TY  - JOUR
AU  - Antić, Katarina M.
AU  - Babić, Marija M.
AU  - Vuković, Jovana S.
AU  - Onjia, Antonije E.
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida Lj.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1394
AB  - A series of poly(2-hydroxyethyl acrylate-co-itaconic acid), P(HEA/IA), hydrogels with different HEA/IA ratio, were synthesized using free radical crosslinking/copolymerization and investigated as sorbents for Pb2+ from aqueous solutions. Hydrogels were characterized using DMA, FTIR, DSC, SEM and AFM. The adsorption was found to be highly dependent on hydrogel composition, solution pH, sorbent weight, ionic strength and contact time. Five isotherm models, Langmuir, Freundlich, Redlich-Peterson, Temkin and Dubinin-Radushkevich, were applied to the sorption data. The best fit was obtained with Redlich-Peterson isotherm. The separation factor, RL, value indicated favorable sorption for Pb2+. The maximum sorption capacities were 392.2 and 409.8 mg/g for P(HEA/2IA) and P(HEA/10IA), respectively. Kinetic data showed best fit with pseudo-second-order model. Thermodynamic studies revealed that the reaction was exothermic and proceeds with a decrease in entropy. Moreover, P(HEA/IA) hydrogel showed the most pronounced sorption toward Pb2+ from environment containing Cu2+, Zn2+, Cd2+, Ni2+ and Co2+. Sorption/desorption experiments, showed that the P(HEA/IA) hydrogels could be reused without significant loss of the initial properties even after three adsorption-desorption cycles.
T2  - Hemijska industrija
T1  - Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels
VL  - 70
IS  - 6
SP  - 695
EP  - 705
DO  - 10.2298/HEMIND151225006A
ER  - 

@article{
author = "Antić, Katarina M. and Babić, Marija M. and Vuković, Jovana S. and Onjia, Antonije E. and Filipović, Jovanka M. and Tomić, Simonida Lj.",
year = "2016",
abstract = "A series of poly(2-hydroxyethyl acrylate-co-itaconic acid), P(HEA/IA), hydrogels with different HEA/IA ratio, were synthesized using free radical crosslinking/copolymerization and investigated as sorbents for Pb2+ from aqueous solutions. Hydrogels were characterized using DMA, FTIR, DSC, SEM and AFM. The adsorption was found to be highly dependent on hydrogel composition, solution pH, sorbent weight, ionic strength and contact time. Five isotherm models, Langmuir, Freundlich, Redlich-Peterson, Temkin and Dubinin-Radushkevich, were applied to the sorption data. The best fit was obtained with Redlich-Peterson isotherm. The separation factor, RL, value indicated favorable sorption for Pb2+. The maximum sorption capacities were 392.2 and 409.8 mg/g for P(HEA/2IA) and P(HEA/10IA), respectively. Kinetic data showed best fit with pseudo-second-order model. Thermodynamic studies revealed that the reaction was exothermic and proceeds with a decrease in entropy. Moreover, P(HEA/IA) hydrogel showed the most pronounced sorption toward Pb2+ from environment containing Cu2+, Zn2+, Cd2+, Ni2+ and Co2+. Sorption/desorption experiments, showed that the P(HEA/IA) hydrogels could be reused without significant loss of the initial properties even after three adsorption-desorption cycles.",
journal = "Hemijska industrija",
title = "Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels",
volume = "70",
number = "6",
pages = "695-705",
doi = "10.2298/HEMIND151225006A"
}

Antić, K. M., Babić, M. M., Vuković, J. S., Onjia, A. E., Filipović, J. M.,& Tomić, S. Lj.. (2016). Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels. in Hemijska industrija, 70(6), 695-705.
https://doi.org/10.2298/HEMIND151225006A

Antić KM, Babić MM, Vuković JS, Onjia AE, Filipović JM, Tomić SL. Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels. in Hemijska industrija. 2016;70(6):695-705.
doi:10.2298/HEMIND151225006A .

Antić, Katarina M., Babić, Marija M., Vuković, Jovana S., Onjia, Antonije E., Filipović, Jovanka M., Tomić, Simonida Lj., "Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels" in Hemijska industrija, 70, no. 6 (2016):695-705,
https://doi.org/10.2298/HEMIND151225006A . .

TY  - JOUR
AU  - Antić, Katarina M.
AU  - Babić, Marija M.
AU  - Vuković Jovasević, Jovana
AU  - Vasiljević-Radović, Dana
AU  - Onjia, Antonije E.
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida Lj.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/467
AB  - Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA) copolymers, were prepared by free radical cross-linking copolymerization and investigated as potential adsorbents for Cd2+ removal from aqueous solution. The hydrogels before and after Cd2+ adsorption were characterized using FTIR, temperature sensitive. In order to evaluate adsorption behavior of samples various factors affecting the Cd2+ uptake behavior, such as: contact time, temperature, pH, ionic strength, adsorbent weight, competitive ions and initial concentration of the metal ions were investigated. Five adsorption isotherms and two kinetic models were studied. The adsorption behavior can be very well described by the pseudo-second order kinetic model and Langmuir isotherm. Multicomponent adsorption studies revealed that adsorption of cadmium depends on the type of metal ions present in the system. Desorption studies showed that hydrogel can be reused three times with only 15% loss of adsorption capacity. All results indicate that the sample with the highest IA content is the most promising adsorbent for Cd2+ removal. (C) 2015 Elsevier B.V. All rights reserved.
T2  - Applied Surface Science
T1  - Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution
VL  - 338
SP  - 178
EP  - 189
DO  - 10.1016/j.apsusc.2015.02.133
ER  - 

@article{
author = "Antić, Katarina M. and Babić, Marija M. and Vuković Jovasević, Jovana and Vasiljević-Radović, Dana and Onjia, Antonije E. and Filipović, Jovanka M. and Tomić, Simonida Lj.",
year = "2015",
abstract = "Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA) copolymers, were prepared by free radical cross-linking copolymerization and investigated as potential adsorbents for Cd2+ removal from aqueous solution. The hydrogels before and after Cd2+ adsorption were characterized using FTIR, temperature sensitive. In order to evaluate adsorption behavior of samples various factors affecting the Cd2+ uptake behavior, such as: contact time, temperature, pH, ionic strength, adsorbent weight, competitive ions and initial concentration of the metal ions were investigated. Five adsorption isotherms and two kinetic models were studied. The adsorption behavior can be very well described by the pseudo-second order kinetic model and Langmuir isotherm. Multicomponent adsorption studies revealed that adsorption of cadmium depends on the type of metal ions present in the system. Desorption studies showed that hydrogel can be reused three times with only 15% loss of adsorption capacity. All results indicate that the sample with the highest IA content is the most promising adsorbent for Cd2+ removal. (C) 2015 Elsevier B.V. All rights reserved.",
journal = "Applied Surface Science",
title = "Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution",
volume = "338",
pages = "178-189",
doi = "10.1016/j.apsusc.2015.02.133"
}

