TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Gluvić, Zoran
AU  - Zafirović, Sonja
AU  - Gao, Xin
AU  - Essack, Magbubah
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10613
AB  - An imbalance between pro-oxidative and antioxidative cellular mechanisms is oxidative stress (OxS) which may be systemic or organ-specific. Although OxS is a consequence of normal body and organ physiology, severely impaired oxidative homeostasis results in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells’ function and viability. The thyroid gland is an organ that exhibits both oxidative and antioxidative processes. In terms of OxS severity, the thyroid gland’s response could be physiological (i.e. hormone production and secretion) or pathological (i.e. development of diseases, such as goitre, thyroid cancer, or thyroiditis). Protective nutritional antioxidants may benefit defensive antioxidative systems in resolving pro-oxidative dominance and redox imbalance, preventing or delaying chronic thyroid diseases. This review provides information on nutritional antioxidants and their protective roles against impaired redox homeostasis in various thyroid pathologies. We also review novel findings related to the connection between the thyroid gland and gut microbiome and analyze the effects of probiotics with antioxidant properties on thyroid diseases. Copyright © 2023 Macvanin, Gluvic, Zafirovic, Gao, Essack and Isenovic.
T2  - Frontiers in Endocrinology
T1  - The protective role of nutritional antioxidants against oxidative stress in thyroid disorders
VL  - 13
DO  - 10.3389/fendo.2022.1092837
ER  - 

@article{
author = "Mačvanin, Mirjana and Gluvić, Zoran and Zafirović, Sonja and Gao, Xin and Essack, Magbubah and Isenović, Esma R.",
year = "2023",
abstract = "An imbalance between pro-oxidative and antioxidative cellular mechanisms is oxidative stress (OxS) which may be systemic or organ-specific. Although OxS is a consequence of normal body and organ physiology, severely impaired oxidative homeostasis results in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells’ function and viability. The thyroid gland is an organ that exhibits both oxidative and antioxidative processes. In terms of OxS severity, the thyroid gland’s response could be physiological (i.e. hormone production and secretion) or pathological (i.e. development of diseases, such as goitre, thyroid cancer, or thyroiditis). Protective nutritional antioxidants may benefit defensive antioxidative systems in resolving pro-oxidative dominance and redox imbalance, preventing or delaying chronic thyroid diseases. This review provides information on nutritional antioxidants and their protective roles against impaired redox homeostasis in various thyroid pathologies. We also review novel findings related to the connection between the thyroid gland and gut microbiome and analyze the effects of probiotics with antioxidant properties on thyroid diseases. Copyright © 2023 Macvanin, Gluvic, Zafirovic, Gao, Essack and Isenovic.",
journal = "Frontiers in Endocrinology",
title = "The protective role of nutritional antioxidants against oxidative stress in thyroid disorders",
volume = "13",
doi = "10.3389/fendo.2022.1092837"
}

Mačvanin, M., Gluvić, Z., Zafirović, S., Gao, X., Essack, M.,& Isenović, E. R.. (2023). The protective role of nutritional antioxidants against oxidative stress in thyroid disorders. in Frontiers in Endocrinology, 13.
https://doi.org/10.3389/fendo.2022.1092837

Mačvanin M, Gluvić Z, Zafirović S, Gao X, Essack M, Isenović ER. The protective role of nutritional antioxidants against oxidative stress in thyroid disorders. in Frontiers in Endocrinology. 2023;13.
doi:10.3389/fendo.2022.1092837 .

Mačvanin, Mirjana, Gluvić, Zoran, Zafirović, Sonja, Gao, Xin, Essack, Magbubah, Isenović, Esma R., "The protective role of nutritional antioxidants against oxidative stress in thyroid disorders" in Frontiers in Endocrinology, 13 (2023),
https://doi.org/10.3389/fendo.2022.1092837 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Gluvić, Zoran
AU  - Bajić, Vladan
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11574
AB  - Diabetes mellitus (DM) is a group of metabolic disorders defined by hyperglycemia induced by insulin resistance, inadequate insulin secretion, or excessive glucagon secretion. In 2021, the global prevalence of diabetes is anticipated to be 10.7% (537 million people). Noncoding RNAs (ncRNAs) appear to have an important role in the initiation and progression of DM, according to a growing body of research. The two major groups of ncRNAs implicated in diabetic disorders are miRNAs and long noncoding RNAs. miRNAs are singlestranded, short (17–25 nucleotides), ncRNAs that influence gene expression at the post-transcriptional level. Because DM has reached epidemic proportions worldwide, it appears that novel diagnostic and therapeutic strategies are required to identify and treat complications associated with these diseases efficiently. miRNAs are gaining attention as biomarkers for DM diagnosis and potential treatment due to their function in maintaining physiological homeostasis via gene expression regulation. In this review, we address the issue of the gradually expanding global prevalence of DM by presenting a complete and upto-date synopsis of various regulatory miRNAs involved in these disorders. We hope this review will spark discussion about ncRNAs as prognostic biomarkers and therapeutic tools for DM. We examine and synthesize recent research that used novel, high-throughput technologies to uncover ncRNAs involved in DM, necessitating a systematic approach to examining and summarizing their roles and possible diagnostic and therapeutic uses.
T2  - World Journal of Diabetes
T1  - Novel insights regarding the role of noncoding RNAs in diabetes
VL  - 14
IS  - 7
SP  - 958
EP  - 976
DO  - 10.4239/wjd.v14.i7.958
ER  - 

@article{
author = "Mačvanin, Mirjana and Gluvić, Zoran and Bajić, Vladan and Isenović, Esma R.",
year = "2023",
abstract = "Diabetes mellitus (DM) is a group of metabolic disorders defined by hyperglycemia induced by insulin resistance, inadequate insulin secretion, or excessive glucagon secretion. In 2021, the global prevalence of diabetes is anticipated to be 10.7% (537 million people). Noncoding RNAs (ncRNAs) appear to have an important role in the initiation and progression of DM, according to a growing body of research. The two major groups of ncRNAs implicated in diabetic disorders are miRNAs and long noncoding RNAs. miRNAs are singlestranded, short (17–25 nucleotides), ncRNAs that influence gene expression at the post-transcriptional level. Because DM has reached epidemic proportions worldwide, it appears that novel diagnostic and therapeutic strategies are required to identify and treat complications associated with these diseases efficiently. miRNAs are gaining attention as biomarkers for DM diagnosis and potential treatment due to their function in maintaining physiological homeostasis via gene expression regulation. In this review, we address the issue of the gradually expanding global prevalence of DM by presenting a complete and upto-date synopsis of various regulatory miRNAs involved in these disorders. We hope this review will spark discussion about ncRNAs as prognostic biomarkers and therapeutic tools for DM. We examine and synthesize recent research that used novel, high-throughput technologies to uncover ncRNAs involved in DM, necessitating a systematic approach to examining and summarizing their roles and possible diagnostic and therapeutic uses.",
journal = "World Journal of Diabetes",
title = "Novel insights regarding the role of noncoding RNAs in diabetes",
volume = "14",
number = "7",
pages = "958-976",
doi = "10.4239/wjd.v14.i7.958"
}

Mačvanin, M., Gluvić, Z., Bajić, V.,& Isenović, E. R.. (2023). Novel insights regarding the role of noncoding RNAs in diabetes. in World Journal of Diabetes, 14(7), 958-976.
https://doi.org/10.4239/wjd.v14.i7.958

Mačvanin M, Gluvić Z, Bajić V, Isenović ER. Novel insights regarding the role of noncoding RNAs in diabetes. in World Journal of Diabetes. 2023;14(7):958-976.
doi:10.4239/wjd.v14.i7.958 .

Mačvanin, Mirjana, Gluvić, Zoran, Bajić, Vladan, Isenović, Esma R., "Novel insights regarding the role of noncoding RNAs in diabetes" in World Journal of Diabetes, 14, no. 7 (2023):958-976,
https://doi.org/10.4239/wjd.v14.i7.958 . .

TY  - JOUR
AU  - Lukić, Nikola
AU  - Mačvanin, Mirjana T.
AU  - Gluvić, Zoran
AU  - Rizzo, Manfredi
AU  - Radak, Đorđe
AU  - Suri, Jasjit S.
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12022
AB  - Type 2 diabetes mellitus (T2DM) has become a worldwide concern in recent years, primarily in highly developed Western societies. T2DM causes systemic complications, such as atherosclerotic heart disease, ischemic stroke, peripheral artery disease, kidney failure, and diabetes-related maculopathy and retinopathy. The growing number of T2DM patients and the treatment of long-term T2DM-related complications pressurize and exhaust public healthcare systems. As a result, strategies for combating T2DM and developing novel drugs are critical global public health requirements. Aside from preventive measures, which are still the most effective way to prevent T2DM, novel and highly effective therapies are emerging. In the spotlight of next-generation T2DM treatment, sodium-glucose co-transporter 2 (SGLT-2) inhibitors are promoted as the most efficient perspective therapy. SGLT-2 inhibitors (SGLT2i) include phlorizin derivatives, such as canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin. SGLT-2, along with SGLT-1, is a member of the SGLT family of proteins that play a role in glucose absorption via active transport mediated by Na+ /K+ ATPase. SGLT-2 is only found in the kidney, specifically the proximal tubule, and is responsible for more than 90% glucose absorption. Inhibition of SGLT-2 reduces glucose absorption, and consequently increases urinary glucose excretion, decreasing blood glucose levels. Thus, the inhibition of SGLT-2 activity ultimately alleviates T2DM-related symptoms and prevents or delays systemic T2DM-associated chronic complications. This review aimed to provide a more detailed understanding of the effects of SGLT2i responsible for the acute improvement in blood glucose regulation, a prerequisite for T2DM-associated cardiovascular complications control.
T2  - Current Medicinal Chemistry
T1  - SGLT-2 Inhibitors: The Next-generation Treatment for Type 2 Diabetes Mellitus
VL  - 31
DO  - 10.2174/0109298673251493231011192520
ER  - 

