Lazarević-Pašti, Tamara

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Authority KeyName Variants
orcid::0000-0001-6220-2079
  • Lazarević-Pašti, Tamara (32)
Projects
Studies of enzyme interactions with toxic and pharmacologically active molecules Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča)
Lithium-ion batteries and fuel cells - research and development bilateral project Germany-Serbia [DAAD]
Bilateral project Germany-Serbia, funded by DAAD [Theoretical and experimental development of novel sensor based on graphene composites for the detection of organophosphate pesticides (SeGraPhos)] Carl Tryggers Foundation for Scientific Research
CMST COST Action [CM1203 (PoCheMoN)] COST action CM1203 Polyoxometalate Chemistry for Molecular Nanoscience (PoCheMoN), COST-STSM-ECOST-STSM-CM1203-030416-072554
COST Action [MP1302] DFG [KA 1663/13-1, KA 1663/12-1]
Effects of metabolic and nonmetabolic stressors on the expression and action of neuroendocrine regulators of energy homeostasis Radiosensitivity of human genome
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200146 (University of Belgrade, Faculty of Physical Chemistry)
Studying climate change and its influence on environment: impacts, adaptation and mitigation Synthesis, processing and characterization of nanostructured materials for application in the field of energy, mechanical engineering, environmental protection and biomedicine
Innovation Fund of the Republic of Serbia [CGS50083] Ministry of Science and Environmental Protection of the Republic of Serbia
Ministry of Science and Technological Development of the Republic of Serbia Russian Science Foundation [19-75-10046]
SAB [100339427, 100403339] Sächsische Aufbaubank (SAB) and the European Social Fund (ESF) - InnoTeam-SimplySafe [100331073]
Sächsische Aufbaubank (SAB)(ESF) [No. 100331073)] Serbian Academy of Science and Arts
Swedish Research Council (2014-5993) Swiss National Science Foundation (200020-153549)
Swiss National Science Foundation (200020-175800) Swiss National Science Foundation (206021-113149)
Tomsk Polytechnic University Competitiveness Enhancement Program

Author's Bibliography

A review of nanocomposite-modified electrochemical sensors for water quality monitoring

Kanoun, Olfa; Lazarević-Pašti, Tamara; Pašti, Igor A.; Nasraoui, Salem; Talbi, Malak; Brahem, Amina; Adiraju, Anurag; Sheremet, Evgeniya; Rodriguez, Raul; Ben Ali, Mounir; Al-Hamry, Ammar

(2021)

TY  - JOUR
AU  - Kanoun, Olfa
AU  - Lazarević-Pašti, Tamara
AU  - Pašti, Igor A.
AU  - Nasraoui, Salem
AU  - Talbi, Malak
AU  - Brahem, Amina
AU  - Adiraju, Anurag
AU  - Sheremet, Evgeniya
AU  - Rodriguez, Raul
AU  - Ben Ali, Mounir
AU  - Al-Hamry, Ammar
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9847
AB  - Electrochemical sensors play a significant role in detecting chemical ions, molecules, and pathogens in water and other applications. These sensors are sensitive, portable, fast, inexpensive, and suitable for online and in-situ measurements compared to other methods. They can provide the detection for any compound that can undergo certain transformations within a potential window. It enables applications in multiple ion detection, mainly since these sensors are primarily non-specific. In this paper, we provide a survey of electrochemical sensors for the detection of water contaminants, i.e., pesticides, nitrate, nitrite, phosphorus, water hardeners, disinfectant, and other emergent contaminants (phenol, estrogen, gallic acid etc.). We focus on the influence of surface modification of the working electrodes by carbon nanomaterials, metallic nanostructures, imprinted polymers and evaluate the corresponding sensing performance. Especially for pesticides, which are challenging and need special care, we highlight biosensors, such as enzymatic sensors, immunobiosensor, aptasensors, and biomimetic sensors. We discuss the sensors’ overall performance, especially concerning real-sample performance and the capability for actual field application.
T2  - Sensors
T1  - A review of nanocomposite-modified electrochemical sensors for water quality monitoring
VL  - 21
IS  - 12
SP  - 4131
DO  - 10.3390/s21124131
ER  - 
@article{
author = "Kanoun, Olfa and Lazarević-Pašti, Tamara and Pašti, Igor A. and Nasraoui, Salem and Talbi, Malak and Brahem, Amina and Adiraju, Anurag and Sheremet, Evgeniya and Rodriguez, Raul and Ben Ali, Mounir and Al-Hamry, Ammar",
year = "2021",
abstract = "Electrochemical sensors play a significant role in detecting chemical ions, molecules, and pathogens in water and other applications. These sensors are sensitive, portable, fast, inexpensive, and suitable for online and in-situ measurements compared to other methods. They can provide the detection for any compound that can undergo certain transformations within a potential window. It enables applications in multiple ion detection, mainly since these sensors are primarily non-specific. In this paper, we provide a survey of electrochemical sensors for the detection of water contaminants, i.e., pesticides, nitrate, nitrite, phosphorus, water hardeners, disinfectant, and other emergent contaminants (phenol, estrogen, gallic acid etc.). We focus on the influence of surface modification of the working electrodes by carbon nanomaterials, metallic nanostructures, imprinted polymers and evaluate the corresponding sensing performance. Especially for pesticides, which are challenging and need special care, we highlight biosensors, such as enzymatic sensors, immunobiosensor, aptasensors, and biomimetic sensors. We discuss the sensors’ overall performance, especially concerning real-sample performance and the capability for actual field application.",
journal = "Sensors",
title = "A review of nanocomposite-modified electrochemical sensors for water quality monitoring",
volume = "21",
number = "12",
pages = "4131",
doi = "10.3390/s21124131"
}
Kanoun, O., Lazarević-Pašti, T., Pašti, I. A., Nasraoui, S., Talbi, M., Brahem, A., Adiraju, A., Sheremet, E., Rodriguez, R., Ben Ali, M.,& Al-Hamry, A.. (2021). A review of nanocomposite-modified electrochemical sensors for water quality monitoring. in Sensors, 21(12), 4131.
https://doi.org/10.3390/s21124131
Kanoun O, Lazarević-Pašti T, Pašti IA, Nasraoui S, Talbi M, Brahem A, Adiraju A, Sheremet E, Rodriguez R, Ben Ali M, Al-Hamry A. A review of nanocomposite-modified electrochemical sensors for water quality monitoring. in Sensors. 2021;21(12):4131.
doi:10.3390/s21124131 .
Kanoun, Olfa, Lazarević-Pašti, Tamara, Pašti, Igor A., Nasraoui, Salem, Talbi, Malak, Brahem, Amina, Adiraju, Anurag, Sheremet, Evgeniya, Rodriguez, Raul, Ben Ali, Mounir, Al-Hamry, Ammar, "A review of nanocomposite-modified electrochemical sensors for water quality monitoring" in Sensors, 21, no. 12 (2021):4131,
https://doi.org/10.3390/s21124131 . .
3
5
2
2

An insight into the efficient dimethoate adsorption on graphene-based materials—a combined experimental and dft study

Anićijević, Vladan J.; Lazarević-Pašti, Tamara; Vasić, Vesna M.; Vasić-Anićijević, Dragana D.

(2021)

TY  - JOUR
AU  - Anićijević, Vladan J.
AU  - Lazarević-Pašti, Tamara
AU  - Vasić, Vesna M.
AU  - Vasić-Anićijević, Dragana D.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9811
AB  - The development of highly efficient methods for removing hazardous substances from the environment attracts increasing attention. Understanding the basic principles of the removal processes using graphene materials is equally essential to confirm their application efficiency and safety. (2) Methods: In this contribution, adsorption of pesticide dimethoate (DMT) on graphene-based materials has been investigated on the molecular level. (3) Results: The experimental results’ analysis revealed a cooperative binding mechanism of the DMT on the adsorption sites of investigated materials—graphene oxide (GO) and industrial graphene (IG). The adsorption data were analyzed using various adsorption isotherms to determine the thermodynamics of the adsorption process. The experimental results were correlated with Density Functional Theory (DFT) calculations of DMT adsorption on the model surfaces that appropriately describe the graphene materials’ reactive features. (4) Conclusions: Considering experimental results, calculated adsorption energies, optimized adsorption geometries, and electronic structure, it was proposed that the dispersive interactions determine the adsorption properties of DMT on plain graphene sites (physisorption). Additionally, it was shown that the existence of vacancy-type defect sites on the surfaces could induce strong and dissociative adsorption (chemisorption) of DMT. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
T2  - Applied Sciences (Switzerland)
T1  - An insight into the efficient dimethoate adsorption on graphene-based materials—a combined experimental and dft study
VL  - 11
IS  - 9
DO  - 10.3390/app11094014
ER  - 
@article{
author = "Anićijević, Vladan J. and Lazarević-Pašti, Tamara and Vasić, Vesna M. and Vasić-Anićijević, Dragana D.",
year = "2021",
abstract = "The development of highly efficient methods for removing hazardous substances from the environment attracts increasing attention. Understanding the basic principles of the removal processes using graphene materials is equally essential to confirm their application efficiency and safety. (2) Methods: In this contribution, adsorption of pesticide dimethoate (DMT) on graphene-based materials has been investigated on the molecular level. (3) Results: The experimental results’ analysis revealed a cooperative binding mechanism of the DMT on the adsorption sites of investigated materials—graphene oxide (GO) and industrial graphene (IG). The adsorption data were analyzed using various adsorption isotherms to determine the thermodynamics of the adsorption process. The experimental results were correlated with Density Functional Theory (DFT) calculations of DMT adsorption on the model surfaces that appropriately describe the graphene materials’ reactive features. (4) Conclusions: Considering experimental results, calculated adsorption energies, optimized adsorption geometries, and electronic structure, it was proposed that the dispersive interactions determine the adsorption properties of DMT on plain graphene sites (physisorption). Additionally, it was shown that the existence of vacancy-type defect sites on the surfaces could induce strong and dissociative adsorption (chemisorption) of DMT. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
journal = "Applied Sciences (Switzerland)",
title = "An insight into the efficient dimethoate adsorption on graphene-based materials—a combined experimental and dft study",
volume = "11",
number = "9",
doi = "10.3390/app11094014"
}
Anićijević, V. J., Lazarević-Pašti, T., Vasić, V. M.,& Vasić-Anićijević, D. D.. (2021). An insight into the efficient dimethoate adsorption on graphene-based materials—a combined experimental and dft study. in Applied Sciences (Switzerland), 11(9).
https://doi.org/10.3390/app11094014
Anićijević VJ, Lazarević-Pašti T, Vasić VM, Vasić-Anićijević DD. An insight into the efficient dimethoate adsorption on graphene-based materials—a combined experimental and dft study. in Applied Sciences (Switzerland). 2021;11(9).
doi:10.3390/app11094014 .
Anićijević, Vladan J., Lazarević-Pašti, Tamara, Vasić, Vesna M., Vasić-Anićijević, Dragana D., "An insight into the efficient dimethoate adsorption on graphene-based materials—a combined experimental and dft study" in Applied Sciences (Switzerland), 11, no. 9 (2021),
https://doi.org/10.3390/app11094014 . .

Does the application of acetylcholinesterase inhibitors in the treatment of Alzheimer’s disease lead to depression?

Mitić, Miloš; Lazarević-Pašti, Tamara

(2021)

TY  - JOUR
AU  - Mitić, Miloš
AU  - Lazarević-Pašti, Tamara
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9839
AB  - Alzheimer’s disease and depression are health conditions affecting millions of people around the world. Both are strongly related to the level of the neurotransmitter acetylcholine. Since cholinergic deficit is characteristic of Alzheimer’s disease, acetylcholinesterase inhibitors are applied as relevant drugs for the treatment of this disease, elevating the level of acetylcholine. On the other hand, a high level of acetylcholine is found to be associated with the symptoms of clinical depression. Areas covered: This article aims to discuss if acetylcholinesterase inhibitors used as anti-Alzheimer’s drugs could be the cause of the symptoms of clinical depression often linked to this neurological disorder. Emphasis will be put on drugs currently in use and on newly investigated natural products, which can inhibit AChE activity. Expert opinion: Currently, it is not proven that the patient treated for Alzheimer’s disease is prone to increased risk for depression due to the acetylcholinesterase inhibition, but there are strong indications. The level of acetylcholine is not the only factor in highly complicated diseases like AD and depression. Still, it needs to be considered isolated, keeping in mind the nature of presently available therapy, especially during a rational drug design process. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
T2  - Expert Opinion on Drug Metabolism and Toxicology
T1  - Does the application of acetylcholinesterase inhibitors in the treatment of Alzheimer’s disease lead to depression?
VL  - 17
IS  - 7
SP  - 841
EP  - 856
DO  - 10.1080/17425255.2021.1931681
ER  - 
@article{
author = "Mitić, Miloš and Lazarević-Pašti, Tamara",
year = "2021",
abstract = "Alzheimer’s disease and depression are health conditions affecting millions of people around the world. Both are strongly related to the level of the neurotransmitter acetylcholine. Since cholinergic deficit is characteristic of Alzheimer’s disease, acetylcholinesterase inhibitors are applied as relevant drugs for the treatment of this disease, elevating the level of acetylcholine. On the other hand, a high level of acetylcholine is found to be associated with the symptoms of clinical depression. Areas covered: This article aims to discuss if acetylcholinesterase inhibitors used as anti-Alzheimer’s drugs could be the cause of the symptoms of clinical depression often linked to this neurological disorder. Emphasis will be put on drugs currently in use and on newly investigated natural products, which can inhibit AChE activity. Expert opinion: Currently, it is not proven that the patient treated for Alzheimer’s disease is prone to increased risk for depression due to the acetylcholinesterase inhibition, but there are strong indications. The level of acetylcholine is not the only factor in highly complicated diseases like AD and depression. Still, it needs to be considered isolated, keeping in mind the nature of presently available therapy, especially during a rational drug design process. © 2021 Informa UK Limited, trading as Taylor & Francis Group.",
journal = "Expert Opinion on Drug Metabolism and Toxicology",
title = "Does the application of acetylcholinesterase inhibitors in the treatment of Alzheimer’s disease lead to depression?",
volume = "17",
number = "7",
pages = "841-856",
doi = "10.1080/17425255.2021.1931681"
}
Mitić, M.,& Lazarević-Pašti, T.. (2021). Does the application of acetylcholinesterase inhibitors in the treatment of Alzheimer’s disease lead to depression?. in Expert Opinion on Drug Metabolism and Toxicology, 17(7), 841-856.
https://doi.org/10.1080/17425255.2021.1931681
Mitić M, Lazarević-Pašti T. Does the application of acetylcholinesterase inhibitors in the treatment of Alzheimer’s disease lead to depression?. in Expert Opinion on Drug Metabolism and Toxicology. 2021;17(7):841-856.
doi:10.1080/17425255.2021.1931681 .
Mitić, Miloš, Lazarević-Pašti, Tamara, "Does the application of acetylcholinesterase inhibitors in the treatment of Alzheimer’s disease lead to depression?" in Expert Opinion on Drug Metabolism and Toxicology, 17, no. 7 (2021):841-856,
https://doi.org/10.1080/17425255.2021.1931681 . .
10
3

A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition

Bondžić, Aleksandra; Lazarević-Pašti, Tamara; Leskovac, Andreja; Petrović, Sandra; Čolović, Mirjana B.; Parac Vogt, Tatjana N.; Janjić, Goran V.

