TY  - JOUR
AU  - Zarić, Božidarka
AU  - Obradović, Milan M.
AU  - Bajić, Vladan P.
AU  - Haidara, Mohamed A.
AU  - Jovanović, Miloš
AU  - Isenović, Esma R.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8485
AB  - Homocysteine (Hcy) is a thiol group containing the amino acid, which naturally occurs in all humans. Hcy is degraded in the body through two metabolic pathways, while a minor part is excreted through kidneys. The chemical reactions that are necessary for degradation of Hcy require the presence of folic acid, vitamins B6 and B12. Consequently, the level of the total Hcy in the serum is influenced by the presence or absence of these vitamins. An elevated level of the Hcy, hyperhomocysteinemia (HHcy) and homocystinuria is connected with occlusive artery disease, especially in the brain, the heart, and the kidney, in addition to venous thrombosis, chronic renal failure, megaloblastic anemia, osteoporosis, depression, Alzheimer's disease, pregnancy problems, and others. Elevated Hcy levels are connected with various pathologies both in adult and child population. Causes of HHcy include genetic mutations and enzyme deficiencies in 5, 10-methylenetetrahydrofolate reductase (MTHFR) methionine synthase (MS), and cystathionine β-synthase (CβS). HHcy can be caused by deficiencies in the folate, vitamin B12 and to a lesser extent, deficiency in B6 vitamin what influences methionine metabolism. Additionally, HHcy can be caused by the rich diet and renal impairment. This review presents literature data from recent research related to Hcy metabolism and the etiology of the Hcy blood level disorder. In addition, we also described various pathological mechanisms induced by hereditary disturbances or nutritional influences and their association with HHcy induced pathology in adults and children and treatment of these metabolic disorders. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
T2  - Current Medicinal Chemistry
T1  - Homocysteine and Hyperhomocysteinaemia
VL  - 26
IS  - 16
SP  - 2948
EP  - 2961
DO  - 10.2174/0929867325666180313105949
ER  - 

@article{
author = "Zarić, Božidarka and Obradović, Milan M. and Bajić, Vladan P. and Haidara, Mohamed A. and Jovanović, Miloš and Isenović, Esma R.",
year = "2019",
abstract = "Homocysteine (Hcy) is a thiol group containing the amino acid, which naturally occurs in all humans. Hcy is degraded in the body through two metabolic pathways, while a minor part is excreted through kidneys. The chemical reactions that are necessary for degradation of Hcy require the presence of folic acid, vitamins B6 and B12. Consequently, the level of the total Hcy in the serum is influenced by the presence or absence of these vitamins. An elevated level of the Hcy, hyperhomocysteinemia (HHcy) and homocystinuria is connected with occlusive artery disease, especially in the brain, the heart, and the kidney, in addition to venous thrombosis, chronic renal failure, megaloblastic anemia, osteoporosis, depression, Alzheimer's disease, pregnancy problems, and others. Elevated Hcy levels are connected with various pathologies both in adult and child population. Causes of HHcy include genetic mutations and enzyme deficiencies in 5, 10-methylenetetrahydrofolate reductase (MTHFR) methionine synthase (MS), and cystathionine β-synthase (CβS). HHcy can be caused by deficiencies in the folate, vitamin B12 and to a lesser extent, deficiency in B6 vitamin what influences methionine metabolism. Additionally, HHcy can be caused by the rich diet and renal impairment. This review presents literature data from recent research related to Hcy metabolism and the etiology of the Hcy blood level disorder. In addition, we also described various pathological mechanisms induced by hereditary disturbances or nutritional influences and their association with HHcy induced pathology in adults and children and treatment of these metabolic disorders. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.",
journal = "Current Medicinal Chemistry",
title = "Homocysteine and Hyperhomocysteinaemia",
volume = "26",
number = "16",
pages = "2948-2961",
doi = "10.2174/0929867325666180313105949"
}

Zarić, B., Obradović, M. M., Bajić, V. P., Haidara, M. A., Jovanović, M.,& Isenović, E. R.. (2019). Homocysteine and Hyperhomocysteinaemia. in Current Medicinal Chemistry, 26(16), 2948-2961.
https://doi.org/10.2174/0929867325666180313105949

Zarić B, Obradović MM, Bajić VP, Haidara MA, Jovanović M, Isenović ER. Homocysteine and Hyperhomocysteinaemia. in Current Medicinal Chemistry. 2019;26(16):2948-2961.
doi:10.2174/0929867325666180313105949 .

