TY  - JOUR
AU  - Đorđević, Aleksandar N.
AU  - Srđenović, Branislava U.
AU  - Seke, Mariana
AU  - Petrović, Danijela
AU  - Injac, Rade
AU  - Mrđanović, Jasminka Ž.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/699
AB  - This review describes the chemical synthesis of polar polyhydroxylated fullerene C-60 derivatives, fullerenols C-60(OH)(n), 2 LT = n LT = 44, C-60 HzOx(OH)(y), and polyanion fullerenols C-60(OH)(15)(ONa)(9), ranging from the very first synthetic methods up to some contemporary approaches to synthesis and separation. It also provides some basic information about physical characteristics of fullerenols. With the increasing number of hydroxyl groups, water solubility of fullerenols increases as well. Fullerenols both in water and biological media build nanoparticles of different dimensions and stability. In different chemical and biological model systems a large number of various polyhydroxylated fullerene derivatives were tested and they showed both their antioxidative and prooxidative characteristics. Several mechanisms have been proposed for the antioxidant activity of fullerenol. In addition, this paper also provides insight into patents referring to the antioxidant properties of fullerenol.
T2  - Journal of Nanomaterials
T1  - Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles
DO  - 10.1155/2015/567073
ER  - 

@article{
author = "Đorđević, Aleksandar N. and Srđenović, Branislava U. and Seke, Mariana and Petrović, Danijela and Injac, Rade and Mrđanović, Jasminka Ž.",
year = "2015",
abstract = "This review describes the chemical synthesis of polar polyhydroxylated fullerene C-60 derivatives, fullerenols C-60(OH)(n), 2 LT = n LT = 44, C-60 HzOx(OH)(y), and polyanion fullerenols C-60(OH)(15)(ONa)(9), ranging from the very first synthetic methods up to some contemporary approaches to synthesis and separation. It also provides some basic information about physical characteristics of fullerenols. With the increasing number of hydroxyl groups, water solubility of fullerenols increases as well. Fullerenols both in water and biological media build nanoparticles of different dimensions and stability. In different chemical and biological model systems a large number of various polyhydroxylated fullerene derivatives were tested and they showed both their antioxidative and prooxidative characteristics. Several mechanisms have been proposed for the antioxidant activity of fullerenol. In addition, this paper also provides insight into patents referring to the antioxidant properties of fullerenol.",
journal = "Journal of Nanomaterials",
title = "Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles",
doi = "10.1155/2015/567073"
}

Đorđević, A. N., Srđenović, B. U., Seke, M., Petrović, D., Injac, R.,& Mrđanović, J. Ž.. (2015). Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles. in Journal of Nanomaterials.
https://doi.org/10.1155/2015/567073

Đorđević AN, Srđenović BU, Seke M, Petrović D, Injac R, Mrđanović JŽ. Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles. in Journal of Nanomaterials. 2015;.
doi:10.1155/2015/567073 .

Đorđević, Aleksandar N., Srđenović, Branislava U., Seke, Mariana, Petrović, Danijela, Injac, Rade, Mrđanović, Jasminka Ž., "Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles" in Journal of Nanomaterials (2015),
https://doi.org/10.1155/2015/567073 . .

TY  - CHAP
AU  - Đorđević, Aleksandar N.
AU  - Injac, Rade
AU  - Jović, Danica
AU  - Mrđanović, Jasminka Ž.
AU  - Seke, Mariana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12696
AB  - The unique size-dependent properties of carbon nanomaterials (CNMs)- graphene, nanotubes (CNTs) and fullerenes- make them very attractive for diagnostic and therapeutic application. This chapter presents possible application of CNMs. Graphene with extraordinary chemical and physical properties has already revealed a great number of potential applications such as environmental toxic material removal, drug delivery, tissue engineering, and fl uorescence-based biomolecular sensing. The CNT derivatives have many interesting properties which make them potentially useful in a living system as biosensors, bioelectronic devices based on enzyme-nanotube or antibody-nanotube conjugates, chemotherapeutic agents, hyperthermia therapy and immunotherapy agents, agent in treatment of central nervous system disorders, and tissue engineering agent. Fullerene C60 derivatives have been used as: drug and gene delivery vectors, magnetic resonance imaging agents, radio protectors, antioxidants, HIV-1 protease inhibitors, antigenotoxic agents, and phototherapy agents. Fullerenols are polyhydroxylated derivatives of fullerene (C60(OH)n) with remarkable antioxidant, xenobiotic-protective, radioprotective, nanodrug and endohedral gadolinium carrier properties.
T2  - Advanced Carbon Materials and Technology
T1  - Bioimpact of Carbon Nanomaterials
SP  - 193
EP  - 271
DO  - 10.1002/9781118895399.ch6
ER  - 