(2020)

TY  - JOUR
AU  - Bondžić, Aleksandra
AU  - Lazarević-Pašti, Tamara
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Čolović, Mirjana B.
AU  - Parac Vogt, Tatjana N.
AU  - Janjić, Goran V.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9028
AB  - Acetylcholinesterase (AChE) inhibitors are important in the treatment of neurodegenerative diseases. Two inhibitors,12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate(POM) type structure, have been shown to inhibit AChE activity in nM concentration. Circular dichroism andtryptophan fluorescence spectroscopy demonstrated that the AChE inhibition was not accompanied by significantchanges in the secondary structure of the enzyme. The molecular docking approach has revealed a newallosteric binding site, termed β-allosteric site (β-AS), which is considered responsible for the inhibition of AChEby POMs. To the best of our knowledge, this is the first study reporting a new allosteric site that is consideredresponsible for AChE inhibition by voluminous and negatively charged molecules such as POMs. The selectedPOMs were further subjected to genotoxicity testing using human peripheral blood cells as a model system. Itwas shown that WSiA and WPA induced a mild cytostatic but not genotoxic effects in human lymphocytes, whichindicates their potential to be used as medicinal drugs. The identification of non-toxic compounds capable ofbinding to an allosteric site that so far has not been considered responsible for enzyme inhibition could befundamental for the development of new drug design strategies and the discovery of more efficient AChEmodulators.
T2  - European Journal of Pharmaceutical Sciences
T1  - A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition
VL  - 151
SP  - 105376
DO  - 10.1016/j.ejps.2020.105376
ER  - 
@article{
author = "Bondžić, Aleksandra and Lazarević-Pašti, Tamara and Leskovac, Andreja and Petrović, Sandra and Čolović, Mirjana B. and Parac Vogt, Tatjana N. and Janjić, Goran V.",
year = "2020",
abstract = "Acetylcholinesterase (AChE) inhibitors are important in the treatment of neurodegenerative diseases. Two inhibitors,12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate(POM) type structure, have been shown to inhibit AChE activity in nM concentration. Circular dichroism andtryptophan fluorescence spectroscopy demonstrated that the AChE inhibition was not accompanied by significantchanges in the secondary structure of the enzyme. The molecular docking approach has revealed a newallosteric binding site, termed β-allosteric site (β-AS), which is considered responsible for the inhibition of AChEby POMs. To the best of our knowledge, this is the first study reporting a new allosteric site that is consideredresponsible for AChE inhibition by voluminous and negatively charged molecules such as POMs. The selectedPOMs were further subjected to genotoxicity testing using human peripheral blood cells as a model system. Itwas shown that WSiA and WPA induced a mild cytostatic but not genotoxic effects in human lymphocytes, whichindicates their potential to be used as medicinal drugs. The identification of non-toxic compounds capable ofbinding to an allosteric site that so far has not been considered responsible for enzyme inhibition could befundamental for the development of new drug design strategies and the discovery of more efficient AChEmodulators.",
journal = "European Journal of Pharmaceutical Sciences",
title = "A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition",
volume = "151",
pages = "105376",
doi = "10.1016/j.ejps.2020.105376"
}
Bondžić, A., Lazarević-Pašti, T., Leskovac, A., Petrović, S., Čolović, M. B., Parac Vogt, T. N.,& Janjić, G. V.. (2020). A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition. in European Journal of Pharmaceutical Sciences, 151, 105376.
https://doi.org/10.1016/j.ejps.2020.105376
Bondžić A, Lazarević-Pašti T, Leskovac A, Petrović S, Čolović MB, Parac Vogt TN, Janjić GV. A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition. in European Journal of Pharmaceutical Sciences. 2020;151:105376.
doi:10.1016/j.ejps.2020.105376 .
Bondžić, Aleksandra, Lazarević-Pašti, Tamara, Leskovac, Andreja, Petrović, Sandra, Čolović, Mirjana B., Parac Vogt, Tatjana N., Janjić, Goran V., "A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition" in European Journal of Pharmaceutical Sciences, 151 (2020):105376,
https://doi.org/10.1016/j.ejps.2020.105376 . .
7

Organophosphates: Application, effects on human health and removal

Anićijević, V.J.; Lazarević-Pašti, Tamara

(2020)

TY  - CHAP
AU  - Anićijević, V.J.
AU  - Lazarević-Pašti, Tamara
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9745
AB  - Organophosphates (OPs) are widely used nowadays. They are applied as pesticides, drugs or chemical warfare agents. Their acute toxicity is ascribed to the inhibition of acetylcholinesterase (AChE), a key enzyme in the transmission of nerve impulses in mammals. The mentioned toxic effect is manifested by the accumulation of acetylcholine and can lead to severe neurological disorders, paralysis or death. Besides, chronic exposure to organophosphates is connected with depression and cancer development in mammals. OPs poisoning therapy is based on the application of specific antidotes as well as non-specific and symptomatic procedures. In this contribution, recent achievements concerning the protection from OPs activity and an overview of the methods for their removal from the environment and decontamination of contaminated persons were presented. The new findings regarding the involvement of organophosphates in cancer development are reviewed. Also, attention was paid on the connection between OPs and clinical depression – the link insufficiently investigated and described in the literature. © 2020 Nova Science Publishers, Inc.
T2  - Organophosphate Pesticides
T1  - Organophosphates: Application, effects on human health and removal
SP  - 1
EP  - 42
ER  - 
@inbook{
author = "Anićijević, V.J. and Lazarević-Pašti, Tamara",
year = "2020",
abstract = "Organophosphates (OPs) are widely used nowadays. They are applied as pesticides, drugs or chemical warfare agents. Their acute toxicity is ascribed to the inhibition of acetylcholinesterase (AChE), a key enzyme in the transmission of nerve impulses in mammals. The mentioned toxic effect is manifested by the accumulation of acetylcholine and can lead to severe neurological disorders, paralysis or death. Besides, chronic exposure to organophosphates is connected with depression and cancer development in mammals. OPs poisoning therapy is based on the application of specific antidotes as well as non-specific and symptomatic procedures. In this contribution, recent achievements concerning the protection from OPs activity and an overview of the methods for their removal from the environment and decontamination of contaminated persons were presented. The new findings regarding the involvement of organophosphates in cancer development are reviewed. Also, attention was paid on the connection between OPs and clinical depression – the link insufficiently investigated and described in the literature. © 2020 Nova Science Publishers, Inc.",
journal = "Organophosphate Pesticides",
booktitle = "Organophosphates: Application, effects on human health and removal",
pages = "1-42"
}
Anićijević, V.J.,& Lazarević-Pašti, T.. (2020). Organophosphates: Application, effects on human health and removal. in Organophosphate Pesticides, 1-42.
Anićijević V, Lazarević-Pašti T. Organophosphates: Application, effects on human health and removal. in Organophosphate Pesticides. 2020;:1-42..
Anićijević, V.J., Lazarević-Pašti, Tamara, "Organophosphates: Application, effects on human health and removal" in Organophosphate Pesticides (2020):1-42.

UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations

Savić, Jasmina; Petrović, Sandra; Leskovac, Andreja; Lazarević-Pašti, Tamara; Nastasijević, Branislav J.; Tanović, Brankica B.; Gašić, Slavica M.; Vasić, Vesna M.

(2019)

TY  - JOUR
AU  - Savić, Jasmina
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
AU  - Lazarević-Pašti, Tamara
AU  - Nastasijević, Branislav J.
AU  - Tanović, Brankica B.
AU  - Gašić, Slavica M.
AU  - Vasić, Vesna M.
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0308814618313670
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7821
AB  - UV-C irradiation is widely used in the food industry. However, the health effects from dietary exposure to the irradiated pesticide residues retained in foodstuffs are underestimated. In this study, technical chlorpyrifos (TCPF) and its oil in water (EW) and emulsifiable concentrate (EC) formulations were irradiated by UV-C, and their photodegradation products were subjected to toxicity assessment, including determination of acetylcholinesterase (AChE) activity, genotoxicity and oxidative stress using human blood cells as a model system. Toxicity studies were performed using the chlorpyrifos concentrations in the range of those proposed as the maximum residue levels in plant commodities. TCPF, EW and EC photodegradation products induced DNA damage and oxidative stress, and their genotoxicity did not decrease as a function of irradiation time. Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. Accordingly, the application of UV-C irradiation must be considered when processing the plants previously treated with chlorpyrifos formulations. © 2018 Elsevier Ltd
T2  - Food Chemistry
T1  - UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations
VL  - 271
SP  - 469
EP  - 478
DO  - 10.1016/j.foodchem.2018.07.207
ER  - 
@article{
author = "Savić, Jasmina and Petrović, Sandra and Leskovac, Andreja and Lazarević-Pašti, Tamara and Nastasijević, Branislav J. and Tanović, Brankica B. and Gašić, Slavica M. and Vasić, Vesna M.",
year = "2019",
abstract = "UV-C irradiation is widely used in the food industry. However, the health effects from dietary exposure to the irradiated pesticide residues retained in foodstuffs are underestimated. In this study, technical chlorpyrifos (TCPF) and its oil in water (EW) and emulsifiable concentrate (EC) formulations were irradiated by UV-C, and their photodegradation products were subjected to toxicity assessment, including determination of acetylcholinesterase (AChE) activity, genotoxicity and oxidative stress using human blood cells as a model system. Toxicity studies were performed using the chlorpyrifos concentrations in the range of those proposed as the maximum residue levels in plant commodities. TCPF, EW and EC photodegradation products induced DNA damage and oxidative stress, and their genotoxicity did not decrease as a function of irradiation time. Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. Accordingly, the application of UV-C irradiation must be considered when processing the plants previously treated with chlorpyrifos formulations. © 2018 Elsevier Ltd",
journal = "Food Chemistry",
title = "UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations",
volume = "271",
pages = "469-478",
doi = "10.1016/j.foodchem.2018.07.207"
}
Savić, J., Petrović, S., Leskovac, A., Lazarević-Pašti, T., Nastasijević, B. J., Tanović, B. B., Gašić, S. M.,& Vasić, V. M.. (2019). UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry, 271, 469-478.
https://doi.org/10.1016/j.foodchem.2018.07.207
Savić J, Petrović S, Leskovac A, Lazarević-Pašti T, Nastasijević BJ, Tanović BB, Gašić SM, Vasić VM. UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry. 2019;271:469-478.
doi:10.1016/j.foodchem.2018.07.207 .
Savić, Jasmina, Petrović, Sandra, Leskovac, Andreja, Lazarević-Pašti, Tamara, Nastasijević, Branislav J., Tanović, Brankica B., Gašić, Slavica M., Vasić, Vesna M., "UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations" in Food Chemistry, 271 (2019):469-478,
https://doi.org/10.1016/j.foodchem.2018.07.207 . .
10
8

Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations

Savić, Jasmina; Petrović, Sandra; Leskovac, Andreja; Lazarević-Pašti, Tamara; Nastasijević, Branislav J.; Tanović, Brankica B.; Gašić, Slavica M.; Vasić, Vesna M.

(2019)

TY  - GEN
AU  - Savić, Jasmina
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
AU  - Lazarević-Pašti, Tamara
AU  - Nastasijević, Branislav J.
AU  - Tanović, Brankica B.
AU  - Gašić, Slavica M.
AU  - Vasić, Vesna M.
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0308814618313670
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7831
AB  - Supplementary data 1: Table 1S. The chromatographic gradient profile; Table 2S. CPF concentration decrease (corresponding initial CPF concentration decrease was set as 0%) for all three forms of CPF depending on irradiation time; Table 3S. CPF and CPO concentrations determined chromatographically for TCPF, EW and EC formulations, as the function of irradiation time; % of CPO comparing to initial CPF concentration in all three forms of CPF; 
Supplementary data 2: Material safety data sheet according to 1907/2006/EC, Article 31/version 1; 
Supplementary data 3: Material safety data sheet according to 1907/2006/EC, Article 31/version 4
T2  - Food Chemistry
T1  - Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations
VL  - 271
SP  - 469
EP  - 478
DO  - 10.1016/j.foodchem.2018.07.207
ER  - 
@misc{
author = "Savić, Jasmina and Petrović, Sandra and Leskovac, Andreja and Lazarević-Pašti, Tamara and Nastasijević, Branislav J. and Tanović, Brankica B. and Gašić, Slavica M. and Vasić, Vesna M.",
year = "2019",
abstract = "Supplementary data 1: Table 1S. The chromatographic gradient profile; Table 2S. CPF concentration decrease (corresponding initial CPF concentration decrease was set as 0%) for all three forms of CPF depending on irradiation time; Table 3S. CPF and CPO concentrations determined chromatographically for TCPF, EW and EC formulations, as the function of irradiation time; % of CPO comparing to initial CPF concentration in all three forms of CPF; 
Supplementary data 2: Material safety data sheet according to 1907/2006/EC, Article 31/version 1; 
Supplementary data 3: Material safety data sheet according to 1907/2006/EC, Article 31/version 4",
journal = "Food Chemistry",
title = "Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations",
volume = "271",
pages = "469-478",
doi = "10.1016/j.foodchem.2018.07.207"
}
Savić, J., Petrović, S., Leskovac, A., Lazarević-Pašti, T., Nastasijević, B. J., Tanović, B. B., Gašić, S. M.,& Vasić, V. M.. (2019). Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry, 271, 469-478.
https://doi.org/10.1016/j.foodchem.2018.07.207
Savić J, Petrović S, Leskovac A, Lazarević-Pašti T, Nastasijević BJ, Tanović BB, Gašić SM, Vasić VM. Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry. 2019;271:469-478.
doi:10.1016/j.foodchem.2018.07.207 .
Savić, Jasmina, Petrović, Sandra, Leskovac, Andreja, Lazarević-Pašti, Tamara, Nastasijević, Branislav J., Tanović, Brankica B., Gašić, Slavica M., Vasić, Vesna M., "Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations" in Food Chemistry, 271 (2019):469-478,
https://doi.org/10.1016/j.foodchem.2018.07.207 . .
10
8