@article{
author = "Lukić, Nikola and Mačvanin, Mirjana T. and Gluvić, Zoran and Rizzo, Manfredi and Radak, Đorđe and Suri, Jasjit S. and Isenović, Esma R.",
year = "2023",
abstract = "Type 2 diabetes mellitus (T2DM) has become a worldwide concern in recent years, primarily in highly developed Western societies. T2DM causes systemic complications, such as atherosclerotic heart disease, ischemic stroke, peripheral artery disease, kidney failure, and diabetes-related maculopathy and retinopathy. The growing number of T2DM patients and the treatment of long-term T2DM-related complications pressurize and exhaust public healthcare systems. As a result, strategies for combating T2DM and developing novel drugs are critical global public health requirements. Aside from preventive measures, which are still the most effective way to prevent T2DM, novel and highly effective therapies are emerging. In the spotlight of next-generation T2DM treatment, sodium-glucose co-transporter 2 (SGLT-2) inhibitors are promoted as the most efficient perspective therapy. SGLT-2 inhibitors (SGLT2i) include phlorizin derivatives, such as canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin. SGLT-2, along with SGLT-1, is a member of the SGLT family of proteins that play a role in glucose absorption via active transport mediated by Na+ /K+ ATPase. SGLT-2 is only found in the kidney, specifically the proximal tubule, and is responsible for more than 90% glucose absorption. Inhibition of SGLT-2 reduces glucose absorption, and consequently increases urinary glucose excretion, decreasing blood glucose levels. Thus, the inhibition of SGLT-2 activity ultimately alleviates T2DM-related symptoms and prevents or delays systemic T2DM-associated chronic complications. This review aimed to provide a more detailed understanding of the effects of SGLT2i responsible for the acute improvement in blood glucose regulation, a prerequisite for T2DM-associated cardiovascular complications control.",
journal = "Current Medicinal Chemistry",
title = "SGLT-2 Inhibitors: The Next-generation Treatment for Type 2 Diabetes Mellitus",
volume = "31",
doi = "10.2174/0109298673251493231011192520"
}

Lukić, N., Mačvanin, M. T., Gluvić, Z., Rizzo, M., Radak, Đ., Suri, J. S.,& Isenović, E. R.. (2023). SGLT-2 Inhibitors: The Next-generation Treatment for Type 2 Diabetes Mellitus. in Current Medicinal Chemistry, 31.
https://doi.org/10.2174/0109298673251493231011192520

Lukić N, Mačvanin MT, Gluvić Z, Rizzo M, Radak Đ, Suri JS, Isenović ER. SGLT-2 Inhibitors: The Next-generation Treatment for Type 2 Diabetes Mellitus. in Current Medicinal Chemistry. 2023;31.
doi:10.2174/0109298673251493231011192520 .

Lukić, Nikola, Mačvanin, Mirjana T., Gluvić, Zoran, Rizzo, Manfredi, Radak, Đorđe, Suri, Jasjit S., Isenović, Esma R., "SGLT-2 Inhibitors: The Next-generation Treatment for Type 2 Diabetes Mellitus" in Current Medicinal Chemistry, 31 (2023),
https://doi.org/10.2174/0109298673251493231011192520 . .

TY  - JOUR
AU  - Mačvanin, Mirjana T.
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12025
AB  - Diabetes mellitus (DM) refers to a complex cluster of metabolic disorders characterized by hyperglycemia caused by inadequate insulin secretion, insulin resistance, or excessive glucagon secretion. If not correctly treated, the prolonged effects of DM-associated metabolic perturbations lead to systemic vascular complications and cardiovascular disease (CVD), the principal cause of mortality among patients with DM. Given the increase in the global prevalence of diabetes, novel diagnostic and therapeutic procedures are necessary for its effective identification and treatment. Recent findings point to an important role of microRNA (miRNAs) in DM initiation and progression, as well as the occurrence of associated cardiovascular complications. miRNAs are short, highly conserved, single-stranded, non-coding RNAs that contribute to the maintenance of physiological homeostasis through the regulation of crucial processes such as metabolism, cell proliferation, and apoptosis. The increased availability of high-throughput methodologies for identifying and characterizing non-coding RNAs has led to considerable interest in miRNAs as potential biomarkers and therapeutic agents for DM. In this review, we first comprehensively detail the regulatory miRNAs involved in the pathophysiology of DM and diabetic cardiomyopathy (DCMP). Subsequently, we summarize findings regarding the utility of several of these miRNAs as potential prognostic and diagnostic biomarkers for DM and DM-associated CVD. Finally, we evaluate the potential of miRNA-based therapeutic approaches for treating DM and DCMP in the clinical setting.
T2  - Cardiology Plus
T1  - Diabetes and associated cardiovascular complications: The role of microRNAs
VL  - 8
IS  - 3
SP  - 167
EP  - 183
DO  - 10.1097/CP9.0000000000000062
ER  - 

@article{
author = "Mačvanin, Mirjana T. and Isenović, Esma R.",
year = "2023",
abstract = "Diabetes mellitus (DM) refers to a complex cluster of metabolic disorders characterized by hyperglycemia caused by inadequate insulin secretion, insulin resistance, or excessive glucagon secretion. If not correctly treated, the prolonged effects of DM-associated metabolic perturbations lead to systemic vascular complications and cardiovascular disease (CVD), the principal cause of mortality among patients with DM. Given the increase in the global prevalence of diabetes, novel diagnostic and therapeutic procedures are necessary for its effective identification and treatment. Recent findings point to an important role of microRNA (miRNAs) in DM initiation and progression, as well as the occurrence of associated cardiovascular complications. miRNAs are short, highly conserved, single-stranded, non-coding RNAs that contribute to the maintenance of physiological homeostasis through the regulation of crucial processes such as metabolism, cell proliferation, and apoptosis. The increased availability of high-throughput methodologies for identifying and characterizing non-coding RNAs has led to considerable interest in miRNAs as potential biomarkers and therapeutic agents for DM. In this review, we first comprehensively detail the regulatory miRNAs involved in the pathophysiology of DM and diabetic cardiomyopathy (DCMP). Subsequently, we summarize findings regarding the utility of several of these miRNAs as potential prognostic and diagnostic biomarkers for DM and DM-associated CVD. Finally, we evaluate the potential of miRNA-based therapeutic approaches for treating DM and DCMP in the clinical setting.",
journal = "Cardiology Plus",
title = "Diabetes and associated cardiovascular complications: The role of microRNAs",
volume = "8",
number = "3",
pages = "167-183",
doi = "10.1097/CP9.0000000000000062"
}

Mačvanin, M. T.,& Isenović, E. R.. (2023). Diabetes and associated cardiovascular complications: The role of microRNAs. in Cardiology Plus, 8(3), 167-183.
https://doi.org/10.1097/CP9.0000000000000062

Mačvanin MT, Isenović ER. Diabetes and associated cardiovascular complications: The role of microRNAs. in Cardiology Plus. 2023;8(3):167-183.
doi:10.1097/CP9.0000000000000062 .

Mačvanin, Mirjana T., Isenović, Esma R., "Diabetes and associated cardiovascular complications: The role of microRNAs" in Cardiology Plus, 8, no. 3 (2023):167-183,
https://doi.org/10.1097/CP9.0000000000000062 . .

TY  - JOUR
AU  - Zarić, Božidarka
AU  - Mačvanin, Mirjana
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10562
AB  - Reactive species are highly-reactive enzymatically, or non-enzymatically produced compounds with important roles in physiological and pathophysiological cellular processes. Although reactive species represent an extensively researched topic in biomedical sciences, many aspects of their roles and functions remain unclear. This review aims to systematically summarize findings regarding the biochemical characteristics of various types of reactive species and specify the localization and mechanisms of their production in cells. In addition, we discuss the specific roles of free radicals in cellular physiology, focusing on the current lines of research that aim to identify the reactive oxygen species-initiated cascades of reactions resulting in adaptive or pathological cellular responses. Finally, we present recent findings regarding the therapeutic modulations of intracellular levels of reactive oxygen species, which may have substantial significance in developing novel agents for treating several diseases.
T2  - The International Journal of Biochemistry and Cell Biology
T1  - Free radicals: Relationship to Human Diseases and Potential Therapeutic applications
VL  - 154
SP  - 106346
DO  - 10.1016/j.biocel.2022.106346
ER  - 

@article{
author = "Zarić, Božidarka and Mačvanin, Mirjana and Isenović, Esma R.",
year = "2023",
abstract = "Reactive species are highly-reactive enzymatically, or non-enzymatically produced compounds with important roles in physiological and pathophysiological cellular processes. Although reactive species represent an extensively researched topic in biomedical sciences, many aspects of their roles and functions remain unclear. This review aims to systematically summarize findings regarding the biochemical characteristics of various types of reactive species and specify the localization and mechanisms of their production in cells. In addition, we discuss the specific roles of free radicals in cellular physiology, focusing on the current lines of research that aim to identify the reactive oxygen species-initiated cascades of reactions resulting in adaptive or pathological cellular responses. Finally, we present recent findings regarding the therapeutic modulations of intracellular levels of reactive oxygen species, which may have substantial significance in developing novel agents for treating several diseases.",
journal = "The International Journal of Biochemistry and Cell Biology",
title = "Free radicals: Relationship to Human Diseases and Potential Therapeutic applications",
volume = "154",
pages = "106346",
doi = "10.1016/j.biocel.2022.106346"
}

Zarić, B., Mačvanin, M.,& Isenović, E. R.. (2023). Free radicals: Relationship to Human Diseases and Potential Therapeutic applications. in The International Journal of Biochemistry and Cell Biology, 154, 106346.
https://doi.org/10.1016/j.biocel.2022.106346

Zarić B, Mačvanin M, Isenović ER. Free radicals: Relationship to Human Diseases and Potential Therapeutic applications. in The International Journal of Biochemistry and Cell Biology. 2023;154:106346.
doi:10.1016/j.biocel.2022.106346 .

Zarić, Božidarka, Mačvanin, Mirjana, Isenović, Esma R., "Free radicals: Relationship to Human Diseases and Potential Therapeutic applications" in The International Journal of Biochemistry and Cell Biology, 154 (2023):106346,
https://doi.org/10.1016/j.biocel.2022.106346 . .