Antić, K. M., Babić, M. M., Vuković Jovasević, J., Vasiljević-Radović, D., Onjia, A. E., Filipović, J. M.,& Tomić, S. Lj.. (2015). Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution. in Applied Surface Science, 338, 178-189.
https://doi.org/10.1016/j.apsusc.2015.02.133

Antić KM, Babić MM, Vuković Jovasević J, Vasiljević-Radović D, Onjia AE, Filipović JM, Tomić SL. Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution. in Applied Surface Science. 2015;338:178-189.
doi:10.1016/j.apsusc.2015.02.133 .

Antić, Katarina M., Babić, Marija M., Vuković Jovasević, Jovana, Vasiljević-Radović, Dana, Onjia, Antonije E., Filipović, Jovanka M., Tomić, Simonida Lj., "Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution" in Applied Surface Science, 338 (2015):178-189,
https://doi.org/10.1016/j.apsusc.2015.02.133 . .

TY  - JOUR
AU  - Milosavljevic, Nedeljko B.
AU  - Ristić, Mirjana
AU  - Perić-Grujić, Aleksandra A.
AU  - Filipović, Jovanka M.
AU  - Štrbac, Svetlana
AU  - Rakočević, Zlatko Lj.
AU  - Kalagasidis Krušić, Melina
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4438
AB  - Novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid were applied as adsorbents for the removal of Zn(2+) ions from aqueous solution. In batch tests, the influence of solution pH, contact time, initial metal ion concentration and temperature was examined. The sorption was found pH dependent, pH 5.5 being the optimum value. The adsorption process was well described by the pseudosecond order kinetic. The hydrogels were characterized by spectral (Fourier transform infrared-FTIR) and structural (SEM/EDX and atomic force microscopy-AFM) analyses. The surface topography changes were observed by atomic force microscopy, while the changes in surface composition were detected using phase imaging AFM. The negative values of free energy and enthalpy indicated that the adsorption is spontaneous and exothermic one. The best fitting isotherms were Langmuir and Redlich-Peterson and it was found that both linear and nonlinear methods were appropriate for obtaining the isotherm parameters. However, the increase of temperature leads to higher adsorption capacity, since swelling degree increased with temperature. (C) 2011 Elsevier B.V. All rights reserved.
T2  - Journal of Hazardous Materials
T1  - Sorption of zinc by novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid
VL  - 192
IS  - 2
SP  - 846
EP  - 854
DO  - 10.1016/j.jhazmat.2011.05.093
ER  - 

@article{
author = "Milosavljevic, Nedeljko B. and Ristić, Mirjana and Perić-Grujić, Aleksandra A. and Filipović, Jovanka M. and Štrbac, Svetlana and Rakočević, Zlatko Lj. and Kalagasidis Krušić, Melina",
year = "2011",
abstract = "Novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid were applied as adsorbents for the removal of Zn(2+) ions from aqueous solution. In batch tests, the influence of solution pH, contact time, initial metal ion concentration and temperature was examined. The sorption was found pH dependent, pH 5.5 being the optimum value. The adsorption process was well described by the pseudosecond order kinetic. The hydrogels were characterized by spectral (Fourier transform infrared-FTIR) and structural (SEM/EDX and atomic force microscopy-AFM) analyses. The surface topography changes were observed by atomic force microscopy, while the changes in surface composition were detected using phase imaging AFM. The negative values of free energy and enthalpy indicated that the adsorption is spontaneous and exothermic one. The best fitting isotherms were Langmuir and Redlich-Peterson and it was found that both linear and nonlinear methods were appropriate for obtaining the isotherm parameters. However, the increase of temperature leads to higher adsorption capacity, since swelling degree increased with temperature. (C) 2011 Elsevier B.V. All rights reserved.",
journal = "Journal of Hazardous Materials",
title = "Sorption of zinc by novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid",
volume = "192",
number = "2",
pages = "846-854",
doi = "10.1016/j.jhazmat.2011.05.093"
}

Milosavljevic, N. B., Ristić, M., Perić-Grujić, A. A., Filipović, J. M., Štrbac, S., Rakočević, Z. Lj.,& Kalagasidis Krušić, M.. (2011). Sorption of zinc by novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid. in Journal of Hazardous Materials, 192(2), 846-854.
https://doi.org/10.1016/j.jhazmat.2011.05.093

Milosavljevic NB, Ristić M, Perić-Grujić AA, Filipović JM, Štrbac S, Rakočević ZL, Kalagasidis Krušić M. Sorption of zinc by novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid. in Journal of Hazardous Materials. 2011;192(2):846-854.
doi:10.1016/j.jhazmat.2011.05.093 .

Milosavljevic, Nedeljko B., Ristić, Mirjana, Perić-Grujić, Aleksandra A., Filipović, Jovanka M., Štrbac, Svetlana, Rakočević, Zlatko Lj., Kalagasidis Krušić, Melina, "Sorption of zinc by novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid" in Journal of Hazardous Materials, 192, no. 2 (2011):846-854,
https://doi.org/10.1016/j.jhazmat.2011.05.093 . .

