TY  - JOUR
AU  - Tsotakos, T.
AU  - Tsoukalas, C.
AU  - Patsis, G.
AU  - Panagiotopoulou, A.
AU  - Nikolić, Nadežda S.
AU  - Janković, Drina
AU  - Đokić, Divna Đ.
AU  - Raptopoulou, C. P.
AU  - Terzis, A.
AU  - Papagiannopoulou, D.
AU  - Pelecanou, M.
AU  - Papadopoulos, M.
AU  - Pirmettis, Ioannis
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4546
AB  - Two rhenium(I) tricarbonyl complexes with the tridentate monoanionic NSO ligands, 4-(benzimidazol-2-yl)-3-thiabutanoic acid (complex 3) and [1-(11-carboxyundecanyl)-4-(benzimidazol-2-yl)]-3-thiabutanoic acid (complex 4) were synthesized and characterized by spectroscopic methods and elemental analysis. X-ray crystallographic analysis of complex 3 revealed a distorted octahedral geometry around rhenium defined by the three facially bound CO groups and the NSO donor atom set of the tridentate ligand. The analogous technetium-99m complexes (complexes 5 and 6) were also prepared quantitatively by reaction of the NSO ligands with the fac-[Tc-99m(H2O)(3)(CO)(3)](+) synthon and their identity was established by chromatographic comparison to their rhenium congeners. Biodistribution in mice of complex 6 bearing the fatty acid chain showed significant heart uptake (6.26 +/- 0.79% ID/g p.i.) at 1 min accompanied, however, with a heart: blood ratio below 1. (C) 2011 Elsevier B. V. All rights reserved.
T2  - Inorganica Chimica Acta
T1  - Benzimidazole derivatives as NSO ligands for the fac-[M(CO)(3)](+) (M = Re, Tc-99m)
VL  - 377
IS  - 1
SP  - 62
EP  - 68
DO  - 10.1016/j.ica.2011.07.035
ER  - 

@article{
author = "Tsotakos, T. and Tsoukalas, C. and Patsis, G. and Panagiotopoulou, A. and Nikolić, Nadežda S. and Janković, Drina and Đokić, Divna Đ. and Raptopoulou, C. P. and Terzis, A. and Papagiannopoulou, D. and Pelecanou, M. and Papadopoulos, M. and Pirmettis, Ioannis",
year = "2011",
abstract = "Two rhenium(I) tricarbonyl complexes with the tridentate monoanionic NSO ligands, 4-(benzimidazol-2-yl)-3-thiabutanoic acid (complex 3) and [1-(11-carboxyundecanyl)-4-(benzimidazol-2-yl)]-3-thiabutanoic acid (complex 4) were synthesized and characterized by spectroscopic methods and elemental analysis. X-ray crystallographic analysis of complex 3 revealed a distorted octahedral geometry around rhenium defined by the three facially bound CO groups and the NSO donor atom set of the tridentate ligand. The analogous technetium-99m complexes (complexes 5 and 6) were also prepared quantitatively by reaction of the NSO ligands with the fac-[Tc-99m(H2O)(3)(CO)(3)](+) synthon and their identity was established by chromatographic comparison to their rhenium congeners. Biodistribution in mice of complex 6 bearing the fatty acid chain showed significant heart uptake (6.26 +/- 0.79% ID/g p.i.) at 1 min accompanied, however, with a heart: blood ratio below 1. (C) 2011 Elsevier B. V. All rights reserved.",
journal = "Inorganica Chimica Acta",
title = "Benzimidazole derivatives as NSO ligands for the fac-[M(CO)(3)](+) (M = Re, Tc-99m)",
volume = "377",
number = "1",
pages = "62-68",
doi = "10.1016/j.ica.2011.07.035"
}

Tsotakos, T., Tsoukalas, C., Patsis, G., Panagiotopoulou, A., Nikolić, N. S., Janković, D., Đokić, D. Đ., Raptopoulou, C. P., Terzis, A., Papagiannopoulou, D., Pelecanou, M., Papadopoulos, M.,& Pirmettis, I.. (2011). Benzimidazole derivatives as NSO ligands for the fac-[M(CO)(3)](+) (M = Re, Tc-99m). in Inorganica Chimica Acta, 377(1), 62-68.
https://doi.org/10.1016/j.ica.2011.07.035

Tsotakos T, Tsoukalas C, Patsis G, Panagiotopoulou A, Nikolić NS, Janković D, Đokić DĐ, Raptopoulou CP, Terzis A, Papagiannopoulou D, Pelecanou M, Papadopoulos M, Pirmettis I. Benzimidazole derivatives as NSO ligands for the fac-[M(CO)(3)](+) (M = Re, Tc-99m). in Inorganica Chimica Acta. 2011;377(1):62-68.
doi:10.1016/j.ica.2011.07.035 .