TY  - JOUR
AU  - Alamro, Hind
AU  - Bajić, Vladan P.
AU  - Mačvanin, Mirjana
AU  - Isenović, Esma R.
AU  - Gojobori, Takashi
AU  - Essack, Magbubah
AU  - Gao, Xin
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10628
AB  - MicroRNAs (miRNAs) are critical regulators of gene expression in healthy and diseased states, and numerous studies have established their tremendous potential as a tool for improving the diagnosis of Type 2 Diabetes Mellitus (T2D) and its comorbidities. In this regard, we computationally identify novel top-ranked hub miRNAs that might be involved in T2D. We accomplish this via two strategies: 1) by ranking miRNAs based on the number of T2D differentially expressed genes (DEGs) they target, and 2) using only the common DEGs between T2D and its comorbidity, Alzheimer’s disease (AD) to predict and rank miRNA. Then classifier models are built using the DEGs targeted by each miRNA as features. Here, we show the T2D DEGs targeted by hsa-mir-1-3p, hsa-mir-16-5p, hsa-mir-124-3p, hsa-mir-34a-5p, hsa-let-7b-5p, hsa-mir-155-5p, hsa-mir-107, hsa-mir-27a-3p, hsa-mir-129-2-3p, and hsa-mir-146a-5p are capable of distinguishing T2D samples from the controls, which serves as a measure of confidence in the miRNAs’ potential role in T2D progression. Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease’s comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir-124-3p models achieved the best scores for the AD datasets. To the best of our knowledge, this is the first study that used predicted miRNAs to determine the features that can separate the diseased samples (T2D or AD) from the normal ones, instead of using conventional non-biology-based feature selection methods.
T2  - Frontiers in Endocrinology
T1  - Type 2 Diabetes Mellitus and its comorbidity, Alzheimer’s disease: Identifying critical microRNA using machine learning
VL  - 13
SP  - 1084656
DO  - 10.3389/fendo.2022.1084656
ER  - 

@article{
author = "Alamro, Hind and Bajić, Vladan P. and Mačvanin, Mirjana and Isenović, Esma R. and Gojobori, Takashi and Essack, Magbubah and Gao, Xin",
year = "2023",
abstract = "MicroRNAs (miRNAs) are critical regulators of gene expression in healthy and diseased states, and numerous studies have established their tremendous potential as a tool for improving the diagnosis of Type 2 Diabetes Mellitus (T2D) and its comorbidities. In this regard, we computationally identify novel top-ranked hub miRNAs that might be involved in T2D. We accomplish this via two strategies: 1) by ranking miRNAs based on the number of T2D differentially expressed genes (DEGs) they target, and 2) using only the common DEGs between T2D and its comorbidity, Alzheimer’s disease (AD) to predict and rank miRNA. Then classifier models are built using the DEGs targeted by each miRNA as features. Here, we show the T2D DEGs targeted by hsa-mir-1-3p, hsa-mir-16-5p, hsa-mir-124-3p, hsa-mir-34a-5p, hsa-let-7b-5p, hsa-mir-155-5p, hsa-mir-107, hsa-mir-27a-3p, hsa-mir-129-2-3p, and hsa-mir-146a-5p are capable of distinguishing T2D samples from the controls, which serves as a measure of confidence in the miRNAs’ potential role in T2D progression. Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease’s comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir-124-3p models achieved the best scores for the AD datasets. To the best of our knowledge, this is the first study that used predicted miRNAs to determine the features that can separate the diseased samples (T2D or AD) from the normal ones, instead of using conventional non-biology-based feature selection methods.",
journal = "Frontiers in Endocrinology",
title = "Type 2 Diabetes Mellitus and its comorbidity, Alzheimer’s disease: Identifying critical microRNA using machine learning",
volume = "13",
pages = "1084656",
doi = "10.3389/fendo.2022.1084656"
}

Alamro, H., Bajić, V. P., Mačvanin, M., Isenović, E. R., Gojobori, T., Essack, M.,& Gao, X.. (2023). Type 2 Diabetes Mellitus and its comorbidity, Alzheimer’s disease: Identifying critical microRNA using machine learning. in Frontiers in Endocrinology, 13, 1084656.
https://doi.org/10.3389/fendo.2022.1084656

Alamro H, Bajić VP, Mačvanin M, Isenović ER, Gojobori T, Essack M, Gao X. Type 2 Diabetes Mellitus and its comorbidity, Alzheimer’s disease: Identifying critical microRNA using machine learning. in Frontiers in Endocrinology. 2023;13:1084656.
doi:10.3389/fendo.2022.1084656 .

Alamro, Hind, Bajić, Vladan P., Mačvanin, Mirjana, Isenović, Esma R., Gojobori, Takashi, Essack, Magbubah, Gao, Xin, "Type 2 Diabetes Mellitus and its comorbidity, Alzheimer’s disease: Identifying critical microRNA using machine learning" in Frontiers in Endocrinology, 13 (2023):1084656,
https://doi.org/10.3389/fendo.2022.1084656 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Gluvić, Zoran
AU  - Radovanović, Jelena
AU  - Essack, Magbubah
AU  - Gao, Xin
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10686
AB  - Cardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV healthMethodsWe searched PubMed and MEDLINE for English and non-English articles with English abstracts published between 1957 (when the first report on IGF-1 identification was published) and 2022. The top search terms were: IGF-1, cardiovascular disease, IGF-1 receptors, IGF-1 and microRNAs, therapeutic interventions with IGF-1, IGF-1 and diabetes, IGF-1 and cardiovascular disease. The search retrieved original peer-reviewed articles, which were further analyzed, focusing on the role of IGF-1 in pathophysiological conditions. We specifically focused on including the most recent findings published in the past five years.ResultsIGF-1, an anabolic growth factor, regulates cell division, proliferation, and survival. In addition to its well-known growth-promoting and metabolic effects, there is mounting evidence that IGF-1 plays a specialized role in the complex activities that underpin CV function. IGF-1 promotes cardiac development and improves cardiac output, stroke volume, contractility, and ejection fraction. Furthermore, IGF-1 mediates many growth hormones (GH) actions. IGF-1 stimulates contractility and tissue remodeling in humans to improve heart function after myocardial infarction. IGF-1 also improves the lipid profile, lowers insulin levels, increases insulin sensitivity, and promotes glucose metabolism. These findings point to the intriguing medicinal potential of IGF-1. Human studies associate low serum levels of free or total IGF-1 with an increased risk of CV and cerebrovascular illness. Extensive human trials are being conducted to investigate the therapeutic efficacy and outcomes of IGF-1-related therapy.DiscussionWe anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs.
T2  - Frontiers in Endocrinology
T1  - New insights on the cardiovascular effects of IGF-1
VL  - 14
SP  - 1142644
DO  - 10.3389/fendo.2023.1142644
ER  - 

@article{
author = "Mačvanin, Mirjana and Gluvić, Zoran and Radovanović, Jelena and Essack, Magbubah and Gao, Xin and Isenović, Esma R.",
year = "2023",
abstract = "Cardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV healthMethodsWe searched PubMed and MEDLINE for English and non-English articles with English abstracts published between 1957 (when the first report on IGF-1 identification was published) and 2022. The top search terms were: IGF-1, cardiovascular disease, IGF-1 receptors, IGF-1 and microRNAs, therapeutic interventions with IGF-1, IGF-1 and diabetes, IGF-1 and cardiovascular disease. The search retrieved original peer-reviewed articles, which were further analyzed, focusing on the role of IGF-1 in pathophysiological conditions. We specifically focused on including the most recent findings published in the past five years.ResultsIGF-1, an anabolic growth factor, regulates cell division, proliferation, and survival. In addition to its well-known growth-promoting and metabolic effects, there is mounting evidence that IGF-1 plays a specialized role in the complex activities that underpin CV function. IGF-1 promotes cardiac development and improves cardiac output, stroke volume, contractility, and ejection fraction. Furthermore, IGF-1 mediates many growth hormones (GH) actions. IGF-1 stimulates contractility and tissue remodeling in humans to improve heart function after myocardial infarction. IGF-1 also improves the lipid profile, lowers insulin levels, increases insulin sensitivity, and promotes glucose metabolism. These findings point to the intriguing medicinal potential of IGF-1. Human studies associate low serum levels of free or total IGF-1 with an increased risk of CV and cerebrovascular illness. Extensive human trials are being conducted to investigate the therapeutic efficacy and outcomes of IGF-1-related therapy.DiscussionWe anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs.",
journal = "Frontiers in Endocrinology",
title = "New insights on the cardiovascular effects of IGF-1",
volume = "14",
pages = "1142644",
doi = "10.3389/fendo.2023.1142644"
}

Mačvanin, M., Gluvić, Z., Radovanović, J., Essack, M., Gao, X.,& Isenović, E. R.. (2023). New insights on the cardiovascular effects of IGF-1. in Frontiers in Endocrinology, 14, 1142644.
https://doi.org/10.3389/fendo.2023.1142644

Mačvanin M, Gluvić Z, Radovanović J, Essack M, Gao X, Isenović ER. New insights on the cardiovascular effects of IGF-1. in Frontiers in Endocrinology. 2023;14:1142644.
doi:10.3389/fendo.2023.1142644 .

Mačvanin, Mirjana, Gluvić, Zoran, Radovanović, Jelena, Essack, Magbubah, Gao, Xin, Isenović, Esma R., "New insights on the cardiovascular effects of IGF-1" in Frontiers in Endocrinology, 14 (2023):1142644,
https://doi.org/10.3389/fendo.2023.1142644 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Zafirović, Sonja
AU  - Obradović, Milan M.
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10687
T2  - Frontiers in Endocrinology
T1  - Editorial: Non-coding RNA in diabetes and cardiovascular diseases
VL  - 14
DO  - 10.3389/fendo.2023.1149857
ER  - 

@article{
author = "Mačvanin, Mirjana and Zafirović, Sonja and Obradović, Milan M. and Isenović, Esma R.",
year = "2023",
journal = "Frontiers in Endocrinology",
title = "Editorial: Non-coding RNA in diabetes and cardiovascular diseases",
volume = "14",
doi = "10.3389/fendo.2023.1149857"
}

Mačvanin, M., Zafirović, S., Obradović, M. M.,& Isenović, E. R.. (2023). Editorial: Non-coding RNA in diabetes and cardiovascular diseases. in Frontiers in Endocrinology, 14.
https://doi.org/10.3389/fendo.2023.1149857

Mačvanin M, Zafirović S, Obradović MM, Isenović ER. Editorial: Non-coding RNA in diabetes and cardiovascular diseases. in Frontiers in Endocrinology. 2023;14.
doi:10.3389/fendo.2023.1149857 .