Non-thermal plasma needle as an effective tool in dimethoate removal from water

Mitrović, Tatjana; Lazović, Saša; Nastasijević, Branislav J.; Pašti, Igor A.; Vasić, Vesna M.; Lazarević-Pašti, Tamara

(2019)

TY  - JOUR
AU  - Mitrović, Tatjana
AU  - Lazović, Saša
AU  - Nastasijević, Branislav J.
AU  - Pašti, Igor A.
AU  - Vasić, Vesna M.
AU  - Lazarević-Pašti, Tamara
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0301479719307716
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8337
AB  - Intensive use of pesticides requires innovative approaches for their removal from the environment. Here we report the method for degradation of dimethoate in water using non-thermal plasma needle and analyze kinetics of dimethoate removal and possible degradation pathways. The effects of dimethoate initial concentration, plasma treatment time, Argon flow rate and the presence of radical promoters on the effectiveness of proposed method are evaluated. With argon flow rate of 0.5 slm (standard litres per minute) 1 × 10−4 M dimethoate can be removed within 30 min of treatment. Using UPLC analysis it was confirmed that one of the decomposition products is dimethoate oxo-analogue omethoate, which is in fact more toxic than dimethoate. However, the overall toxicity of contaminated water was reduced upon the treatment. The addition of H2O2 as a free radical promoter enhances dimethoate removal, while K2S2O8 results with selective conversion to omethoate. Using mass spectrometry in combination with the theoretical calculations, possible degradation pathways were proposed. The feasibility of the proposed method for dimethoate degradation in real water samples is confirmed. The proposed method is demonstrated as a highly effective approach for dimethoate removal without significant accumulation of undesirable toxic products and secondary waste. © 2019 Elsevier Ltd
T2  - Journal of Environmental Management
T1  - Non-thermal plasma needle as an effective tool in dimethoate removal from water
VL  - 246
SP  - 63
EP  - 70
DO  - 10.1016/j.jenvman.2019.05.143
ER  - 
@article{
author = "Mitrović, Tatjana and Lazović, Saša and Nastasijević, Branislav J. and Pašti, Igor A. and Vasić, Vesna M. and Lazarević-Pašti, Tamara",
year = "2019",
abstract = "Intensive use of pesticides requires innovative approaches for their removal from the environment. Here we report the method for degradation of dimethoate in water using non-thermal plasma needle and analyze kinetics of dimethoate removal and possible degradation pathways. The effects of dimethoate initial concentration, plasma treatment time, Argon flow rate and the presence of radical promoters on the effectiveness of proposed method are evaluated. With argon flow rate of 0.5 slm (standard litres per minute) 1 × 10−4 M dimethoate can be removed within 30 min of treatment. Using UPLC analysis it was confirmed that one of the decomposition products is dimethoate oxo-analogue omethoate, which is in fact more toxic than dimethoate. However, the overall toxicity of contaminated water was reduced upon the treatment. The addition of H2O2 as a free radical promoter enhances dimethoate removal, while K2S2O8 results with selective conversion to omethoate. Using mass spectrometry in combination with the theoretical calculations, possible degradation pathways were proposed. The feasibility of the proposed method for dimethoate degradation in real water samples is confirmed. The proposed method is demonstrated as a highly effective approach for dimethoate removal without significant accumulation of undesirable toxic products and secondary waste. © 2019 Elsevier Ltd",
journal = "Journal of Environmental Management",
title = "Non-thermal plasma needle as an effective tool in dimethoate removal from water",
volume = "246",
pages = "63-70",
doi = "10.1016/j.jenvman.2019.05.143"
}
Mitrović, T., Lazović, S., Nastasijević, B. J., Pašti, I. A., Vasić, V. M.,& Lazarević-Pašti, T.. (2019). Non-thermal plasma needle as an effective tool in dimethoate removal from water. in Journal of Environmental Management, 246, 63-70.
https://doi.org/10.1016/j.jenvman.2019.05.143
Mitrović T, Lazović S, Nastasijević BJ, Pašti IA, Vasić VM, Lazarević-Pašti T. Non-thermal plasma needle as an effective tool in dimethoate removal from water. in Journal of Environmental Management. 2019;246:63-70.
doi:10.1016/j.jenvman.2019.05.143 .
Mitrović, Tatjana, Lazović, Saša, Nastasijević, Branislav J., Pašti, Igor A., Vasić, Vesna M., Lazarević-Pašti, Tamara, "Non-thermal plasma needle as an effective tool in dimethoate removal from water" in Journal of Environmental Management, 246 (2019):63-70,
https://doi.org/10.1016/j.jenvman.2019.05.143 . .
9
9

Detection of Dimethoate Pesticide using Layer by Layer Deposition of PDAC/GO on Ag electrode

Ega, Tharun K; Al-Hamry, Ammar; Kanoun, Olfa; Lazarević-Pašti, Tamara; Bogdanović, Danica B.; Pašti, Igor A.; Rodriguez, Raul D.; Sheremet, Evgeniya; Paterno, Leonardo G.

(IEEE, 2019)

TY  - CONF
AU  - Ega, Tharun K
AU  - Al-Hamry, Ammar
AU  - Kanoun, Olfa
AU  - Lazarević-Pašti, Tamara
AU  - Bogdanović, Danica B.
AU  - Pašti, Igor A.
AU  - Rodriguez, Raul D.
AU  - Sheremet, Evgeniya
AU  - Paterno, Leonardo G.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8665
AB  - Dimethoate (DMT) is an organophosphate pesticide (OP), which is widely used against insects and mites and their control in agriculture. As other OPs, DMT is also an inhibitor of acetylcholinesterase, which is responsible for the disabling of cholinesterase required for the functioning of the central nervous system. This pesticide can invade living cells of the human body through contact or ingestion. We report an electrochemical sensor based on a layer by layer deposition of PDAC/GO on silver electrodes. The sensor fabrication, physical characterization i.e. Raman spectroscopy and scanning electron microscopy of PDAC/GO based films, and its electrochemical characterization are discussed. The detection of DMT by analyzing electrochemical measurements including cyclic voltammetry and impedance spectroscopy shows that functionalization using layer by layer deposition improves electrochemical response and presents a basis for detection of DMT. The highest response is observed in the case of only one PDAC/GO layer which is attributed to the properly balanced interaction between DMT and PDAC/GO layer, and the increase of electrical resistivity of the PDAC/GO layer with its thickness. © 2019 IEEE.
PB  - IEEE
C3  - 2019 16th International Multi-Conference on Systems, Signals & Devices (SSD)
C3  - 2019 16th International Multi-Conference on Systems, Signals & Devices (SSD)
T1  - Detection of Dimethoate Pesticide using Layer by Layer Deposition of PDAC/GO on Ag electrode
SP  - 621
EP  - 625
DO  - 10.1109/SSD.2019.8893253
ER  - 
@conference{
author = "Ega, Tharun K and Al-Hamry, Ammar and Kanoun, Olfa and Lazarević-Pašti, Tamara and Bogdanović, Danica B. and Pašti, Igor A. and Rodriguez, Raul D. and Sheremet, Evgeniya and Paterno, Leonardo G.",
year = "2019",
abstract = "Dimethoate (DMT) is an organophosphate pesticide (OP), which is widely used against insects and mites and their control in agriculture. As other OPs, DMT is also an inhibitor of acetylcholinesterase, which is responsible for the disabling of cholinesterase required for the functioning of the central nervous system. This pesticide can invade living cells of the human body through contact or ingestion. We report an electrochemical sensor based on a layer by layer deposition of PDAC/GO on silver electrodes. The sensor fabrication, physical characterization i.e. Raman spectroscopy and scanning electron microscopy of PDAC/GO based films, and its electrochemical characterization are discussed. The detection of DMT by analyzing electrochemical measurements including cyclic voltammetry and impedance spectroscopy shows that functionalization using layer by layer deposition improves electrochemical response and presents a basis for detection of DMT. The highest response is observed in the case of only one PDAC/GO layer which is attributed to the properly balanced interaction between DMT and PDAC/GO layer, and the increase of electrical resistivity of the PDAC/GO layer with its thickness. © 2019 IEEE.",
publisher = "IEEE",
journal = "2019 16th International Multi-Conference on Systems, Signals & Devices (SSD), 2019 16th International Multi-Conference on Systems, Signals & Devices (SSD)",
title = "Detection of Dimethoate Pesticide using Layer by Layer Deposition of PDAC/GO on Ag electrode",
pages = "621-625",
doi = "10.1109/SSD.2019.8893253"
}
Ega, T. K., Al-Hamry, A., Kanoun, O., Lazarević-Pašti, T., Bogdanović, D. B., Pašti, I. A., Rodriguez, R. D., Sheremet, E.,& Paterno, L. G.. (2019). Detection of Dimethoate Pesticide using Layer by Layer Deposition of PDAC/GO on Ag electrode. in 2019 16th International Multi-Conference on Systems, Signals & Devices (SSD)
IEEE., 621-625.
https://doi.org/10.1109/SSD.2019.8893253
Ega TK, Al-Hamry A, Kanoun O, Lazarević-Pašti T, Bogdanović DB, Pašti IA, Rodriguez RD, Sheremet E, Paterno LG. Detection of Dimethoate Pesticide using Layer by Layer Deposition of PDAC/GO on Ag electrode. in 2019 16th International Multi-Conference on Systems, Signals & Devices (SSD). 2019;:621-625.
doi:10.1109/SSD.2019.8893253 .
Ega, Tharun K, Al-Hamry, Ammar, Kanoun, Olfa, Lazarević-Pašti, Tamara, Bogdanović, Danica B., Pašti, Igor A., Rodriguez, Raul D., Sheremet, Evgeniya, Paterno, Leonardo G., "Detection of Dimethoate Pesticide using Layer by Layer Deposition of PDAC/GO on Ag electrode" in 2019 16th International Multi-Conference on Systems, Signals & Devices (SSD) (2019):621-625,
https://doi.org/10.1109/SSD.2019.8893253 . .
4
2

Electrochemical Sensor based on Reduced Graphene Oxide/PDAC for Dimethoate Pesticide Detection

Al-Hamry, A.; Ega, Tharun K.; Pašti, Igor A.; Bajuk-Bogdanović, Danica; Lazarević-Pašti, Tamara; Rodriguez, Raul D.; Sheremet, Evgeniya S.; Kanoun, Olfa

(2019)

TY  - JOUR
AU  - Al-Hamry, A.
AU  - Ega, Tharun K.
AU  - Pašti, Igor A.
AU  - Bajuk-Bogdanović, Danica
AU  - Lazarević-Pašti, Tamara
AU  - Rodriguez, Raul D.
AU  - Sheremet, Evgeniya S.
AU  - Kanoun, Olfa
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9764
AB  - Extensive use of pesticides and their accumulation in the environment requires swift actions in terms of their removal, detection, and quantification. Currently, golden standard methods used for quantification of pesticides require expensive instrumentation and are not suitable for quick measurements outside of properly equipped laboratory. Here we investigate the detection of dimethoate (DMT) using PDAC/reduced graphene oxide (rGO)-modified Ag electrodes. The sensor performance depends on the temperature used for the reduction of graphene oxide (GO) in PDAC/GO bi-layer on Ag electrode. Using this combination of nanomaterials, we show the quantification of DMT with either voltammetry or impedance spectroscopies. The former approach relies on direct electrochemical transformations of DMT which are observed at relatively high anodic potential around 0.3 V vs. saturated calomel electrode. Impedance spectroscopy shows complex behavior with increasing DMT concentration, but seems to be rather sensitive to low DMT concentrations. These results present a possible direction to the development of highly efficient electrochemical sensors for pesticide detection. © 2019 IEEE.
T2  - 5th International Conference on Nanotechnology for Instrumentation and Measurement, NanofIM 2019
T1  - Electrochemical Sensor based on Reduced Graphene Oxide/PDAC for Dimethoate Pesticide Detection
DO  - 10.1109/NanofIM49467.2019.9233479
ER  - 
@article{
author = "Al-Hamry, A. and Ega, Tharun K. and Pašti, Igor A. and Bajuk-Bogdanović, Danica and Lazarević-Pašti, Tamara and Rodriguez, Raul D. and Sheremet, Evgeniya S. and Kanoun, Olfa",
year = "2019",
abstract = "Extensive use of pesticides and their accumulation in the environment requires swift actions in terms of their removal, detection, and quantification. Currently, golden standard methods used for quantification of pesticides require expensive instrumentation and are not suitable for quick measurements outside of properly equipped laboratory. Here we investigate the detection of dimethoate (DMT) using PDAC/reduced graphene oxide (rGO)-modified Ag electrodes. The sensor performance depends on the temperature used for the reduction of graphene oxide (GO) in PDAC/GO bi-layer on Ag electrode. Using this combination of nanomaterials, we show the quantification of DMT with either voltammetry or impedance spectroscopies. The former approach relies on direct electrochemical transformations of DMT which are observed at relatively high anodic potential around 0.3 V vs. saturated calomel electrode. Impedance spectroscopy shows complex behavior with increasing DMT concentration, but seems to be rather sensitive to low DMT concentrations. These results present a possible direction to the development of highly efficient electrochemical sensors for pesticide detection. © 2019 IEEE.",
journal = "5th International Conference on Nanotechnology for Instrumentation and Measurement, NanofIM 2019",
title = "Electrochemical Sensor based on Reduced Graphene Oxide/PDAC for Dimethoate Pesticide Detection",
doi = "10.1109/NanofIM49467.2019.9233479"
}
Al-Hamry, A., Ega, T. K., Pašti, I. A., Bajuk-Bogdanović, D., Lazarević-Pašti, T., Rodriguez, R. D., Sheremet, E. S.,& Kanoun, O.. (2019). Electrochemical Sensor based on Reduced Graphene Oxide/PDAC for Dimethoate Pesticide Detection. in 5th International Conference on Nanotechnology for Instrumentation and Measurement, NanofIM 2019.
https://doi.org/10.1109/NanofIM49467.2019.9233479
Al-Hamry A, Ega TK, Pašti IA, Bajuk-Bogdanović D, Lazarević-Pašti T, Rodriguez RD, Sheremet ES, Kanoun O. Electrochemical Sensor based on Reduced Graphene Oxide/PDAC for Dimethoate Pesticide Detection. in 5th International Conference on Nanotechnology for Instrumentation and Measurement, NanofIM 2019. 2019;.
doi:10.1109/NanofIM49467.2019.9233479 .
Al-Hamry, A., Ega, Tharun K., Pašti, Igor A., Bajuk-Bogdanović, Danica, Lazarević-Pašti, Tamara, Rodriguez, Raul D., Sheremet, Evgeniya S., Kanoun, Olfa, "Electrochemical Sensor based on Reduced Graphene Oxide/PDAC for Dimethoate Pesticide Detection" in 5th International Conference on Nanotechnology for Instrumentation and Measurement, NanofIM 2019 (2019),
https://doi.org/10.1109/NanofIM49467.2019.9233479 . .