Tsotakos, T., Tsoukalas, C., Patsis, G., Panagiotopoulou, A., Nikolić, Nadežda S., Janković, Drina, Đokić, Divna Đ., Raptopoulou, C. P., Terzis, A., Papagiannopoulou, D., Pelecanou, M., Papadopoulos, M., Pirmettis, Ioannis, "Benzimidazole derivatives as NSO ligands for the fac-[M(CO)(3)](+) (M = Re, Tc-99m)" in Inorganica Chimica Acta, 377, no. 1 (2011):62-68,
https://doi.org/10.1016/j.ica.2011.07.035 . .

TY  - JOUR
AU  - Kyprianidou, P.
AU  - Tsoukalas, C.
AU  - Patsis, G.
AU  - Papagiannopoulou, D.
AU  - Nikolić, Nadežda S.
AU  - Janković, Drina
AU  - Đokić, Divna Đ.
AU  - Raptopoulou, C. P.
AU  - Pelecanou, M.
AU  - Papadopoulos, M.
AU  - Pirmettis, Ioannis
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3811
AB  - Two rhenium(l) tricarbonyl complexes, with the monoanionic tridentate NSO type ligand, 4-(imidazolin-2-yl)-3-thiabutanoic acid and 4-(N-ethylimidazolin-2-yl)-3-thiabutanoic acid were synthesized and isolated in pure form. Both complexes were characterized by spectroscopic methods and elemental analysis. The solid-state structure of 4-(imidazolin-2-yl)-3-thiabutanoic acid and of both complexes was established by X-ray crystallography. The geometry about the rhenium is octahedral. The analogous technetium-99m complexes were also prepared quantitatively by the reaction of both ligands with the fac-[(99m)Tc(CO)(3)(H(2)O)(3)](+) synthon and their identity was established by chromatographic comparison to their rhenium congeners. (C) 2009 Elsevier Ltd. All rights reserved.
T2  - Polyhedron
T1  - Rhenium(I) and technetium-99m(I) fac-tricarbonyl complexes with 4-(imidazolin-2-yl)-3-thiabutanoic acid derivatives as tridentate ligands: Synthesis and structural characterization
VL  - 28
IS  - 15
SP  - 3171
EP  - 3176
DO  - 10.1016/j.poly.2009.04.005
ER  - 

@article{
author = "Kyprianidou, P. and Tsoukalas, C. and Patsis, G. and Papagiannopoulou, D. and Nikolić, Nadežda S. and Janković, Drina and Đokić, Divna Đ. and Raptopoulou, C. P. and Pelecanou, M. and Papadopoulos, M. and Pirmettis, Ioannis",
year = "2009",
abstract = "Two rhenium(l) tricarbonyl complexes, with the monoanionic tridentate NSO type ligand, 4-(imidazolin-2-yl)-3-thiabutanoic acid and 4-(N-ethylimidazolin-2-yl)-3-thiabutanoic acid were synthesized and isolated in pure form. Both complexes were characterized by spectroscopic methods and elemental analysis. The solid-state structure of 4-(imidazolin-2-yl)-3-thiabutanoic acid and of both complexes was established by X-ray crystallography. The geometry about the rhenium is octahedral. The analogous technetium-99m complexes were also prepared quantitatively by the reaction of both ligands with the fac-[(99m)Tc(CO)(3)(H(2)O)(3)](+) synthon and their identity was established by chromatographic comparison to their rhenium congeners. (C) 2009 Elsevier Ltd. All rights reserved.",
journal = "Polyhedron",
title = "Rhenium(I) and technetium-99m(I) fac-tricarbonyl complexes with 4-(imidazolin-2-yl)-3-thiabutanoic acid derivatives as tridentate ligands: Synthesis and structural characterization",
volume = "28",
number = "15",
pages = "3171-3176",
doi = "10.1016/j.poly.2009.04.005"
}