Mačvanin, Mirjana, Zafirović, Sonja, Obradović, Milan M., Isenović, Esma R., "Editorial: Non-coding RNA in diabetes and cardiovascular diseases" in Frontiers in Endocrinology, 14 (2023),
https://doi.org/10.3389/fendo.2023.1149857 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Obradović, Milan M.
AU  - Zafirović, Sonja
AU  - Stanimirović, Julijana
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10757
AB  - Metabolic diseases such as obesity, diabetes, dyslipidemia, and insulin resistance are characterized by glucose and lipid metabolism alterations and represent a global health problem. Many studies have established the crucial role of micro-ribonucleic acids (miRNAs) in controlling metabolic processes in various tissues. miRNAs are single-stranded, highly conserved non-coding RNAs containing 20-24 oligonucleotides that are expressed in a tissue-specific manner. miRNAs mainly interact through base pairing with 3' untranslated regions of target gene mRNAs to promote inhibition of their translation. miRNAs regulate the expression of as many as 30% of the human genes and have a role in crucial physiological processes such as human growth and development, cell proliferation, apoptosis, and metabolism. The number of miRNA molecules with a confirmed role in the pathogenesis of metabolic diseases is quickly expanding due to the availability of high-throughput methodologies for their identification. In this review, we present recent findings regarding the role of miRNAs as endocrine signaling molecules involved in the regulation of insulin production and fat metabolism. We discuss the potential of extracellular miRNAs present in biological fluids miRNAs as biomarkers for the prediction of diabetes and MetS. We also give an updated overview of therapeutic interventions based on antisense oligonucleotides and the CRISPR/Cas9 editing platform for manipulating levels of miRNAs involved in metabolic disorders. © 2023 Bentham Science Publishers.
T2  - Current Medicinal Chemistry
T1  - The Role of miRNAs in Metabolic Diseases
VL  - 30
IS  - 17
SP  - 1922
EP  - 1944
DO  - 10.2174/0929867329666220801161536
ER  - 

@article{
author = "Mačvanin, Mirjana and Obradović, Milan M. and Zafirović, Sonja and Stanimirović, Julijana and Isenović, Esma R.",
year = "2023",
abstract = "Metabolic diseases such as obesity, diabetes, dyslipidemia, and insulin resistance are characterized by glucose and lipid metabolism alterations and represent a global health problem. Many studies have established the crucial role of micro-ribonucleic acids (miRNAs) in controlling metabolic processes in various tissues. miRNAs are single-stranded, highly conserved non-coding RNAs containing 20-24 oligonucleotides that are expressed in a tissue-specific manner. miRNAs mainly interact through base pairing with 3' untranslated regions of target gene mRNAs to promote inhibition of their translation. miRNAs regulate the expression of as many as 30% of the human genes and have a role in crucial physiological processes such as human growth and development, cell proliferation, apoptosis, and metabolism. The number of miRNA molecules with a confirmed role in the pathogenesis of metabolic diseases is quickly expanding due to the availability of high-throughput methodologies for their identification. In this review, we present recent findings regarding the role of miRNAs as endocrine signaling molecules involved in the regulation of insulin production and fat metabolism. We discuss the potential of extracellular miRNAs present in biological fluids miRNAs as biomarkers for the prediction of diabetes and MetS. We also give an updated overview of therapeutic interventions based on antisense oligonucleotides and the CRISPR/Cas9 editing platform for manipulating levels of miRNAs involved in metabolic disorders. © 2023 Bentham Science Publishers.",
journal = "Current Medicinal Chemistry",
title = "The Role of miRNAs in Metabolic Diseases",
volume = "30",
number = "17",
pages = "1922-1944",
doi = "10.2174/0929867329666220801161536"
}

Mačvanin, M., Obradović, M. M., Zafirović, S., Stanimirović, J.,& Isenović, E. R.. (2023). The Role of miRNAs in Metabolic Diseases. in Current Medicinal Chemistry, 30(17), 1922-1944.
https://doi.org/10.2174/0929867329666220801161536

Mačvanin M, Obradović MM, Zafirović S, Stanimirović J, Isenović ER. The Role of miRNAs in Metabolic Diseases. in Current Medicinal Chemistry. 2023;30(17):1922-1944.
doi:10.2174/0929867329666220801161536 .

Mačvanin, Mirjana, Obradović, Milan M., Zafirović, Sonja, Stanimirović, Julijana, Isenović, Esma R., "The Role of miRNAs in Metabolic Diseases" in Current Medicinal Chemistry, 30, no. 17 (2023):1922-1944,
https://doi.org/10.2174/0929867329666220801161536 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Gluvić, Zoran
AU  - Radovanović, Jelena
AU  - Essack, Magbubah
AU  - Gao, Xin
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10774
AB  - Diabetes mellitus (DM) is on the rise, necessitating the development of novel therapeutic and preventive strategies to mitigate the disease’s debilitating effects. Diabetic cardiomyopathy (DCMP) is among the leading causes of morbidity and mortality in diabetic patients globally. DCMP manifests as cardiomyocyte hypertrophy, apoptosis, and myocardial interstitial fibrosis before progressing to heart failure. Evidence suggests that non-coding RNAs, such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), regulate diabetic cardiomyopathy-related processes such as insulin resistance, cardiomyocyte apoptosis and inflammation, emphasizing their heart-protective effects. This paper reviewed the literature data from animal and human studies on the non-trivial roles of miRNAs and lncRNAs in the context of DCMP in diabetes and demonstrated their future potential in DCMP treatment in diabetic patients.
T2  - Frontiers in Endocrinology
T1  - Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs
VL  - 14
DO  - 10.3389/fendo.2023.1124613
ER  - 

@article{
author = "Mačvanin, Mirjana and Gluvić, Zoran and Radovanović, Jelena and Essack, Magbubah and Gao, Xin and Isenović, Esma R.",
year = "2023",
abstract = "Diabetes mellitus (DM) is on the rise, necessitating the development of novel therapeutic and preventive strategies to mitigate the disease’s debilitating effects. Diabetic cardiomyopathy (DCMP) is among the leading causes of morbidity and mortality in diabetic patients globally. DCMP manifests as cardiomyocyte hypertrophy, apoptosis, and myocardial interstitial fibrosis before progressing to heart failure. Evidence suggests that non-coding RNAs, such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), regulate diabetic cardiomyopathy-related processes such as insulin resistance, cardiomyocyte apoptosis and inflammation, emphasizing their heart-protective effects. This paper reviewed the literature data from animal and human studies on the non-trivial roles of miRNAs and lncRNAs in the context of DCMP in diabetes and demonstrated their future potential in DCMP treatment in diabetic patients.",
journal = "Frontiers in Endocrinology",
title = "Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs",
volume = "14",
doi = "10.3389/fendo.2023.1124613"
}

Mačvanin, M., Gluvić, Z., Radovanović, J., Essack, M., Gao, X.,& Isenović, E. R.. (2023). Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs. in Frontiers in Endocrinology, 14.
https://doi.org/10.3389/fendo.2023.1124613

Mačvanin M, Gluvić Z, Radovanović J, Essack M, Gao X, Isenović ER. Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs. in Frontiers in Endocrinology. 2023;14.
doi:10.3389/fendo.2023.1124613 .

Mačvanin, Mirjana, Gluvić, Zoran, Radovanović, Jelena, Essack, Magbubah, Gao, Xin, Isenović, Esma R., "Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs" in Frontiers in Endocrinology, 14 (2023),
https://doi.org/10.3389/fendo.2023.1124613 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Gluvić, Zoran
AU  - Zarić, Božidarka
AU  - Essack, Magbubah
AU  - Gao, Xin
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11405
AB  - After the metabolic syndrome and its components, thyroid disorders represent the most common endocrine disorders, with increasing prevalence in the last two decades. Thyroid dysfunctions are distinguished by hyperthyroidism, hypothyroidism, or inflammation (thyroiditis) of the thyroid gland, in addition to the presence of thyroid nodules that can be benign or malignant. Thyroid cancer is typically detected via an ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) and cytological examination of the specimen. This approach has significant limitations due to the small sample size and inability to characterize follicular lesions adequately. Due to the rapid advancement of high-throughput molecular biology techniques, it is now possible to identify new biomarkers for thyroid neoplasms that can supplement traditional imaging modalities in postoperative surveillance and aid in the preoperative cytology examination of indeterminate or follicular lesions. Here, we review current knowledge regarding biomarkers that have been reliable in detecting thyroid neoplasms, making them valuable tools for assessing the efficacy of surgical procedures or adjunctive treatment after surgery. We are particularly interested in providing an up-to-date and systematic review of emerging biomarkers, such as mRNA and non-coding RNAs, that can potentially detect thyroid neoplasms in clinical settings. We discuss evidence for miRNA, lncRNA and circRNA dysregulation in several thyroid neoplasms and assess their potential for use as diagnostic and prognostic biomarkers.
T2  - Frontiers in Endocrinology
T1  - New biomarkers: prospect for diagnosis and monitoring of thyroid disease
VL  - 14
SP  - 1218320
DO  - 10.3389/fendo.2023.1218320
ER  - 

@article{
author = "Mačvanin, Mirjana and Gluvić, Zoran and Zarić, Božidarka and Essack, Magbubah and Gao, Xin and Isenović, Esma R.",
year = "2023",
abstract = "After the metabolic syndrome and its components, thyroid disorders represent the most common endocrine disorders, with increasing prevalence in the last two decades. Thyroid dysfunctions are distinguished by hyperthyroidism, hypothyroidism, or inflammation (thyroiditis) of the thyroid gland, in addition to the presence of thyroid nodules that can be benign or malignant. Thyroid cancer is typically detected via an ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) and cytological examination of the specimen. This approach has significant limitations due to the small sample size and inability to characterize follicular lesions adequately. Due to the rapid advancement of high-throughput molecular biology techniques, it is now possible to identify new biomarkers for thyroid neoplasms that can supplement traditional imaging modalities in postoperative surveillance and aid in the preoperative cytology examination of indeterminate or follicular lesions. Here, we review current knowledge regarding biomarkers that have been reliable in detecting thyroid neoplasms, making them valuable tools for assessing the efficacy of surgical procedures or adjunctive treatment after surgery. We are particularly interested in providing an up-to-date and systematic review of emerging biomarkers, such as mRNA and non-coding RNAs, that can potentially detect thyroid neoplasms in clinical settings. We discuss evidence for miRNA, lncRNA and circRNA dysregulation in several thyroid neoplasms and assess their potential for use as diagnostic and prognostic biomarkers.",
journal = "Frontiers in Endocrinology",
title = "New biomarkers: prospect for diagnosis and monitoring of thyroid disease",
volume = "14",
pages = "1218320",
doi = "10.3389/fendo.2023.1218320"
}

Mačvanin, M., Gluvić, Z., Zarić, B., Essack, M., Gao, X.,& Isenović, E. R.. (2023). New biomarkers: prospect for diagnosis and monitoring of thyroid disease. in Frontiers in Endocrinology, 14, 1218320.
https://doi.org/10.3389/fendo.2023.1218320

Mačvanin M, Gluvić Z, Zarić B, Essack M, Gao X, Isenović ER. New biomarkers: prospect for diagnosis and monitoring of thyroid disease. in Frontiers in Endocrinology. 2023;14:1218320.
doi:10.3389/fendo.2023.1218320 .