@inbook{
author = "Đorđević, Aleksandar N. and Injac, Rade and Jović, Danica and Mrđanović, Jasminka Ž. and Seke, Mariana",
year = "2014",
abstract = "The unique size-dependent properties of carbon nanomaterials (CNMs)- graphene, nanotubes (CNTs) and fullerenes- make them very attractive for diagnostic and therapeutic application. This chapter presents possible application of CNMs. Graphene with extraordinary chemical and physical properties has already revealed a great number of potential applications such as environmental toxic material removal, drug delivery, tissue engineering, and fl uorescence-based biomolecular sensing. The CNT derivatives have many interesting properties which make them potentially useful in a living system as biosensors, bioelectronic devices based on enzyme-nanotube or antibody-nanotube conjugates, chemotherapeutic agents, hyperthermia therapy and immunotherapy agents, agent in treatment of central nervous system disorders, and tissue engineering agent. Fullerene C60 derivatives have been used as: drug and gene delivery vectors, magnetic resonance imaging agents, radio protectors, antioxidants, HIV-1 protease inhibitors, antigenotoxic agents, and phototherapy agents. Fullerenols are polyhydroxylated derivatives of fullerene (C60(OH)n) with remarkable antioxidant, xenobiotic-protective, radioprotective, nanodrug and endohedral gadolinium carrier properties.",
journal = "Advanced Carbon Materials and Technology",
booktitle = "Bioimpact of Carbon Nanomaterials",
pages = "193-271",
doi = "10.1002/9781118895399.ch6"
}

Đorđević, A. N., Injac, R., Jović, D., Mrđanović, J. Ž.,& Seke, M.. (2014). Bioimpact of Carbon Nanomaterials. in Advanced Carbon Materials and Technology, 193-271.
https://doi.org/10.1002/9781118895399.ch6

Đorđević AN, Injac R, Jović D, Mrđanović JŽ, Seke M. Bioimpact of Carbon Nanomaterials. in Advanced Carbon Materials and Technology. 2014;:193-271.
doi:10.1002/9781118895399.ch6 .

Đorđević, Aleksandar N., Injac, Rade, Jović, Danica, Mrđanović, Jasminka Ž., Seke, Mariana, "Bioimpact of Carbon Nanomaterials" in Advanced Carbon Materials and Technology (2014):193-271,
https://doi.org/10.1002/9781118895399.ch6 . .

TY  - JOUR
AU  - Labudović-Borović, Milica
AU  - Icevic, Ivana
AU  - Kanački, Zdenko
AU  - Zikic, Dragan
AU  - Seke, Mariana
AU  - Injac, Rade
AU  - Đorđević, Aleksandar N.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5924
AB  - Cardioprotective effects of fullerenol C-60(OH)(24) nanoparticles (FNP) were investigated in pigs after a single treatment with doxorubicin (DOX). Semithin and ultrathin sections of myocardial tissue routinely prepared for transmission electron microscopy were analyzed. Extensive intracellular damage was confirmed in cardiomyocytes of DOX-treated animals. By means of ultrastructural analysis, a certain degree of parenchymal degeneration was confirmed even in animals treated with FNP alone, including both the oral and the intraperitoneal application of the substance. The cardioprotective effects of FNP in animals previously treated with DOX were recognized to a certain extent, but were not fully confirmed at the ultrastructural level. Nevertheless, the myocardial morphology of DOX-treated animals improved after the admission of FNP. Irregular orientation of myofibrils, myofibrillar disruption, intracellular edema, and vacuolization were reduced, but not completely eliminated. Reduction of these cellular alterations was achieved if FNP was applied orally 6 h prior to DOX treatment in a dose of 18 mg/kg. However, numerous defects, including the inner mitochondrial membrane and the plasma membrane disruption of certain cells persisted. In FNP/DOX-treated animals, the presence of multinuclear cells with mitosis-like figures resembling metaphase or anaphase were observed, indicating that DOX and FNP could have a complex influence on the cell cycle of cardiomyocytes. Based on this experiment, further careful increase in dosage may be advised to enhance FNP-induced cardioprotection. These investigations should, however, always be combined with ultrastructural analysis. The FNP/DOX interaction is an excellent model for the investigation of cardiomyocyte cell death and cell cycle mechanisms.
T2  - Ultrastructural Pathology
T1  - Effects of Fullerenol C-60(OH)(24) Nanoparticles on a Single-dose Doxorubicin-induced Cardiotoxicity in Pigs: An Ultrastructural Study
VL  - 38
IS  - 2
SP  - 150
EP  - 163
DO  - 10.3109/01913123.2013.822045
ER  - 