TY  - JOUR
AU  - Milosavljevic, Nedeljko B.
AU  - Ristić, Mirjana
AU  - Perić-Grujić, Aleksandra A.
AU  - Filipović, Jovanka M.
AU  - Štrbac, Svetlana
AU  - Rakočević, Zlatko Lj.
AU  - Kalagasidis Krušić, Melina
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4533
AB  - A removal of Cu2+ ions from aqueous solutions onto hydrogels of chitosan. itaconic and methacrylic acid has been investigated using batch adsorption technique. The extent of adsorption was investigated as a function of pH, adsorbent dose, initial metal ion concentration, contact time and temperature. The FIR spectra showed that -NH2, -OH and -COOH groups are involved in the Cu2+ ions adsorption. The surface topography changes were observed by AFM, where the phase images indicated that sorption takes place on the surface of the hydrogel and in the bulk. Pseudo-first order, pseudo-second order and intraparticle diffusion models were analyzed and showed that the Cu2+ ions adsorption followed pseudo-second order kinetics. The equilibrium data were analyzed using Langmuir, Freundlich and Redlich-Peterson isotherms and the best interpretation was given by Redlich-Peterson. The adsorption capacity was found to be 122.59 mg/g, based on the non-linear Langmuir isotherm. Based on the separation factor. R-L, the Cu2+ ion adsorption is favorable, while the low activation energies indicate physisorption. Desorption experiments, done with a nitric acid, showed that the investigated hydrogels could be reused without significant losses of the initial properties even after three adsorption-sorption cycles. (C) 2011 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces. A: Physicochemical and Engineering Aspects
T1  - Removal of Cu2+ ions using hydrogels of chitosan, itaconic and methacrylic acid: FTIR, SEM/EDX, AFM, kinetic and equilibrium study
VL  - 388
IS  - 1-3
SP  - 59
EP  - 69
DO  - 10.1016/j.colsurfa.2011.08.011
ER  - 

@article{
author = "Milosavljevic, Nedeljko B. and Ristić, Mirjana and Perić-Grujić, Aleksandra A. and Filipović, Jovanka M. and Štrbac, Svetlana and Rakočević, Zlatko Lj. and Kalagasidis Krušić, Melina",
year = "2011",
abstract = "A removal of Cu2+ ions from aqueous solutions onto hydrogels of chitosan. itaconic and methacrylic acid has been investigated using batch adsorption technique. The extent of adsorption was investigated as a function of pH, adsorbent dose, initial metal ion concentration, contact time and temperature. The FIR spectra showed that -NH2, -OH and -COOH groups are involved in the Cu2+ ions adsorption. The surface topography changes were observed by AFM, where the phase images indicated that sorption takes place on the surface of the hydrogel and in the bulk. Pseudo-first order, pseudo-second order and intraparticle diffusion models were analyzed and showed that the Cu2+ ions adsorption followed pseudo-second order kinetics. The equilibrium data were analyzed using Langmuir, Freundlich and Redlich-Peterson isotherms and the best interpretation was given by Redlich-Peterson. The adsorption capacity was found to be 122.59 mg/g, based on the non-linear Langmuir isotherm. Based on the separation factor. R-L, the Cu2+ ion adsorption is favorable, while the low activation energies indicate physisorption. Desorption experiments, done with a nitric acid, showed that the investigated hydrogels could be reused without significant losses of the initial properties even after three adsorption-sorption cycles. (C) 2011 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces. A: Physicochemical and Engineering Aspects",
title = "Removal of Cu2+ ions using hydrogels of chitosan, itaconic and methacrylic acid: FTIR, SEM/EDX, AFM, kinetic and equilibrium study",
volume = "388",
number = "1-3",
pages = "59-69",
doi = "10.1016/j.colsurfa.2011.08.011"
}

Milosavljevic, N. B., Ristić, M., Perić-Grujić, A. A., Filipović, J. M., Štrbac, S., Rakočević, Z. Lj.,& Kalagasidis Krušić, M.. (2011). Removal of Cu2+ ions using hydrogels of chitosan, itaconic and methacrylic acid: FTIR, SEM/EDX, AFM, kinetic and equilibrium study. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 388(1-3), 59-69.
https://doi.org/10.1016/j.colsurfa.2011.08.011

Milosavljevic NB, Ristić M, Perić-Grujić AA, Filipović JM, Štrbac S, Rakočević ZL, Kalagasidis Krušić M. Removal of Cu2+ ions using hydrogels of chitosan, itaconic and methacrylic acid: FTIR, SEM/EDX, AFM, kinetic and equilibrium study. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects. 2011;388(1-3):59-69.
doi:10.1016/j.colsurfa.2011.08.011 .

Milosavljevic, Nedeljko B., Ristić, Mirjana, Perić-Grujić, Aleksandra A., Filipović, Jovanka M., Štrbac, Svetlana, Rakočević, Zlatko Lj., Kalagasidis Krušić, Melina, "Removal of Cu2+ ions using hydrogels of chitosan, itaconic and methacrylic acid: FTIR, SEM/EDX, AFM, kinetic and equilibrium study" in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 388, no. 1-3 (2011):59-69,
https://doi.org/10.1016/j.colsurfa.2011.08.011 . .

TY  - JOUR
AU  - Milosavljevic, Nedeljko B.
AU  - Kljajević, Ljiljana M.
AU  - Popović, Ivanka G.
AU  - Filipović, Jovanka M.
AU  - Kalagasidis Krušić, Melina
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4003
AB  - Chitosan is a biodegradable, non-toxic, biocompatible polymer convenient for use in drug delivery. In this study, hybrid polymeric networks (HPNs) based on chitosan, itaconic acid and poly(vinyl alcohol) (PVA) were prepared and characterized. Chitosan was dissolved in itaconic acid in order to obtain ionic crosslinking with the dicarboxylic acid. In the second step, this chitosan/itaconic acid network was mixed with PVA and chemically crosslinked with glutaraldehyde. The chitosan/itaconic acid ratio was kept constant, while the concentrations of PVA and glutaraldehyde were varied. All samples were characterized using swelling studies, dynamic mechanical analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction and scanning electron microscopy. The equilibrium degrees of swelling obtained for the HPNs were higher than most of the values reported for chitosan hydrogels obtained by dissolving chitosan in acetic acid or HCI aqueous solutions. This method of synthesis also resulted in hydrogels with better mechanical properties and thermal stability. By changing the PVA content and the degree of crosslinking, it is possible to finely tune the properties of the HPNs, which could make them suitable as potential matrices in controlled drug delivery. (C) 2010 Society of Chemical Industry
T2  - Polymer International
T1  - Chitosan, itaconic acid and poly(vinyl alcohol) hybrid polymer networks of high degree of swelling and good mechanical strength
VL  - 59
IS  - 5
SP  - 686
EP  - 694
DO  - 10.1002/pi.2756
ER  - 

