TY  - JOUR
AU  - Jelić, Dijana
AU  - Đermanović, Mirjana
AU  - Marković, Anđela
AU  - Manić, Nebojša
AU  - Veličković, Suzana
AU  - Veljković, Filip M.
AU  - Janković, Bojan Ž.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10738
AB  - This work provides detailed mechanistic analysis of thermo-oxidative degradation behavior of vitamin D3—Ca (CaCO3 form) solid state supplement formulation. Analytical techniques such Attenuated Total Reflection Fourier-transform Infrared (ATR-FTIR) spectroscopy and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) were used for analysis of homogeneity of active pharmaceutical ingredients (APIs) throughout excipients contained within solid dosage forms. Information gained from MALDI-MS experiments was used to improve and better understand interactions present, later clearly disclosed through kinetic modeling. It was found that process mechanism proceeds via two single-step unbranched reactions and two steps of consecutive reactions. Key features include vitamin D3 meltings and degradation via hydrogen abstraction followed by addition of oxygen forming 1-hydroxy-vitamin D3 and further through its dehydration to 1-keto-vitamin D3. Identified product 1-hydroxy-vitamin D3 is substantial for enhancing the immune response of human body in fight against respiratory viruses. Another two degradation products, namely pyrocalciferol and isopyrocalciferol, produced by thermal isomerization at higher temperatures, were also identified. These vitamin epimers have crucial role in functioning of immune cells. Degradation process of mineral structure occurs through water molecules removal, forming anhydrous polymorph of CaCO3, where formation of solid (CaO) and gaseous (CO2) products participates in kinetically stabilized additive-functionalized amorphous CaCO3 crystallization. Confirmation of correctness of proposed degradation mechanism was verified by modulated dynamic (MD) predictions. Information obtained is valuable and suitable for safety evaluations of given supplement, but also could be applied for solid state forms, which are generally sensitive to oxidative conditions. © 2023, Akadémiai Kiadó, Budapest, Hungary.
T2  - Journal of Thermal Analysis and Calorimetry
T1  - Novel insight in thermo-oxidative kinetics of vitamin D-based supplement formulation using TG–DTG–DTA, ATR-FTIR and MALDI-MS techniques
VL  - 148
SP  - 4281
EP  - 4305
DO  - 10.1007/s10973-023-12017-3
ER  - 

@article{
author = "Jelić, Dijana and Đermanović, Mirjana and Marković, Anđela and Manić, Nebojša and Veličković, Suzana and Veljković, Filip M. and Janković, Bojan Ž.",
year = "2023",
abstract = "This work provides detailed mechanistic analysis of thermo-oxidative degradation behavior of vitamin D3—Ca (CaCO3 form) solid state supplement formulation. Analytical techniques such Attenuated Total Reflection Fourier-transform Infrared (ATR-FTIR) spectroscopy and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) were used for analysis of homogeneity of active pharmaceutical ingredients (APIs) throughout excipients contained within solid dosage forms. Information gained from MALDI-MS experiments was used to improve and better understand interactions present, later clearly disclosed through kinetic modeling. It was found that process mechanism proceeds via two single-step unbranched reactions and two steps of consecutive reactions. Key features include vitamin D3 meltings and degradation via hydrogen abstraction followed by addition of oxygen forming 1-hydroxy-vitamin D3 and further through its dehydration to 1-keto-vitamin D3. Identified product 1-hydroxy-vitamin D3 is substantial for enhancing the immune response of human body in fight against respiratory viruses. Another two degradation products, namely pyrocalciferol and isopyrocalciferol, produced by thermal isomerization at higher temperatures, were also identified. These vitamin epimers have crucial role in functioning of immune cells. Degradation process of mineral structure occurs through water molecules removal, forming anhydrous polymorph of CaCO3, where formation of solid (CaO) and gaseous (CO2) products participates in kinetically stabilized additive-functionalized amorphous CaCO3 crystallization. Confirmation of correctness of proposed degradation mechanism was verified by modulated dynamic (MD) predictions. Information obtained is valuable and suitable for safety evaluations of given supplement, but also could be applied for solid state forms, which are generally sensitive to oxidative conditions. © 2023, Akadémiai Kiadó, Budapest, Hungary.",
journal = "Journal of Thermal Analysis and Calorimetry",
title = "Novel insight in thermo-oxidative kinetics of vitamin D-based supplement formulation using TG–DTG–DTA, ATR-FTIR and MALDI-MS techniques",
volume = "148",
pages = "4281-4305",
doi = "10.1007/s10973-023-12017-3"
}

