TY  - CONF
AU  - Prokopović, J.
AU  - Adžić, Miroslav
AU  - Nićiforović, Ana
AU  - Vučić, Vesna
AU  - Zarić, Božidarka
AU  - Radojčić, Marija B.
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9433
AB  - The molecular mechanism of gamma-ionizing radiation (IR) resistance of human prostate cancer cells PC-3 is not known. Since low-LET-IR effects are primarily achieved through generation of reactive oxygen species (ROS), IR-induced expression of ROSmetabolizing antioxidant enzymes, Mn- and CuZn-superoxide dismutase (Mn- and CuZnSOD) and catalase (CAT), and their upstream regulator transcription factor NFκB was followed. Significant elevation of both SODs was found in cells irradiated with 10- and 20 Gy, while CAT and NFkB expression was unchanged. Since, such conditions lead to accumulation of H2O2, it is concluded that radioresistance of PC-3 cells may emerge from positive feed-forward vicious circle established between H2O2 activation of NFκB and elevated MnSOD activity.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
T1  - Superoxide dismutases in radioresistant PC-3 human prostate carcinoma cells
SP  - 422
EP  - 424
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9433
ER  - 

@conference{
author = "Prokopović, J. and Adžić, Miroslav and Nićiforović, Ana and Vučić, Vesna and Zarić, Božidarka and Radojčić, Marija B.",
year = "2006",
abstract = "The molecular mechanism of gamma-ionizing radiation (IR) resistance of human prostate cancer cells PC-3 is not known. Since low-LET-IR effects are primarily achieved through generation of reactive oxygen species (ROS), IR-induced expression of ROSmetabolizing antioxidant enzymes, Mn- and CuZn-superoxide dismutase (Mn- and CuZnSOD) and catalase (CAT), and their upstream regulator transcription factor NFκB was followed. Significant elevation of both SODs was found in cells irradiated with 10- and 20 Gy, while CAT and NFkB expression was unchanged. Since, such conditions lead to accumulation of H2O2, it is concluded that radioresistance of PC-3 cells may emerge from positive feed-forward vicious circle established between H2O2 activation of NFκB and elevated MnSOD activity.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry",
title = "Superoxide dismutases in radioresistant PC-3 human prostate carcinoma cells",
pages = "422-424",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9433"
}

Prokopović, J., Adžić, M., Nićiforović, A., Vučić, V., Zarić, B.,& Radojčić, M. B.. (2006). Superoxide dismutases in radioresistant PC-3 human prostate carcinoma cells. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
Society of Physical Chemists of Serbia., 422-424.
https://hdl.handle.net/21.15107/rcub_vinar_9433

Prokopović J, Adžić M, Nićiforović A, Vučić V, Zarić B, Radojčić MB. Superoxide dismutases in radioresistant PC-3 human prostate carcinoma cells. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry. 2006;:422-424.
https://hdl.handle.net/21.15107/rcub_vinar_9433 .

Prokopović, J., Adžić, Miroslav, Nićiforović, Ana, Vučić, Vesna, Zarić, Božidarka, Radojčić, Marija B., "Superoxide dismutases in radioresistant PC-3 human prostate carcinoma cells" in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry (2006):422-424,
https://hdl.handle.net/21.15107/rcub_vinar_9433 .