TY  - JOUR
AU  - Mijajlović, Marina Ž.
AU  - Nikolić, Miloš V.
AU  - Jevtić, Verica V.
AU  - Ratković, Zoran R.
AU  - Marković-Simović, Bojana
AU  - Volarevic, Vladislav
AU  - Arsenijević, Nebojša N.
AU  - Novaković, Slađana B.
AU  - Bogdanović, Goran A.
AU  - Trifunović, Srećko R.
AU  - Radić, Gordana P.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/497
AB  - The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)(2)] consists of neutral complex molecules, where the Pd(II) ion is placed in a cis-square-planar coordination environment formed by O and S atoms of two deprotonated S-butyl-thiosalicylic acid ligands. The cytotoxic effects of the S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding palladium(II) complexes are reported here. The analysis of cancer cell viability showed that all the tested complexes are cytotoxic to human colon carcinoma cells (HCT-116 and CaCo-2) and human lung carcinoma epithelial cells (A549). The antitumor activities of the above mentioned Pd(II) complexes are higher in comparison to the corresponding ligands. (C) 2015 Elsevier Ltd. All rights reserved.
T2  - Polyhedron
T1  - Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)]
VL  - 90
SP  - 34
EP  - 40
DO  - 10.1016/j.poly.2015.01.041
ER  - 

@article{
author = "Mijajlović, Marina Ž. and Nikolić, Miloš V. and Jevtić, Verica V. and Ratković, Zoran R. and Marković-Simović, Bojana and Volarevic, Vladislav and Arsenijević, Nebojša N. and Novaković, Slađana B. and Bogdanović, Goran A. and Trifunović, Srećko R. and Radić, Gordana P.",
year = "2015",
abstract = "The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)(2)] consists of neutral complex molecules, where the Pd(II) ion is placed in a cis-square-planar coordination environment formed by O and S atoms of two deprotonated S-butyl-thiosalicylic acid ligands. The cytotoxic effects of the S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding palladium(II) complexes are reported here. The analysis of cancer cell viability showed that all the tested complexes are cytotoxic to human colon carcinoma cells (HCT-116 and CaCo-2) and human lung carcinoma epithelial cells (A549). The antitumor activities of the above mentioned Pd(II) complexes are higher in comparison to the corresponding ligands. (C) 2015 Elsevier Ltd. All rights reserved.",
journal = "Polyhedron",
title = "Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)]",
volume = "90",
pages = "34-40",
doi = "10.1016/j.poly.2015.01.041"
}

Mijajlović, M. Ž., Nikolić, M. V., Jevtić, V. V., Ratković, Z. R., Marković-Simović, B., Volarevic, V., Arsenijević, N. N., Novaković, S. B., Bogdanović, G. A., Trifunović, S. R.,& Radić, G. P.. (2015). Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)]. in Polyhedron, 90, 34-40.
https://doi.org/10.1016/j.poly.2015.01.041

Mijajlović MŽ, Nikolić MV, Jevtić VV, Ratković ZR, Marković-Simović B, Volarevic V, Arsenijević NN, Novaković SB, Bogdanović GA, Trifunović SR, Radić GP. Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)]. in Polyhedron. 2015;90:34-40.
doi:10.1016/j.poly.2015.01.041 .

Mijajlović, Marina Ž., Nikolić, Miloš V., Jevtić, Verica V., Ratković, Zoran R., Marković-Simović, Bojana, Volarevic, Vladislav, Arsenijević, Nebojša N., Novaković, Slađana B., Bogdanović, Goran A., Trifunović, Srećko R., Radić, Gordana P., "Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)]" in Polyhedron, 90 (2015):34-40,
https://doi.org/10.1016/j.poly.2015.01.041 . .

TY  - JOUR
AU  - Volarevic, Vladislav
AU  - Paunović, Verica G.
AU  - Marković, Zoran M.
AU  - Marković-Simović, Bojana
AU  - Misirkić-Marjanović, Maja
AU  - Todorović-Marković, Biljana
AU  - Bojic, Sanja
AU  - Vucicevic, Ljubica
AU  - Jovanović, Svetlana P.
AU  - Arsenijević, Nebojša N.
AU  - Holclajtner-Antunović, Ivanka D.
AU  - Milosavljević, Momir
AU  - Dramićanin, Miroslav
AU  - Kravić-Stevović, Tamara K.
AU  - Ćirić, Darko
AU  - Lukić, Miodrag L.
AU  - Trajković, Vladimir S.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/324
AB  - We investigated the effect of large (40 nm) graphene quantum dots (GQDs) in concanavalin A (Con A; 12 mg/kg i.v.)-induced mouse hepatitis, a T cell-mediated liver injury resembling fulminant hepatitis in humans. Intravenously injected GQDs (50 mg/kg) accumulated in liver and reduced Con A-mediated liver damage, as demonstrated by histopathological analysis and a decrease in liver lipid peroxidation and serum levels of liver transaminases. The cleavage of apoptotic markers caspase-3/PARP and mRNA levels of proapoptotic mediators Puma, Noxa, Bax, Bak1, Bim, Apaf1, and p21, as well as LC3-I conversion to autophagosome-associated LC3-II and expression of autophagy-related (Atg) genes Atg4b, Atg7, Atg12, and beclin-1, were attenuated by GQDs, indicating a decrease in both apoptosis and autophagy in the liver tissue. This was associated with the reduced liver infiltration of immune cells, particularly the T cells producing proinflammatory cytokine IFN-?, and a decrease in IFN-gamma serum levels. In the spleen of GQD-exposed mice, mRNA expression of IFN-? and its transcription factor T-bet was reduced, while that of the IL-33 ligand ST2 was increased. The hepatoprotective effect of GQDs was less pronounced in ST2-deficient mice, indicating that it might depend on ST2 upregulation. In vitro, GQDs inhibited splenocyte IFN-gamma production, reduced the activation of extracellular signal-regulated kinase in macrophage and T cell lines, inhibited macrophage production of the free radical nitric oxide, and reduced its cytotoxicity toward hepatocyte cell line HepG2. Therefore, GQDs alleviate immune-mediated fulminant hepatitis by interfering with T cell and macrophage activation and possibly by exerting a direct hepatoprotective effect.
T2  - ACS Nano
T1  - Large Graphene Quantum Dots Alleviate Immune-Mediated Liver Damage
VL  - 8
IS  - 12
SP  - 12098
EP  - 12109
DO  - 10.1021/nn502466z
ER  - 