Mačvanin, Mirjana, Gluvić, Zoran, Zarić, Božidarka, Essack, Magbubah, Gao, Xin, Isenović, Esma R., "New biomarkers: prospect for diagnosis and monitoring of thyroid disease" in Frontiers in Endocrinology, 14 (2023):1218320,
https://doi.org/10.3389/fendo.2023.1218320 . .

TY  - JOUR
AU  - Obradović, Milan M.
AU  - Samardžić, Vladimir
AU  - Mačvanin, Mirjana
AU  - Zafirović, Sonja
AU  - Gluvić, Zoran
AU  - Grubin, Jasmina
AU  - Gao, Xin
AU  - Essack, Magbubah
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11567
AB  - Thyroid nodules (TN) are localized morphological changes in the thyroid gland and can be benign or malignant.Objective: The present study investigates the relationships between biochemical markers in serum (s) and their homologs in washout (w) after fine-needle aspiration biopsy (FNAB) of the TN of interest and their correlation with cytology specimen findings.We investigated the relationships between serum biochemical markers nitric oxide (NO), thyroglobulin (TG), and calcitonin (CT), their homologs in washout after FNAB of the TN of interest, and cytology findings of biopsy samples classified according to the Bethesda system for thyroid cytopathology in this study, which included 86 subjects.Results: Washout TG (TGw) level positively correlates with the cytology finding of the biopsy. A higher level of TGw correlates with higher categories of the Bethesda classification and indicates a higher malignant potential. The levels of serum NO (NOs), serum TG (TGs), serum CT (CTs), and washout CT (CTw) do not correlate with the cytology finding of the biopsy, and the higher levels of washout NO (NOw) correspond to the more suspicious ultrasound findings.The findings of our study suggest that TGw and NOw could be used as potential predictors of malignancy in TN.
T2  - Frontiers in Endocrinology
T1  - Nitric oxide, thyroglobulin, and calcitonin: Unravelling the nature of thyroid nodules
VL  - 14
SP  - 1241223
DO  - 10.3389/fendo.2023.1241223
ER  - 

@article{
author = "Obradović, Milan M. and Samardžić, Vladimir and Mačvanin, Mirjana and Zafirović, Sonja and Gluvić, Zoran and Grubin, Jasmina and Gao, Xin and Essack, Magbubah and Isenović, Esma R.",
year = "2023",
abstract = "Thyroid nodules (TN) are localized morphological changes in the thyroid gland and can be benign or malignant.Objective: The present study investigates the relationships between biochemical markers in serum (s) and their homologs in washout (w) after fine-needle aspiration biopsy (FNAB) of the TN of interest and their correlation with cytology specimen findings.We investigated the relationships between serum biochemical markers nitric oxide (NO), thyroglobulin (TG), and calcitonin (CT), their homologs in washout after FNAB of the TN of interest, and cytology findings of biopsy samples classified according to the Bethesda system for thyroid cytopathology in this study, which included 86 subjects.Results: Washout TG (TGw) level positively correlates with the cytology finding of the biopsy. A higher level of TGw correlates with higher categories of the Bethesda classification and indicates a higher malignant potential. The levels of serum NO (NOs), serum TG (TGs), serum CT (CTs), and washout CT (CTw) do not correlate with the cytology finding of the biopsy, and the higher levels of washout NO (NOw) correspond to the more suspicious ultrasound findings.The findings of our study suggest that TGw and NOw could be used as potential predictors of malignancy in TN.",
journal = "Frontiers in Endocrinology",
title = "Nitric oxide, thyroglobulin, and calcitonin: Unravelling the nature of thyroid nodules",
volume = "14",
pages = "1241223",
doi = "10.3389/fendo.2023.1241223"
}

Obradović, M. M., Samardžić, V., Mačvanin, M., Zafirović, S., Gluvić, Z., Grubin, J., Gao, X., Essack, M.,& Isenović, E. R.. (2023). Nitric oxide, thyroglobulin, and calcitonin: Unravelling the nature of thyroid nodules. in Frontiers in Endocrinology, 14, 1241223.
https://doi.org/10.3389/fendo.2023.1241223

Obradović MM, Samardžić V, Mačvanin M, Zafirović S, Gluvić Z, Grubin J, Gao X, Essack M, Isenović ER. Nitric oxide, thyroglobulin, and calcitonin: Unravelling the nature of thyroid nodules. in Frontiers in Endocrinology. 2023;14:1241223.
doi:10.3389/fendo.2023.1241223 .

Obradović, Milan M., Samardžić, Vladimir, Mačvanin, Mirjana, Zafirović, Sonja, Gluvić, Zoran, Grubin, Jasmina, Gao, Xin, Essack, Magbubah, Isenović, Esma R., "Nitric oxide, thyroglobulin, and calcitonin: Unravelling the nature of thyroid nodules" in Frontiers in Endocrinology, 14 (2023):1241223,
https://doi.org/10.3389/fendo.2023.1241223 . .

TY  - JOUR
AU  - Tomić, Aleksandra
AU  - Zafirović, Sonja
AU  - Gluvić, Zoran
AU  - Samardžić, Vladimir
AU  - Mačvanin, Mirjana
AU  - Radunović, Maja
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11875
AB  - Background:Subacute thyroiditis (SAT) is an organ-specific disease that various drugs, including COVID-19vaccines, can trigger. COVID-19 infection has been associated with thyroid gland damage and disease SARS-CoV-2direct action, euthyroid sick syndrome, and immune-mediated mechanisms are all potential mechanisms of thyroiddamage. It denotes thyroid gland inflammation, most commonly of viral origin, and belongs to the transitory, self-limiting thyroid gland diseases group, causing complications in approximately 15% of patients in the formof permanent hypothyroidism. Some authors say SAT is the most common thyroid disease associated withCOVID-19.Purpose:The occurrence of SAT many weeks after administering the second COVID-19 vaccine is rare and has limiteddocumentation in academic literature. This study aims to present the occurrence of SAT after administering the COVID-19vaccine. We present the case of a 37-year-old man who developed SAT 23 days after receiving the second dose of PfizerBioNTech’s COVID-19 mRNA vaccine.Research design and study sample:Due to neck pain and an elevated body temperature (up to 38.2°C), a 37-year-old male subject presented for examination 23 days after receiving the second Pfizer BioNTech mRNA vaccineagainst SARS-CoV-2 viral infection. The patient deniedever having an autoimmune disease or any other disease.Painful neck palpation and afirm, slightly enlarged thyroid gland with no surrounding lymphadenopathy wereidentified during the exam. The heart rate was 104 beatsper minute. All of the remaining physicalfindings werenormal.Data collection and/or Analysis:Data collected during the disease are integral to the medical record.Results:Hematology and biochemistry analyses at the initial and follow-up visits revealed minor leukocytosis, normocyticanaemia, and thrombocytosis, followed by a mild increase in lactate dehydrogenase and decreased iron levels. The patient’sthyroid function and morphology had recovered entirely from post-vaccine SAT.Conclusions: Results from this study emphasise the need for healthcare professionals to promptly report any case of SATrelated to COVID-19 vaccination. Further investigation is warranted to understand the immunopathogenesis of COVID-19-associated thyroiditis and the impact of COVID-19 immunization on this condition.
T2  - Antiviral Therapy
T1  - Subacute thyroiditis following COVID-19 vaccination: Case presentation
VL  - 28
IS  - 5
DO  - 10.1177/13596535231208831
ER  - 

@article{
author = "Tomić, Aleksandra and Zafirović, Sonja and Gluvić, Zoran and Samardžić, Vladimir and Mačvanin, Mirjana and Radunović, Maja and Isenović, Esma R.",
year = "2023",
abstract = "Background:Subacute thyroiditis (SAT) is an organ-specific disease that various drugs, including COVID-19vaccines, can trigger. COVID-19 infection has been associated with thyroid gland damage and disease SARS-CoV-2direct action, euthyroid sick syndrome, and immune-mediated mechanisms are all potential mechanisms of thyroiddamage. It denotes thyroid gland inflammation, most commonly of viral origin, and belongs to the transitory, self-limiting thyroid gland diseases group, causing complications in approximately 15% of patients in the formof permanent hypothyroidism. Some authors say SAT is the most common thyroid disease associated withCOVID-19.Purpose:The occurrence of SAT many weeks after administering the second COVID-19 vaccine is rare and has limiteddocumentation in academic literature. This study aims to present the occurrence of SAT after administering the COVID-19vaccine. We present the case of a 37-year-old man who developed SAT 23 days after receiving the second dose of PfizerBioNTech’s COVID-19 mRNA vaccine.Research design and study sample:Due to neck pain and an elevated body temperature (up to 38.2°C), a 37-year-old male subject presented for examination 23 days after receiving the second Pfizer BioNTech mRNA vaccineagainst SARS-CoV-2 viral infection. The patient deniedever having an autoimmune disease or any other disease.Painful neck palpation and afirm, slightly enlarged thyroid gland with no surrounding lymphadenopathy wereidentified during the exam. The heart rate was 104 beatsper minute. All of the remaining physicalfindings werenormal.Data collection and/or Analysis:Data collected during the disease are integral to the medical record.Results:Hematology and biochemistry analyses at the initial and follow-up visits revealed minor leukocytosis, normocyticanaemia, and thrombocytosis, followed by a mild increase in lactate dehydrogenase and decreased iron levels. The patient’sthyroid function and morphology had recovered entirely from post-vaccine SAT.Conclusions: Results from this study emphasise the need for healthcare professionals to promptly report any case of SATrelated to COVID-19 vaccination. Further investigation is warranted to understand the immunopathogenesis of COVID-19-associated thyroiditis and the impact of COVID-19 immunization on this condition.",
journal = "Antiviral Therapy",
title = "Subacute thyroiditis following COVID-19 vaccination: Case presentation",
volume = "28",
number = "5",
doi = "10.1177/13596535231208831"
}

Tomić, A., Zafirović, S., Gluvić, Z., Samardžić, V., Mačvanin, M., Radunović, M.,& Isenović, E. R.. (2023). Subacute thyroiditis following COVID-19 vaccination: Case presentation. in Antiviral Therapy, 28(5).
https://doi.org/10.1177/13596535231208831

Tomić A, Zafirović S, Gluvić Z, Samardžić V, Mačvanin M, Radunović M, Isenović ER. Subacute thyroiditis following COVID-19 vaccination: Case presentation. in Antiviral Therapy. 2023;28(5).
doi:10.1177/13596535231208831 .