The impact of the structure of graphene-based materials on the removal of organophosphorus pesticides from water

Lazarević-Pašti, Tamara; Anićijević, Vladan J.; Baljozović, Miloš; Vasić Anićijević, Dragana D.; Gutić, Sanjin J.; Vasić, Vesna M.; Skorodumova, Natalia V.; Pašti, Igor A.

(2018)

TY  - JOUR
AU  - Lazarević-Pašti, Tamara
AU  - Anićijević, Vladan J.
AU  - Baljozović, Miloš
AU  - Vasić Anićijević, Dragana D.
AU  - Gutić, Sanjin J.
AU  - Vasić, Vesna M.
AU  - Skorodumova, Natalia V.
AU  - Pašti, Igor A.
PY  - 2018
UR  - http://xlink.rsc.org/?DOI=C8EN00171E
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7730
AB  - The wide use of pesticides in modern agriculture and other areas results in an urgent need for their efficient removal from the environment. Adsorption of pesticides is one of the most commonly used strategies for this task. Here we analyze the adsorption of two organophosphorus pesticides, dimethoate (DMT) and chlorpyrifos (CPF), on graphene-based materials. The adsorption was found to be very sensitive to the structure of the adsorbents used. In particular, aliphatic DMT was found to prefer hydrophilic oxidized graphene surfaces. The CPF molecule, which contains an aromatic moiety, prefers adsorption on the surface of a graphene basal plane with high structural order and preserved π electron system. The toxicity of pesticide solutions is reduced after adsorption, suggesting that there is no oxidation of DMT and CPF to more toxic oxo forms. We emphasize that the combination of structural properties of adsorbents and adsorbates defines the adsorption of organophosphorus pesticides on graphene-based materials, while the specific surface area of adsorbents is not the major factor.
T2  - Environmental Science: Nano
T1  - The impact of the structure of graphene-based materials on the removal of organophosphorus pesticides from water
VL  - 5
IS  - 6
SP  - 1482
EP  - 1494
DO  - 10.1039/C8EN00171E
ER  - 
@article{
author = "Lazarević-Pašti, Tamara and Anićijević, Vladan J. and Baljozović, Miloš and Vasić Anićijević, Dragana D. and Gutić, Sanjin J. and Vasić, Vesna M. and Skorodumova, Natalia V. and Pašti, Igor A.",
year = "2018",
abstract = "The wide use of pesticides in modern agriculture and other areas results in an urgent need for their efficient removal from the environment. Adsorption of pesticides is one of the most commonly used strategies for this task. Here we analyze the adsorption of two organophosphorus pesticides, dimethoate (DMT) and chlorpyrifos (CPF), on graphene-based materials. The adsorption was found to be very sensitive to the structure of the adsorbents used. In particular, aliphatic DMT was found to prefer hydrophilic oxidized graphene surfaces. The CPF molecule, which contains an aromatic moiety, prefers adsorption on the surface of a graphene basal plane with high structural order and preserved π electron system. The toxicity of pesticide solutions is reduced after adsorption, suggesting that there is no oxidation of DMT and CPF to more toxic oxo forms. We emphasize that the combination of structural properties of adsorbents and adsorbates defines the adsorption of organophosphorus pesticides on graphene-based materials, while the specific surface area of adsorbents is not the major factor.",
journal = "Environmental Science: Nano",
title = "The impact of the structure of graphene-based materials on the removal of organophosphorus pesticides from water",
volume = "5",
number = "6",
pages = "1482-1494",
doi = "10.1039/C8EN00171E"
}
Lazarević-Pašti, T., Anićijević, V. J., Baljozović, M., Vasić Anićijević, D. D., Gutić, S. J., Vasić, V. M., Skorodumova, N. V.,& Pašti, I. A.. (2018). The impact of the structure of graphene-based materials on the removal of organophosphorus pesticides from water. in Environmental Science: Nano, 5(6), 1482-1494.
https://doi.org/10.1039/C8EN00171E
Lazarević-Pašti T, Anićijević VJ, Baljozović M, Vasić Anićijević DD, Gutić SJ, Vasić VM, Skorodumova NV, Pašti IA. The impact of the structure of graphene-based materials on the removal of organophosphorus pesticides from water. in Environmental Science: Nano. 2018;5(6):1482-1494.
doi:10.1039/C8EN00171E .
Lazarević-Pašti, Tamara, Anićijević, Vladan J., Baljozović, Miloš, Vasić Anićijević, Dragana D., Gutić, Sanjin J., Vasić, Vesna M., Skorodumova, Natalia V., Pašti, Igor A., "The impact of the structure of graphene-based materials on the removal of organophosphorus pesticides from water" in Environmental Science: Nano, 5, no. 6 (2018):1482-1494,
https://doi.org/10.1039/C8EN00171E . .
7
32
33

Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents

Leskovac, Andreja; Petrović, Sandra; Lazarević-Pašti, Tamara; Krstić, Milena P.; Vasić, Vesna M.

(2018)

TY  - JOUR
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Lazarević-Pašti, Tamara
AU  - Krstić, Milena P.
AU  - Vasić, Vesna M.
PY  - 2018
UR  - http://link.springer.com/10.1007/s00775-018-1560-x
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7765
AB  - In recent years, the search for effective anticancer compounds based on transition metal complexes has been the focus of medical investigations. The synergy between the ruthenium(II) and N-alkylphenothiazine counter-ions (chlorpromazine hydrochloride, thioridazine hydrochloride and trifluoperazine dihydrochloride, respectively) through the formation of three different complexes (1–3) was investigated. We explored whether the selected counter-ions and complexes might affect redox homeostasis and genome integrity of normal human blood cells, and induce an inhibition of Na+/K+-ATPase and AChE at pharmacologically relevant doses. Our results have shown that counter-ions and complexes did not affect the activity of Na+/K+-ATPase, while AChE activity was inhibited in a dose-dependent manner. All investigated compounds disturbed the viability and redox homeostasis of lymphocytes. Complexes 1 and 2 displayed potent cytotoxic and prooxidant action while complex 3 behaved as a weaker genotoxic inducer. Still, the tested complexes appeared to be less genotoxic and more cytostatic than the corresponding counter-ions. The effects of selected complexes were also tested in PC12 and U2OS cancer cells with special attention being given to the ability of phenothiazines to affect dopamine D2 receptors. Using the confocal laser scanning microscopy, we observed that all the complexes reduced cell viability. Although all investigated complexes have been bound to the dopamine receptor D2-eGFP, only complex 3 reduced its surface density and increased its lateral mobility in investigated cell lines. Albeit the role of alternative targets for complex 3 cannot be ruled out, its effects should be further examined as potential treatment strategy against cancer cells that overexpress D2.
T2  - JBIC Journal of Biological Inorganic Chemistry
T1  - Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents
VL  - 23
IS  - 5
SP  - 689
EP  - 704
DO  - 10.1007/s00775-018-1560-x
ER  - 
@article{
author = "Leskovac, Andreja and Petrović, Sandra and Lazarević-Pašti, Tamara and Krstić, Milena P. and Vasić, Vesna M.",
year = "2018",
abstract = "In recent years, the search for effective anticancer compounds based on transition metal complexes has been the focus of medical investigations. The synergy between the ruthenium(II) and N-alkylphenothiazine counter-ions (chlorpromazine hydrochloride, thioridazine hydrochloride and trifluoperazine dihydrochloride, respectively) through the formation of three different complexes (1–3) was investigated. We explored whether the selected counter-ions and complexes might affect redox homeostasis and genome integrity of normal human blood cells, and induce an inhibition of Na+/K+-ATPase and AChE at pharmacologically relevant doses. Our results have shown that counter-ions and complexes did not affect the activity of Na+/K+-ATPase, while AChE activity was inhibited in a dose-dependent manner. All investigated compounds disturbed the viability and redox homeostasis of lymphocytes. Complexes 1 and 2 displayed potent cytotoxic and prooxidant action while complex 3 behaved as a weaker genotoxic inducer. Still, the tested complexes appeared to be less genotoxic and more cytostatic than the corresponding counter-ions. The effects of selected complexes were also tested in PC12 and U2OS cancer cells with special attention being given to the ability of phenothiazines to affect dopamine D2 receptors. Using the confocal laser scanning microscopy, we observed that all the complexes reduced cell viability. Although all investigated complexes have been bound to the dopamine receptor D2-eGFP, only complex 3 reduced its surface density and increased its lateral mobility in investigated cell lines. Albeit the role of alternative targets for complex 3 cannot be ruled out, its effects should be further examined as potential treatment strategy against cancer cells that overexpress D2.",
journal = "JBIC Journal of Biological Inorganic Chemistry",
title = "Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents",
volume = "23",
number = "5",
pages = "689-704",
doi = "10.1007/s00775-018-1560-x"
}
Leskovac, A., Petrović, S., Lazarević-Pašti, T., Krstić, M. P.,& Vasić, V. M.. (2018). Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents. in JBIC Journal of Biological Inorganic Chemistry, 23(5), 689-704.
https://doi.org/10.1007/s00775-018-1560-x
Leskovac A, Petrović S, Lazarević-Pašti T, Krstić MP, Vasić VM. Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents. in JBIC Journal of Biological Inorganic Chemistry. 2018;23(5):689-704.
doi:10.1007/s00775-018-1560-x .
Leskovac, Andreja, Petrović, Sandra, Lazarević-Pašti, Tamara, Krstić, Milena P., Vasić, Vesna M., "Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents" in JBIC Journal of Biological Inorganic Chemistry, 23, no. 5 (2018):689-704,
https://doi.org/10.1007/s00775-018-1560-x . .
3
1

Modulators of Acetylcholinesterase Activity: From Alzheimers Disease to Anti-Cancer Drugs

Lazarević-Pašti, Tamara; Leskovac, Andreja; Momić, Tatjana; Petrović, Sandra; Vasić, Vesna M.

(2017)

TY  - JOUR
AU  - Lazarević-Pašti, Tamara
AU  - Leskovac, Andreja
AU  - Momić, Tatjana
AU  - Petrović, Sandra
AU  - Vasić, Vesna M.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1796
AB  - Background: Acetylcholinesterase (AChE) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs for different neurodegenerative diseases (such as Alzheimers and Parkinsons) as well as toxins. At the same time, there are increasing evidence that in non-neuronal context, AChE is involved in the regulation of cell proliferation, differentiation, apoptosis and cell-cell interaction. An irregular expression of AChE has been found in different types of tumors, suggesting the involvement of AChE in the regulation of tumor development. Having all this in mind, there is a possibility that some AChE inhibitors could be used as anti-cancer agents. Objective: This contribution will discuss a broad range of possible application of different AChE inhibitors as drugs, from well-known anti-Alzheimers disease drugs to their use in cancer treatment in future. Emphasis will be put on various known AChE inhibitors classes, whose application as drugs could be controversy, as well as on newly investigated natural products, which can also modulate AChE activity. Conclusion: It is not clear a patient treated for neurodegenerative condition prone to increased risk for some types of cancer and vice versa. This is necessary to keep in mind during rational drug design process for all therapies, which are based on AChE as a target molecule.
T2  - Current Medicinal Chemistry
T1  - Modulators of Acetylcholinesterase Activity: From Alzheimers Disease to Anti-Cancer Drugs
VL  - 24
IS  - 30
SP  - 3283
EP  - 3309
DO  - 10.2174/0929867324666170705123509
ER  - 
@article{
author = "Lazarević-Pašti, Tamara and Leskovac, Andreja and Momić, Tatjana and Petrović, Sandra and Vasić, Vesna M.",
year = "2017",
abstract = "Background: Acetylcholinesterase (AChE) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs for different neurodegenerative diseases (such as Alzheimers and Parkinsons) as well as toxins. At the same time, there are increasing evidence that in non-neuronal context, AChE is involved in the regulation of cell proliferation, differentiation, apoptosis and cell-cell interaction. An irregular expression of AChE has been found in different types of tumors, suggesting the involvement of AChE in the regulation of tumor development. Having all this in mind, there is a possibility that some AChE inhibitors could be used as anti-cancer agents. Objective: This contribution will discuss a broad range of possible application of different AChE inhibitors as drugs, from well-known anti-Alzheimers disease drugs to their use in cancer treatment in future. Emphasis will be put on various known AChE inhibitors classes, whose application as drugs could be controversy, as well as on newly investigated natural products, which can also modulate AChE activity. Conclusion: It is not clear a patient treated for neurodegenerative condition prone to increased risk for some types of cancer and vice versa. This is necessary to keep in mind during rational drug design process for all therapies, which are based on AChE as a target molecule.",
journal = "Current Medicinal Chemistry",
title = "Modulators of Acetylcholinesterase Activity: From Alzheimers Disease to Anti-Cancer Drugs",
volume = "24",
number = "30",
pages = "3283-3309",
doi = "10.2174/0929867324666170705123509"
}
Lazarević-Pašti, T., Leskovac, A., Momić, T., Petrović, S.,& Vasić, V. M.. (2017). Modulators of Acetylcholinesterase Activity: From Alzheimers Disease to Anti-Cancer Drugs. in Current Medicinal Chemistry, 24(30), 3283-3309.
https://doi.org/10.2174/0929867324666170705123509
Lazarević-Pašti T, Leskovac A, Momić T, Petrović S, Vasić VM. Modulators of Acetylcholinesterase Activity: From Alzheimers Disease to Anti-Cancer Drugs. in Current Medicinal Chemistry. 2017;24(30):3283-3309.
doi:10.2174/0929867324666170705123509 .
Lazarević-Pašti, Tamara, Leskovac, Andreja, Momić, Tatjana, Petrović, Sandra, Vasić, Vesna M., "Modulators of Acetylcholinesterase Activity: From Alzheimers Disease to Anti-Cancer Drugs" in Current Medicinal Chemistry, 24, no. 30 (2017):3283-3309,
https://doi.org/10.2174/0929867324666170705123509 . .
7
45
40

Adsorption of Organophosphate Pesticide Dimethoate on Gold Nanospheres and Nanorods

Momić, Tatjana; Lazarević-Pašti, Tamara; Bogdanović, Una; Vodnik, Vesna; Mraković, Ana Đ.; Rakočević, Zlatko Lj.; Pavlović, Vladimir B.; Vasić, Vesna M.