@article{
author = "Volarevic, Vladislav and Paunović, Verica G. and Marković, Zoran M. and Marković-Simović, Bojana and Misirkić-Marjanović, Maja and Todorović-Marković, Biljana and Bojic, Sanja and Vucicevic, Ljubica and Jovanović, Svetlana P. and Arsenijević, Nebojša N. and Holclajtner-Antunović, Ivanka D. and Milosavljević, Momir and Dramićanin, Miroslav and Kravić-Stevović, Tamara K. and Ćirić, Darko and Lukić, Miodrag L. and Trajković, Vladimir S.",
year = "2014",
abstract = "We investigated the effect of large (40 nm) graphene quantum dots (GQDs) in concanavalin A (Con A; 12 mg/kg i.v.)-induced mouse hepatitis, a T cell-mediated liver injury resembling fulminant hepatitis in humans. Intravenously injected GQDs (50 mg/kg) accumulated in liver and reduced Con A-mediated liver damage, as demonstrated by histopathological analysis and a decrease in liver lipid peroxidation and serum levels of liver transaminases. The cleavage of apoptotic markers caspase-3/PARP and mRNA levels of proapoptotic mediators Puma, Noxa, Bax, Bak1, Bim, Apaf1, and p21, as well as LC3-I conversion to autophagosome-associated LC3-II and expression of autophagy-related (Atg) genes Atg4b, Atg7, Atg12, and beclin-1, were attenuated by GQDs, indicating a decrease in both apoptosis and autophagy in the liver tissue. This was associated with the reduced liver infiltration of immune cells, particularly the T cells producing proinflammatory cytokine IFN-?, and a decrease in IFN-gamma serum levels. In the spleen of GQD-exposed mice, mRNA expression of IFN-? and its transcription factor T-bet was reduced, while that of the IL-33 ligand ST2 was increased. The hepatoprotective effect of GQDs was less pronounced in ST2-deficient mice, indicating that it might depend on ST2 upregulation. In vitro, GQDs inhibited splenocyte IFN-gamma production, reduced the activation of extracellular signal-regulated kinase in macrophage and T cell lines, inhibited macrophage production of the free radical nitric oxide, and reduced its cytotoxicity toward hepatocyte cell line HepG2. Therefore, GQDs alleviate immune-mediated fulminant hepatitis by interfering with T cell and macrophage activation and possibly by exerting a direct hepatoprotective effect.",
journal = "ACS Nano",
title = "Large Graphene Quantum Dots Alleviate Immune-Mediated Liver Damage",
volume = "8",
number = "12",
pages = "12098-12109",
doi = "10.1021/nn502466z"
}

Volarevic, V., Paunović, V. G., Marković, Z. M., Marković-Simović, B., Misirkić-Marjanović, M., Todorović-Marković, B., Bojic, S., Vucicevic, L., Jovanović, S. P., Arsenijević, N. N., Holclajtner-Antunović, I. D., Milosavljević, M., Dramićanin, M., Kravić-Stevović, T. K., Ćirić, D., Lukić, M. L.,& Trajković, V. S.. (2014). Large Graphene Quantum Dots Alleviate Immune-Mediated Liver Damage. in ACS Nano, 8(12), 12098-12109.
https://doi.org/10.1021/nn502466z

Volarevic V, Paunović VG, Marković ZM, Marković-Simović B, Misirkić-Marjanović M, Todorović-Marković B, Bojic S, Vucicevic L, Jovanović SP, Arsenijević NN, Holclajtner-Antunović ID, Milosavljević M, Dramićanin M, Kravić-Stevović TK, Ćirić D, Lukić ML, Trajković VS. Large Graphene Quantum Dots Alleviate Immune-Mediated Liver Damage. in ACS Nano. 2014;8(12):12098-12109.
doi:10.1021/nn502466z .

