TY  - CHAP
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8408
AB  - Cancer of the reproductive tract is an important source of morbidity and mortality among women worldwide. Factors affecting endometrial cancer and endometrial hyperplasia are known to be similar. Endometrial hyperplasia is abnormal proliferation of the glands and the stroma resulting in architectural and cytological modifications. Due to hormonal changes, this condition is most common among women who are nearing the menopause or have reached the menopause. Antioxidant system has a role in preventing cancer initiation and promotion. Since the carcinogenesis occurs in several stages, it is likely that the antioxidant defense depends on the type of cell and tissue. The objective of this study was to investigate whether antioxidant enzymes activities and lipid hydroperoxides concentration in patients with endometrial hyperplasia are influenced by the changes in sex hormones level (estradiol, progesterone, FSH, and LH) during the menstrual cycle and in postmenopause. The material we used consisted of blood and endometrial tissue specimens of women diagnosed with endometrial hyperplasia simplex. Patients were divided in groups depending on the phase of the menstrual cycle: follicular phase, luteal phase and postmenopause. The activities of antioxidant enzymes and the lipid hydroperoxides level were compared among the phases to test the differences and a linear regression model was used to evaluate the associations between hormone levels and antioxidant/oxidant variables. In the blood of examined patients, we observed a phase-related changes of LOOH concentrations. Significant negative correlation between FSH concentration and GR activity (r= -0.42, p<0.05) and significant positive correlation between LH and LOOH concentrations (r= 0.038, p<0.05) was found. In hyperplasia simplex tissue we recorded significant phase-related changes of LOOH level as well as of AO enzyme activities. SOD and CAT had similar activity pattern, which was higher in luteal phase and in postmenopause, compared to follicular phase (p<0.05). GPx and GR activities did not show any statistical difference. Also, negative correlation between progesterone and GR activity (r=-0.036, p<0.05) was observed. Hormonal influence on AO system is of importance in gynecological diseases etiology since they may promote cell proliferation but are also used in conservative therapy, especially for hyperplasia simplex. However, the role of ROS production as a risk factor for endometrial hyperplasia still needs to be clarified as well as the role of AO status in response to gonadotropins and sex steroids.
T2  - Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder
T1  - Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia
IS  - Ch. 9
SP  - 243
EP  - 279
DO  - 10.5772/60853
ER  - 

@inbook{
editor = "Gowder, Sivakumar Joghi Thatha",
author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Pavlović, Ivan and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B.",
year = "2015",
abstract = "Cancer of the reproductive tract is an important source of morbidity and mortality among women worldwide. Factors affecting endometrial cancer and endometrial hyperplasia are known to be similar. Endometrial hyperplasia is abnormal proliferation of the glands and the stroma resulting in architectural and cytological modifications. Due to hormonal changes, this condition is most common among women who are nearing the menopause or have reached the menopause. Antioxidant system has a role in preventing cancer initiation and promotion. Since the carcinogenesis occurs in several stages, it is likely that the antioxidant defense depends on the type of cell and tissue. The objective of this study was to investigate whether antioxidant enzymes activities and lipid hydroperoxides concentration in patients with endometrial hyperplasia are influenced by the changes in sex hormones level (estradiol, progesterone, FSH, and LH) during the menstrual cycle and in postmenopause. The material we used consisted of blood and endometrial tissue specimens of women diagnosed with endometrial hyperplasia simplex. Patients were divided in groups depending on the phase of the menstrual cycle: follicular phase, luteal phase and postmenopause. The activities of antioxidant enzymes and the lipid hydroperoxides level were compared among the phases to test the differences and a linear regression model was used to evaluate the associations between hormone levels and antioxidant/oxidant variables. In the blood of examined patients, we observed a phase-related changes of LOOH concentrations. Significant negative correlation between FSH concentration and GR activity (r= -0.42, p<0.05) and significant positive correlation between LH and LOOH concentrations (r= 0.038, p<0.05) was found. In hyperplasia simplex tissue we recorded significant phase-related changes of LOOH level as well as of AO enzyme activities. SOD and CAT had similar activity pattern, which was higher in luteal phase and in postmenopause, compared to follicular phase (p<0.05). GPx and GR activities did not show any statistical difference. Also, negative correlation between progesterone and GR activity (r=-0.036, p<0.05) was observed. Hormonal influence on AO system is of importance in gynecological diseases etiology since they may promote cell proliferation but are also used in conservative therapy, especially for hyperplasia simplex. However, the role of ROS production as a risk factor for endometrial hyperplasia still needs to be clarified as well as the role of AO status in response to gonadotropins and sex steroids.",
journal = "Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder",
booktitle = "Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia",
number = "Ch. 9",
pages = "243-279",
doi = "10.5772/60853"
}

Gowder, S. J. T., Pejić, S., Todorović, A., Stojiljković, V., Pavlović, I., Gavrilović, L., Popović, N. M.,& Pajović, S. B.. (2015). Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia. in Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder(Ch. 9), 243-279.
https://doi.org/10.5772/60853

Gowder SJT, Pejić S, Todorović A, Stojiljković V, Pavlović I, Gavrilović L, Popović NM, Pajović SB. Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia. in Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder. 2015;(Ch. 9):243-279.
doi:10.5772/60853 .

Gowder, Sivakumar Joghi Thatha, Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Pavlović, Ivan, Gavrilović, Ljubica, Popović, Nataša M., Pajović, Snežana B., "Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia" in Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder, no. Ch. 9 (2015):243-279,
https://doi.org/10.5772/60853 . .