(2016)

TY  - JOUR
AU  - Momić, Tatjana
AU  - Lazarević-Pašti, Tamara
AU  - Bogdanović, Una
AU  - Vodnik, Vesna
AU  - Mraković, Ana Đ.
AU  - Rakočević, Zlatko Lj.
AU  - Pavlović, Vladimir B.
AU  - Vasić, Vesna M.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1347
AB  - Organophosphorus pesticide dimethoate was adsorbed onto gold nanospheres and nanorods in aqueous solution using batch technique. Adsorption of dimethoate onto gold nanoparticles was confirmed by UV-Vis spectrophotometry, TEM, AFM, and FTIR analysis. The adsorption of nanospheres resulted in aggregation which was not the case with nanorods. Nanoparticles adsorption features were characterized using Langmuir and Freundlich isotherm models. The Langmuir adsorption isotherm was found to have the best fit to the experimental data for both types of nanoparticles. Adsorption capacity detected for nanospheres is 456 mg/g and for nanorods is 57.1 mg/g. Also, nanoparticles were successfully used for dimethoate removal from spiked drinking water while nanospheres were shown to be more efficient than nanorods.
T2  - Journal of Nanomaterials
T1  - Adsorption of Organophosphate Pesticide Dimethoate on Gold Nanospheres and Nanorods
DO  - 10.1155/2016/8910271
ER  - 
@article{
author = "Momić, Tatjana and Lazarević-Pašti, Tamara and Bogdanović, Una and Vodnik, Vesna and Mraković, Ana Đ. and Rakočević, Zlatko Lj. and Pavlović, Vladimir B. and Vasić, Vesna M.",
year = "2016",
abstract = "Organophosphorus pesticide dimethoate was adsorbed onto gold nanospheres and nanorods in aqueous solution using batch technique. Adsorption of dimethoate onto gold nanoparticles was confirmed by UV-Vis spectrophotometry, TEM, AFM, and FTIR analysis. The adsorption of nanospheres resulted in aggregation which was not the case with nanorods. Nanoparticles adsorption features were characterized using Langmuir and Freundlich isotherm models. The Langmuir adsorption isotherm was found to have the best fit to the experimental data for both types of nanoparticles. Adsorption capacity detected for nanospheres is 456 mg/g and for nanorods is 57.1 mg/g. Also, nanoparticles were successfully used for dimethoate removal from spiked drinking water while nanospheres were shown to be more efficient than nanorods.",
journal = "Journal of Nanomaterials",
title = "Adsorption of Organophosphate Pesticide Dimethoate on Gold Nanospheres and Nanorods",
doi = "10.1155/2016/8910271"
}
Momić, T., Lazarević-Pašti, T., Bogdanović, U., Vodnik, V., Mraković, A. Đ., Rakočević, Z. Lj., Pavlović, V. B.,& Vasić, V. M.. (2016). Adsorption of Organophosphate Pesticide Dimethoate on Gold Nanospheres and Nanorods. in Journal of Nanomaterials.
https://doi.org/10.1155/2016/8910271
Momić T, Lazarević-Pašti T, Bogdanović U, Vodnik V, Mraković AĐ, Rakočević ZL, Pavlović VB, Vasić VM. Adsorption of Organophosphate Pesticide Dimethoate on Gold Nanospheres and Nanorods. in Journal of Nanomaterials. 2016;.
doi:10.1155/2016/8910271 .
Momić, Tatjana, Lazarević-Pašti, Tamara, Bogdanović, Una, Vodnik, Vesna, Mraković, Ana Đ., Rakočević, Zlatko Lj., Pavlović, Vladimir B., Vasić, Vesna M., "Adsorption of Organophosphate Pesticide Dimethoate on Gold Nanospheres and Nanorods" in Journal of Nanomaterials (2016),
https://doi.org/10.1155/2016/8910271 . .
26
14

Heteroatom-doped mesoporous carbons as efficient adsorbents for removal of dimethoate and omethoate from water

Lazarević-Pašti, Tamara; Pašti, Igor A.; Jokić, Bojan M.; Babić, Biljana M.; Vasić, Vesna M.

(2016)

TY  - JOUR
AU  - Lazarević-Pašti, Tamara
AU  - Pašti, Igor A.
AU  - Jokić, Bojan M.
AU  - Babić, Biljana M.
AU  - Vasić, Vesna M.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1178
AB  - Extensive use of organophosphate pesticides (OPs) invokes development of efficient procedures for their removal from the environment. By introducing low levels ( LT 1 at%) of B, N or P into the structure of mesoporous carbons, we have produced a series of materials with different surface chemical composition, textural properties and level of structural disorder. These adsorbents were applied for removal of dimethoate and its oxo-analogue omethoate from aqueous solutions under batch adsorption conditions and by filtration using modified nylon membrane filters. Adsorption capacities up to 164 mg g(-1) were measured, with OPs uptake typically above 80% for dimethoate concentration as high as 5 x 10(-3) mol dm(-3). After the adsorption, neurotoxic effects of OP-containing water samples were significantly reduced or completely removed. The level of structural disorder was identified as a key parameter for efficient removal of dimethoate and omethoate while in the filtration experiments surface area of adsorbents also played an important role. While the presented research appeals to new fundamental studies of OP-carbon surface interactions, it also indicates a possible strategy in designing new efficient adsorbents for OPs removal from water.
T2  - RSC Advances
T1  - Heteroatom-doped mesoporous carbons as efficient adsorbents for removal of dimethoate and omethoate from water
VL  - 6
IS  - 67
SP  - 62128
EP  - 62139
DO  - 10.1039/c6ra06736k
ER  - 
@article{
author = "Lazarević-Pašti, Tamara and Pašti, Igor A. and Jokić, Bojan M. and Babić, Biljana M. and Vasić, Vesna M.",
year = "2016",
abstract = "Extensive use of organophosphate pesticides (OPs) invokes development of efficient procedures for their removal from the environment. By introducing low levels ( LT 1 at%) of B, N or P into the structure of mesoporous carbons, we have produced a series of materials with different surface chemical composition, textural properties and level of structural disorder. These adsorbents were applied for removal of dimethoate and its oxo-analogue omethoate from aqueous solutions under batch adsorption conditions and by filtration using modified nylon membrane filters. Adsorption capacities up to 164 mg g(-1) were measured, with OPs uptake typically above 80% for dimethoate concentration as high as 5 x 10(-3) mol dm(-3). After the adsorption, neurotoxic effects of OP-containing water samples were significantly reduced or completely removed. The level of structural disorder was identified as a key parameter for efficient removal of dimethoate and omethoate while in the filtration experiments surface area of adsorbents also played an important role. While the presented research appeals to new fundamental studies of OP-carbon surface interactions, it also indicates a possible strategy in designing new efficient adsorbents for OPs removal from water.",
journal = "RSC Advances",
title = "Heteroatom-doped mesoporous carbons as efficient adsorbents for removal of dimethoate and omethoate from water",
volume = "6",
number = "67",
pages = "62128-62139",
doi = "10.1039/c6ra06736k"
}
Lazarević-Pašti, T., Pašti, I. A., Jokić, B. M., Babić, B. M.,& Vasić, V. M.. (2016). Heteroatom-doped mesoporous carbons as efficient adsorbents for removal of dimethoate and omethoate from water. in RSC Advances, 6(67), 62128-62139.
https://doi.org/10.1039/c6ra06736k
Lazarević-Pašti T, Pašti IA, Jokić BM, Babić BM, Vasić VM. Heteroatom-doped mesoporous carbons as efficient adsorbents for removal of dimethoate and omethoate from water. in RSC Advances. 2016;6(67):62128-62139.
doi:10.1039/c6ra06736k .
Lazarević-Pašti, Tamara, Pašti, Igor A., Jokić, Bojan M., Babić, Biljana M., Vasić, Vesna M., "Heteroatom-doped mesoporous carbons as efficient adsorbents for removal of dimethoate and omethoate from water" in RSC Advances, 6, no. 67 (2016):62128-62139,
https://doi.org/10.1039/c6ra06736k . .
16
15

Adsorption of malathion on mesoporous monetite obtained by mechanochemical treatment of brushite

Mirković, Miljana M.; Lazarević-Pašti, Tamara; Došen, Anja M.; Čebela, Maria; Rosić, Aleksandra A.; Matović, Branko; Babić, Biljana M.

(2016)

TY  - JOUR
AU  - Mirković, Miljana M.
AU  - Lazarević-Pašti, Tamara
AU  - Došen, Anja M.
AU  - Čebela, Maria
AU  - Rosić, Aleksandra A.
AU  - Matović, Branko
AU  - Babić, Biljana M.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/930
AB  - Mesoporous monetite (CaHPO4), obtained by mechanochemical treatment of previously synthesized brushite (CaHPO4 center dot 2H(2)O), was used as efficient adsorbent for the organic pesticide malathion. The structure of brushite was confirmed by Raman spectroscopy. The phase transformation process was investigated by X-ray powder diffraction (XRD) and Fourier transformation infra-red spectroscopy (FTIR). The microstructure and morphology were determined by scanning electron microscopy (SEM) and the nitrogen adsorption-desorption method. It was found that five minutes of milling induces brushite-monetite phase transformation. Adsorption of malathion from aqueous solutions showed that this pesticide can be successfully adsorbed on surface of this material.
T2  - RSC Advances
T1  - Adsorption of malathion on mesoporous monetite obtained by mechanochemical treatment of brushite
VL  - 6
IS  - 15
SP  - 12219
EP  - 12225
DO  - 10.1039/c5ra27554g
ER  - 
@article{
author = "Mirković, Miljana M. and Lazarević-Pašti, Tamara and Došen, Anja M. and Čebela, Maria and Rosić, Aleksandra A. and Matović, Branko and Babić, Biljana M.",
year = "2016",
abstract = "Mesoporous monetite (CaHPO4), obtained by mechanochemical treatment of previously synthesized brushite (CaHPO4 center dot 2H(2)O), was used as efficient adsorbent for the organic pesticide malathion. The structure of brushite was confirmed by Raman spectroscopy. The phase transformation process was investigated by X-ray powder diffraction (XRD) and Fourier transformation infra-red spectroscopy (FTIR). The microstructure and morphology were determined by scanning electron microscopy (SEM) and the nitrogen adsorption-desorption method. It was found that five minutes of milling induces brushite-monetite phase transformation. Adsorption of malathion from aqueous solutions showed that this pesticide can be successfully adsorbed on surface of this material.",
journal = "RSC Advances",
title = "Adsorption of malathion on mesoporous monetite obtained by mechanochemical treatment of brushite",
volume = "6",
number = "15",
pages = "12219-12225",
doi = "10.1039/c5ra27554g"
}
Mirković, M. M., Lazarević-Pašti, T., Došen, A. M., Čebela, M., Rosić, A. A., Matović, B.,& Babić, B. M.. (2016). Adsorption of malathion on mesoporous monetite obtained by mechanochemical treatment of brushite. in RSC Advances, 6(15), 12219-12225.
https://doi.org/10.1039/c5ra27554g
Mirković MM, Lazarević-Pašti T, Došen AM, Čebela M, Rosić AA, Matović B, Babić BM. Adsorption of malathion on mesoporous monetite obtained by mechanochemical treatment of brushite. in RSC Advances. 2016;6(15):12219-12225.
doi:10.1039/c5ra27554g .
Mirković, Miljana M., Lazarević-Pašti, Tamara, Došen, Anja M., Čebela, Maria, Rosić, Aleksandra A., Matović, Branko, Babić, Biljana M., "Adsorption of malathion on mesoporous monetite obtained by mechanochemical treatment of brushite" in RSC Advances, 6, no. 15 (2016):12219-12225,
https://doi.org/10.1039/c5ra27554g . .
31
29
31

Myeloperoxidase Inhibitors as Potential Drugs

Lazarević-Pašti, Tamara; Leskovac, Andreja; Vasić, Vesna M.