@article{
author = "Milosavljevic, Nedeljko B. and Kljajević, Ljiljana M. and Popović, Ivanka G. and Filipović, Jovanka M. and Kalagasidis Krušić, Melina",
year = "2010",
abstract = "Chitosan is a biodegradable, non-toxic, biocompatible polymer convenient for use in drug delivery. In this study, hybrid polymeric networks (HPNs) based on chitosan, itaconic acid and poly(vinyl alcohol) (PVA) were prepared and characterized. Chitosan was dissolved in itaconic acid in order to obtain ionic crosslinking with the dicarboxylic acid. In the second step, this chitosan/itaconic acid network was mixed with PVA and chemically crosslinked with glutaraldehyde. The chitosan/itaconic acid ratio was kept constant, while the concentrations of PVA and glutaraldehyde were varied. All samples were characterized using swelling studies, dynamic mechanical analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction and scanning electron microscopy. The equilibrium degrees of swelling obtained for the HPNs were higher than most of the values reported for chitosan hydrogels obtained by dissolving chitosan in acetic acid or HCI aqueous solutions. This method of synthesis also resulted in hydrogels with better mechanical properties and thermal stability. By changing the PVA content and the degree of crosslinking, it is possible to finely tune the properties of the HPNs, which could make them suitable as potential matrices in controlled drug delivery. (C) 2010 Society of Chemical Industry",
journal = "Polymer International",
title = "Chitosan, itaconic acid and poly(vinyl alcohol) hybrid polymer networks of high degree of swelling and good mechanical strength",
volume = "59",
number = "5",
pages = "686-694",
doi = "10.1002/pi.2756"
}

Milosavljevic, N. B., Kljajević, L. M., Popović, I. G., Filipović, J. M.,& Kalagasidis Krušić, M.. (2010). Chitosan, itaconic acid and poly(vinyl alcohol) hybrid polymer networks of high degree of swelling and good mechanical strength. in Polymer International, 59(5), 686-694.
https://doi.org/10.1002/pi.2756

Milosavljevic NB, Kljajević LM, Popović IG, Filipović JM, Kalagasidis Krušić M. Chitosan, itaconic acid and poly(vinyl alcohol) hybrid polymer networks of high degree of swelling and good mechanical strength. in Polymer International. 2010;59(5):686-694.
doi:10.1002/pi.2756 .

Milosavljevic, Nedeljko B., Kljajević, Ljiljana M., Popović, Ivanka G., Filipović, Jovanka M., Kalagasidis Krušić, Melina, "Chitosan, itaconic acid and poly(vinyl alcohol) hybrid polymer networks of high degree of swelling and good mechanical strength" in Polymer International, 59, no. 5 (2010):686-694,
https://doi.org/10.1002/pi.2756 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Dobić, Sava N.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3961
AB  - pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings. (C) 2009 Elsevier Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application
VL  - 79
IS  - 5
SP  - 643
EP  - 649
DO  - 10.1016/j.radphyschem.2009.11.015
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Dobić, Sava N. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2010",
abstract = "pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings. (C) 2009 Elsevier Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application",
volume = "79",
number = "5",
pages = "643-649",
doi = "10.1016/j.radphyschem.2009.11.015"
}

Tomić, S. Lj., Mićić, M. M., Dobić, S. N., Filipović, J. M.,& Suljovrujić, E. H.. (2010). Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. in Radiation Physics and Chemistry, 79(5), 643-649.
https://doi.org/10.1016/j.radphyschem.2009.11.015

Tomić SL, Mićić MM, Dobić SN, Filipović JM, Suljovrujić EH. Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. in Radiation Physics and Chemistry. 2010;79(5):643-649.
doi:10.1016/j.radphyschem.2009.11.015 .

Tomić, Simonida Lj., Mićić, Maja M., Dobić, Sava N., Filipović, Jovanka M., Suljovrujić, Edin H., "Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application" in Radiation Physics and Chemistry, 79, no. 5 (2010):643-649,
https://doi.org/10.1016/j.radphyschem.2009.11.015 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4026
AB  - In this work, novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and different poly(alkylene glycol)(meth)acrylates (BIS) were prepared by radiation-induced copolymerization. The influence of different BIS types with variation in chain length, based on ethylene glycol (EG) and/or propylene glycol (PG) pendant units, on the nature and inherent properties of P(HEMA/BIS) copolymeric hydrogels was the main idea of this paper. Swelling studies were conducted for all types of P(HEMA/BIS) copolymeric hydrogels in a wide pH and temperature range. Additional characterization of structure, morphology and thermal behaviour of the obtained hydrogels was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The modelling of drug release and diffusion characteristics was tested using cephalexin (CEX). The results indicate that P(HEMA/BIS) hydrogels properties are significantly dependent on the type of BIS. The hydrogels with ethylene glycol (EG) pendant chains show a noticeable pH and/or temperature sensitivity and can be considered smart hydrogels. The introduction of propylene glycol (PG) units, pure and mixed with ethylene glycol (EG) pendant chains, can additionally tune the characteristics of such gels. Furthermore, drug release studies indicate that these types of P(HEMA/BIS) copolymeric hydrogels are suitable candidates for controlled drug release systems. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Chemical Engineering Journal
T1  - Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels
VL  - 160
IS  - 2
SP  - 801
EP  - 809
DO  - 10.1016/j.cej.2010.03.089
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2010",
abstract = "In this work, novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and different poly(alkylene glycol)(meth)acrylates (BIS) were prepared by radiation-induced copolymerization. The influence of different BIS types with variation in chain length, based on ethylene glycol (EG) and/or propylene glycol (PG) pendant units, on the nature and inherent properties of P(HEMA/BIS) copolymeric hydrogels was the main idea of this paper. Swelling studies were conducted for all types of P(HEMA/BIS) copolymeric hydrogels in a wide pH and temperature range. Additional characterization of structure, morphology and thermal behaviour of the obtained hydrogels was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The modelling of drug release and diffusion characteristics was tested using cephalexin (CEX). The results indicate that P(HEMA/BIS) hydrogels properties are significantly dependent on the type of BIS. The hydrogels with ethylene glycol (EG) pendant chains show a noticeable pH and/or temperature sensitivity and can be considered smart hydrogels. The introduction of propylene glycol (PG) units, pure and mixed with ethylene glycol (EG) pendant chains, can additionally tune the characteristics of such gels. Furthermore, drug release studies indicate that these types of P(HEMA/BIS) copolymeric hydrogels are suitable candidates for controlled drug release systems. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Chemical Engineering Journal",
title = "Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels",
volume = "160",
number = "2",
pages = "801-809",
doi = "10.1016/j.cej.2010.03.089"
}

Tomić, S. Lj., Mićić, M. M., Filipović, J. M.,& Suljovrujić, E. H.. (2010). Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels. in Chemical Engineering Journal, 160(2), 801-809.
https://doi.org/10.1016/j.cej.2010.03.089

Tomić SL, Mićić MM, Filipović JM, Suljovrujić EH. Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels. in Chemical Engineering Journal. 2010;160(2):801-809.
doi:10.1016/j.cej.2010.03.089 .