Kyprianidou, P., Tsoukalas, C., Patsis, G., Papagiannopoulou, D., Nikolić, N. S., Janković, D., Đokić, D. Đ., Raptopoulou, C. P., Pelecanou, M., Papadopoulos, M.,& Pirmettis, I.. (2009). Rhenium(I) and technetium-99m(I) fac-tricarbonyl complexes with 4-(imidazolin-2-yl)-3-thiabutanoic acid derivatives as tridentate ligands: Synthesis and structural characterization. in Polyhedron, 28(15), 3171-3176.
https://doi.org/10.1016/j.poly.2009.04.005

Kyprianidou P, Tsoukalas C, Patsis G, Papagiannopoulou D, Nikolić NS, Janković D, Đokić DĐ, Raptopoulou CP, Pelecanou M, Papadopoulos M, Pirmettis I. Rhenium(I) and technetium-99m(I) fac-tricarbonyl complexes with 4-(imidazolin-2-yl)-3-thiabutanoic acid derivatives as tridentate ligands: Synthesis and structural characterization. in Polyhedron. 2009;28(15):3171-3176.
doi:10.1016/j.poly.2009.04.005 .

Kyprianidou, P., Tsoukalas, C., Patsis, G., Papagiannopoulou, D., Nikolić, Nadežda S., Janković, Drina, Đokić, Divna Đ., Raptopoulou, C. P., Pelecanou, M., Papadopoulos, M., Pirmettis, Ioannis, "Rhenium(I) and technetium-99m(I) fac-tricarbonyl complexes with 4-(imidazolin-2-yl)-3-thiabutanoic acid derivatives as tridentate ligands: Synthesis and structural characterization" in Polyhedron, 28, no. 15 (2009):3171-3176,
https://doi.org/10.1016/j.poly.2009.04.005 . .

TY  - CONF
AU  - Janković, Drina
AU  - Pirmettis, Ioannis
AU  - Matović, Ljiljana
AU  - Đokić, Divna
AU  - Vranješ, Sanja
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9444
AB  - There is an increasing interest for the 99mTc labelling of biomolecules by using bifunctional chelating agents. To find new ligand, which can be linked to the small biomolecules and coordinated with technetium-99m tricarbonyl complexes, is a challenging task. The investigated NSC and NSC5 ligands allow the preparation 99mTc(I) stable complexes in high yield. The 99mTc complexes were characterized by comparing their HPLC profiles with those of the respective Re(I) compounds. Biodistribution and stability studies were carried out, including challenge with histidine. These complexes also proved to be stable in vivo and showed a very good biological behaviour. The radiochemical and biological features of the novel 99mTc complexes, as well as, the nature of the ligands, make them very promising candidates for labelling of tumour specific biomolecules.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
T1  - Tricarbonyltechnetium (I) labelled ligands with nso donor atom set: in vitro and in vivo evaluation
SP  - 460
EP  - 462
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9444
ER  - 

@conference{
author = "Janković, Drina and Pirmettis, Ioannis and Matović, Ljiljana and Đokić, Divna and Vranješ, Sanja",
year = "2006",
abstract = "There is an increasing interest for the 99mTc labelling of biomolecules by using bifunctional chelating agents. To find new ligand, which can be linked to the small biomolecules and coordinated with technetium-99m tricarbonyl complexes, is a challenging task. The investigated NSC and NSC5 ligands allow the preparation 99mTc(I) stable complexes in high yield. The 99mTc complexes were characterized by comparing their HPLC profiles with those of the respective Re(I) compounds. Biodistribution and stability studies were carried out, including challenge with histidine. These complexes also proved to be stable in vivo and showed a very good biological behaviour. The radiochemical and biological features of the novel 99mTc complexes, as well as, the nature of the ligands, make them very promising candidates for labelling of tumour specific biomolecules.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry",
title = "Tricarbonyltechnetium (I) labelled ligands with nso donor atom set: in vitro and in vivo evaluation",
pages = "460-462",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9444"
}

Janković, D., Pirmettis, I., Matović, L., Đokić, D.,& Vranješ, S.. (2006). Tricarbonyltechnetium (I) labelled ligands with nso donor atom set: in vitro and in vivo evaluation. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
Society of Physical Chemists of Serbia., 460-462.
https://hdl.handle.net/21.15107/rcub_vinar_9444

Janković D, Pirmettis I, Matović L, Đokić D, Vranješ S. Tricarbonyltechnetium (I) labelled ligands with nso donor atom set: in vitro and in vivo evaluation. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry. 2006;:460-462.
https://hdl.handle.net/21.15107/rcub_vinar_9444 .