(2015)

TY  - JOUR
AU  - Lazarević-Pašti, Tamara
AU  - Leskovac, Andreja
AU  - Vasić, Vesna M.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/700
AB  - Myeloperoxidase (MPO) is an important member of the haem peroxidase - cyclooxygenase superfamily. This enzyme is physiologically expressed in circulating neutrophils, monocytes and some tissue macrophages including microglia. MPO plays an essential role in the antimicrobial and antiviral system of humans. The microbicidal activity of MPO exists due to its capability to oxidize halide and pseudohalide ions (Cl-, Br-, I- and SCN-) by H2O2, thereby producing respective hypohalous acids (HOX). During the phagocytosis of pathogens, azurophilic granules release their content together with MPO into phagolysosomes. On the other hand, MPO can be discharged outside the phagocytes. Due to this, tissue damage during inflammation is greatly promoted by MPO-derived oxidants. Regarding its activity, MPO is a key factor in a great number of conditions within the group of cardiovascular diseases, inflammatory diseases, neurodegenerative diseases, kidney diseases and immune-mediated diseases. Therefore, MPO and its downstream inflammatory pathways might be attractive targets for both prognostic and therapeutic intervention in the prophylaxis of all mentioned illnesses. Nowadays, structure and reaction mechanism of MPO are known, which enable rational strategy in the development of specific MPO inhibitors that still preserve MPO activity during host defense from bacteria, but hinder pathophysiologically persistent activation of MPO. Various methods for MPO activity inhibition and unfavorable effects of MPO-derived oxidants remodeling will be discussed. Emphasis will be put on various known inhibitors, as well as on newly investigated natural products, which can also inhibit MPO activity.
T2  - Current Drug Metabolism
T1  - Myeloperoxidase Inhibitors as Potential Drugs
VL  - 16
IS  - 3
SP  - 168
EP  - 190
DO  - 10.2174/138920021603150812120640
ER  - 
@article{
author = "Lazarević-Pašti, Tamara and Leskovac, Andreja and Vasić, Vesna M.",
year = "2015",
abstract = "Myeloperoxidase (MPO) is an important member of the haem peroxidase - cyclooxygenase superfamily. This enzyme is physiologically expressed in circulating neutrophils, monocytes and some tissue macrophages including microglia. MPO plays an essential role in the antimicrobial and antiviral system of humans. The microbicidal activity of MPO exists due to its capability to oxidize halide and pseudohalide ions (Cl-, Br-, I- and SCN-) by H2O2, thereby producing respective hypohalous acids (HOX). During the phagocytosis of pathogens, azurophilic granules release their content together with MPO into phagolysosomes. On the other hand, MPO can be discharged outside the phagocytes. Due to this, tissue damage during inflammation is greatly promoted by MPO-derived oxidants. Regarding its activity, MPO is a key factor in a great number of conditions within the group of cardiovascular diseases, inflammatory diseases, neurodegenerative diseases, kidney diseases and immune-mediated diseases. Therefore, MPO and its downstream inflammatory pathways might be attractive targets for both prognostic and therapeutic intervention in the prophylaxis of all mentioned illnesses. Nowadays, structure and reaction mechanism of MPO are known, which enable rational strategy in the development of specific MPO inhibitors that still preserve MPO activity during host defense from bacteria, but hinder pathophysiologically persistent activation of MPO. Various methods for MPO activity inhibition and unfavorable effects of MPO-derived oxidants remodeling will be discussed. Emphasis will be put on various known inhibitors, as well as on newly investigated natural products, which can also inhibit MPO activity.",
journal = "Current Drug Metabolism",
title = "Myeloperoxidase Inhibitors as Potential Drugs",
volume = "16",
number = "3",
pages = "168-190",
doi = "10.2174/138920021603150812120640"
}
Lazarević-Pašti, T., Leskovac, A.,& Vasić, V. M.. (2015). Myeloperoxidase Inhibitors as Potential Drugs. in Current Drug Metabolism, 16(3), 168-190.
https://doi.org/10.2174/138920021603150812120640
Lazarević-Pašti T, Leskovac A, Vasić VM. Myeloperoxidase Inhibitors as Potential Drugs. in Current Drug Metabolism. 2015;16(3):168-190.
doi:10.2174/138920021603150812120640 .
Lazarević-Pašti, Tamara, Leskovac, Andreja, Vasić, Vesna M., "Myeloperoxidase Inhibitors as Potential Drugs" in Current Drug Metabolism, 16, no. 3 (2015):168-190,
https://doi.org/10.2174/138920021603150812120640 . .
3
57
49
53

Chronic administration of fluoxetine or clozapine induces oxidative stress in rat liver: A histopathological study

Martinović, Jelena; Todorović, Nevena; Tomanović, Nada; Bošković, Maja; Djordjevic, Snezana; Lazarević-Pašti, Tamara; Bernardi, Rick E.; Đurđević, Aleksandra; Filipović, Dragana

(2014)

TY  - JOUR
AU  - Martinović, Jelena
AU  - Todorović, Nevena
AU  - Tomanović, Nada
AU  - Bošković, Maja
AU  - Djordjevic, Snezana
AU  - Lazarević-Pašti, Tamara
AU  - Bernardi, Rick E.
AU  - Đurđević, Aleksandra
AU  - Filipović, Dragana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6043
AB  - Chronic exposure to stress contributes to the etiology of mood disorders, and the liver as a target organ of antidepressant and antipsychotic drug metabolism is vulnerable to drug-induced toxicity. We investigated the effects of chronic administration of fluoxetine (15 mg/kg/day) or clozapine (20 mg/kg/day) on liver injury via the measurement of liver enzymes, oxidative stress and histopathology in rats exposed to chronic social isolation (21 days), an animal model of depression, and controls. The activity of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the liver content of carbonyl groups, malonyldialdehyde (MDA), reduced glutathione (GSH), cytosolic glutathione S-transferase (GST) and nitric oxide (NO) metabolites were determined. We also characterized nuclear factor-kappa B (NF-kappa B), cyclooxygenase-2 (COX-2) and CuZn-superoxide dismutase (CuZnSOD) protein expression as well as histopathological changes. Increased serum ALT activity in chronically-isolated and control animals treated with both drugs was found while increased AST activity was observed only in fluoxetine-treated rats (chronically-isolated and controls). Increased carbonyl content, MDA, GST activity and decreased GSH levels in drug-treated controls/chronically-isolated animals suggest a link between drugs and hepatic oxidative stress. Increased NO levels associated with NF-kappa B activation and the concomitant increased COX-2 expression together with compromised CuZnSOD expression in clozapine-treated chronically-isolated rats likely reinforce oxidative stress, observed by increased lipid peroxidation and GSH depletion. In contrast, fluoxetine reduced NO levels in chronically-isolated rats. Isolation induced oxidative stress but histological changes were similar to those observed in vehicle-treated controls. Chronic administration of fluoxetine in both chronically-isolated and control animals resulted in more or less normal hepatic architecture, while clozapine in both groups resulted in liver injury. These data suggest that clozapine appears to have a higher potential to induce liver toxicity than fluoxetine. (C) 2014 Elsevier B.V. All rights reserved.
T2  - European Journal of Pharmaceutical Sciences
T1  - Chronic administration of fluoxetine or clozapine induces oxidative stress in rat liver: A histopathological study
VL  - 59
SP  - 20
EP  - 30
DO  - 10.1016/j.ejps.2014.04.010
ER  - 
@article{
author = "Martinović, Jelena and Todorović, Nevena and Tomanović, Nada and Bošković, Maja and Djordjevic, Snezana and Lazarević-Pašti, Tamara and Bernardi, Rick E. and Đurđević, Aleksandra and Filipović, Dragana",
year = "2014",
abstract = "Chronic exposure to stress contributes to the etiology of mood disorders, and the liver as a target organ of antidepressant and antipsychotic drug metabolism is vulnerable to drug-induced toxicity. We investigated the effects of chronic administration of fluoxetine (15 mg/kg/day) or clozapine (20 mg/kg/day) on liver injury via the measurement of liver enzymes, oxidative stress and histopathology in rats exposed to chronic social isolation (21 days), an animal model of depression, and controls. The activity of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the liver content of carbonyl groups, malonyldialdehyde (MDA), reduced glutathione (GSH), cytosolic glutathione S-transferase (GST) and nitric oxide (NO) metabolites were determined. We also characterized nuclear factor-kappa B (NF-kappa B), cyclooxygenase-2 (COX-2) and CuZn-superoxide dismutase (CuZnSOD) protein expression as well as histopathological changes. Increased serum ALT activity in chronically-isolated and control animals treated with both drugs was found while increased AST activity was observed only in fluoxetine-treated rats (chronically-isolated and controls). Increased carbonyl content, MDA, GST activity and decreased GSH levels in drug-treated controls/chronically-isolated animals suggest a link between drugs and hepatic oxidative stress. Increased NO levels associated with NF-kappa B activation and the concomitant increased COX-2 expression together with compromised CuZnSOD expression in clozapine-treated chronically-isolated rats likely reinforce oxidative stress, observed by increased lipid peroxidation and GSH depletion. In contrast, fluoxetine reduced NO levels in chronically-isolated rats. Isolation induced oxidative stress but histological changes were similar to those observed in vehicle-treated controls. Chronic administration of fluoxetine in both chronically-isolated and control animals resulted in more or less normal hepatic architecture, while clozapine in both groups resulted in liver injury. These data suggest that clozapine appears to have a higher potential to induce liver toxicity than fluoxetine. (C) 2014 Elsevier B.V. All rights reserved.",
journal = "European Journal of Pharmaceutical Sciences",
title = "Chronic administration of fluoxetine or clozapine induces oxidative stress in rat liver: A histopathological study",
volume = "59",
pages = "20-30",
doi = "10.1016/j.ejps.2014.04.010"
}
Martinović, J., Todorović, N., Tomanović, N., Bošković, M., Djordjevic, S., Lazarević-Pašti, T., Bernardi, R. E., Đurđević, A.,& Filipović, D.. (2014). Chronic administration of fluoxetine or clozapine induces oxidative stress in rat liver: A histopathological study. in European Journal of Pharmaceutical Sciences, 59, 20-30.
https://doi.org/10.1016/j.ejps.2014.04.010
Martinović J, Todorović N, Tomanović N, Bošković M, Djordjevic S, Lazarević-Pašti T, Bernardi RE, Đurđević A, Filipović D. Chronic administration of fluoxetine or clozapine induces oxidative stress in rat liver: A histopathological study. in European Journal of Pharmaceutical Sciences. 2014;59:20-30.
doi:10.1016/j.ejps.2014.04.010 .
Martinović, Jelena, Todorović, Nevena, Tomanović, Nada, Bošković, Maja, Djordjevic, Snezana, Lazarević-Pašti, Tamara, Bernardi, Rick E., Đurđević, Aleksandra, Filipović, Dragana, "Chronic administration of fluoxetine or clozapine induces oxidative stress in rat liver: A histopathological study" in European Journal of Pharmaceutical Sciences, 59 (2014):20-30,
https://doi.org/10.1016/j.ejps.2014.04.010 . .
43
38
40

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

Čolović, Mirjana B.; Krstić, Danijela Z.; Lazarević-Pašti, Tamara; Bondžić, Aleksandra; Vasić, Vesna M.

(2013)

TY  - JOUR
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Lazarević-Pašti, Tamara
AU  - Bondžić, Aleksandra
AU  - Vasić, Vesna M.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5474
AB  - Acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation, induced by various inhibitors, leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds. In the case of reversible inhibitors being commonly applied in neurodegenerative disorders treatment, special attention is paid to currently approved drugs (donepezil, rivastigmine and galantamine) in the pharmacotherapy of Alzheimers disease, and toxic carbamates used as pesticides. Subsequently, mechanism of irreversible acetylcholinesterase inhibition induced by organophosphorus compounds (insecticides and nerve agents), and their specific and nonspecific toxic effects are described, as well as irreversible inhibitors having pharmacological implementation. In addition, the pharmacological treatment of intoxication caused by organophosphates is presented, with emphasis on oxime reactivators of the inhibited enzyme activity administering as causal drugs after the poisoning. Besides, organophosphorus and carbamate insecticides can be detoxified in mammals through enzymatic hydrolysis before they reach targets in the nervous system. Carboxylesterases most effectively decompose carbamates, whereas the most successful route of organophosphates detoxification is their degradation by corresponding phosphotriesterases.
T2  - Current Neuropharmacology
T1  - Acetylcholinesterase Inhibitors: Pharmacology and Toxicology
VL  - 11
IS  - 3
SP  - 315
EP  - 335
DO  - 10.2174/1570159X11311030006
ER  - 
@article{
author = "Čolović, Mirjana B. and Krstić, Danijela Z. and Lazarević-Pašti, Tamara and Bondžić, Aleksandra and Vasić, Vesna M.",
year = "2013",
abstract = "Acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation, induced by various inhibitors, leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds. In the case of reversible inhibitors being commonly applied in neurodegenerative disorders treatment, special attention is paid to currently approved drugs (donepezil, rivastigmine and galantamine) in the pharmacotherapy of Alzheimers disease, and toxic carbamates used as pesticides. Subsequently, mechanism of irreversible acetylcholinesterase inhibition induced by organophosphorus compounds (insecticides and nerve agents), and their specific and nonspecific toxic effects are described, as well as irreversible inhibitors having pharmacological implementation. In addition, the pharmacological treatment of intoxication caused by organophosphates is presented, with emphasis on oxime reactivators of the inhibited enzyme activity administering as causal drugs after the poisoning. Besides, organophosphorus and carbamate insecticides can be detoxified in mammals through enzymatic hydrolysis before they reach targets in the nervous system. Carboxylesterases most effectively decompose carbamates, whereas the most successful route of organophosphates detoxification is their degradation by corresponding phosphotriesterases.",
journal = "Current Neuropharmacology",
title = "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology",
volume = "11",
number = "3",
pages = "315-335",
doi = "10.2174/1570159X11311030006"
}
Čolović, M. B., Krstić, D. Z., Lazarević-Pašti, T., Bondžić, A.,& Vasić, V. M.. (2013). Acetylcholinesterase Inhibitors: Pharmacology and Toxicology. in Current Neuropharmacology, 11(3), 315-335.
https://doi.org/10.2174/1570159X11311030006
Čolović MB, Krstić DZ, Lazarević-Pašti T, Bondžić A, Vasić VM. Acetylcholinesterase Inhibitors: Pharmacology and Toxicology. in Current Neuropharmacology. 2013;11(3):315-335.
doi:10.2174/1570159X11311030006 .
Čolović, Mirjana B., Krstić, Danijela Z., Lazarević-Pašti, Tamara, Bondžić, Aleksandra, Vasić, Vesna M., "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology" in Current Neuropharmacology, 11, no. 3 (2013):315-335,
https://doi.org/10.2174/1570159X11311030006 . .
76
1136
1050
1127

Investigation of reaction between quercetin and Au(III) in acidic media: mechanism and identification of reaction products

Bondžić, Aleksandra; Lazarević-Pašti, Tamara; Bondzic, Bojan P.; Čolović, Mirjana B.; Jadranin, Milka B.; Vasić, Vesna M.