Volarevic, Vladislav, Paunović, Verica G., Marković, Zoran M., Marković-Simović, Bojana, Misirkić-Marjanović, Maja, Todorović-Marković, Biljana, Bojic, Sanja, Vucicevic, Ljubica, Jovanović, Svetlana P., Arsenijević, Nebojša N., Holclajtner-Antunović, Ivanka D., Milosavljević, Momir, Dramićanin, Miroslav, Kravić-Stevović, Tamara K., Ćirić, Darko, Lukić, Miodrag L., Trajković, Vladimir S., "Large Graphene Quantum Dots Alleviate Immune-Mediated Liver Damage" in ACS Nano, 8, no. 12 (2014):12098-12109,
https://doi.org/10.1021/nn502466z . .

TY  - JOUR
AU  - Dimitrijevic, Dejana P.
AU  - Glodovic, Verica V.
AU  - Radić, Gordana P.
AU  - Garcia-Granda, Santiago
AU  - Menendez-Taboada, Laura
AU  - Milovanović, Marija
AU  - Volarevic, Vladislav
AU  - Arsenijević, Nebojša N.
AU  - Bogdanović, Goran A.
AU  - Trifunović, Srećko R.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5556
AB  - The synthesis of ethylenediamine-N,N-di-S,S-(2,2-dibenzyl)acetic acid (H-2-S,S-eddba) and its ethyl-, propyl-, butyl-esters (R-2-S,S-eddba) are reported here. The esters were used for synthesis of the corresponding platinum(IV) complexes, [PtCl4(R-2-S,S-eddba)]. The compounds were characterized by elemental analysis, infrared, H-1 and C-13 NMR spectroscopy. The structure of propyl ester of H-2-S,S-eddba was confirmed by single-crystal X-ray analysis. All [PtCl4(R-2-S,S-eddba)] complexes displayed significantly higher in vitro cytotoxicity in comparison to cisplatin. (C) 2013 Published by Elsevier B.V.
T2  - Inorganica Chimica Acta
T1  - Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetic acid. Crystal structure of O,O -dipropyl-ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetate dihydrochloride
VL  - 402
SP  - 83
EP  - 89
DO  - 10.1016/j.ica.2013.03.039
ER  - 

@article{
author = "Dimitrijevic, Dejana P. and Glodovic, Verica V. and Radić, Gordana P. and Garcia-Granda, Santiago and Menendez-Taboada, Laura and Milovanović, Marija and Volarevic, Vladislav and Arsenijević, Nebojša N. and Bogdanović, Goran A. and Trifunović, Srećko R.",
year = "2013",
abstract = "The synthesis of ethylenediamine-N,N-di-S,S-(2,2-dibenzyl)acetic acid (H-2-S,S-eddba) and its ethyl-, propyl-, butyl-esters (R-2-S,S-eddba) are reported here. The esters were used for synthesis of the corresponding platinum(IV) complexes, [PtCl4(R-2-S,S-eddba)]. The compounds were characterized by elemental analysis, infrared, H-1 and C-13 NMR spectroscopy. The structure of propyl ester of H-2-S,S-eddba was confirmed by single-crystal X-ray analysis. All [PtCl4(R-2-S,S-eddba)] complexes displayed significantly higher in vitro cytotoxicity in comparison to cisplatin. (C) 2013 Published by Elsevier B.V.",
journal = "Inorganica Chimica Acta",
title = "Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetic acid. Crystal structure of O,O -dipropyl-ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetate dihydrochloride",
volume = "402",
pages = "83-89",
doi = "10.1016/j.ica.2013.03.039"
}

Dimitrijevic, D. P., Glodovic, V. V., Radić, G. P., Garcia-Granda, S., Menendez-Taboada, L., Milovanović, M., Volarevic, V., Arsenijević, N. N., Bogdanović, G. A.,& Trifunović, S. R.. (2013). Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetic acid. Crystal structure of O,O -dipropyl-ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetate dihydrochloride. in Inorganica Chimica Acta, 402, 83-89.
https://doi.org/10.1016/j.ica.2013.03.039

Dimitrijevic DP, Glodovic VV, Radić GP, Garcia-Granda S, Menendez-Taboada L, Milovanović M, Volarevic V, Arsenijević NN, Bogdanović GA, Trifunović SR. Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetic acid. Crystal structure of O,O -dipropyl-ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetate dihydrochloride. in Inorganica Chimica Acta. 2013;402:83-89.
doi:10.1016/j.ica.2013.03.039 .

Dimitrijevic, Dejana P., Glodovic, Verica V., Radić, Gordana P., Garcia-Granda, Santiago, Menendez-Taboada, Laura, Milovanović, Marija, Volarevic, Vladislav, Arsenijević, Nebojša N., Bogdanović, Goran A., Trifunović, Srećko R., "Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetic acid. Crystal structure of O,O -dipropyl-ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetate dihydrochloride" in Inorganica Chimica Acta, 402 (2013):83-89,
https://doi.org/10.1016/j.ica.2013.03.039 . .