Tomić, Aleksandra, Zafirović, Sonja, Gluvić, Zoran, Samardžić, Vladimir, Mačvanin, Mirjana, Radunović, Maja, Isenović, Esma R., "Subacute thyroiditis following COVID-19 vaccination: Case presentation" in Antiviral Therapy, 28, no. 5 (2023),
https://doi.org/10.1177/13596535231208831 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Gluvić, Zoran
AU  - Klisić, Aleksandra
AU  - Manojlović, Mia
AU  - Suri, Jasjit
AU  - Rizzo, Manfredi
AU  - Isenović, Esma
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12021
AB  - Cardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on blood vessel walls, forming lipid-laden macrophages (foam cells) that secrete compounds involved in plaque formation. Given the fact that foam cells are one of the key culprits that underlie the pathophysiology of atherosclerosis, special attention has been paid to the investigation of the efficient therapeutic approach to overcome the dysregulation of metabolism of cholesterol in macrophages, decrease the foam cell formation and/or to force its degradation. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory serine proteinase that has emerged as a significant regulator of the lipid metabolism pathway. PCSK9 activation leads to the degradation of LDL receptors (LDLRs), increasing LDL cholesterol (LDL-C) levels in the circulation. PCSK9 pathway dysregulation has been identified as one of the mechanisms involved in atherosclerosis. In addition, microRNAs (miRNAs) are investigated as important epigenetic factors in the pathophysiology of atherosclerosis and dysregulation of lipid metabolism. This review article summarizes the recent findings connecting the role of PCSK9 in atherosclerosis and the involvement of various miRNAs in regulating the expression of PCSK9-related genes. We also discuss PCSK9 pathway-targeting therapeutic interventions based on PCSK9 inhibition, miRNA levels manipulation by therapeutic agents, and the most recent advances in PSCK9 gene editing using CRISPR/Cas9 platform, meganuclease, and base editors.
T2  - Current Medicinal Chemistry
T1  - The Link between miRNAs and PCKS9 in Atherosclerosis
VL  - 31
DO  - 10.2174/0109298673262124231102042914
ER  - 

@article{
author = "Mačvanin, Mirjana and Gluvić, Zoran and Klisić, Aleksandra and Manojlović, Mia and Suri, Jasjit and Rizzo, Manfredi and Isenović, Esma",
year = "2023",
abstract = "Cardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on blood vessel walls, forming lipid-laden macrophages (foam cells) that secrete compounds involved in plaque formation. Given the fact that foam cells are one of the key culprits that underlie the pathophysiology of atherosclerosis, special attention has been paid to the investigation of the efficient therapeutic approach to overcome the dysregulation of metabolism of cholesterol in macrophages, decrease the foam cell formation and/or to force its degradation. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory serine proteinase that has emerged as a significant regulator of the lipid metabolism pathway. PCSK9 activation leads to the degradation of LDL receptors (LDLRs), increasing LDL cholesterol (LDL-C) levels in the circulation. PCSK9 pathway dysregulation has been identified as one of the mechanisms involved in atherosclerosis. In addition, microRNAs (miRNAs) are investigated as important epigenetic factors in the pathophysiology of atherosclerosis and dysregulation of lipid metabolism. This review article summarizes the recent findings connecting the role of PCSK9 in atherosclerosis and the involvement of various miRNAs in regulating the expression of PCSK9-related genes. We also discuss PCSK9 pathway-targeting therapeutic interventions based on PCSK9 inhibition, miRNA levels manipulation by therapeutic agents, and the most recent advances in PSCK9 gene editing using CRISPR/Cas9 platform, meganuclease, and base editors.",
journal = "Current Medicinal Chemistry",
title = "The Link between miRNAs and PCKS9 in Atherosclerosis",
volume = "31",
doi = "10.2174/0109298673262124231102042914"
}

Mačvanin, M., Gluvić, Z., Klisić, A., Manojlović, M., Suri, J., Rizzo, M.,& Isenović, E.. (2023). The Link between miRNAs and PCKS9 in Atherosclerosis. in Current Medicinal Chemistry, 31.
https://doi.org/10.2174/0109298673262124231102042914

Mačvanin M, Gluvić Z, Klisić A, Manojlović M, Suri J, Rizzo M, Isenović E. The Link between miRNAs and PCKS9 in Atherosclerosis. in Current Medicinal Chemistry. 2023;31.
doi:10.2174/0109298673262124231102042914 .

Mačvanin, Mirjana, Gluvić, Zoran, Klisić, Aleksandra, Manojlović, Mia, Suri, Jasjit, Rizzo, Manfredi, Isenović, Esma, "The Link between miRNAs and PCKS9 in Atherosclerosis" in Current Medicinal Chemistry, 31 (2023),
https://doi.org/10.2174/0109298673262124231102042914 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Stanimirović, Julijana
AU  - Isenović, Esma R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10545
AB  - Timely and accurate evaluation of clinical parameters associated with endothelial dysfunctionis critical in diagnosing and treating atherosclerosis, which represents a severe health problem, accountingfor at least 30% of deaths globally. A critical early event in the pathogenesis of atherosclerosis is the oxidativemodification of low-density lipoprotein (LDL). Oxidized LDL (OxLDL) represents numerouschanges in lipid and apolipoprotein B (apo B) fractions of LDLs generated by lipid peroxidation. Anotherindicator of perturbed vascular homeostasis is homocysteine (Hcy), an amino acid containing sulfhydrylgroup,an intermediate methionine and cysteine biosynthesis product. The total level of Hcy in plasmacorrelates better than cholesterol with the risk of cardiovascular disease. In addition, nitric oxide (NO)plays an essential role in regulating vascular physiological homeostasis due to its involvement in intravascularfree radical and oxidant reactions. Reduced NO decreases oxidative stress in the vascular wall,which reduces the rate of LDL oxidation and the expression of redox-sensitive genes involved in atherogenesis.Endothelial dysfunction is typically associated with increased levels of OxLDL, decreased nitricoxide (NO), and hyperhomocysteinemia. Thus, OxLDL, Hcy, and NO are representative parameters ofoxidative stress and endothelial dysfunction. Considering the important role of oxLDL, Hcy and NO inoxidative stress, atherogenesis and accompanying endothelial dysfunction, the challenge of the presentwork was to systematically present available methods for reliable measurement of these parameters andassess their potential for the use in the clinical setting. Here we present a comprehensive overview ofanalytical methods for measuring OxLDL, HCy, and NO in biological samples and discuss their advantagesand potential problems regarding their application in clinical settings.
T2  - Current Analytical Chemistry
T1  - Methods for Measurements of Oxidized LDL, Homocysteine and Nitric Oxide as Clinical Parameters of Oxidative Stress and Endothelial Dysfunction
VL  - 18
IS  - 10
SP  - 1040
EP  - 1056
DO  - 10.2174/1573411018666220827142613
ER  - 

@article{
author = "Mačvanin, Mirjana and Stanimirović, Julijana and Isenović, Esma R.",
year = "2022",
abstract = "Timely and accurate evaluation of clinical parameters associated with endothelial dysfunctionis critical in diagnosing and treating atherosclerosis, which represents a severe health problem, accountingfor at least 30% of deaths globally. A critical early event in the pathogenesis of atherosclerosis is the oxidativemodification of low-density lipoprotein (LDL). Oxidized LDL (OxLDL) represents numerouschanges in lipid and apolipoprotein B (apo B) fractions of LDLs generated by lipid peroxidation. Anotherindicator of perturbed vascular homeostasis is homocysteine (Hcy), an amino acid containing sulfhydrylgroup,an intermediate methionine and cysteine biosynthesis product. The total level of Hcy in plasmacorrelates better than cholesterol with the risk of cardiovascular disease. In addition, nitric oxide (NO)plays an essential role in regulating vascular physiological homeostasis due to its involvement in intravascularfree radical and oxidant reactions. Reduced NO decreases oxidative stress in the vascular wall,which reduces the rate of LDL oxidation and the expression of redox-sensitive genes involved in atherogenesis.Endothelial dysfunction is typically associated with increased levels of OxLDL, decreased nitricoxide (NO), and hyperhomocysteinemia. Thus, OxLDL, Hcy, and NO are representative parameters ofoxidative stress and endothelial dysfunction. Considering the important role of oxLDL, Hcy and NO inoxidative stress, atherogenesis and accompanying endothelial dysfunction, the challenge of the presentwork was to systematically present available methods for reliable measurement of these parameters andassess their potential for the use in the clinical setting. Here we present a comprehensive overview ofanalytical methods for measuring OxLDL, HCy, and NO in biological samples and discuss their advantagesand potential problems regarding their application in clinical settings.",
journal = "Current Analytical Chemistry",
title = "Methods for Measurements of Oxidized LDL, Homocysteine and Nitric Oxide as Clinical Parameters of Oxidative Stress and Endothelial Dysfunction",
volume = "18",
number = "10",
pages = "1040-1056",
doi = "10.2174/1573411018666220827142613"
}

Mačvanin, M., Stanimirović, J.,& Isenović, E. R.. (2022). Methods for Measurements of Oxidized LDL, Homocysteine and Nitric Oxide as Clinical Parameters of Oxidative Stress and Endothelial Dysfunction. in Current Analytical Chemistry, 18(10), 1040-1056.
https://doi.org/10.2174/1573411018666220827142613

Mačvanin M, Stanimirović J, Isenović ER. Methods for Measurements of Oxidized LDL, Homocysteine and Nitric Oxide as Clinical Parameters of Oxidative Stress and Endothelial Dysfunction. in Current Analytical Chemistry. 2022;18(10):1040-1056.
doi:10.2174/1573411018666220827142613 .