(2013)

TY  - JOUR
AU  - Bondžić, Aleksandra
AU  - Lazarević-Pašti, Tamara
AU  - Bondzic, Bojan P.
AU  - Čolović, Mirjana B.
AU  - Jadranin, Milka B.
AU  - Vasić, Vesna M.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5362
AB  - The aim of the present paper was to investigate the reaction of quercetin, the flavonol very often used as a dietary supplement, with [AuCl4](-) ions. The reaction was studied spectrophotometrically using the equimolar solutions in 1 : 1 water-methanol at pH similar to 2. The spectrophotometric data indicated the formation of the products with an absorption maximum at 295 nm in all cases, characteristic of the oxidized forms of quercetin. HPLC coupled with DAD and LC-MS analysis of the reaction products suggested that the oxidation of quercetin resulted in the generation of similar metabolites including quinone and various oxidized quercetin-solvent adducts. In addition, cyclic voltammetric measurements confirmed that under applied experimental conditions, the reduction of Au(III) to Au(0) took place. The reduction species in the reaction mixture were Au(III) ions, while Au(I) disproportionates back to Au(III) and Au(0). The newly generated Au(III) ions further oxidized 3-4-dihydroxy groups of quercetin adducts obtained after first 2e(-) oxidation, giving the final reaction products. Based on the identification of reaction products, the reaction mechanism for the oxidation of quercetin in the presence of Au(III) which involves two 2e(-) transfer processes was proposed.
T2  - New Journal of Chemistry
T1  - Investigation of reaction between quercetin and Au(III) in acidic media: mechanism and identification of reaction products
VL  - 37
IS  - 4
SP  - 901
EP  - 908
DO  - 10.1039/c2nj40742f
ER  - 
@article{
author = "Bondžić, Aleksandra and Lazarević-Pašti, Tamara and Bondzic, Bojan P. and Čolović, Mirjana B. and Jadranin, Milka B. and Vasić, Vesna M.",
year = "2013",
abstract = "The aim of the present paper was to investigate the reaction of quercetin, the flavonol very often used as a dietary supplement, with [AuCl4](-) ions. The reaction was studied spectrophotometrically using the equimolar solutions in 1 : 1 water-methanol at pH similar to 2. The spectrophotometric data indicated the formation of the products with an absorption maximum at 295 nm in all cases, characteristic of the oxidized forms of quercetin. HPLC coupled with DAD and LC-MS analysis of the reaction products suggested that the oxidation of quercetin resulted in the generation of similar metabolites including quinone and various oxidized quercetin-solvent adducts. In addition, cyclic voltammetric measurements confirmed that under applied experimental conditions, the reduction of Au(III) to Au(0) took place. The reduction species in the reaction mixture were Au(III) ions, while Au(I) disproportionates back to Au(III) and Au(0). The newly generated Au(III) ions further oxidized 3-4-dihydroxy groups of quercetin adducts obtained after first 2e(-) oxidation, giving the final reaction products. Based on the identification of reaction products, the reaction mechanism for the oxidation of quercetin in the presence of Au(III) which involves two 2e(-) transfer processes was proposed.",
journal = "New Journal of Chemistry",
title = "Investigation of reaction between quercetin and Au(III) in acidic media: mechanism and identification of reaction products",
volume = "37",
number = "4",
pages = "901-908",
doi = "10.1039/c2nj40742f"
}
Bondžić, A., Lazarević-Pašti, T., Bondzic, B. P., Čolović, M. B., Jadranin, M. B.,& Vasić, V. M.. (2013). Investigation of reaction between quercetin and Au(III) in acidic media: mechanism and identification of reaction products. in New Journal of Chemistry, 37(4), 901-908.
https://doi.org/10.1039/c2nj40742f
Bondžić A, Lazarević-Pašti T, Bondzic BP, Čolović MB, Jadranin MB, Vasić VM. Investigation of reaction between quercetin and Au(III) in acidic media: mechanism and identification of reaction products. in New Journal of Chemistry. 2013;37(4):901-908.
doi:10.1039/c2nj40742f .
Bondžić, Aleksandra, Lazarević-Pašti, Tamara, Bondzic, Bojan P., Čolović, Mirjana B., Jadranin, Milka B., Vasić, Vesna M., "Investigation of reaction between quercetin and Au(III) in acidic media: mechanism and identification of reaction products" in New Journal of Chemistry, 37, no. 4 (2013):901-908,
https://doi.org/10.1039/c2nj40742f . .
13
15
16

Electrochemical oxidation of diazinon in aqueous solutions via electrogenerated halogens - Diazinon fate and implications for its detection

Lazarević-Pašti, Tamara; Bondžić, Aleksandra; Pašti, Igor A.; Mentus, Slavko V.; Vasić, Vesna M.

(2013)

TY  - JOUR
AU  - Lazarević-Pašti, Tamara
AU  - Bondžić, Aleksandra
AU  - Pašti, Igor A.
AU  - Mentus, Slavko V.
AU  - Vasić, Vesna M.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5410
AB  - Organophosphorous pesticide diazinon was indirectly oxidized to diazoxon by means of electrogenerated Cl-2, Br-2 or I-2 under galvanostatic conditions using rotating glassy carbon disk electrode. The rate of oxidation was the highest in the case of electrogenerated Br-2. In the presence of electrogenerated Br-2 diazinon was completely converted to diazoxon after 15 min of electrochemical treatment at all concentrations investigated. On the basis of thermodynamic and kinetic arguments it was showed that diazinon oxidation is governed by both kinetics and speciation of halogen species. Diazoxon is rapidly formed during its reaction with active oxidant species, while formed diazoxon is being stable and not degraded at appreciable rate by reactive halogen species. Described oxidation procedure was used as a pre-step for diazinon detection using AChE test coupled with optical detection. Diazinon detection limit was reduced by three orders of magnitude compared to unoxidized diazinon. This enabled diazinon detection at the lowest possible concentration using described methodology, as determined by diazoxon detection limit. (C) 2013 Elsevier B.V. All rights reserved.
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical oxidation of diazinon in aqueous solutions via electrogenerated halogens - Diazinon fate and implications for its detection
VL  - 692
SP  - 40
EP  - 45
DO  - 10.1016/j.jelechem.2013.01.005
ER  - 
@article{
author = "Lazarević-Pašti, Tamara and Bondžić, Aleksandra and Pašti, Igor A. and Mentus, Slavko V. and Vasić, Vesna M.",
year = "2013",
abstract = "Organophosphorous pesticide diazinon was indirectly oxidized to diazoxon by means of electrogenerated Cl-2, Br-2 or I-2 under galvanostatic conditions using rotating glassy carbon disk electrode. The rate of oxidation was the highest in the case of electrogenerated Br-2. In the presence of electrogenerated Br-2 diazinon was completely converted to diazoxon after 15 min of electrochemical treatment at all concentrations investigated. On the basis of thermodynamic and kinetic arguments it was showed that diazinon oxidation is governed by both kinetics and speciation of halogen species. Diazoxon is rapidly formed during its reaction with active oxidant species, while formed diazoxon is being stable and not degraded at appreciable rate by reactive halogen species. Described oxidation procedure was used as a pre-step for diazinon detection using AChE test coupled with optical detection. Diazinon detection limit was reduced by three orders of magnitude compared to unoxidized diazinon. This enabled diazinon detection at the lowest possible concentration using described methodology, as determined by diazoxon detection limit. (C) 2013 Elsevier B.V. All rights reserved.",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical oxidation of diazinon in aqueous solutions via electrogenerated halogens - Diazinon fate and implications for its detection",
volume = "692",
pages = "40-45",
doi = "10.1016/j.jelechem.2013.01.005"
}
Lazarević-Pašti, T., Bondžić, A., Pašti, I. A., Mentus, S. V.,& Vasić, V. M.. (2013). Electrochemical oxidation of diazinon in aqueous solutions via electrogenerated halogens - Diazinon fate and implications for its detection. in Journal of Electroanalytical Chemistry, 692, 40-45.
https://doi.org/10.1016/j.jelechem.2013.01.005
Lazarević-Pašti T, Bondžić A, Pašti IA, Mentus SV, Vasić VM. Electrochemical oxidation of diazinon in aqueous solutions via electrogenerated halogens - Diazinon fate and implications for its detection. in Journal of Electroanalytical Chemistry. 2013;692:40-45.
doi:10.1016/j.jelechem.2013.01.005 .
Lazarević-Pašti, Tamara, Bondžić, Aleksandra, Pašti, Igor A., Mentus, Slavko V., Vasić, Vesna M., "Electrochemical oxidation of diazinon in aqueous solutions via electrogenerated halogens - Diazinon fate and implications for its detection" in Journal of Electroanalytical Chemistry, 692 (2013):40-45,
https://doi.org/10.1016/j.jelechem.2013.01.005 . .
18
16
21

The Antiradical, Anti-Inflammatory and Anti-Genotoxic Potential of Herbal Preparation Chlamyfin

Leskovac, Andreja; Joksić, Gordana; Pašti, Igor A.; Lazarević-Pašti, Tamara; Nastasijević, Branislav J.; Petrović, Sandra

(2013)

TY  - JOUR
AU  - Leskovac, Andreja
AU  - Joksić, Gordana
AU  - Pašti, Igor A.
AU  - Lazarević-Pašti, Tamara
AU  - Nastasijević, Branislav J.
AU  - Petrović, Sandra
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5830
AB  - Herbal preparation Chlamyfin was investigated for its total polyphenol content, 2,2-diphenyl-1picrylhydrazyl (DPPH) scavenging activity, and anti-inflammatory and genotoxic properties. A high total polyphenol content provided evidence of high DPPH radical scavenging activity (IC50 = 4.96 +/- 0.23 mu g/ml). Analysis of the electrochemical behavior of Chlamyfin indicated high reducing ability, i.e., high antioxidant capacity, in agreement with the DPPH test. Analysis of myeloperoxidase (MPO) inhibition by Chlamyfin suggested anti-inflammatory action (IC50 values of 5.40 mu g/ml and 4.45 i_tg/m1 for an incubation time of 10 and 30 min, respectively). For genotoxic assessment, oxidative stress was induced by irradiation of peripheral whole blood with gamma-radiation in vitro. In the presence of Chlamyfin, reduced incidence of micronuclei without disturbance to the proliferative potential of cells was evidenced in both irradiated and unirradiated samples, indicating its genoprotective properties. It was shown that Chlamyfm, in addition to its bactericidal effect, also possesses strong antioxidant, anti-inflammatory and anti-genotoxic properties.
T2  - Macedonian Journal of Chemistry and Chemical Engineering
T1  - The Antiradical, Anti-Inflammatory and Anti-Genotoxic Potential of Herbal Preparation Chlamyfin
VL  - 32
IS  - 2
SP  - 227
EP  - 237
ER  - 
@article{
author = "Leskovac, Andreja and Joksić, Gordana and Pašti, Igor A. and Lazarević-Pašti, Tamara and Nastasijević, Branislav J. and Petrović, Sandra",
year = "2013",
abstract = "Herbal preparation Chlamyfin was investigated for its total polyphenol content, 2,2-diphenyl-1picrylhydrazyl (DPPH) scavenging activity, and anti-inflammatory and genotoxic properties. A high total polyphenol content provided evidence of high DPPH radical scavenging activity (IC50 = 4.96 +/- 0.23 mu g/ml). Analysis of the electrochemical behavior of Chlamyfin indicated high reducing ability, i.e., high antioxidant capacity, in agreement with the DPPH test. Analysis of myeloperoxidase (MPO) inhibition by Chlamyfin suggested anti-inflammatory action (IC50 values of 5.40 mu g/ml and 4.45 i_tg/m1 for an incubation time of 10 and 30 min, respectively). For genotoxic assessment, oxidative stress was induced by irradiation of peripheral whole blood with gamma-radiation in vitro. In the presence of Chlamyfin, reduced incidence of micronuclei without disturbance to the proliferative potential of cells was evidenced in both irradiated and unirradiated samples, indicating its genoprotective properties. It was shown that Chlamyfm, in addition to its bactericidal effect, also possesses strong antioxidant, anti-inflammatory and anti-genotoxic properties.",
journal = "Macedonian Journal of Chemistry and Chemical Engineering",
title = "The Antiradical, Anti-Inflammatory and Anti-Genotoxic Potential of Herbal Preparation Chlamyfin",
volume = "32",
number = "2",
pages = "227-237"
}
Leskovac, A., Joksić, G., Pašti, I. A., Lazarević-Pašti, T., Nastasijević, B. J.,& Petrović, S.. (2013). The Antiradical, Anti-Inflammatory and Anti-Genotoxic Potential of Herbal Preparation Chlamyfin. in Macedonian Journal of Chemistry and Chemical Engineering, 32(2), 227-237.
Leskovac A, Joksić G, Pašti IA, Lazarević-Pašti T, Nastasijević BJ, Petrović S. The Antiradical, Anti-Inflammatory and Anti-Genotoxic Potential of Herbal Preparation Chlamyfin. in Macedonian Journal of Chemistry and Chemical Engineering. 2013;32(2):227-237..
Leskovac, Andreja, Joksić, Gordana, Pašti, Igor A., Lazarević-Pašti, Tamara, Nastasijević, Branislav J., Petrović, Sandra, "The Antiradical, Anti-Inflammatory and Anti-Genotoxic Potential of Herbal Preparation Chlamyfin" in Macedonian Journal of Chemistry and Chemical Engineering, 32, no. 2 (2013):227-237.
4

Influence of organophosphorus pesticides on peroxidase and chlorination activity of human myeloperoxidase

Lazarević-Pašti, Tamara; Momić, Tatjana; Radojevic, Milos M.; Vasić, Vesna M.