Janković, Drina, Pirmettis, Ioannis, Matović, Ljiljana, Đokić, Divna, Vranješ, Sanja, "Tricarbonyltechnetium (I) labelled ligands with nso donor atom set: in vitro and in vivo evaluation" in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry (2006):460-462,
https://hdl.handle.net/21.15107/rcub_vinar_9444 .

TY  - CONF
AU  - Đokić, Divna
AU  - Janković, Drina
AU  - Stamenković, Lj.
AU  - Nikolić, N.
AU  - Mirković, Marija D.
AU  - Pirmettis, Ioannis
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9437
AB  - 99mTc-MIBI is a promising radiopharmaceutical for myocardial perfusion imaging agent, but it has also shown good results in identifying several types of tumors, such as breast, lung and thyroid cancers. It is a lipophilic, cationic technetium (1) complex. In this paper a complete study on the synthesis of 2-metohy-isobutyl-isonitrile (MIBI) as well as a formulation of a lyophilized kit for labeling with 99mTc is presented. Investigation on effective factors as well as finding out the optimum parameters to obtain the highest labelling efficiency and radiochemical purity of 99mTc-MIBI complex were performed. The radiochemical purity of the labelled preparation was high (>95%). Biodistribution study performed in health male Wistar rats showed satisfactory biokinetics results. 99mTc-MIBI was accumulated in sufficient amount into the hearth tissue for myocardial perfusion imaging. MIBI in kit formulation was found to be stable and also safe for administration.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
T1  - 99mTc-hexakis-(2-metoxy-isobutyl-isonitrile) ( 99mTc-MIBI) a new myocardial imaging agent: synthesis of MIBI, optimising conditions for radiolabelling with 99mTc at high radiochemical purity and in vivo behavior
SP  - 434
EP  - 436
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9437
ER  - 

@conference{
author = "Đokić, Divna and Janković, Drina and Stamenković, Lj. and Nikolić, N. and Mirković, Marija D. and Pirmettis, Ioannis",
year = "2006",
abstract = "99mTc-MIBI is a promising radiopharmaceutical for myocardial perfusion imaging agent, but it has also shown good results in identifying several types of tumors, such as breast, lung and thyroid cancers. It is a lipophilic, cationic technetium (1) complex. In this paper a complete study on the synthesis of 2-metohy-isobutyl-isonitrile (MIBI) as well as a formulation of a lyophilized kit for labeling with 99mTc is presented. Investigation on effective factors as well as finding out the optimum parameters to obtain the highest labelling efficiency and radiochemical purity of 99mTc-MIBI complex were performed. The radiochemical purity of the labelled preparation was high (>95%). Biodistribution study performed in health male Wistar rats showed satisfactory biokinetics results. 99mTc-MIBI was accumulated in sufficient amount into the hearth tissue for myocardial perfusion imaging. MIBI in kit formulation was found to be stable and also safe for administration.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry",
title = "99mTc-hexakis-(2-metoxy-isobutyl-isonitrile) ( 99mTc-MIBI) a new myocardial imaging agent: synthesis of MIBI, optimising conditions for radiolabelling with 99mTc at high radiochemical purity and in vivo behavior",
pages = "434-436",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9437"
}

Đokić, D., Janković, D., Stamenković, Lj., Nikolić, N., Mirković, M. D.,& Pirmettis, I.. (2006). 99mTc-hexakis-(2-metoxy-isobutyl-isonitrile) ( 99mTc-MIBI) a new myocardial imaging agent: synthesis of MIBI, optimising conditions for radiolabelling with 99mTc at high radiochemical purity and in vivo behavior. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
Society of Physical Chemists of Serbia., 434-436.
https://hdl.handle.net/21.15107/rcub_vinar_9437

Đokić D, Janković D, Stamenković L, Nikolić N, Mirković MD, Pirmettis I. 99mTc-hexakis-(2-metoxy-isobutyl-isonitrile) ( 99mTc-MIBI) a new myocardial imaging agent: synthesis of MIBI, optimising conditions for radiolabelling with 99mTc at high radiochemical purity and in vivo behavior. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry. 2006;:434-436.
https://hdl.handle.net/21.15107/rcub_vinar_9437 .