@article{
author = "Labudović-Borović, Milica and Icevic, Ivana and Kanački, Zdenko and Zikic, Dragan and Seke, Mariana and Injac, Rade and Đorđević, Aleksandar N.",
year = "2014",
abstract = "Cardioprotective effects of fullerenol C-60(OH)(24) nanoparticles (FNP) were investigated in pigs after a single treatment with doxorubicin (DOX). Semithin and ultrathin sections of myocardial tissue routinely prepared for transmission electron microscopy were analyzed. Extensive intracellular damage was confirmed in cardiomyocytes of DOX-treated animals. By means of ultrastructural analysis, a certain degree of parenchymal degeneration was confirmed even in animals treated with FNP alone, including both the oral and the intraperitoneal application of the substance. The cardioprotective effects of FNP in animals previously treated with DOX were recognized to a certain extent, but were not fully confirmed at the ultrastructural level. Nevertheless, the myocardial morphology of DOX-treated animals improved after the admission of FNP. Irregular orientation of myofibrils, myofibrillar disruption, intracellular edema, and vacuolization were reduced, but not completely eliminated. Reduction of these cellular alterations was achieved if FNP was applied orally 6 h prior to DOX treatment in a dose of 18 mg/kg. However, numerous defects, including the inner mitochondrial membrane and the plasma membrane disruption of certain cells persisted. In FNP/DOX-treated animals, the presence of multinuclear cells with mitosis-like figures resembling metaphase or anaphase were observed, indicating that DOX and FNP could have a complex influence on the cell cycle of cardiomyocytes. Based on this experiment, further careful increase in dosage may be advised to enhance FNP-induced cardioprotection. These investigations should, however, always be combined with ultrastructural analysis. The FNP/DOX interaction is an excellent model for the investigation of cardiomyocyte cell death and cell cycle mechanisms.",
journal = "Ultrastructural Pathology",
title = "Effects of Fullerenol C-60(OH)(24) Nanoparticles on a Single-dose Doxorubicin-induced Cardiotoxicity in Pigs: An Ultrastructural Study",
volume = "38",
number = "2",
pages = "150-163",
doi = "10.3109/01913123.2013.822045"
}

Labudović-Borović, M., Icevic, I., Kanački, Z., Zikic, D., Seke, M., Injac, R.,& Đorđević, A. N.. (2014). Effects of Fullerenol C-60(OH)(24) Nanoparticles on a Single-dose Doxorubicin-induced Cardiotoxicity in Pigs: An Ultrastructural Study. in Ultrastructural Pathology, 38(2), 150-163.
https://doi.org/10.3109/01913123.2013.822045

Labudović-Borović M, Icevic I, Kanački Z, Zikic D, Seke M, Injac R, Đorđević AN. Effects of Fullerenol C-60(OH)(24) Nanoparticles on a Single-dose Doxorubicin-induced Cardiotoxicity in Pigs: An Ultrastructural Study. in Ultrastructural Pathology. 2014;38(2):150-163.
doi:10.3109/01913123.2013.822045 .

Labudović-Borović, Milica, Icevic, Ivana, Kanački, Zdenko, Zikic, Dragan, Seke, Mariana, Injac, Rade, Đorđević, Aleksandar N., "Effects of Fullerenol C-60(OH)(24) Nanoparticles on a Single-dose Doxorubicin-induced Cardiotoxicity in Pigs: An Ultrastructural Study" in Ultrastructural Pathology, 38, no. 2 (2014):150-163,
https://doi.org/10.3109/01913123.2013.822045 . .