Jelić, D., Đermanović, M., Marković, A., Manić, N., Veličković, S., Veljković, F. M.,& Janković, B. Ž.. (2023). Novel insight in thermo-oxidative kinetics of vitamin D-based supplement formulation using TG–DTG–DTA, ATR-FTIR and MALDI-MS techniques. in Journal of Thermal Analysis and Calorimetry, 148, 4281-4305.
https://doi.org/10.1007/s10973-023-12017-3

Jelić D, Đermanović M, Marković A, Manić N, Veličković S, Veljković FM, Janković BŽ. Novel insight in thermo-oxidative kinetics of vitamin D-based supplement formulation using TG–DTG–DTA, ATR-FTIR and MALDI-MS techniques. in Journal of Thermal Analysis and Calorimetry. 2023;148:4281-4305.
doi:10.1007/s10973-023-12017-3 .

Jelić, Dijana, Đermanović, Mirjana, Marković, Anđela, Manić, Nebojša, Veličković, Suzana, Veljković, Filip M., Janković, Bojan Ž., "Novel insight in thermo-oxidative kinetics of vitamin D-based supplement formulation using TG–DTG–DTA, ATR-FTIR and MALDI-MS techniques" in Journal of Thermal Analysis and Calorimetry, 148 (2023):4281-4305,
https://doi.org/10.1007/s10973-023-12017-3 . .

TY  - JOUR
AU  - Đermanović, Mirjana
AU  - Baralić, Ivana
AU  - Pejić, Snežana
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8566
AB  - The mercury concentration was quantified in frozen and canned fish found in the market of the Republic of Srpska, Bosnia and Herzegovina. Using the method of amalgamation by atomic absorption spectrophotometry with a direct mercury analyzer (DMA-80), significant differences in mercury concentrations among the analyzed fish were found. Frozen pangasius and canned tuna had the highest mercury concentration (59.1 μg/kg and 54.1 μg/kg, respectively). Also, fish from Vietnam had the highest level of total mercury in comparison to fish from other countries. Determined levels of mercury in our samples were below the limit set by the European and Bosnian and Herzegovinian legislation (500 μg/kg wet weight). We have concluded that consumption of commercial fish in the market of the Republic of Srpska does not present any health risk for the average consumer. Nevertheless, a surveillance system of mercury content in fishery products, especially in certain species that concentrate mercury, is crucial for public health protection. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
T2  - Biological Trace Element Research
T1  - Total Mercury Levels in Commercial Fish in Market of the Republic of Srpska, Bosnia and Herzegovina
VL  - 194
IS  - 2
SP  - 545
EP  - 551
DO  - 10.1007/s12011-019-01805-4
ER  - 

@article{
author = "Đermanović, Mirjana and Baralić, Ivana and Pejić, Snežana",
year = "2020",
abstract = "The mercury concentration was quantified in frozen and canned fish found in the market of the Republic of Srpska, Bosnia and Herzegovina. Using the method of amalgamation by atomic absorption spectrophotometry with a direct mercury analyzer (DMA-80), significant differences in mercury concentrations among the analyzed fish were found. Frozen pangasius and canned tuna had the highest mercury concentration (59.1 μg/kg and 54.1 μg/kg, respectively). Also, fish from Vietnam had the highest level of total mercury in comparison to fish from other countries. Determined levels of mercury in our samples were below the limit set by the European and Bosnian and Herzegovinian legislation (500 μg/kg wet weight). We have concluded that consumption of commercial fish in the market of the Republic of Srpska does not present any health risk for the average consumer. Nevertheless, a surveillance system of mercury content in fishery products, especially in certain species that concentrate mercury, is crucial for public health protection. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.",
journal = "Biological Trace Element Research",
title = "Total Mercury Levels in Commercial Fish in Market of the Republic of Srpska, Bosnia and Herzegovina",
volume = "194",
number = "2",
pages = "545-551",
doi = "10.1007/s12011-019-01805-4"
}

Đermanović, M., Baralić, I.,& Pejić, S.. (2020). Total Mercury Levels in Commercial Fish in Market of the Republic of Srpska, Bosnia and Herzegovina. in Biological Trace Element Research, 194(2), 545-551.
https://doi.org/10.1007/s12011-019-01805-4

Đermanović M, Baralić I, Pejić S. Total Mercury Levels in Commercial Fish in Market of the Republic of Srpska, Bosnia and Herzegovina. in Biological Trace Element Research. 2020;194(2):545-551.
doi:10.1007/s12011-019-01805-4 .

Đermanović, Mirjana, Baralić, Ivana, Pejić, Snežana, "Total Mercury Levels in Commercial Fish in Market of the Republic of Srpska, Bosnia and Herzegovina" in Biological Trace Element Research, 194, no. 2 (2020):545-551,
https://doi.org/10.1007/s12011-019-01805-4 . .