G.. (2011). Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes. in Biological Chemistry, 392(7), 625-632.
https://doi.org/10.1515/BC.2011.064

Petrović S, Leskovac A, Kotur-Stevuljevic J, Joksić J, Guć-Šćekić M, Vujić D, Joksić G. Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes. in Biological Chemistry. 2011;392(7):625-632.
doi:10.1515/BC.2011.064 .

Petrović, Sandra, Leskovac, Andreja, Kotur-Stevuljevic, Jelena, Joksić, Jelena, Guć-Šćekić, Marija, Vujić, Dragana, Joksić, Gordana, "Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes" in Biological Chemistry, 392, no. 7 (2011):625-632,
https://doi.org/10.1515/BC.2011.064 . .