Zarić, Božidarka, Obradović, Milan M., Bajić, Vladan P., Haidara, Mohamed A., Jovanović, Miloš, Isenović, Esma R., "Homocysteine and Hyperhomocysteinaemia" in Current Medicinal Chemistry, 26, no. 16 (2019):2948-2961,
https://doi.org/10.2174/0929867325666180313105949 . .

TY  - JOUR
AU  - Vladimirov, Sote
AU  - Čudina, Olivera
AU  - Agbaba, Danica
AU  - Jovanovic, M
AU  - Živanov-Stakić, Dobrila
PY  - 1996
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7217
AB  - The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product has an absorption maximum at 380 nm. A linear relationship between absorbance and concentration was established in the concentration range 3.19 x 10(-6)-3.19 x 10(-5) mol l(-1) (the regression equation was y = 0.013 167 3 + 0.019 025 9x; correlation coefficient r = 0.9991; n = 6). The detection limit was 1.2 mu g ml(-1) (molar absorptivity found was 1.97 x 10(4) l mol(-1) cm(-1)). The reliability of the proposed method was checked at three different concentrations; the relative standard deviation (RSD) varied from 1.03 to 2.01%. The described method applied to the determination of desoximetasone in ointment gave precise and reproducible results; the recovery was 98.55% with RSD = 2.40% (n = 10).
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine
VL  - 14
IS  - 8-10
SP  - 947
EP  - 950
DO  - 10.1016/0731-7085(95)01681-3
ER  - 

@article{
author = "Vladimirov, Sote and Čudina, Olivera and Agbaba, Danica and Jovanovic, M and Živanov-Stakić, Dobrila",
year = "1996",
abstract = "The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product has an absorption maximum at 380 nm. A linear relationship between absorbance and concentration was established in the concentration range 3.19 x 10(-6)-3.19 x 10(-5) mol l(-1) (the regression equation was y = 0.013 167 3 + 0.019 025 9x; correlation coefficient r = 0.9991; n = 6). The detection limit was 1.2 mu g ml(-1) (molar absorptivity found was 1.97 x 10(4) l mol(-1) cm(-1)). The reliability of the proposed method was checked at three different concentrations; the relative standard deviation (RSD) varied from 1.03 to 2.01%. The described method applied to the determination of desoximetasone in ointment gave precise and reproducible results; the recovery was 98.55% with RSD = 2.40% (n = 10).",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine",
volume = "14",
number = "8-10",
pages = "947-950",
doi = "10.1016/0731-7085(95)01681-3"
}

Vladimirov, S., Čudina, O., Agbaba, D., Jovanovic, M.,& Živanov-Stakić, D.. (1996). Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine. in Journal of Pharmaceutical and Biomedical Analysis, 14(8-10), 947-950.
https://doi.org/10.1016/0731-7085(95)01681-3

Vladimirov S, Čudina O, Agbaba D, Jovanovic M, Živanov-Stakić D. Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine. in Journal of Pharmaceutical and Biomedical Analysis. 1996;14(8-10):947-950.
doi:10.1016/0731-7085(95)01681-3 .

Vladimirov, Sote, Čudina, Olivera, Agbaba, Danica, Jovanovic, M, Živanov-Stakić, Dobrila, "Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine" in Journal of Pharmaceutical and Biomedical Analysis, 14, no. 8-10 (1996):947-950,
https://doi.org/10.1016/0731-7085(95)01681-3 . .