TY  - JOUR
AU  - Ognjanović, Miloš
AU  - Jaćimović, Željko
AU  - Kosović-Perutović, Milica
AU  - Besu Žižak, Irina
AU  - Stanojković, Tatjana
AU  - Žižak, Željko
AU  - Dojčinović, Biljana
AU  - Stanković, Dalibor M.
AU  - Antić, Bratislav
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10733
AB  - Partial cation substitution can significantly change the physical properties of parent compounds. By controlling the chemical composition and knowing the mutual relationship between composition and physical properties, it is possible to tailor the properties of materials to those that are superior for desired technological application. Using the polyol synthesis procedure, a series of yttrium-substituted iron oxide nanoconstructs, γ-Fe2−xYxO3 (YIONs), was prepared. It was found that Y3+ could substitute Fe3+ in the crystal structures of maghemite (γ-Fe2O3) up to a limited concentration of ~1.5% (γ-Fe1.969Y0.031O3). Analysis of TEM micrographs showed that crystallites or particles were aggregated in flower-like structures with diameters from 53.7 ± 6.2 nm to 97.3 ± 37.0 nm, depending on yttrium concentration. To be investigated for potential applications as magnetic hyperthermia agents, YIONs were tested twice: their heating efficiency was tested and their toxicity was investigated. The Specific Absorption Rate (SAR) values were in the range of 32.6 W/g to 513 W/g and significantly decreased with increased yttrium concentration in the samples. Intrinsic loss power (ILP) for γ-Fe2O3 and γ-Fe1.995Y0.005O3 were ~8–9 nH·m2/Kg, which pointed to their excellent heating efficiency. IC50 values of investigated samples against cancer (HeLa) and normal (MRC-5) cells decreased with increased yttrium concentration and were higher than ~300 μg/mL. The samples of γ-Fe2−xYxO3 did not show a genotoxic effect. The results of toxicity studies show that YIONs are suitable for further in vitro/in vivo studies toward to their potential medical applications, while results of heat generation point to their potential use in magnetic hyperthermia cancer treatment or use as self-heating systems for other technological applications such as catalysis.
T2  - Nanomaterials
T1  - Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity
VL  - 13
IS  - 5
SP  - 870
DO  - 10.3390/nano13050870
ER  - 

@article{
author = "Ognjanović, Miloš and Jaćimović, Željko and Kosović-Perutović, Milica and Besu Žižak, Irina and Stanojković, Tatjana and Žižak, Željko and Dojčinović, Biljana and Stanković, Dalibor M. and Antić, Bratislav",
year = "2023",
abstract = "Partial cation substitution can significantly change the physical properties of parent compounds. By controlling the chemical composition and knowing the mutual relationship between composition and physical properties, it is possible to tailor the properties of materials to those that are superior for desired technological application. Using the polyol synthesis procedure, a series of yttrium-substituted iron oxide nanoconstructs, γ-Fe2−xYxO3 (YIONs), was prepared. It was found that Y3+ could substitute Fe3+ in the crystal structures of maghemite (γ-Fe2O3) up to a limited concentration of ~1.5% (γ-Fe1.969Y0.031O3). Analysis of TEM micrographs showed that crystallites or particles were aggregated in flower-like structures with diameters from 53.7 ± 6.2 nm to 97.3 ± 37.0 nm, depending on yttrium concentration. To be investigated for potential applications as magnetic hyperthermia agents, YIONs were tested twice: their heating efficiency was tested and their toxicity was investigated. The Specific Absorption Rate (SAR) values were in the range of 32.6 W/g to 513 W/g and significantly decreased with increased yttrium concentration in the samples. Intrinsic loss power (ILP) for γ-Fe2O3 and γ-Fe1.995Y0.005O3 were ~8–9 nH·m2/Kg, which pointed to their excellent heating efficiency. IC50 values of investigated samples against cancer (HeLa) and normal (MRC-5) cells decreased with increased yttrium concentration and were higher than ~300 μg/mL. The samples of γ-Fe2−xYxO3 did not show a genotoxic effect. The results of toxicity studies show that YIONs are suitable for further in vitro/in vivo studies toward to their potential medical applications, while results of heat generation point to their potential use in magnetic hyperthermia cancer treatment or use as self-heating systems for other technological applications such as catalysis.",
journal = "Nanomaterials",
title = "Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity",
volume = "13",
number = "5",
pages = "870",
doi = "10.3390/nano13050870"
}

Ognjanović, M., Jaćimović, Ž., Kosović-Perutović, M., Besu Žižak, I., Stanojković, T., Žižak, Ž., Dojčinović, B., Stanković, D. M.,& Antić, B.. (2023). Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity. in Nanomaterials, 13(5), 870.
https://doi.org/10.3390/nano13050870

Ognjanović M, Jaćimović Ž, Kosović-Perutović M, Besu Žižak I, Stanojković T, Žižak Ž, Dojčinović B, Stanković DM, Antić B. Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity. in Nanomaterials. 2023;13(5):870.
doi:10.3390/nano13050870 .