Tomić, Simonida Lj., Mićić, Maja M., Filipović, Jovanka M., Suljovrujić, Edin H., "Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels" in Chemical Engineering Journal, 160, no. 2 (2010):801-809,
https://doi.org/10.1016/j.cej.2010.03.089 . .

TY  - JOUR
AU  - Jovasevic, Jovana S.
AU  - Mićić, Maja M.
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
AU  - Dimitrijević, Suzana I.
AU  - Tomić, Simonida Lj.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4052
AB  - New hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid, poly(vinylpyrrolidone) and silver salt. FTIR spectroscopy has confirmed binding of silver particles in hydrogels. Swelling studies performed in in vitro conditions showed dependence on PVP content and temperature. It can be seen that the antimicrobial activity of the Ag/P(HEMA/IA)PVP hybrid hydrogels depends on the PVP moiety and with the increase of PVP content the microbial contamination is more efficiently reduced. The best sensitivity was obtained for the polymers tested for antimicrobial activity against the yeast C. albicans, one of the most commonly encountered human pathogens, causing a wide variety of infections ranging from mucosal infections in generally healthy persons to life-threatening systemic infections in individuals with impaired immunity. A slightly less susceptible to antimicrobial effect of hydrogels was obtained for the Gram-positive bacteria S. aureus, where the reduction of cells was about 70% after two hours of exposure, for the sample with the highest PVP content. The least susceptible to the antimicrobial activity of hydrogels examined was the Gram-negative bacteria E. coli, where the percent of cell reduction was below 20%. Bearing in mind the influence of the time of exposure of microbes to the Ag//P(HEMA/IA)/PVP hybrid hydrogels, it was observed that the reduction of the number of cells depends on time, microbial culture and type of hybrid hydrogel sample. Due to their swelling and antimicrobial properties, silver/poly(2-hydroxyethyl methacrylate/itaconic acid)/poly(vinylpyrrolidone) hybrid hydrogles show potential to use in the field of biomedicine, especially for treatment of skin and burns in dermocosmetics.
T2  - Hemijska industrija
T1  - Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver
VL  - 64
IS  - 3
SP  - 209
EP  - 214
DO  - 10.2298/HEMIND091221030J
ER  - 

@article{
author = "Jovasevic, Jovana S. and Mićić, Maja M. and Suljovrujić, Edin H. and Filipović, Jovanka M. and Dimitrijević, Suzana I. and Tomić, Simonida Lj.",
year = "2010",
abstract = "New hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid, poly(vinylpyrrolidone) and silver salt. FTIR spectroscopy has confirmed binding of silver particles in hydrogels. Swelling studies performed in in vitro conditions showed dependence on PVP content and temperature. It can be seen that the antimicrobial activity of the Ag/P(HEMA/IA)PVP hybrid hydrogels depends on the PVP moiety and with the increase of PVP content the microbial contamination is more efficiently reduced. The best sensitivity was obtained for the polymers tested for antimicrobial activity against the yeast C. albicans, one of the most commonly encountered human pathogens, causing a wide variety of infections ranging from mucosal infections in generally healthy persons to life-threatening systemic infections in individuals with impaired immunity. A slightly less susceptible to antimicrobial effect of hydrogels was obtained for the Gram-positive bacteria S. aureus, where the reduction of cells was about 70% after two hours of exposure, for the sample with the highest PVP content. The least susceptible to the antimicrobial activity of hydrogels examined was the Gram-negative bacteria E. coli, where the percent of cell reduction was below 20%. Bearing in mind the influence of the time of exposure of microbes to the Ag//P(HEMA/IA)/PVP hybrid hydrogels, it was observed that the reduction of the number of cells depends on time, microbial culture and type of hybrid hydrogel sample. Due to their swelling and antimicrobial properties, silver/poly(2-hydroxyethyl methacrylate/itaconic acid)/poly(vinylpyrrolidone) hybrid hydrogles show potential to use in the field of biomedicine, especially for treatment of skin and burns in dermocosmetics.",
journal = "Hemijska industrija",
title = "Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver",
volume = "64",
number = "3",
pages = "209-214",
doi = "10.2298/HEMIND091221030J"
}

Jovasevic, J. S., Mićić, M. M., Suljovrujić, E. H., Filipović, J. M., Dimitrijević, S. I.,& Tomić, S. Lj.. (2010). Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver. in Hemijska industrija, 64(3), 209-214.
https://doi.org/10.2298/HEMIND091221030J

Jovasevic JS, Mićić MM, Suljovrujić EH, Filipović JM, Dimitrijević SI, Tomić SL. Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver. in Hemijska industrija. 2010;64(3):209-214.
doi:10.2298/HEMIND091221030J .

Jovasevic, Jovana S., Mićić, Maja M., Suljovrujić, Edin H., Filipović, Jovanka M., Dimitrijević, Suzana I., Tomić, Simonida Lj., "Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver" in Hemijska industrija, 64, no. 3 (2010):209-214,
https://doi.org/10.2298/HEMIND091221030J . .

TY  - JOUR
AU  - Milosavljevic, Nedeljko B.
AU  - Ristić, Mirjana
AU  - Perić-Grujić, Aleksandra A.
AU  - Filipović, Jovanka M.
AU  - Štrbac, Svetlana
AU  - Rakočević, Zlatko Lj.
AU  - Kalagasidis Krušić, Melina
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4173
AB  - A hydrogel has been synthesized by ionic crosslinking of chitosan (Ch) with itaconic acid (IA), followed by a free radical polymerization and crosslinking of Ch/IA network by adding methacrylic acid and the crosslinker. The resulting material (Ch/IA/MAA hydrogel) was characterized by spectral (Fourier transform infrared (FTIR)), thermal (thermogravimetric analysis (TGA)) and structural (SEM/EDX and atomic force microscopy (AFM)) analyses. The prepared hydrogel was investigated as potential adsorbent for removal of Cd2+ ions from aqueous solution. The effect of various physico-chemical parameters such as pH, adsorbent dosage, adsorbate concentration and contact time was studied in batch experiments. The results of spectral analyses of Cd-loaded hydrogel have shown that active functional groups are -NH2, -OH and -COOH. SEM/EDX analysis and AFM surface topography and phase images indicated that apart from the adsorption on the surface of the hydrogel, sorption takes place in the bulk, as well. The experimental kinetic and equilibrium data were better fitted by pseudo-second order kinetic model and Langmuir adsorption isotherm. The parameters obtained in thermodynamic studies showed that the adsorption of Cd2+ on Ch/IA/MAA hydrogel was spontaneous and exothermic in nature. Desorption studies were carried out using acid leaching (HNO3) and it has been shown that the regenerated hydrogel can be reused three times without any loss of adsorption capacity. The maximum adsorption of 285.7 mg/g has been obtained at pH 5.5 and the results of adsorption/desorption experiments implies that the Ch/IA/MAA hydrogel may be used as efficient sorbent for removal of Cd2+ ions from aqueous solution. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Chemical Engineering Journal
T1  - Hydrogel based on chitosan, itaconic acid and methacrylic acid as adsorbent of Cd2+ ions from aqueous solution
VL  - 165
IS  - 2
SP  - 554
EP  - 562
DO  - 10.1016/j.cej.2010.09.072
ER  - 