(2013)

TY  - JOUR
AU  - Lazarević-Pašti, Tamara
AU  - Momić, Tatjana
AU  - Radojevic, Milos M.
AU  - Vasić, Vesna M.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5650
AB  - Inhibitory effects of five organophosphorus pesticides (diazinon, malathion, chlorpyrifos, azinphosmethyl and phorate) and their oxo-analogs on human myeloperoxidase (MPO) activity were investigated. While inspecting separately peroxidase and chlorination activity, it was observed that investigated OPs affect peroxidase activity, but not chlorination activity. Among investigated pesticides, malathion and malaoxon have showed the highest power to inhibit MPO peroxidase activity With IC50 values of the order of 3 x 10(-7) and 5 x 10(-9) M, respectively. It was proposed that inhibition trend is rendered by molecular structure which invokes steric hindrance for OPs interaction with MPO active center responsible for peroxidase activity. In addition, it was concluded that physiological function of MPO is not affected by any of the investigated OPs. (C) 2013 Elsevier Inc. All rights reserved.
T2  - Pesticide Biochemistry and Physiology
T1  - Influence of organophosphorus pesticides on peroxidase and chlorination activity of human myeloperoxidase
VL  - 107
IS  - 1
SP  - 55
EP  - 60
DO  - 10.1016/j.pestbp.2013.05.004
ER  - 
@article{
author = "Lazarević-Pašti, Tamara and Momić, Tatjana and Radojevic, Milos M. and Vasić, Vesna M.",
year = "2013",
abstract = "Inhibitory effects of five organophosphorus pesticides (diazinon, malathion, chlorpyrifos, azinphosmethyl and phorate) and their oxo-analogs on human myeloperoxidase (MPO) activity were investigated. While inspecting separately peroxidase and chlorination activity, it was observed that investigated OPs affect peroxidase activity, but not chlorination activity. Among investigated pesticides, malathion and malaoxon have showed the highest power to inhibit MPO peroxidase activity With IC50 values of the order of 3 x 10(-7) and 5 x 10(-9) M, respectively. It was proposed that inhibition trend is rendered by molecular structure which invokes steric hindrance for OPs interaction with MPO active center responsible for peroxidase activity. In addition, it was concluded that physiological function of MPO is not affected by any of the investigated OPs. (C) 2013 Elsevier Inc. All rights reserved.",
journal = "Pesticide Biochemistry and Physiology",
title = "Influence of organophosphorus pesticides on peroxidase and chlorination activity of human myeloperoxidase",
volume = "107",
number = "1",
pages = "55-60",
doi = "10.1016/j.pestbp.2013.05.004"
}
Lazarević-Pašti, T., Momić, T., Radojevic, M. M.,& Vasić, V. M.. (2013). Influence of organophosphorus pesticides on peroxidase and chlorination activity of human myeloperoxidase. in Pesticide Biochemistry and Physiology, 107(1), 55-60.
https://doi.org/10.1016/j.pestbp.2013.05.004
Lazarević-Pašti T, Momić T, Radojevic MM, Vasić VM. Influence of organophosphorus pesticides on peroxidase and chlorination activity of human myeloperoxidase. in Pesticide Biochemistry and Physiology. 2013;107(1):55-60.
doi:10.1016/j.pestbp.2013.05.004 .
Lazarević-Pašti, Tamara, Momić, Tatjana, Radojevic, Milos M., Vasić, Vesna M., "Influence of organophosphorus pesticides on peroxidase and chlorination activity of human myeloperoxidase" in Pesticide Biochemistry and Physiology, 107, no. 1 (2013):55-60,
https://doi.org/10.1016/j.pestbp.2013.05.004 . .
6
5
8

Switching between voltammetry and potentiometry in order to determine H+ or OH- ion concentration over the entire pH scale by means of tungsten disk electrode

Pašti, Igor A.; Lazarević-Pašti, Tamara; Mentus, Slavko V.

(2012)

TY  - JOUR
AU  - Pašti, Igor A.
AU  - Lazarević-Pašti, Tamara
AU  - Mentus, Slavko V.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4704
AB  - This study demonstrates that tungsten rotating disk electrode can be used for pH or H+/OH- concentration measurements in practically entire pH range, using the combination of voltammetric and potentiometric techniques. In strong acidic (c(H+) GT 10(-3) mol dm(-3)), and alkaline (c(OH-) GT 10(-3) mol dm(-3)) solutions, rotating tungsten disk electrode can be used as a maintenance-free electrode for voltammetric determination of H+ and OH- ion concentration. After an appropriate electrochemical oxidation, the same electrode, in a stationary regime, may be used as a potentiometric sensor in the range 3 LT pH LT 11, with the response -49.5 +/- 2.3 mV per one pH unit. (C) 2011 Elsevier B.V. All rights reserved.
T2  - Journal of Electroanalytical Chemistry
T1  - Switching between voltammetry and potentiometry in order to determine H+ or OH- ion concentration over the entire pH scale by means of tungsten disk electrode
VL  - 665
SP  - 83
EP  - 89
DO  - 10.1016/j.jelechem.2011.11.019
ER  - 
@article{
author = "Pašti, Igor A. and Lazarević-Pašti, Tamara and Mentus, Slavko V.",
year = "2012",
abstract = "This study demonstrates that tungsten rotating disk electrode can be used for pH or H+/OH- concentration measurements in practically entire pH range, using the combination of voltammetric and potentiometric techniques. In strong acidic (c(H+) GT 10(-3) mol dm(-3)), and alkaline (c(OH-) GT 10(-3) mol dm(-3)) solutions, rotating tungsten disk electrode can be used as a maintenance-free electrode for voltammetric determination of H+ and OH- ion concentration. After an appropriate electrochemical oxidation, the same electrode, in a stationary regime, may be used as a potentiometric sensor in the range 3 LT pH LT 11, with the response -49.5 +/- 2.3 mV per one pH unit. (C) 2011 Elsevier B.V. All rights reserved.",
journal = "Journal of Electroanalytical Chemistry",
title = "Switching between voltammetry and potentiometry in order to determine H+ or OH- ion concentration over the entire pH scale by means of tungsten disk electrode",
volume = "665",
pages = "83-89",
doi = "10.1016/j.jelechem.2011.11.019"
}
Pašti, I. A., Lazarević-Pašti, T.,& Mentus, S. V.. (2012). Switching between voltammetry and potentiometry in order to determine H+ or OH- ion concentration over the entire pH scale by means of tungsten disk electrode. in Journal of Electroanalytical Chemistry, 665, 83-89.
https://doi.org/10.1016/j.jelechem.2011.11.019
Pašti IA, Lazarević-Pašti T, Mentus SV. Switching between voltammetry and potentiometry in order to determine H+ or OH- ion concentration over the entire pH scale by means of tungsten disk electrode. in Journal of Electroanalytical Chemistry. 2012;665:83-89.
doi:10.1016/j.jelechem.2011.11.019 .
Pašti, Igor A., Lazarević-Pašti, Tamara, Mentus, Slavko V., "Switching between voltammetry and potentiometry in order to determine H+ or OH- ion concentration over the entire pH scale by means of tungsten disk electrode" in Journal of Electroanalytical Chemistry, 665 (2012):83-89,
https://doi.org/10.1016/j.jelechem.2011.11.019 . .
15
13

Primena oksidacije organo-tiofosfatnih pesticida u metodama za njihovu detekciju na bazi inhibicije acetilholinesteraze

Lazarević-Pašti, Tamara

(Универзитет у Београду, Хемијски факултет, 2012)

TY  - THES
AU  - Lazarević-Pašti, Tamara
PY  - 2012
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=332
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:5873/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=41104655
UR  - http://nardus.mpn.gov.rs/123456789/3468
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7267
AB  - Ispitana je inhibicija slobodne acetilholinesteraze (AChE) odabranim organotiofosfatima (OP) (diazinon, malation, hlorpirifos, azinfos-metil, forat) i njihovim oksoanalozima (diazokson, malaokson, hlorpirifos-okson, azinfos-metil-okson, forat-okson), pri čemu su optimizovani uslovi za detekciju najniže koncentracije tih jedinjenja primenom AChE testa. Određene su IC50 vrednosti za sva navedena jedinjenja. U cilju povećanja osetljivosti AChE testa, ispitivani organo-tiofosfati prevedeni su u okso-analoge u prisustvu enzima mijeloperoksidaze (MPO). To je potvreno pomoćuUPLC i GC/MS analize. Nastali oksidacioni proizvodi stabilni su najmanje 1h. Maksimalne koncentracije oksona dobijaju se kada se organo-tiofosfati inkubiraju sa 100 nM MPO u prisustvu H2O2 koncentracije 50 μM, pri pH 6, na temperaturi 25 °C u toku 10 minuta. Oksidacija OP u prisustvu MPO pod navedenim uslovima primenjena je u modifikaciji metode za detekciju OP na bazi inhibicije AChE. Određena je granica detekcije modifikovane metode, kao i efikasnost oksidacije i njena primena na smešu OP. Gore navedeni organo-tiofosfati prevedeni su u odgovarajue oksone i pomoću elektrohemijski generisanih halogena. Proizvodi koji nastaju identifikovani su kao oksoni pomoću UPLC analize. Utvrđeno je da je najefikasnija oksidacija elektrogenerisanim bromom u toku 15 minuta. Određena je i granica detekcije AChE testa za odreivanje OP kada su OP oksidovani elektrohemijski generisanim bromom...
AB  - The inhibition of acetylcholinesterase in the presence of selected organothiophosphates (diazinon, malathion, chlorpyrifos, azinphos-methyl, phorate) andtheir oxo-analogues (diazoxon, malaoxon, chlorpyrifos-oxon, azinphos-methyl-oxon,phorate-oxon) was examined. Experimental conditions were optimized to detect the lowestposible concentrations of these compounds using AChE test. IC50 values were determinedfor all the mentioned compounds.Investigated organothiophosphates have been converted into their oxo-analogues inthe presence of the enzyme myeloperoxidase. Oxidation products were detected usingUPLC and GC/MS analysis. It was found that the products are stable within minimum 1h.In order to optimize oxidation procedure and achieve maximum concentrations of oxons,the optimal concentrations of H2O2 (50 μM) and MPO (100 nM) were determined. Also,the optimal incubation time of OPs and MPO (10 min), as well as the optimal pH (6) andtemperature (25 °C) were estimated. Oxidation of OPs in the presence of MPO underoptimal conditions was applied as a modification of the method for detecting OP usingAChE test. The detection limits were determined for the modified method, as well as theefficiency of oxidation and its application for the analysi of sintetic mixture of OPs.Examined organothiophosphates have been converted into their oxo-forms usingelectrochemically generated halogens. Products have been identified as oxons using UPLCanalysis. It was found that the the most efficient oxidation of OPs was carried out by after15 minutes of oxidation with electrogenerated bromine. Detection limits were determined,too.
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Primena oksidacije organo-tiofosfatnih pesticida u metodama za njihovu detekciju na bazi inhibicije acetilholinesteraze
T1  - Application of organothiophosphate pesticides oxidation in methods for their detection based on acetylcholinesterase inhibition
UR  - https://hdl.handle.net/21.15107/rcub_nardus_3468
ER  - 
@phdthesis{
author = "Lazarević-Pašti, Tamara",
year = "2012",
abstract = "Ispitana je inhibicija slobodne acetilholinesteraze (AChE) odabranim organotiofosfatima (OP) (diazinon, malation, hlorpirifos, azinfos-metil, forat) i njihovim oksoanalozima (diazokson, malaokson, hlorpirifos-okson, azinfos-metil-okson, forat-okson), pri čemu su optimizovani uslovi za detekciju najniže koncentracije tih jedinjenja primenom AChE testa. Određene su IC50 vrednosti za sva navedena jedinjenja. U cilju povećanja osetljivosti AChE testa, ispitivani organo-tiofosfati prevedeni su u okso-analoge u prisustvu enzima mijeloperoksidaze (MPO). To je potvreno pomoćuUPLC i GC/MS analize. Nastali oksidacioni proizvodi stabilni su najmanje 1h. Maksimalne koncentracije oksona dobijaju se kada se organo-tiofosfati inkubiraju sa 100 nM MPO u prisustvu H2O2 koncentracije 50 μM, pri pH 6, na temperaturi 25 °C u toku 10 minuta. Oksidacija OP u prisustvu MPO pod navedenim uslovima primenjena je u modifikaciji metode za detekciju OP na bazi inhibicije AChE. Određena je granica detekcije modifikovane metode, kao i efikasnost oksidacije i njena primena na smešu OP. Gore navedeni organo-tiofosfati prevedeni su u odgovarajue oksone i pomoću elektrohemijski generisanih halogena. Proizvodi koji nastaju identifikovani su kao oksoni pomoću UPLC analize. Utvrđeno je da je najefikasnija oksidacija elektrogenerisanim bromom u toku 15 minuta. Određena je i granica detekcije AChE testa za odreivanje OP kada su OP oksidovani elektrohemijski generisanim bromom..., The inhibition of acetylcholinesterase in the presence of selected organothiophosphates (diazinon, malathion, chlorpyrifos, azinphos-methyl, phorate) andtheir oxo-analogues (diazoxon, malaoxon, chlorpyrifos-oxon, azinphos-methyl-oxon,phorate-oxon) was examined. Experimental conditions were optimized to detect the lowestposible concentrations of these compounds using AChE test. IC50 values were determinedfor all the mentioned compounds.Investigated organothiophosphates have been converted into their oxo-analogues inthe presence of the enzyme myeloperoxidase. Oxidation products were detected usingUPLC and GC/MS analysis. It was found that the products are stable within minimum 1h.In order to optimize oxidation procedure and achieve maximum concentrations of oxons,the optimal concentrations of H2O2 (50 μM) and MPO (100 nM) were determined. Also,the optimal incubation time of OPs and MPO (10 min), as well as the optimal pH (6) andtemperature (25 °C) were estimated. Oxidation of OPs in the presence of MPO underoptimal conditions was applied as a modification of the method for detecting OP usingAChE test. The detection limits were determined for the modified method, as well as theefficiency of oxidation and its application for the analysi of sintetic mixture of OPs.Examined organothiophosphates have been converted into their oxo-forms usingelectrochemically generated halogens. Products have been identified as oxons using UPLCanalysis. It was found that the the most efficient oxidation of OPs was carried out by after15 minutes of oxidation with electrogenerated bromine. Detection limits were determined,too.",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Primena oksidacije organo-tiofosfatnih pesticida u metodama za njihovu detekciju na bazi inhibicije acetilholinesteraze, Application of organothiophosphate pesticides oxidation in methods for their detection based on acetylcholinesterase inhibition",
url = "https://hdl.handle.net/21.15107/rcub_nardus_3468"
}
Lazarević-Pašti, T.. (2012). Primena oksidacije organo-tiofosfatnih pesticida u metodama za njihovu detekciju na bazi inhibicije acetilholinesteraze. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_3468
Lazarević-Pašti T. Primena oksidacije organo-tiofosfatnih pesticida u metodama za njihovu detekciju na bazi inhibicije acetilholinesteraze. in Универзитет у Београду. 2012;.
https://hdl.handle.net/21.15107/rcub_nardus_3468 .
Lazarević-Pašti, Tamara, "Primena oksidacije organo-tiofosfatnih pesticida u metodama za njihovu detekciju na bazi inhibicije acetilholinesteraze" in Универзитет у Београду (2012),
https://hdl.handle.net/21.15107/rcub_nardus_3468 .