Ognjanović, Miloš, Jaćimović, Željko, Kosović-Perutović, Milica, Besu Žižak, Irina, Stanojković, Tatjana, Žižak, Željko, Dojčinović, Biljana, Stanković, Dalibor M., Antić, Bratislav, "Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity" in Nanomaterials, 13, no. 5 (2023):870,
https://doi.org/10.3390/nano13050870 . .

TY  - JOUR
AU  - Ognjanović, Miloš
AU  - Stanković, Dalibor M.
AU  - Jaćimović, Željko K.
AU  - Kosović-Perutović, Milica
AU  - Mariano, José F. M. L.
AU  - Krehula, Stjepko
AU  - Musić, Svetozar
AU  - Antić, Bratislav
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10215
AB  - Nickel acetate tetrahydrate (NAT) sample series were used to modify screen-printed carbon electrodes (SPCE). The samples were hybrid Ni/NiO nanocomposites, where the NiO phase increased with an applied treatment temperature. Results of electrochemical measurements pointed that the Ni/NiO550/SPCE-modified electrode had the best analytical performance toward the detection of riboflavin (RF). The Ni/NiO550/SPCE-based sensor showed linear response with RF in the concentration range of 0.5–75 μM and 0.15 μM LOD in BRBS. Sensor offered fast response time, good repeatability, and selectivity with an RSD of 1.4 %. Our results show that the Ni:NiO nanocomposite ratio strongly influenced the electroanalytical performance of SPCE.
T2  - Electroanalysis
T1  - Construction of Sensor for Submicromolar Detection of Riboflavin by Surface Modification of SPCE with Thermal Degradation Products of Nickel Acetate Tetrahydrate
VL  - 34
IS  - 9
SP  - 1431
EP  - 1440
DO  - 10.1002/elan.202100602
ER  - 

@article{
author = "Ognjanović, Miloš and Stanković, Dalibor M. and Jaćimović, Željko K. and Kosović-Perutović, Milica and Mariano, José F. M. L. and Krehula, Stjepko and Musić, Svetozar and Antić, Bratislav",
year = "2022",
abstract = "Nickel acetate tetrahydrate (NAT) sample series were used to modify screen-printed carbon electrodes (SPCE). The samples were hybrid Ni/NiO nanocomposites, where the NiO phase increased with an applied treatment temperature. Results of electrochemical measurements pointed that the Ni/NiO550/SPCE-modified electrode had the best analytical performance toward the detection of riboflavin (RF). The Ni/NiO550/SPCE-based sensor showed linear response with RF in the concentration range of 0.5–75 μM and 0.15 μM LOD in BRBS. Sensor offered fast response time, good repeatability, and selectivity with an RSD of 1.4 %. Our results show that the Ni:NiO nanocomposite ratio strongly influenced the electroanalytical performance of SPCE.",
journal = "Electroanalysis",
title = "Construction of Sensor for Submicromolar Detection of Riboflavin by Surface Modification of SPCE with Thermal Degradation Products of Nickel Acetate Tetrahydrate",
volume = "34",
number = "9",
pages = "1431-1440",
doi = "10.1002/elan.202100602"
}

Ognjanović, M., Stanković, D. M., Jaćimović, Ž. K., Kosović-Perutović, M., Mariano, J. F. M. L., Krehula, S., Musić, S.,& Antić, B.. (2022). Construction of Sensor for Submicromolar Detection of Riboflavin by Surface Modification of SPCE with Thermal Degradation Products of Nickel Acetate Tetrahydrate. in Electroanalysis, 34(9), 1431-1440.
https://doi.org/10.1002/elan.202100602

Ognjanović M, Stanković DM, Jaćimović ŽK, Kosović-Perutović M, Mariano JFML, Krehula S, Musić S, Antić B. Construction of Sensor for Submicromolar Detection of Riboflavin by Surface Modification of SPCE with Thermal Degradation Products of Nickel Acetate Tetrahydrate. in Electroanalysis. 2022;34(9):1431-1440.
doi:10.1002/elan.202100602 .

Ognjanović, Miloš, Stanković, Dalibor M., Jaćimović, Željko K., Kosović-Perutović, Milica, Mariano, José F. M. L., Krehula, Stjepko, Musić, Svetozar, Antić, Bratislav, "Construction of Sensor for Submicromolar Detection of Riboflavin by Surface Modification of SPCE with Thermal Degradation Products of Nickel Acetate Tetrahydrate" in Electroanalysis, 34, no. 9 (2022):1431-1440,
https://doi.org/10.1002/elan.202100602 . .