@article{
author = "Milosavljevic, Nedeljko B. and Ristić, Mirjana and Perić-Grujić, Aleksandra A. and Filipović, Jovanka M. and Štrbac, Svetlana and Rakočević, Zlatko Lj. and Kalagasidis Krušić, Melina",
year = "2010",
abstract = "A hydrogel has been synthesized by ionic crosslinking of chitosan (Ch) with itaconic acid (IA), followed by a free radical polymerization and crosslinking of Ch/IA network by adding methacrylic acid and the crosslinker. The resulting material (Ch/IA/MAA hydrogel) was characterized by spectral (Fourier transform infrared (FTIR)), thermal (thermogravimetric analysis (TGA)) and structural (SEM/EDX and atomic force microscopy (AFM)) analyses. The prepared hydrogel was investigated as potential adsorbent for removal of Cd2+ ions from aqueous solution. The effect of various physico-chemical parameters such as pH, adsorbent dosage, adsorbate concentration and contact time was studied in batch experiments. The results of spectral analyses of Cd-loaded hydrogel have shown that active functional groups are -NH2, -OH and -COOH. SEM/EDX analysis and AFM surface topography and phase images indicated that apart from the adsorption on the surface of the hydrogel, sorption takes place in the bulk, as well. The experimental kinetic and equilibrium data were better fitted by pseudo-second order kinetic model and Langmuir adsorption isotherm. The parameters obtained in thermodynamic studies showed that the adsorption of Cd2+ on Ch/IA/MAA hydrogel was spontaneous and exothermic in nature. Desorption studies were carried out using acid leaching (HNO3) and it has been shown that the regenerated hydrogel can be reused three times without any loss of adsorption capacity. The maximum adsorption of 285.7 mg/g has been obtained at pH 5.5 and the results of adsorption/desorption experiments implies that the Ch/IA/MAA hydrogel may be used as efficient sorbent for removal of Cd2+ ions from aqueous solution. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Chemical Engineering Journal",
title = "Hydrogel based on chitosan, itaconic acid and methacrylic acid as adsorbent of Cd2+ ions from aqueous solution",
volume = "165",
number = "2",
pages = "554-562",
doi = "10.1016/j.cej.2010.09.072"
}

Milosavljevic, N. B., Ristić, M., Perić-Grujić, A. A., Filipović, J. M., Štrbac, S., Rakočević, Z. Lj.,& Kalagasidis Krušić, M.. (2010). Hydrogel based on chitosan, itaconic acid and methacrylic acid as adsorbent of Cd2+ ions from aqueous solution. in Chemical Engineering Journal, 165(2), 554-562.
https://doi.org/10.1016/j.cej.2010.09.072

Milosavljevic NB, Ristić M, Perić-Grujić AA, Filipović JM, Štrbac S, Rakočević ZL, Kalagasidis Krušić M. Hydrogel based on chitosan, itaconic acid and methacrylic acid as adsorbent of Cd2+ ions from aqueous solution. in Chemical Engineering Journal. 2010;165(2):554-562.
doi:10.1016/j.cej.2010.09.072 .

Milosavljevic, Nedeljko B., Ristić, Mirjana, Perić-Grujić, Aleksandra A., Filipović, Jovanka M., Štrbac, Svetlana, Rakočević, Zlatko Lj., Kalagasidis Krušić, Melina, "Hydrogel based on chitosan, itaconic acid and methacrylic acid as adsorbent of Cd2+ ions from aqueous solution" in Chemical Engineering Journal, 165, no. 2 (2010):554-562,
https://doi.org/10.1016/j.cej.2010.09.072 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Krezović, Bojana D.
AU  - Dobić, Sava N.
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3967
AB  - pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.
T2  - Hemijska industrija
T1  - Smart Hydrogels Based on Itaconic Acid for Biomedical Application
VL  - 63
IS  - 6
SP  - 603
EP  - 610
DO  - 10.2298/HEMIND0906603T
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Krezović, Bojana D. and Dobić, Sava N. and Suljovrujić, Edin H. and Filipović, Jovanka M.",
year = "2009",
abstract = "pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.",
journal = "Hemijska industrija",
title = "Smart Hydrogels Based on Itaconic Acid for Biomedical Application",
volume = "63",
number = "6",
pages = "603-610",
doi = "10.2298/HEMIND0906603T"
}

Tomić, S. Lj., Mićić, M. M., Krezović, B. D., Dobić, S. N., Suljovrujić, E. H.,& Filipović, J. M.. (2009). Smart Hydrogels Based on Itaconic Acid for Biomedical Application. in Hemijska industrija, 63(6), 603-610.
https://doi.org/10.2298/HEMIND0906603T

Tomić SL, Mićić MM, Krezović BD, Dobić SN, Suljovrujić EH, Filipović JM. Smart Hydrogels Based on Itaconic Acid for Biomedical Application. in Hemijska industrija. 2009;63(6):603-610.
doi:10.2298/HEMIND0906603T .

Tomić, Simonida Lj., Mićić, Maja M., Krezović, Bojana D., Dobić, Sava N., Suljovrujić, Edin H., Filipović, Jovanka M., "Smart Hydrogels Based on Itaconic Acid for Biomedical Application" in Hemijska industrija, 63, no. 6 (2009):603-610,
https://doi.org/10.2298/HEMIND0906603T . .