Đokić, Divna, Janković, Drina, Stamenković, Lj., Nikolić, N., Mirković, Marija D., Pirmettis, Ioannis, "99mTc-hexakis-(2-metoxy-isobutyl-isonitrile) ( 99mTc-MIBI) a new myocardial imaging agent: synthesis of MIBI, optimising conditions for radiolabelling with 99mTc at high radiochemical purity and in vivo behavior" in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry (2006):434-436,
https://hdl.handle.net/21.15107/rcub_vinar_9437 .

TY  - JOUR
AU  - Đokić, Divna Đ.
AU  - Janković, Drina
AU  - Stamenkovic, LL
AU  - Pirmettis, Ioannis
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2770
AB  - The confirmation that N-substituted imidodiacetic acids, as small and simple ligand systems containing amines and carboxylic acids, could be coordinated to the tricarbonyl core and form inert complexes with [Tc-99m (CO)(3)(H2O)(3)](+). is demonstrated. The HPLC quality control results of Tc-99m-carbonyl tagged IDA molecules, performed by gradient HPLC, have shown that HIDA, EHIDA and p-butyl-IDA form complexes with [Tc-99m(CO)(3)(H2O)(3)](+), with a labeling yield of similar to90% for each of Tc-99m(CO)(3) IDA derivatives. However, the changes in the structure of labeled compounds, e.g., EHIDA, influence the changes in the biological behavior. In comparison with Tc-99m-EHIDA, the biliary excretion of Tc-99m(CO)(3) EHIDA was lower, but the urinary excretion higher.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - Chemical and biological evaluation of Tc-99m (CO)(3) and Tc-99m complexes of some IDA derivatives
VL  - 260
IS  - 3
SP  - 471
EP  - 476
DO  - 10.1023/B:JRNC.0000028204.03708.89
ER  - 

@article{
author = "Đokić, Divna Đ. and Janković, Drina and Stamenkovic, LL and Pirmettis, Ioannis",
year = "2004",
abstract = "The confirmation that N-substituted imidodiacetic acids, as small and simple ligand systems containing amines and carboxylic acids, could be coordinated to the tricarbonyl core and form inert complexes with [Tc-99m (CO)(3)(H2O)(3)](+). is demonstrated. The HPLC quality control results of Tc-99m-carbonyl tagged IDA molecules, performed by gradient HPLC, have shown that HIDA, EHIDA and p-butyl-IDA form complexes with [Tc-99m(CO)(3)(H2O)(3)](+), with a labeling yield of similar to90% for each of Tc-99m(CO)(3) IDA derivatives. However, the changes in the structure of labeled compounds, e.g., EHIDA, influence the changes in the biological behavior. In comparison with Tc-99m-EHIDA, the biliary excretion of Tc-99m(CO)(3) EHIDA was lower, but the urinary excretion higher.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "Chemical and biological evaluation of Tc-99m (CO)(3) and Tc-99m complexes of some IDA derivatives",
volume = "260",
number = "3",
pages = "471-476",
doi = "10.1023/B:JRNC.0000028204.03708.89"
}

Đokić, D. Đ., Janković, D., Stamenkovic, L.,& Pirmettis, I.. (2004). Chemical and biological evaluation of Tc-99m (CO)(3) and Tc-99m complexes of some IDA derivatives. in Journal of Radioanalytical and Nuclear Chemistry, 260(3), 471-476.
https://doi.org/10.1023/B:JRNC.0000028204.03708.89

Đokić DĐ, Janković D, Stamenkovic L, Pirmettis I. Chemical and biological evaluation of Tc-99m (CO)(3) and Tc-99m complexes of some IDA derivatives. in Journal of Radioanalytical and Nuclear Chemistry. 2004;260(3):471-476.
doi:10.1023/B:JRNC.0000028204.03708.89 .

Đokić, Divna Đ., Janković, Drina, Stamenkovic, LL, Pirmettis, Ioannis, "Chemical and biological evaluation of Tc-99m (CO)(3) and Tc-99m complexes of some IDA derivatives" in Journal of Radioanalytical and Nuclear Chemistry, 260, no. 3 (2004):471-476,
https://doi.org/10.1023/B:JRNC.0000028204.03708.89 . .