TY  - CONF
AU  - Jaćimović, Željko
AU  - Ognjanović, Miloš
AU  - Kosović-Perutović, Milica
AU  - Dojčinović, Biljana
AU  - Stanković, Dalibor
AU  - Antić, Bratislav
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11680
AB  - Nanoferrites have been intensively studied because of the possibility of their use in the fields such as medicine, sensors, environmental, agriculture, weather, battery, etc. Often, they are used as modal systems in fundamental science to study physical and chemical phenomena at the nanoscale. Various pathways were applied for the synthesis of nanoferrites with the same composition were led to different microstructure and structure properties, which further influenced magnetic, electric, catalytic and other properties. Consequently, with a controlled synthesis, it is possible to tune the properties of nanoferrites important for applications. On the other side, properties can be controlled by changing chemical composition. In ternary nanoferrites often deviation of stoichiometry accompanied with cation polyvalence was found [1]. The main idea of our work was the application of the polyol-modified method developed for the synthesis of flower-structured iron oxides nanoparticles in the preparation of ternary ZnxMnyFezO4 samples to seek a correlation among chemical composition and microstructure with magnetic hyperthermia efficiency and electrochemical properties. A series of the samples ZnxMnyFezO4 was prepared by polyol process using a slightly modified procedure described in ref [2]. By elemental analysis performed using the ICP technique, the content of cations in the formula unit was determined as follow: Zn0.640Fe2.360O4, Zn0.394Mn0.138Fe2.468O4, Zn0.309Mn0.240Fe2.451O4, Zn0.182Mn0.344Fe2.474O4, Zn0.098Mn0.447Fe2.455O4, Mn0.624Fe2.376O4. The ICP results pointed to the presence of multivalent cations, Mn2+/Mn3+ and Fe3+/Fe2+. Zn has stable valence +2, while the oxidation state of +4 for Mn couldn’t be excluded. Different oxidation states of Mn and Fe and possible deviation of stoichiometry, can create physical effects [3] and make ZnxMnyFezO4 suitable material in practical applications, used for modification of working electrodesin electrochemical sensors. Consequently, we have performed basic electrochemical characterisation of nanoferrites. Cyclic voltammetry of 5 mM K3[Fe(CN)]6/K4[Fe(CN)]6 (1:1) in 0.1 M KCl at bare SPCE and ZnxMnyFezO4-modified SPCE showed that the highest peak current (Ip) was achieved using a Zn0.098Mn0.447Fe2.455O4/SPCE. The Ip was about 22% higher than the bare electrode. X-ray diffraction pattern showed the samples were single-phase crystallising in spinel structure type. Morphology and particle size of the samples were analysed from TEM micrographs. Particles (or crystallites) were agglomerated in a flower-like structure (Figure 1). The diameter of the flowers was around 50-60 nm. Superparamagnetic behaviour of the samples was found from magnetization versus field measurements (hysteresis loops). Prepared samples were in the form of stable colloids with hydrodynamic diameter in the range of 50-120 nm. The heating properties of the samples were analysed from the data of specific absorption rate (SAR), Figure 1b. The highest SAR value was found for Zn0.098Mn0.447Fe2.455O4. The best heating efficiency and electrochemical properties had the same sample. To correlate ZnxMnyFezO4 different efficiency in magnetic hyperthermia and electrochemical sensor applications with parameters like cation distribution in two non-equivalent spinel crystallographic sites (space group, Fd-3m), local distortion on cationic sites, crystallite size and defects, an integrated study of samples structure and microstructure is in progress.
PB  - Sociedade Portuguesa de Química
C3  - ECC8 : 8th EuChemS Chemistry Congress : programme and the book of abstracts; Aug 28 - Sep 1, Lisbon, Portugal
T1  - Ternary flower-structured nanoferrites with polyvalent cations for potential applications in electrochemical sensors and magnetic hyperthermia
SP  - 850
EP  - 850
DO  - 10.52590/E.ECC8
ER  - 