TY  - JOUR
AU  - Mićić, Maja M.
AU  - Tomić, Simonida Lj.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6851
AB  - Silver(I) itaconic acid-based hydrogel complexes were synthesized and characterized in order to examine the potential use of these systems; FTIR, AFM, in vitro fluid-uptake, metal sorption and antibacterial activity assay measurements were used for the characterization. Metal (silver(I)) ion uptaken by IA-based hydrogels was determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified and the stability in in vitro condition was determined. Incorporation of silver(l) ions into hydrogels and the influence of these ions on the diffusion properties of hydrogels were analyzed and discussed, too; it was found that the itaconic acid moiety in hydrogels is the determining factor which influences metal ion binding and therefore fluid uptake inside the polymeric network. Furthermore, Silver(I) itaconic acid-based hydrogel showed a satisfactory antibacterial activity. The most advanced feature of these materials is that the silver ions embedded throughout the networks leaches out via controlled manner with time in aqueous media. Therefore, the ions escape from the swollen networks with time and interact with the bacteria. Because of a good dispersion of silver ions in Ag(I)-P(HEMA/2IA) hydrogel complex, we have evaluated the antibacterial activity for this sample. As expected, the number of colonies grown surrounding the Ag(I)-P(HEMA/2IA) hydrogel complex was found to be almost nil, whereas the pare P(HEMA/2IA) hydrogel did not show any effect on Escherichia coli. Therefore, we conclude that the Ag(I)-P(HEMA/IA) hydrogel complexes are excellent antibacterial materials. Due to these facts, the silver ion IA-based hydrogel complexes reported here might be used as smart materials in the range of biomedical applications, including drug-delivery devices, biosensors, wound healing dressings, tissue reconstruction and organ repair.
T2  - Hemijska industrija
T1  - Silver(I)-Complexes with An Itaconic Acid-Based Hydrogel
VL  - 63
IS  - 3
SP  - 137
EP  - 142
DO  - 10.2298/HEMIND0903137M
ER  - 

@article{
author = "Mićić, Maja M. and Tomić, Simonida Lj. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2009",
abstract = "Silver(I) itaconic acid-based hydrogel complexes were synthesized and characterized in order to examine the potential use of these systems; FTIR, AFM, in vitro fluid-uptake, metal sorption and antibacterial activity assay measurements were used for the characterization. Metal (silver(I)) ion uptaken by IA-based hydrogels was determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified and the stability in in vitro condition was determined. Incorporation of silver(l) ions into hydrogels and the influence of these ions on the diffusion properties of hydrogels were analyzed and discussed, too; it was found that the itaconic acid moiety in hydrogels is the determining factor which influences metal ion binding and therefore fluid uptake inside the polymeric network. Furthermore, Silver(I) itaconic acid-based hydrogel showed a satisfactory antibacterial activity. The most advanced feature of these materials is that the silver ions embedded throughout the networks leaches out via controlled manner with time in aqueous media. Therefore, the ions escape from the swollen networks with time and interact with the bacteria. Because of a good dispersion of silver ions in Ag(I)-P(HEMA/2IA) hydrogel complex, we have evaluated the antibacterial activity for this sample. As expected, the number of colonies grown surrounding the Ag(I)-P(HEMA/2IA) hydrogel complex was found to be almost nil, whereas the pare P(HEMA/2IA) hydrogel did not show any effect on Escherichia coli. Therefore, we conclude that the Ag(I)-P(HEMA/IA) hydrogel complexes are excellent antibacterial materials. Due to these facts, the silver ion IA-based hydrogel complexes reported here might be used as smart materials in the range of biomedical applications, including drug-delivery devices, biosensors, wound healing dressings, tissue reconstruction and organ repair.",
journal = "Hemijska industrija",
title = "Silver(I)-Complexes with An Itaconic Acid-Based Hydrogel",
volume = "63",
number = "3",
pages = "137-142",
doi = "10.2298/HEMIND0903137M"
}

Mićić, M. M., Tomić, S. Lj., Filipović, J. M.,& Suljovrujić, E. H.. (2009). Silver(I)-Complexes with An Itaconic Acid-Based Hydrogel. in Hemijska industrija, 63(3), 137-142.
https://doi.org/10.2298/HEMIND0903137M

Mićić MM, Tomić SL, Filipović JM, Suljovrujić EH. Silver(I)-Complexes with An Itaconic Acid-Based Hydrogel. in Hemijska industrija. 2009;63(3):137-142.
doi:10.2298/HEMIND0903137M .

Mićić, Maja M., Tomić, Simonida Lj., Filipović, Jovanka M., Suljovrujić, Edin H., "Silver(I)-Complexes with An Itaconic Acid-Based Hydrogel" in Hemijska industrija, 63, no. 3 (2009):137-142,
https://doi.org/10.2298/HEMIND0903137M . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6667
AB  - The copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were synthesized by gamma radiation induced radical polymerization. Swelling and thermodynamic properties of PHEMA and copolymeric P(HEMA/IA) hydrogels with different IA contents (2, 3.5 and 5 mol%) were studied in a wide pH and temperature range. Initial studies of so-prepared hydrogels show interesting pH and temperature sensitivity in swelling and drug release behavior. Special attention was devoted to temperature investigations around physiological temperature (37 degrees C), where small changes in temperature significantly influence swelling and drug release of these hydrogels. Due to maximum swelling of hydrogels around 40 degrees C, the P(HEMA/IA) hydrogel containing 5mol% of IA without and with drug-antibiotic (gentamicin) were investigated at pH 7.40 and in the temperature range 25-42 degrees C, in order to evaluate their potential for medical applications. (c) 2007 Elsevier Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation
VL  - 76
IS  - 8-9
SP  - 1390
EP  - 1394
DO  - 10.1016/j.radphyschem.2007.02.038
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "The copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were synthesized by gamma radiation induced radical polymerization. Swelling and thermodynamic properties of PHEMA and copolymeric P(HEMA/IA) hydrogels with different IA contents (2, 3.5 and 5 mol%) were studied in a wide pH and temperature range. Initial studies of so-prepared hydrogels show interesting pH and temperature sensitivity in swelling and drug release behavior. Special attention was devoted to temperature investigations around physiological temperature (37 degrees C), where small changes in temperature significantly influence swelling and drug release of these hydrogels. Due to maximum swelling of hydrogels around 40 degrees C, the P(HEMA/IA) hydrogel containing 5mol% of IA without and with drug-antibiotic (gentamicin) were investigated at pH 7.40 and in the temperature range 25-42 degrees C, in order to evaluate their potential for medical applications. (c) 2007 Elsevier Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation",
volume = "76",
number = "8-9",
pages = "1390-1394",
doi = "10.1016/j.radphyschem.2007.02.038"
}

Tomić, S. Lj., Mićić, M. M., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation. in Radiation Physics and Chemistry, 76(8-9), 1390-1394.
https://doi.org/10.1016/j.radphyschem.2007.02.038

Tomić SL, Mićić MM, Filipović JM, Suljovrujić EH. Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation. in Radiation Physics and Chemistry. 2007;76(8-9):1390-1394.
doi:10.1016/j.radphyschem.2007.02.038 .