Mačvanin, Mirjana, Stanimirović, Julijana, Isenović, Esma R., "Methods for Measurements of Oxidized LDL, Homocysteine and Nitric Oxide as Clinical Parameters of Oxidative Stress and Endothelial Dysfunction" in Current Analytical Chemistry, 18, no. 10 (2022):1040-1056,
https://doi.org/10.2174/1573411018666220827142613 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Rizzo, Manfredi
AU  - Radovanović, Jelena N.
AU  - Sonmez, Alper
AU  - Paneni, Francesco
AU  - Isenović, Esma R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10569
AB  - (1) Background: Obesity is closely connected to the pathophysiology of cardiovascular diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that disrupt cardiovascular homeostasis by activating inflammatory processes that recruit immune cells to the site of injury and reduce nitric oxide levels, resulting in increased blood pressure, endothelial cell migration, proliferation, and apoptosis. Adipose tissue produces adipokines, such as chemerin, that may alter immune responses, lipid metabolism, vascular homeostasis, and angiogenesis. (2) Methods: We performed PubMed and MEDLINE searches for articles with English abstracts published between 1997 (when the first report on chemerin identification was published) and 2022. The search retrieved original peer-reviewed articles analyzed in the context of the role of chemerin in CVDs, explicitly focusing on the most recent findings published in the past five years. (3) Results: This review summarizes up-to-date findings related to mechanisms of chemerin action, its role in the development and progression of CVDs, and novel strategies for developing chemerin-targeting therapeutic agents for treating CVDs. (4) Conclusions: Extensive evidence points to chemerin’s role in vascular inflammation, angiogenesis, and blood pressure modulation, which opens up exciting perspectives for developing chemerin-targeting therapeutic agents for the treatment of CVDs.
T2  - Biomedicines
T1  - Role of Chemerin in Cardiovascular Diseases
VL  - 10
IS  - 11
SP  - 2970
DO  - 10.3390/biomedicines10112970
ER  - 

@article{
author = "Mačvanin, Mirjana and Rizzo, Manfredi and Radovanović, Jelena N. and Sonmez, Alper and Paneni, Francesco and Isenović, Esma R.",
year = "2022",
abstract = "(1) Background: Obesity is closely connected to the pathophysiology of cardiovascular diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that disrupt cardiovascular homeostasis by activating inflammatory processes that recruit immune cells to the site of injury and reduce nitric oxide levels, resulting in increased blood pressure, endothelial cell migration, proliferation, and apoptosis. Adipose tissue produces adipokines, such as chemerin, that may alter immune responses, lipid metabolism, vascular homeostasis, and angiogenesis. (2) Methods: We performed PubMed and MEDLINE searches for articles with English abstracts published between 1997 (when the first report on chemerin identification was published) and 2022. The search retrieved original peer-reviewed articles analyzed in the context of the role of chemerin in CVDs, explicitly focusing on the most recent findings published in the past five years. (3) Results: This review summarizes up-to-date findings related to mechanisms of chemerin action, its role in the development and progression of CVDs, and novel strategies for developing chemerin-targeting therapeutic agents for treating CVDs. (4) Conclusions: Extensive evidence points to chemerin’s role in vascular inflammation, angiogenesis, and blood pressure modulation, which opens up exciting perspectives for developing chemerin-targeting therapeutic agents for the treatment of CVDs.",
journal = "Biomedicines",
title = "Role of Chemerin in Cardiovascular Diseases",
volume = "10",
number = "11",
pages = "2970",
doi = "10.3390/biomedicines10112970"
}

Mačvanin, M., Rizzo, M., Radovanović, J. N., Sonmez, A., Paneni, F.,& Isenović, E. R.. (2022). Role of Chemerin in Cardiovascular Diseases. in Biomedicines, 10(11), 2970.
https://doi.org/10.3390/biomedicines10112970

Mačvanin M, Rizzo M, Radovanović JN, Sonmez A, Paneni F, Isenović ER. Role of Chemerin in Cardiovascular Diseases. in Biomedicines. 2022;10(11):2970.
doi:10.3390/biomedicines10112970 .

Mačvanin, Mirjana, Rizzo, Manfredi, Radovanović, Jelena N., Sonmez, Alper, Paneni, Francesco, Isenović, Esma R., "Role of Chemerin in Cardiovascular Diseases" in Biomedicines, 10, no. 11 (2022):2970,
https://doi.org/10.3390/biomedicines10112970 . .

TY  - CONF
AU  - Tomasović, M.
AU  - Šinik, M.
AU  - Joksimović, Bojan
AU  - Lačković, M.
AU  - Samardžić, Vladimir
AU  - Gluvić, Zoran
AU  - Vujović, M.
AU  - Zafirović, Sonja
AU  - Mačvanin, Mirjana
AU  - Isenović, Esma R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12034
AB  - Uvod i cilj. Hipotiroza je često endokrinološko oboljenje, sa širokim spektrom kliničke prezentacije: od asimptomatske do multiorganske, koja prognostički može biti ozbiljna. Atipične prezentacije hipotiroze retko mogu biti i inicijalne, poput perikardnog izliva (PI). Prikazujemo bolesnika sa novodijagnostikovanom primarnom hipotirozom, prezentovanom simptomima i znacima srčane insuficijencije, sa ehokardiografski detektovanim PI. Metode. Bolesnik je obrađen klinički, elektrokardiografski, laboratorijski i ultrasonografski (štitasta žlezda i srce). Rezultati. Muškarac star 47 godina se javlja u hitnu internističku ambulantu zbog otoka nogu, lica i zamaranja, trajanja oko godinu dana. Anamnestički bez poznatih komorbiditeta. Objektivno se kod hipometaboličnog bolesnika sa JVP 1+, bez prisustva Bekove trijade, detektuju pretibijalni edemi, bez drugog patološkog nalaza po sistemima. TA 110/70 mmHg, P 56/min. EKG: sinusni ritam, frekvence oko 55/min, niže voltaže, bez ST i T promena. U laboratorijskim analizama beleže se blaga normocitna anemija, HLP 2b i povišene vrednosti CK i transaminaza. TFT ukazuju na autoimunsku primarnu hipotirozu (TSH 35, FT4 <1.93, Anti TPO 234). Ehokardiografski nalaz ukazuje na cirkularni PI, bez znakova preteće tamponade, dok ultrazvuk štitaste žlezde odgovara hroničnom tiroiditisu. Vrednosti tumorskih i sistemskih autoimunskih markera su bez odstupanja. Započinje se postepenom supstitucijom levotiroksinom. Kontrolna ehokardiografska studija (pet nedelja nakon inicijalne) ukazuje na smanjenje PI, dok se laboratorijski registruje pad nivoa TSH (6.35). Zaključak. PI je retka inicijalna prezentacija hipotiroze, koja ako se prepozna blagovremeno, sprečava razvoj ozbiljnog kardiovaskularnog morbiditeta. Potrebno je, posebno kod mlađih bolesnika, razmotriti postojanje pridruženih uzroka PI (SBVT, maligne i infektivne bolesti), koji se klinički mogu prezentovati mitigirano.
C3  - KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka
T1  - Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja
SP  - 134
EP  - 134
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12034
ER  - 

@conference{
author = "Tomasović, M. and Šinik, M. and Joksimović, Bojan and Lačković, M. and Samardžić, Vladimir and Gluvić, Zoran and Vujović, M. and Zafirović, Sonja and Mačvanin, Mirjana and Isenović, Esma R.",
year = "2022",
abstract = "Uvod i cilj. Hipotiroza je često endokrinološko oboljenje, sa širokim spektrom kliničke prezentacije: od asimptomatske do multiorganske, koja prognostički može biti ozbiljna. Atipične prezentacije hipotiroze retko mogu biti i inicijalne, poput perikardnog izliva (PI). Prikazujemo bolesnika sa novodijagnostikovanom primarnom hipotirozom, prezentovanom simptomima i znacima srčane insuficijencije, sa ehokardiografski detektovanim PI. Metode. Bolesnik je obrađen klinički, elektrokardiografski, laboratorijski i ultrasonografski (štitasta žlezda i srce). Rezultati. Muškarac star 47 godina se javlja u hitnu internističku ambulantu zbog otoka nogu, lica i zamaranja, trajanja oko godinu dana. Anamnestički bez poznatih komorbiditeta. Objektivno se kod hipometaboličnog bolesnika sa JVP 1+, bez prisustva Bekove trijade, detektuju pretibijalni edemi, bez drugog patološkog nalaza po sistemima. TA 110/70 mmHg, P 56/min. EKG: sinusni ritam, frekvence oko 55/min, niže voltaže, bez ST i T promena. U laboratorijskim analizama beleže se blaga normocitna anemija, HLP 2b i povišene vrednosti CK i transaminaza. TFT ukazuju na autoimunsku primarnu hipotirozu (TSH 35, FT4 <1.93, Anti TPO 234). Ehokardiografski nalaz ukazuje na cirkularni PI, bez znakova preteće tamponade, dok ultrazvuk štitaste žlezde odgovara hroničnom tiroiditisu. Vrednosti tumorskih i sistemskih autoimunskih markera su bez odstupanja. Započinje se postepenom supstitucijom levotiroksinom. Kontrolna ehokardiografska studija (pet nedelja nakon inicijalne) ukazuje na smanjenje PI, dok se laboratorijski registruje pad nivoa TSH (6.35). Zaključak. PI je retka inicijalna prezentacija hipotiroze, koja ako se prepozna blagovremeno, sprečava razvoj ozbiljnog kardiovaskularnog morbiditeta. Potrebno je, posebno kod mlađih bolesnika, razmotriti postojanje pridruženih uzroka PI (SBVT, maligne i infektivne bolesti), koji se klinički mogu prezentovati mitigirano.",
journal = "KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka",
title = "Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja",
pages = "134-134",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12034"
}

Tomasović, M., Šinik, M., Joksimović, B., Lačković, M., Samardžić, V., Gluvić, Z., Vujović, M., Zafirović, S., Mačvanin, M.,& Isenović, E. R.. (2022). Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja. in KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka, 134-134.
https://hdl.handle.net/21.15107/rcub_vinar_12034

Tomasović M, Šinik M, Joksimović B, Lačković M, Samardžić V, Gluvić Z, Vujović M, Zafirović S, Mačvanin M, Isenović ER. Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja. in KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka. 2022;:134-134.
https://hdl.handle.net/21.15107/rcub_vinar_12034 .