@conference{
author = "Jaćimović, Željko and Ognjanović, Miloš and Kosović-Perutović, Milica and Dojčinović, Biljana and Stanković, Dalibor and Antić, Bratislav",
year = "2022",
abstract = "Nanoferrites have been intensively studied because of the possibility of their use in the fields such as medicine, sensors, environmental, agriculture, weather, battery, etc. Often, they are used as modal systems in fundamental science to study physical and chemical phenomena at the nanoscale. Various pathways were applied for the synthesis of nanoferrites with the same composition were led to different microstructure and structure properties, which further influenced magnetic, electric, catalytic and other properties. Consequently, with a controlled synthesis, it is possible to tune the properties of nanoferrites important for applications. On the other side, properties can be controlled by changing chemical composition. In ternary nanoferrites often deviation of stoichiometry accompanied with cation polyvalence was found [1]. The main idea of our work was the application of the polyol-modified method developed for the synthesis of flower-structured iron oxides nanoparticles in the preparation of ternary ZnxMnyFezO4 samples to seek a correlation among chemical composition and microstructure with magnetic hyperthermia efficiency and electrochemical properties. A series of the samples ZnxMnyFezO4 was prepared by polyol process using a slightly modified procedure described in ref [2]. By elemental analysis performed using the ICP technique, the content of cations in the formula unit was determined as follow: Zn0.640Fe2.360O4, Zn0.394Mn0.138Fe2.468O4, Zn0.309Mn0.240Fe2.451O4, Zn0.182Mn0.344Fe2.474O4, Zn0.098Mn0.447Fe2.455O4, Mn0.624Fe2.376O4. The ICP results pointed to the presence of multivalent cations, Mn2+/Mn3+ and Fe3+/Fe2+. Zn has stable valence +2, while the oxidation state of +4 for Mn couldn’t be excluded. Different oxidation states of Mn and Fe and possible deviation of stoichiometry, can create physical effects [3] and make ZnxMnyFezO4 suitable material in practical applications, used for modification of working electrodesin electrochemical sensors. Consequently, we have performed basic electrochemical characterisation of nanoferrites. Cyclic voltammetry of 5 mM K3[Fe(CN)]6/K4[Fe(CN)]6 (1:1) in 0.1 M KCl at bare SPCE and ZnxMnyFezO4-modified SPCE showed that the highest peak current (Ip) was achieved using a Zn0.098Mn0.447Fe2.455O4/SPCE. The Ip was about 22% higher than the bare electrode. X-ray diffraction pattern showed the samples were single-phase crystallising in spinel structure type. Morphology and particle size of the samples were analysed from TEM micrographs. Particles (or crystallites) were agglomerated in a flower-like structure (Figure 1). The diameter of the flowers was around 50-60 nm. Superparamagnetic behaviour of the samples was found from magnetization versus field measurements (hysteresis loops). Prepared samples were in the form of stable colloids with hydrodynamic diameter in the range of 50-120 nm. The heating properties of the samples were analysed from the data of specific absorption rate (SAR), Figure 1b. The highest SAR value was found for Zn0.098Mn0.447Fe2.455O4. The best heating efficiency and electrochemical properties had the same sample. To correlate ZnxMnyFezO4 different efficiency in magnetic hyperthermia and electrochemical sensor applications with parameters like cation distribution in two non-equivalent spinel crystallographic sites (space group, Fd-3m), local distortion on cationic sites, crystallite size and defects, an integrated study of samples structure and microstructure is in progress.",
publisher = "Sociedade Portuguesa de Química",
journal = "ECC8 : 8th EuChemS Chemistry Congress : programme and the book of abstracts; Aug 28 - Sep 1, Lisbon, Portugal",
title = "Ternary flower-structured nanoferrites with polyvalent cations for potential applications in electrochemical sensors and magnetic hyperthermia",
pages = "850-850",
doi = "10.52590/E.ECC8"
}

Jaćimović, Ž., Ognjanović, M., Kosović-Perutović, M., Dojčinović, B., Stanković, D.,& Antić, B.. (2022). Ternary flower-structured nanoferrites with polyvalent cations for potential applications in electrochemical sensors and magnetic hyperthermia. in ECC8 : 8th EuChemS Chemistry Congress : programme and the book of abstracts; Aug 28 - Sep 1, Lisbon, Portugal
Sociedade Portuguesa de Química., 850-850.
https://doi.org/10.52590/E.ECC8

Jaćimović Ž, Ognjanović M, Kosović-Perutović M, Dojčinović B, Stanković D, Antić B. Ternary flower-structured nanoferrites with polyvalent cations for potential applications in electrochemical sensors and magnetic hyperthermia. in ECC8 : 8th EuChemS Chemistry Congress : programme and the book of abstracts; Aug 28 - Sep 1, Lisbon, Portugal. 2022;:850-850.
doi:10.52590/E.ECC8 .

Jaćimović, Željko, Ognjanović, Miloš, Kosović-Perutović, Milica, Dojčinović, Biljana, Stanković, Dalibor, Antić, Bratislav, "Ternary flower-structured nanoferrites with polyvalent cations for potential applications in electrochemical sensors and magnetic hyperthermia" in ECC8 : 8th EuChemS Chemistry Congress : programme and the book of abstracts; Aug 28 - Sep 1, Lisbon, Portugal (2022):850-850,
https://doi.org/10.52590/E.ECC8 . .