Tomić, Simonida Lj., Mićić, Maja M., Filipović, Jovanka M., Suljovrujić, Edin H., "Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation" in Radiation Physics and Chemistry, 76, no. 8-9 (2007):1390-1394,
https://doi.org/10.1016/j.radphyschem.2007.02.038 . .

TY  - JOUR
AU  - Mićić, Maja M.
AU  - Tomić, Simonida Lj.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6742
AB  - New types of hydrogels were prepared by the radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid and four different poly(alkylene glycol) (meth)acrylate components (Bisomers) in a water/ethanol mixture as solvent. The polymers swell in water at 25 degrees C to yield homogeneous transparent hydrogels. All the hydrogels displayed pH sensitive behavior in buffers of the pH range from 2.20 to 7.40, under conditions similar to those of biological fluids. The presence of these two comonomers, which were added to HEMA, increased the swelling degree of the hydrogels and gave gels with better elasticity. The hydrogels were thermally stable in the vicinity of the physiological temperature (37 degrees C). The copolymer containing pure poly(ethylene glycol) acrylate units generally had the best properties. The tests performed on the hydrogels confirmed that they were neither hernolytic nor cytotoxic. The copolymer samples showed better cell viability and less hemolytic activity than the PHEMA sample, confirming the assumption that poly(alkylene glycols) improve the biocompatibility of hydrogels. Due to their swelling and mechanical characteristics, as well as the very good biocompatibility and bioadhesive properties, poly(Bisomer/HEMA/IA) hydrogels are promising for utilization in the field of biomedicals, especially for the controlled release of drugs.
T2  - Hemijska industrija
T1  - Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid
VL  - 61
IS  - 2
SP  - 83
EP  - 89
DO  - 10.2298/HEMIND0702083M
ER  - 

@article{
author = "Mićić, Maja M. and Tomić, Simonida Lj. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "New types of hydrogels were prepared by the radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid and four different poly(alkylene glycol) (meth)acrylate components (Bisomers) in a water/ethanol mixture as solvent. The polymers swell in water at 25 degrees C to yield homogeneous transparent hydrogels. All the hydrogels displayed pH sensitive behavior in buffers of the pH range from 2.20 to 7.40, under conditions similar to those of biological fluids. The presence of these two comonomers, which were added to HEMA, increased the swelling degree of the hydrogels and gave gels with better elasticity. The hydrogels were thermally stable in the vicinity of the physiological temperature (37 degrees C). The copolymer containing pure poly(ethylene glycol) acrylate units generally had the best properties. The tests performed on the hydrogels confirmed that they were neither hernolytic nor cytotoxic. The copolymer samples showed better cell viability and less hemolytic activity than the PHEMA sample, confirming the assumption that poly(alkylene glycols) improve the biocompatibility of hydrogels. Due to their swelling and mechanical characteristics, as well as the very good biocompatibility and bioadhesive properties, poly(Bisomer/HEMA/IA) hydrogels are promising for utilization in the field of biomedicals, especially for the controlled release of drugs.",
journal = "Hemijska industrija",
title = "Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid",
volume = "61",
number = "2",
pages = "83-89",
doi = "10.2298/HEMIND0702083M"
}

Mićić, M. M., Tomić, S. Lj., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid. in Hemijska industrija, 61(2), 83-89.
https://doi.org/10.2298/HEMIND0702083M

Mićić MM, Tomić SL, Filipović JM, Suljovrujić EH. Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid. in Hemijska industrija. 2007;61(2):83-89.
doi:10.2298/HEMIND0702083M .

Mićić, Maja M., Tomić, Simonida Lj., Filipović, Jovanka M., Suljovrujić, Edin H., "Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid" in Hemijska industrija, 61, no. 2 (2007):83-89,
https://doi.org/10.2298/HEMIND0702083M . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3073
AB  - Novel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms of swelling in conditions similar to the biological fluids (pH range 2.20-7.40 buffer solutions), compression-strain measurements, thermal properties and morphology. The influence of the type of Bisomer and of the itaconic acid on swelling and mechanical properties, as well as on morphology and thermal behavior of the resulting hydrogels, were investigated. The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity. All hydrogels showed satisfactory bioadhesive properties, so these materials have potential as drug carriers or biological glue and sealants.
T2  - Polymer Bulletin
T1  - Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid
VL  - 57
IS  - 5
SP  - 691
EP  - 702
DO  - 10.1007/s00289-006-0606-3
ER  - 

@article{
author = "Tomić, Simonida Lj. and Suljovrujić, Edin H. and Filipović, Jovanka M.",
year = "2006",
abstract = "Novel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms of swelling in conditions similar to the biological fluids (pH range 2.20-7.40 buffer solutions), compression-strain measurements, thermal properties and morphology. The influence of the type of Bisomer and of the itaconic acid on swelling and mechanical properties, as well as on morphology and thermal behavior of the resulting hydrogels, were investigated. The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity. All hydrogels showed satisfactory bioadhesive properties, so these materials have potential as drug carriers or biological glue and sealants.",
journal = "Polymer Bulletin",
title = "Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid",
volume = "57",
number = "5",
pages = "691-702",
doi = "10.1007/s00289-006-0606-3"
}

Tomić, S. Lj., Suljovrujić, E. H.,& Filipović, J. M.. (2006). Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid. in Polymer Bulletin, 57(5), 691-702.
https://doi.org/10.1007/s00289-006-0606-3

Tomić SL, Suljovrujić EH, Filipović JM. Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid. in Polymer Bulletin. 2006;57(5):691-702.
doi:10.1007/s00289-006-0606-3 .

Tomić, Simonida Lj., Suljovrujić, Edin H., Filipović, Jovanka M., "Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid" in Polymer Bulletin, 57, no. 5 (2006):691-702,
https://doi.org/10.1007/s00289-006-0606-3 . .