Tomasović, M., Šinik, M., Joksimović, Bojan, Lačković, M., Samardžić, Vladimir, Gluvić, Zoran, Vujović, M., Zafirović, Sonja, Mačvanin, Mirjana, Isenović, Esma R., "Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja" in KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka (2022):134-134,
https://hdl.handle.net/21.15107/rcub_vinar_12034 .

TY  - JOUR
AU  - Sevaljevic, L
AU  - Isenović, Esma R.
AU  - Vulović, Mojca D.
AU  - Mačvanin, Mirjana
AU  - Žakula, Zorica
AU  - Kanazir, Dušan T.
AU  - Ribarac-Stepić, Nevena B.
PY  - 2001
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2450
AB  - The responses of liver glucocorticoid receptor (GR) and genes coding for a glucocorticoid-inducible tyrosine aminotransferase (TAT) and two acute-phase proteins (APP) [alpha (2)-macroglobulin (alpha (2)-M) and gamma -fibrinogen (Fb)] to changes in glucocorticoid (GC) and proinflammatory (AP) cytokine contents have been examined in rats after single or combined treatments with turpentine oil, dexamethasone (Dex) and adrenalectomy. Activation of two APP genes in turpentine-induced inflammation was accompanied by an increase in the level of GR mRNA and a preferential translocation of GR-GC complexes to the nucleoplasm, while the expression of TAT remained unaltered. Dex alone caused a decrease in the levels of GR and Fb mRNAs, activation of TAT and alpha (2)-M genes, a decrease in the affinity of hormone binding sites and redistribution of translocated GR-Dex complexes within the nuclei. Inflammation potentiated the effect which Dex alone exerted on the GIR content and the number of GR binding sites but counteracted its influence on the affinity of GR binding sites and nuclear distribution of GR-Dex complexes.
T2  - Biological Signals and Receptors
T1  - The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines
VL  - 10
IS  - 5
SP  - 299
EP  - 309
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2450
ER  - 

@article{
author = "Sevaljevic, L and Isenović, Esma R. and Vulović, Mojca D. and Mačvanin, Mirjana and Žakula, Zorica and Kanazir, Dušan T. and Ribarac-Stepić, Nevena B.",
year = "2001",
abstract = "The responses of liver glucocorticoid receptor (GR) and genes coding for a glucocorticoid-inducible tyrosine aminotransferase (TAT) and two acute-phase proteins (APP) [alpha (2)-macroglobulin (alpha (2)-M) and gamma -fibrinogen (Fb)] to changes in glucocorticoid (GC) and proinflammatory (AP) cytokine contents have been examined in rats after single or combined treatments with turpentine oil, dexamethasone (Dex) and adrenalectomy. Activation of two APP genes in turpentine-induced inflammation was accompanied by an increase in the level of GR mRNA and a preferential translocation of GR-GC complexes to the nucleoplasm, while the expression of TAT remained unaltered. Dex alone caused a decrease in the levels of GR and Fb mRNAs, activation of TAT and alpha (2)-M genes, a decrease in the affinity of hormone binding sites and redistribution of translocated GR-Dex complexes within the nuclei. Inflammation potentiated the effect which Dex alone exerted on the GIR content and the number of GR binding sites but counteracted its influence on the affinity of GR binding sites and nuclear distribution of GR-Dex complexes.",
journal = "Biological Signals and Receptors",
title = "The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines",
volume = "10",
number = "5",
pages = "299-309",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2450"
}

Sevaljevic, L., Isenović, E. R., Vulović, M. D., Mačvanin, M., Žakula, Z., Kanazir, D. T.,& Ribarac-Stepić, N. B.. (2001). The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines. in Biological Signals and Receptors, 10(5), 299-309.
https://hdl.handle.net/21.15107/rcub_vinar_2450

Sevaljevic L, Isenović ER, Vulović MD, Mačvanin M, Žakula Z, Kanazir DT, Ribarac-Stepić NB. The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines. in Biological Signals and Receptors. 2001;10(5):299-309.
https://hdl.handle.net/21.15107/rcub_vinar_2450 .

Sevaljevic, L, Isenović, Esma R., Vulović, Mojca D., Mačvanin, Mirjana, Žakula, Zorica, Kanazir, Dušan T., Ribarac-Stepić, Nevena B., "The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines" in Biological Signals and Receptors, 10, no. 5 (2001):299-309,
https://hdl.handle.net/21.15107/rcub_vinar_2450 .

TY  - JOUR
AU  - Sevaljevic, L
AU  - Mačvanin, Mirjana
AU  - Žakula, Zorica
AU  - Kanazir, Dušan T.
AU  - Ribarac-Stepić, Nevena B.
PY  - 1998
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2189
AB  - Hormonal requirements for full hepatic expression of alpha(2)-macroglobulin (alpha(2)M), alpha(1)-acid glycoprotein (AGP), haptoglobin (Hp) and gamma-fibrinogen (Fb) were assessed at the level of mRNA. Prior to exposure to turpentine-induced inflammation, rats were either depleted of glucocorticoids by adrenalectomy or supplemented with an excess of dexamethasone. Adrenalectomy alone did not affect the basal level of acute phase protein (APP) expression except for alpha(2)M mRNA, the level of which was enhanced. In contrast, dexamethasone treatment alone promoted full induction of alpha(2)M, significant, but not maximal increase of AGP and Hp mRNAs and suppression of Fb. In adrenalectomized rats, acute phase (AP)-cytokines, released in response to inflammation, promoted full expression of Fb and Hp and increased the level of AGP mRNA whereas alpha(2)M mRNA remained at the basal level. Inflammation in dexamethasone pretreated rats elicited changes which, in comparison to mRNA values for dexamethasone unpretreated inflamed rats, were seen as overexpression of alpha(2)M, full expression of AGP and incomplete expression of Hp, whereas Fb mRNA remained at the basal level. These data suggest that glucocorticoids are the principal inducers of a(2)M and AP-cytokines of Fb. For full induction of AGP, additive actions of glucocorticoids and AP-cytokines are required whereas expression of Hp is predominantly controlled by AP-cytokines. (C) 1998 Elsevier Science Ltd. All rights reserved.
T2  - Journal of Steroid Biochemistry and Molecular Biology
T1  - Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver
VL  - 66
IS  - 5-6
SP  - 347
EP  - 353
DO  - 10.1016/S0960-0760(98)00060-0
ER  - 

@article{
author = "Sevaljevic, L and Mačvanin, Mirjana and Žakula, Zorica and Kanazir, Dušan T. and Ribarac-Stepić, Nevena B.",
year = "1998",
abstract = "Hormonal requirements for full hepatic expression of alpha(2)-macroglobulin (alpha(2)M), alpha(1)-acid glycoprotein (AGP), haptoglobin (Hp) and gamma-fibrinogen (Fb) were assessed at the level of mRNA. Prior to exposure to turpentine-induced inflammation, rats were either depleted of glucocorticoids by adrenalectomy or supplemented with an excess of dexamethasone. Adrenalectomy alone did not affect the basal level of acute phase protein (APP) expression except for alpha(2)M mRNA, the level of which was enhanced. In contrast, dexamethasone treatment alone promoted full induction of alpha(2)M, significant, but not maximal increase of AGP and Hp mRNAs and suppression of Fb. In adrenalectomized rats, acute phase (AP)-cytokines, released in response to inflammation, promoted full expression of Fb and Hp and increased the level of AGP mRNA whereas alpha(2)M mRNA remained at the basal level. Inflammation in dexamethasone pretreated rats elicited changes which, in comparison to mRNA values for dexamethasone unpretreated inflamed rats, were seen as overexpression of alpha(2)M, full expression of AGP and incomplete expression of Hp, whereas Fb mRNA remained at the basal level. These data suggest that glucocorticoids are the principal inducers of a(2)M and AP-cytokines of Fb. For full induction of AGP, additive actions of glucocorticoids and AP-cytokines are required whereas expression of Hp is predominantly controlled by AP-cytokines. (C) 1998 Elsevier Science Ltd. All rights reserved.",
journal = "Journal of Steroid Biochemistry and Molecular Biology",
title = "Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver",
volume = "66",
number = "5-6",
pages = "347-353",
doi = "10.1016/S0960-0760(98)00060-0"
}

Sevaljevic, L., Mačvanin, M., Žakula, Z., Kanazir, D. T.,& Ribarac-Stepić, N. B.. (1998). Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver. in Journal of Steroid Biochemistry and Molecular Biology, 66(5-6), 347-353.
https://doi.org/10.1016/S0960-0760(98)00060-0

Sevaljevic L, Mačvanin M, Žakula Z, Kanazir DT, Ribarac-Stepić NB. Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver. in Journal of Steroid Biochemistry and Molecular Biology. 1998;66(5-6):347-353.
doi:10.1016/S0960-0760(98)00060-0 .

Sevaljevic, L, Mačvanin, Mirjana, Žakula, Zorica, Kanazir, Dušan T., Ribarac-Stepić, Nevena B., "Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver" in Journal of Steroid Biochemistry and Molecular Biology, 66, no. 5-6 (1998):347-353,
https://doi.org/10.1016/S0960-0760(98)00060-0 . .